ライフサイエンスコーパス: unmethylated

1 gnal amplification when they are unmodified (unmethylated).

2 ently catalyze C2 methylation if the site is unmethylated.

3 , in D2 embryos the transgene is essentially unmethylated.

4 possibility that Dnmt2-only genomes might be unmethylated.

5 ch lytic viral gene promoters remain largely unmethylated.

6 in exon definition, but only when Lys-77 is unmethylated.

7 dues within CpGs and those that were largely unmethylated.

8 d CpG islands show a strong preference to be unmethylated.

9 A methylation between generations and remain unmethylated.

10 sults suggest that the Ae. aegypti genome is unmethylated.

11 line where lytic viral promoters are largely unmethylated.

12 d that only transformed cells contained some unmethylated 12S rRNA transcripts, with all detectable 1

13 r IFIT1, IFN-responsive genes that recognize unmethylated 2'-O RNA, resulted in restored replication

14 igonucleotide in which the methylation of an unmethylated 5'-CG-3' site is enzymatically coupled to t

15 hree C5-methylated cytosine residues and one unmethylated 5'-CG-3' site.

16 ter, located in an intron of the neighboring unmethylated Aire gene.

17 onfirmed in vivo binding of Rex1 only to the unmethylated allele of these two regions.

18 show that CTCF binds to both methylated and unmethylated alleles of the KvDMR.

19 , and H4K91ac enrichment was specific to the unmethylated alleles.

20 e annotations associated with genes uniquely unmethylated among those with PTSD.

21 al for selectivity and stabilization, as the unmethylated analogue, mesoporphyrin IX, does not stabil

22 Nucleosomes reconstituted on an unmethylated and a methylated DNA both exhibit dynamic c

23 he approximately 70-repeat allele (which was unmethylated and associated with upregulation of C9orf72

24 most DNA methyltransferases operate at both unmethylated and hemi-methylated sites, BcgI methyltrans

25 design allows activity measurements on both unmethylated and hemimethylated DNA substrates.

26 preference for mCpG as compared to mismatch, unmethylated and hydroxymethylated DNA.

27 Then unmethylated and methylated complementary target ssDNA w

28 te the interaction between Dipyridamole with unmethylated and methylated cytosine.

29 ich significantly interacted with hybridized unmethylated and methylated DNA.

30 CP2) when free in solution and when bound to unmethylated and methylated DNA.

31 toimmune hepatitis exhibited lower levels of unmethylated and methylated INS compared with subjects w

32 that absolute levels (rather than ratios) of unmethylated and methylated INS DNA differ between subje

33 sed droplet digital PCR to measure levels of unmethylated and methylated INS DNA in serum from subjec

34 Our study shows that elevations in both unmethylated and methylated INS DNA occurs in new-onset

35 At 1 year postonset, both unmethylated and methylated INS DNA returned to control

36 mpared with control subjects, levels of both unmethylated and methylated INS DNA were elevated at T1D

37 tional differences were observed between the unmethylated and methylated nucleosomes.

38 Upon the addition of the target unmethylated and methylated ssDNA, the fluorescence inte

39 The compactness of both unmethylated and methylated tetra-nucleosomes is depende

40 and several prosurvival lymphoma genes were unmethylated and overexpressed.

41 The difference between the unmethylated and the methylated nucleosome persists with

42 FadE uses SBT unmethylated and untreated data to determine background

43 ing mammalian embryo, one allele of a DMD is unmethylated, and the opposite parental allele is methyl

44 ngly, in both patients and controls, DNA was unmethylated at a CpG island in PR3, whereas in healthy

45 domain (ARD) as a reader of histone H4 tails unmethylated at K20 (H4K20me0), which are specific to ne

46 ule that specifically binds histone H3 tails unmethylated at K4 and R2 and acetylated at two key lysi

47 ion enzyme (restriction glycosylase) excises unmethylated bases from its recognition sequence.

