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1 e percentage of the SGNs in this strain were unmyelinated.
2 missive neuronal somata and dendrites remain unmyelinated.
3 are immunopositive for VR1 are predominantly unmyelinated.
4 on postnatal day 1 (P1) when WM tracts were unmyelinated.
5 ent for NRG1 type III are disproportionately unmyelinated, aberrantly ensheathed, and hypomyelinated,
6 pha3 expression is similar in myelinated and unmyelinated adult sensory neurons, suggesting that ARTN
8 ehavioral responses and neuronal activity in unmyelinated afferent fibers were assessed in monkey aft
9 eceptor within skeletal muscle (localized to unmyelinated afferent fibres) elicits increases in MAP a
12 ta-methylene ATP suggest that myelinated and unmyelinated afferent pathways engage both mGluR-GABA me
13 of the sciatic nerve to trace myelinated and unmyelinated afferent terminations, respectively, in the
14 an with a tracer that labels non-peptidergic unmyelinated afferents (Griffonia simplicifolia isolecti
15 eA neurons received inputs derived from only unmyelinated afferents [transient receptor potential cat
16 nts is particularly surprising because these unmyelinated afferents are thought to respond to the gra
17 activates a subpopulation of myelinated and unmyelinated afferents in monkey, (4) the time course of
18 elated peptide and isolectin B4, and injured unmyelinated afferents labeled with vasoactive intestina
19 additional and separate phenotypic marker of unmyelinated afferents rather than operated by TRPV1.
20 l ganglion neurons (SGNs) are small caliber, unmyelinated afferents that extend dendritic arbors hund
21 sly uncharacterized subset of myelinated and unmyelinated afferents, few of which express the proinfl
22 ae I and IIo and in terminals of peptidergic unmyelinated afferents, it is suggested that presynaptic
34 r PNS myelination driving axonal wrapping by unmyelinated and myelinated Schwann cells and enhancing
36 istinct sodium channel alpha subunits to the unmyelinated and myelinated zones of the same retinal ga
37 morphometrically evaluated at intraorbital (unmyelinated and myelinated) and intracranial sections.
38 tive (NET-ir) axonal profiles were typically unmyelinated and occasionally were observed to form symm
39 Nociception is produced by stimulation of unmyelinated and small myelinated fibers in the joint an
40 ents from these neurons can be myelinated or unmyelinated and their terminals in these laminae can be
41 early overlapped in laminae I-II with normal unmyelinated and thin myelinated afferents labeled with
42 odulate afferent transmission by myelinated, unmyelinated, and peptidergic afferents in the dorsal ho
43 tigate its effect on the morphology of small unmyelinated as well as myelinated sensory axons and rel
44 , neocortical auditory fields are relatively unmyelinated at birth and only attain adult-like MFLD va
45 apses; (ii) postsynaptic disorders affecting unmyelinated auditory nerve dendrites; (iii) postsynapti
46 s in which the small, lightly myelinated and unmyelinated autonomic nerve fibres are selectively targ
49 conduction delays of action potentials in an unmyelinated axon depended on the history of activity an
50 region that corresponded most closely to the unmyelinated axon initial segment, as defined by Golgi a
52 ssociated with microstructural WM injury and unmyelinated axon loss at P1, diagnosed by diffusion ten
54 be explained in one of two ways: either the unmyelinated axon of the immature cerebral hemispheres i
56 odelling emphasises uncertainties about fine unmyelinated axon physiology but, when informed by biolo
59 daily to adult rats to examine its effect on unmyelinated axon-Schwann cell units in intact periphera
65 y to TAI, the present study examines whether unmyelinated axons also respond differentially to FK506,
66 ic level demonstrate that 32.4+/-2.9% of the unmyelinated axons and 21.6+/-4.7% of the myelinated axo
67 nfirmed the localization of endomorphin-2 to unmyelinated axons and axon terminals in the trigeminal
69 eurotrophins and tyrosine phosphorylation in unmyelinated axons and dendrites, where Na(V)1.2 channel
71 c profiles, but it was also present in small unmyelinated axons and in a few axon terminals and glia,
72 chwann cell proliferation and death, loss of unmyelinated axons and marked heat and cold pain insensi