48 The transgene DNA fragment was unmethylated before it was injected into the pronucleus,

49 on1A within a potential CpG island, which is unmethylated both in cell lines and in primary lymphoma

50 drated membranes containing trimethylated or unmethylated bovine c8-rings and bacterial c10- or c11-r

51 In addition, FDM1 binds unmethylated but not methylated DNAs through its coiled-

52 ressed precisely when the neighboring CGI is unmethylated but remain silenced otherwise.

53 peri-tumoral lung tissues in which SOX30 was unmethylated, but was silenced or downregulated in lung

54 unoxidized C, rather than methylated C from unmethylated C.

55 s targeted preferentially towards mRNAs with unmethylated caps in contrast to the canonical decapping

56 DNA rich in unmethylated CG motifs (CpGs) engage Toll-Like Receptor

57 sociated Tremor Ataxia Syndrome, result from unmethylated CGG repeat expansions in the 5' untranslate

58 data also show that GC skew is predictive of unmethylated CGI promoters in a range of vertebrate spec

59 te DNA sequence, and both hemimethylated and unmethylated cognate DNA sequences.

60 egrates sequencing reads from methylated and unmethylated compartments and estimates CpG methylation

61 es were retained in the wells, distinct from unmethylated complexes.

62 ed CpG sites to current levels obtained with unmethylated copies of the DNA reveals the precise locat

63 nly observed when two head-to-head oriented, unmethylated copies of the site were present; single sit

64 stinguishes between the H3K9Me3 mark and its unmethylated counterpart.

65 were predictive of 5-hmC changes, suggesting unmethylated CpG and H3K4me2 as potential upstream signa

66 roducts such as lipopolysaccharide (LPS) and unmethylated CpG containing DNA to the liver via the por

67 holera toxin, E. coli labile toxin (LT), and unmethylated CpG dinucleotide (CpG).

68 The CXXC specifically binds to unmethylated CpG dinucleotide and positions the CXXC-BAH

69 G antibodies develop in humans against short unmethylated CpG dinucleotide sequences after administra

70 Oligodeoxynucleotides (ODNs) containing unmethylated CpG dinucleotides act as agonists of TLR9 a

71 es, including the classic Alb1 gene, contain unmethylated CpG dinucleotides and evidence of pioneer f

72 entify an autoinhibitory mechanism, in which unmethylated CpG dinucleotides are occluded from the act

73 , our results suggest that a high density of unmethylated CpG dinucleotides is sufficient for vertebr

74 ural (phosphodiester) backbone and show that unmethylated CpG dinucleotides within dsDNA are required

75 X CXXC domain binds DNA sequences containing unmethylated CpG dinucleotides, localizes to promoters a

76 n the CXXC3 domain of Mbd1, which recognizes unmethylated CpG dinucleotides.

77 ft changes between binding to methylated and unmethylated CpG dinucleotides.

78 Exposure of humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces thes

79 TLR9 recognizes unmethylated CpG DNA and induces innate immune responses

80 Toll-like receptor 9 (TLR9) recognizes unmethylated CpG DNA and is activated by fungal DNA.

81 Unmethylated CpG DNA signals through TLR9 to induce type

82 h a hyper-accessible state characteristic of unmethylated CpG island promoters.

83 ed by the preferential binding of TET1-FL to unmethylated CpG islands (CGIs) through its CXXC domain.

84 ET1 (TET1FL) has a CXXC domain that binds to unmethylated CpG islands (CGIs).

85 RNA markers of transcription initiation, and unmethylated CpG islands also overlapped significantly w

86 ated with exons as compared to introns while unmethylated CpG islands near transcription start sites

87 ment with an oligodeoxynucleotide containing unmethylated CpG motif (CpG-ODN) and alanyl-glutamine in

88 x structure, which specifically binds to the unmethylated CpG motif but in a completely different man

89 Oligodeoxynucleotides containing unmethylated CpG motifs act as ligands of Toll-like rece

90 Activation of TLR9 by direct injection of unmethylated CpG nucleotides into a tumor can induce a t

91 on of the TLR4 ligand LPS or the TLR9 ligand unmethylated CpG oligodeoxynucleotide before transient b

92 K plays an essential role in DC responses to unmethylated CpG oligodeoxynucleotide: although response

93 ntact sensitization and by adjuvants such as unmethylated CpG oligonucleotide (CpG) and LPS that indu

94 receptor, TLR9, which signals in response to unmethylated CpG sequences in microbial DNA.

95 whereas the presence of 6-thioguanine at the unmethylated CpG site abolished almost completely the me

96 gonucleotide with one hemimethylated and two unmethylated CpG sites, which are also recognition sites

97 ltransferase domains bound to DNA-containing unmethylated CpG sites.

98 Temporal changes of H3K4me2, unmethylated CpG, and H2A.Z were predictive of 5-hmC cha

99 Most vertebrate promoters lie in unmethylated CpG-dense islands, whereas methylation of t

100 During bacterial and viral infections, unmethylated CpG-DNA released by proliferating and dying

101 ed DNA; and a CXXC3 zinc finger, which binds unmethylated CpG-it is unclear whether these two domains

102 ay a bimodal distribution with enrichment of unmethylated CpGs and depletion of fully methylated CpGs

103 CxxC finger protein 1 (Cfp1), which binds to unmethylated CpGs and links H3K4me3 with CpG islands (CG

104 nzyme is a cost-effective method to pinpoint unmethylated CpGs at single base-pair resolution.

105 abnormal methylation of a subset of normally unmethylated CpGs, a characteristic of the CpG island me

106 ophils, showed a euchromatic CD177 promoter, unmethylated CpGs, and c-Jun and c-Fos binding.

107 Grouping unmethylated CpGs, characterized by high MSCC scores (7%

108 ronger localization to methylated as well as unmethylated CpGs.

109 drome tumors with MSH2 methylation than MSH2-unmethylated CRCs.

110 lfite conversion technique (i.e., converting unmethylated Cs to Us and then to Ts after PCR amplifica

111 risation in normal cells (CTCF binds to both unmethylated CTCF-BS3 and CTCF-BS2).

112 Oligodeoxynucleotides containing unmethylated cytidyl guanosyl dinucleotide motifs (CpG O

113 ion to accurately estimate the parameters of unmethylated cytosine (5C), 5mC and 5hmC from Infinium m

114 Intratumoral injection of an unmethylated cytosine guanine dinucleotide (CpG)-enriche

115 sulting in a gap that is then filled with an unmethylated cytosine nucleotide by as yet unknown DNA p

116 In contrast, the unmethylated cytosine's exocyclic N4 amino group (NH2) a

117 70 pM) in the presence of human stimulatory unmethylated cytosine-guanine-rich DNA A (hCpGAs).

118 lizes to methylated and, to a lesser degree, unmethylated cytosine-guanosine dinucleotides (CpGs), ye

119 In contrast, mouse macrophages contain unmethylated cytosine-phosphate-guanine (CpG) dinucleoti

120 Normal B cells can be activated by specific unmethylated cytosine-phosphate-guanosine (CpG) DNA moti

121 n of base-excision repair machinery restores unmethylated cytosine.

122 ision repair pathway that finally inserts an unmethylated cytosine.

123 hidden Markov model to distinguish 5-mC from unmethylated cytosine.

124 r one could explain the E446D preference for unmethylated cytosine.