73 DAT and TH were localized primarily in small unmyelinated axons and morphologically heterogeneous axo
74 omy) of the rat is highly selective, sparing unmyelinated axons and myelinated sensory axons; Walleri
75 rbB-family receptors in interactions between unmyelinated axons and non-myelinating Schwann cells in
76 rm cortex layers, which are characterized by unmyelinated axons and perisynaptic astroglial envelopes
77 athway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes
78 siological evidence, however, indicates that unmyelinated axons are more vulnerable than myelinated a
80 hough GLT1 is present on developing OLs when unmyelinated axons are prevalent in the developing rat c
81 all population of type II neurons with their unmyelinated axons are undetectable with most recording
82 oexpression, we studied large populations of unmyelinated axons by using quantitative single-label EM
87 ittle is known about repolarization in thin, unmyelinated axons forming en passant synapses, which re
89 s further substantiate a distinctive role of unmyelinated axons in TAI, and suggest a highly efficaci
90 studies to assess large myelinated and small unmyelinated axons in the db/db type II diabetes mouse m
92 rily on the plasma membrane of dendrites and unmyelinated axons in the hippocampus and cerebellum, wi
93 ecently, vesicular release of glutamate from unmyelinated axons in the rat corpus callosum has been s
95 s, which resulted in the segregation of many unmyelinated axons into a 1:1 relationship with Schwann
98 ve fibre layer (RNFL) is composed largely of unmyelinated axons of retinal ganglion cells, and is acc
102 nce of the large number of thin-diameter and unmyelinated axons that connect different cortical areas
103 slow-conducting, and energetically expensive unmyelinated axons to large, fast-conducting, and energe
105 etwork of 30 multicompartmental neurons with unmyelinated axons was used to infer that: axon-axon gap
106 ure myelinating Schwann cells (SCs), whereas unmyelinated axons were aberrantly ensheathed in Remak b
107 Two phases of increase in the number of unmyelinated axons were observed at C7, while only one s
108 he area occupied by glial cell processes and unmyelinated axons which significantly increased followi
111 small- and medium-sized myelinated and small unmyelinated axons, although sensory nerve action potent
112 N2D is predominantly expressed in dendrites, unmyelinated axons, and axon terminals within the STN.
113 abeling was seen in small axon terminals and unmyelinated axons, and the postsynaptic density (PSD) f
114 labeling was also present in numerous small unmyelinated axons, axon terminals, and glial processes.
116 ium channels are uniformly distributed along unmyelinated axons, but are highly concentrated at nodes
117 in this model may be the less myelinated or unmyelinated axons, extracellular matrix, or synaptic fi
118 noreactive (KOR-ir) neuronal structures were unmyelinated axons, followed by axon terminals, dendrite
119 sults are specific to signal transmission in unmyelinated axons, I suggest that the conclusions are l
120 es of partially denervated Schwann cells and unmyelinated axons, or the byproducts of Wallerian degen
122 and dendrites, but the proportion of labeled unmyelinated axons, terminals, and glia was higher than
124 cross the CC, presumably in conjunction with unmyelinated axons, to colonize the contralateral hemisp
125 ial afferents is exclusively associated with unmyelinated axons, VR1 identifies C-fiber afferent path
126 ain conduction times are especially great in unmyelinated axons, which may transmit information via f
136 axonal excitability and synaptic function in unmyelinated axons.SIGNIFICANCE STATEMENT Voltage-gated
137 es several new features of AP propagation in unmyelinated axons: (1) branches of a single axonal arbo
140 elinated A fibers and isolectin B4 (IB4) for unmyelinated C fibers and both labels were quantified in
142 These results further support the role of unmyelinated C fibers in injury-induced modulation of sp
143 t involved large Abeta myelinated fibers and unmyelinated C fibers were most affected by chemotherapy
144 ted with altered nerve function, we measured unmyelinated C-fiber conduction velocities (CV) in nerve