125 ligodeoxynucleotide CpG 7909, which contains unmethylated cytosine/guanine (CpG) motifs, has potent i

126 ted cytosines over the sum of methylated and unmethylated cytosines at position 5 (%5mC)] varied acro

127 esses resulting in replacement of 5meCs with unmethylated cytosines is a hallmark of primordial germ

128 Unmethylated cytosines may be converted to uracil throug

129 Sodium bisulfite treatment (SBT) causes unmethylated cytosines to be sequenced as thymine, which

130 ges, whereas lipoteichoic acid and synthetic unmethylated deoxycytidine-deoxyguanosine dinucleotides,

131 odeoxyribonucleotides (ODNs) containing CpG (unmethylated deoxycytidylyl-deoxyguanosine dinucleotide)

132 y EP300 in the bodies of expressed genes are unmethylated despite the dense gene-body methylation sur

133 Although the Npas2 promoter remains largely unmethylated, differential Npas2 promoter occupancy of a

134 ons (177-plex) using dilutions of methylated/unmethylated DNA and in DNA from clinical lung cancer sa

135 hylated at lysine 4 correlated strongly with unmethylated DNA and occurred primarily at promoter regi

136 T1, and CGBP CXXC domains could each bind to unmethylated DNA but with differing affinity.

137 protein affinity for cytosine-methylated and unmethylated DNA duplexes or with the rates of AGT-media

138 ermore, the discrimination of methylated and unmethylated DNA is demonstrated in the presence of only

139 sform C. jejuni, whereas otherwise identical unmethylated DNA is not.

140 he endonuclease reaction of these enzymes on unmethylated DNA is preceded by bidirectional translocat

141 specific binding activity to methylated and unmethylated DNA motifs of distinct sequences.

142 y is sensitive to distinguish methylated and unmethylated DNA sequences at single CpG resolution by d

143 M enzymes need to interact with two separate unmethylated DNA sequences in inversely repeated head-to

144 ce with respect to relative adsorption of an unmethylated DNA source and this was detected using surf

145 While the two proteins bound unmethylated DNA with indistinguishable affinity, their

146 When MeCP2 binds to unmethylated DNA, H/DX is slowed several orders of magni

147 D3 MBD on hydroxymethylated, methylated, and unmethylated DNA.

148 fic endonuclease that cleaves methylated and unmethylated DNA.

149 crease in ionic blockage current relative to unmethylated DNA.

150 trodes in comparison to the adenine-enriched unmethylated DNA.

151 t would differentiate between methylated and unmethylated DNA.

152 onstrate that EcoKI becomes unstable on long unmethylated DNA; reuse of the methyltransferase subunit

153 ted in exhausted CD8(+) T cells and remained unmethylated even when virus titers decreased.

154 a level between that of fully methylated and unmethylated exons, highlighting gene context-dependent

155 Unmethylated, expressed HNF1B, primarily present in clea

156 ted host DNA and an endonuclease function on unmethylated foreign DNA.

157 MJD2A on the latent genome maintains H3K9 in unmethylated form and signals the readiness of specific

158 These results suggest that the unmethylated form of the EBV genome can undergo viral re

159 conversion of 5-methyl-cytosine back to the unmethylated form, the data were consistent with the use

160 The methylated and unmethylated forms of an oriLyt-containing plasmid repli

161 me-DNA complex methylates both strands of an unmethylated GATC site prior to dissociation from the DN

162 tients With Newly Diagnosed Glioblastoma and Unmethylated Gene Promoter Status; NCT00813943), and Rad

163 genes and had slower evolutionary rates than unmethylated genes, suggesting that WGD genes evolve mor

164 ave been reported to evolve more slowly than unmethylated genes.

165 Methylated genes evolve faster than unmethylated genes; DNA methylation changes between homo

166 ethylation establishment occurs on a largely unmethylated genome and in nondividing cells, making it

167 lular differentiation in organisms that have unmethylated genomes (such as Caenorhaditis elegans and

168 een organisms that have either methylated or unmethylated genomes, DNA methylation endows genomes wit

169 generally unavailable to organisms that have unmethylated genomes.

170 ion, smtB repression significantly increased unmethylated GlcCer levels and compromised filamentous g

171 Although increased levels of unmethylated GlcCer were observed in smtA and smtB mutan

172 that DeltasdeA accumulated C8-saturated and unmethylated GlcCer, while gcsA deletion impaired GlcCer

173 Three patients with MGMT unmethylated glioblastoma multiforme survived 6.5, 8.7,

174 robes selective for methylation-specific and unmethylated GSTP1 sequences were immobilized onto the s

175 G-rich strands, with a binding preference of unmethylated > 5hmCpG > 5mCpG, where methylated DNA-prot

176 rotein ca. -5.0 kcal/mol more favorably than unmethylated GTP.

177 ne mutants that mimicked the conformation of unmethylated H3 K79 increased the rate of silencing esta

178 erence for substrates with less methylation [unmethylated H3K27 (H3K27me0):me1:me2 k(cat)/K(m) ratio

179 show that the PHD1 preferentially recognizes unmethylated H3K4 histone tail, product of KDM5A-mediate

180 s able to predict the relative abundances of unmethylated, hemimethylated, fully methylated, and hydr

181 antly inhibited by stoichiometric amounts of unmethylated histone H3, but not by histones previously

182 ough its ability to bind both methylated and unmethylated histone residues.

183 teraction between Dnmt3-ADD domain with H3K4 unmethylated histone tails that is disrupted by histone

184 stablish the histone code on newly assembled unmethylated histones and thus may act as epigenetic mar

185 We found that this gene is unmethylated/hypomethylated and enriched in activating h

186 However, it has been suggested that the unmethylated IG-DMR acts as a positive regulator activat

187 nd H3 di- and tri-methylated lysine 4 on the unmethylated IGFBP3 promoter.

188 lize to Polycomb group target genes that are unmethylated in 11 different fetal tissue types, we show

189 Although the proximal promoter region was unmethylated in all three cell lines, methylation of a 4

190 s in the starting coding region were largely unmethylated in both groups.

191 glioma stem cells (GSC) and glioma cells but unmethylated in CD133+ve ones.

192 de IV primary glioblastomas (67.5%), but was unmethylated in grade I astrocytomas and in DNA from age

193 Surprisingly, the PD-1 promoter remained unmethylated in HIV-specific CD8 T cells from subjects w

194 In contrast, CpCpG sites remain unmethylated in IBM1-independent genes and do not promot

195 d that the insulin gene promoter is uniquely unmethylated in insulin-expressing pancreatic beta-cells

196 oter is embedded within a CpG island that is unmethylated in normal cells and is spanned by three DNa

197 bisulfite genome sequencing; whereas, it was unmethylated in normal cervical tissues (p < 0.05).

198 We also found that the SAMHD1 promoter is unmethylated in primary CD4(+) T lymphocytes, which expr

199 However, the ectopic ICR remains unmethylated in sperm.

200 at the transcriptional regulatory region was unmethylated in the PD-1(hi) HIV-specific CD8 T cells, w

201 an overlapping Pol II transcript and remain unmethylated in the presence of trans-acting 24-nt siRNA

202 tional regulatory region continued to remain unmethylated in these donor CD8 T cells generated from a

203 in secretion, indicating that the changes in unmethylated INS DNA are indicative of beta cell killing

204 t, methylated INS DNA remained elevated, but unmethylated INS DNA fell.

205 a-cell death by measuring relative levels of unmethylated INS DNA in serum and used it to measure bet

206 althy controls and higher than the levels of unmethylated INS DNA in the at-risk progressor and at-ri

207 We conclude that a blood test that measures unmethylated INS DNA serves as a marker of active beta c

208 who progressed to T1D had average levels of unmethylated INS DNA that were elevated modestly compare

209 Subjects at high risk for T1D had levels of unmethylated INS DNA that were higher than those of heal

210 progressed to T1D, the observed increases in unmethylated INS DNA were associated with decreases in i

211 ethylated TNFA promoter when compared to the unmethylated insert (P = 0.03).

212 with an assay that detects beta cell-derived unmethylated insulin (INS) DNA.

213 intensities or (iii) combined methylated and unmethylated intensities.

214 ns as a dual lysine reader, probing for both unmethylated K4 and methylated K9 modifications on the h

215 rrow binding pocket to selectively recognize unmethylated K4 of histone H3.

216 In backcrosses to an unmethylated Ler allele, the newly methylated F1 Ler seg

217 t to At3g43340 and At3g43350, the originally unmethylated Ler genomic segment receives the C24 (m)C p

218 Furthermore, serum unmethylated LINE-1 was at higher levels in both stage I

219 old selectivity in covalent labeling over an unmethylated lysine peptide.

220 ead family member FoxD3 is essential for the unmethylated mark observed at the Alb1 enhancer in ES ce

221 ifferentially methylated region (DMR) on the unmethylated maternal allele.

222 se to EBF:ER and Pax5:ER, resulting in fully unmethylated mb-1 promoters.

223 producible and clearly discriminated between unmethylated, methylated and even partially methylated D

224 The ratio of the unmethylated/methylated KLOTHO promoter DNA did not chan

225 results offer an explanation for how and why unmethylated microsatellite repeats can be destabilized

226 in enrichment of the targeted methylated or unmethylated minority-epigenetic-alleles.

227 onstrate that HESO1 is an enzyme uridylating unmethylated miRNAs and siRNAs in hen1.

228 lso suggest that uridylation may destabilize unmethylated miRNAs through an unknown mechanism and com

229 However, enzymes uridylating unmethylated miRNAs, siRNAs, or piRNAs in hen1 are unkno

230 e methylated molecule in approximately 5,000 unmethylated molecules in DNA from plasma or fecal sampl

231 e accomplished include the discrimination of unmethylated, mono-, di-, and trimethylated lysines on a

232 rthermore, KLF4 binds specific methylated or unmethylated motifs in human embryonic stem cells in viv

233 Capped but unmethylated mRNAs generated in yeast cells with a defec

234 Patients with unmethylated O(6)-methylguanine-DNA methyltransferase (M

235 gh expression of hepatocyte growth factor or unmethylated O(6)-methylguanine-DNA methyltransferase ma

236 n individual DNA molecules, we show that the unmethylated OCT4 distal enhancer has an NDR, whereas NA

237 y shift assays revealed increased binding of unmethylated oligos with nucleoproteins of cells maintai

238 t fraction of Cyclin D1 mRNA was found to be unmethylated on the mRNA cap and thus dormant in mammary

239 nt homeodomain (PHD(4-6)) of MLL4 recognizes unmethylated or asymmetrically dimethylated histone H4 A

240 ong known to exist in two functional states: unmethylated or methylated at the 5-position of the pyri

241 se results suggest that MBD2 targets NuRD to unmethylated or methylated CpG islands where its distinc

242 f human DNA and 668 KB of mouse DNA that was unmethylated or methylated in order to investigate the e

243 e versa (1425.1 for methylated vs 1828.0 for unmethylated; P < .001).

244 ed regions, with preferential binding to the unmethylated parental allele.

245 n precise inheritance of both methylated and unmethylated parental alleles.

246 f viral DNA regulates viral gene expression, unmethylated, partially methylated, and fully methylated

247 The Kcnq1ot1 non-coding RNA emerges from the unmethylated paternal KvDMR in antisense direction, resu

248 couraging survival results in methylated and unmethylated patients suggest that blocking AMPA recepto

249 Additionally, binding of NEAT2 to unmethylated Pc2 promotes E2F1 SUMOylation, leading to a

250 the consequence of binding of methylated and unmethylated Pc2 to the ncRNAs TUG1 and MALAT1/NEAT2, lo

251 Here we use antibodies specific for the unmethylated phosphatases to show that PP6 is carboxyl-m

252 ased on the ability of O-methylated (but not unmethylated) precursors to bypass the BioC requirement

253 rphology, implying the presence of a pool of unmethylated prenyl proteins in these cells under normal

254 f JMJD1A facilitates efficient production of unmethylated product from dimethyl-H3K9 and decreases th

255 y a full CGG repeat expansion but exhibit an unmethylated promoter and lack the FXS phenotype.

256 1 or -Dnmt3a fusion protein to methylated or unmethylated promoter sequences caused activation or sil

257 d when considering only those tumors with an unmethylated promoter, whereas the related factor, TFAP2

258 en highly methylated repetitive elements and unmethylated promoter-CGIs in normal tissues.

259 Noninduced proviruses have unmethylated promoters and are integrated into active tr

260 to regulate transcription of methylated and unmethylated promoters in a luciferase reporter assay.

261 entially induces H3K9 histone acetylation of unmethylated promoters in vivo.

262 d to repress transcription of methylated and unmethylated promoters.

263 -methylcytosine, 5-hydroxymethylcytosine and unmethylated proportions from methylation array data.

264 This activation requires an unmethylated PWS-IC in the gametes and during early embr

265 guish between methylated (petrogenic) versus unmethylated (pyrogenic) phenanthrenes; such antibodies

266 About 50% of MSCC-defined unmethylated regions do not overlap algorithm-defined CG

267 e cytosine methylation, it is less clear how unmethylated regions in mammalian genomes are protected

268 discovery rate), we found a large number of unmethylated regions not qualifying as CGIs located in i

269 lled restriction sites, whereas R recognizes unmethylated restriction sites as non-self and introduce

270 AtLSMT-L is able to interact with unmethylated Rubisco, but the complex is catalytically u

271 ed histone methylation pattern compared with unmethylated samples and that these changes are reversib

272 Oligonucleotide probes targeting unmethylated sequences generate local double stranded re

273 re, tethering SUVH2 with a zinc finger to an unmethylated site is sufficient to recruit Pol V and est

274 almost all Type IIB systems, BcgI needs two unmethylated sites for nuclease activity; it cuts both s

275 effect on the binding affinity of SP1 to the unmethylated sites in H9c2 cells, hearts of fetuses and

276 d target DNA methylation de novo at normally unmethylated sites in the genomes of root cells from a d

277 ot distinguish between hydroxymethylated and unmethylated sites.

278 moter was observed under HG, especially with unmethylated Sp-1 oligo.

279 ncreased in linear range by concentration of unmethylated ssDNA from 1.6 x 10(-15) to 6.6 x 10(-13)M

280 pendent on preservation of the methylated or unmethylated state and the type of sequence.

281 ial is correlated with and predictive of the unmethylated state of CGIs.

282 maintaining the transcriptionally active and unmethylated state of CpG island promoters.

283 tly, how sequence architecture mediates this unmethylated state remains unclear.

284 A hallmark of CpG islands is their unmethylated state, and determining how DNA methylation

285 ensity alone is a minor determinant of their unmethylated state.

286 ent conversion of dimethylated H3K9 into the unmethylated state.

287 the recognition of lysines in methylated and unmethylated states, whether they are substrates, reacti

288 We show that PRMT5-MEP50 prefers unmethylated substrates, consistent with a distributive

289 ess 60-fold higher ISG15 compared with SULF2 unmethylated (SULF2U) NSCLC cell lines and normal human

290 he PP2A catalytic subunit, selective for the unmethylated tail and perturbing/inactivating the phosph

291 We analyzed its association with an unmethylated target site on fluorescence-labeled DNA in

292 e stranded regions resulting to digestion of unmethylated targets, and leaving methylated targets int

293 However, 27 GANTC sites remained unmethylated throughout the cell cycle, suggesting that

294 Furthermore, switching from unmethylated to hemimethylated cognate DNA involves dete

295 Elevated ratios of circulating unmethylated to methylated preproinsulin (INS) DNA have

296 transcription from previously unidentified, unmethylated transcription start sites, suggesting that

297 iched with CpG sites, are hypomethylated and unmethylated under HG ambience and hyperglycemic states

298 ver development, these regions become highly unmethylated, which is a distinct trend from that observ

299 wo distinct chromatin configurations: one is unmethylated with an NDR upstream of the TSS; another is

300 er-associated genomic regions and are mostly unmethylated within highly methylated mammalian genomes.