145 G neurons, whereas it was decreased in small unmyelinated C-fiber neurons as a result of diabetes.
146 with peripherin and isolectin B4 markers of unmyelinated C-fiber neurons; 68% colabeled with antibod
149 asodilation via antidromic activation of the unmyelinated C-fibers and/or the small myelinated fibers
152 myelinated dorsal root axons, but rarely in unmyelinated C-fibers, and heavily expressed in the dors
153 ry bladder consist of myelinated Adelta- and unmyelinated C-fibers, the neuronal cell bodies of which
157 bserve pruriceptive itch which includes both unmyelinated C-fibres and thinly myelinated Adelta nerve
159 to assess the changes in myelinated (A) and unmyelinated (C) cutaneous nociceptors after transection
160 inosa (SG) is a major termination region for unmyelinated (C) primary afferent fibers; however, how t
162 us (NTS) neurons via myelinated (A-type) and unmyelinated (C-type) axons in the solitary tract (ST).
163 taining glutamate homeostasis at a time when unmyelinated callosal axons are engaging in glutamatergi
164 of sensory neurons, including small-diameter unmyelinated cells that respond to capsaicin (but not mu
165 primary afferents but are also expressed in unmyelinated cranial visceral primary afferents linked t
166 Previous studies using reporter proteins in unmyelinated cultured neurons suggest that an ankyrinG-b
168 ng electrophysiological recordings of single unmyelinated cutaneous fibres and their compound action
169 ber tactile afferents are a subpopulation of unmyelinated cutaneous sensory neurons activated by gent
170 capable of firing at high frequencies, small unmyelinated DRG neurons typically display much lower ma
174 2 in the organ of Corti was localized to the unmyelinated efferent axons and their endings on the inn
176 ined the effects of C-peptide replacement on unmyelinated fiber function in the hind paw, sural nerve
178 d restored the diabetes-induced reduction of unmyelinated fiber number (P < 0.01) and mean axonal siz
179 tion of the sciatic nerve revealed a loss of unmyelinated fibers and extensive ultrastructural damage
182 ements of conduction velocity indicated that unmyelinated fibers are responsible for glutamatergic si
183 es revealed early preferential loss of small unmyelinated fibers followed by prominent demyelination
184 old reduction in the density of regenerating unmyelinated fibers in LAR-/- nerves distal to the crush
186 1.2 channels were predominately localized in unmyelinated fibers in the cortex, hippocampus, spinal c
188 otion that altered potassium homeostasis and unmyelinated fibers may represent a potential vehicle fo
190 n of the labeling patterns suggests that AEN unmyelinated fibers project primarily to the ventral tip
191 eripherin (a marker of thinly myelinated and unmyelinated fibers) or calcitonin gene-related peptide
192 se to cowhage is different in myelinated and unmyelinated fibers, (5) the time of peak itch sensation
193 ngs in hypertonic P18 kits decreased only in unmyelinated fibers, despite a loss in both myelinated a
194 ever, although 65% of the AEN is composed of unmyelinated fibers, it has not been determined whether
195 he role of degeneration of myelinated versus unmyelinated fibers, we investigated the effects of an L
196 amatic proliferation in the Schwann cells of unmyelinated fibers, which resulted in the segregation o
201 Moreover, SARM1 knockout mice do not lose unmyelinated fibres in the skin or myelinated axons in t
202 ity is a functional signature of a subset of unmyelinated fibres innervating the urinary bladder.
203 e activity from different sets of peripheral unmyelinated fibres through neural circuitry that includ
205 ns of propagating action potentials in small unmyelinated fibres, such as the axons within mammalian
206 r ablation of high-threshold, small-diameter unmyelinated group C nerve fibers (C-fibers) has limited
207 y the mechanisms underlying AP initiation in unmyelinated hippocampal mossy fibers of adult mice, we
209 positive for TRPV1 and CGRP and most likely unmyelinated, in that most colonic afferents were not po
211 es them as a poorly understood population of unmyelinated, low threshold mechanoreceptors (C-LTMRs).
212 terneurons suggests that myelinated, but not unmyelinated, LTMRs play a critical role in the expressi
214 Thus, sodium channel gating and density in unmyelinated mossy fiber axons appear to be specialized
216 but significantly improved measures of small unmyelinated nerve fiber architecture and function.
217 by the preprotachykinin A (PPT-A) gene, from unmyelinated nerve fibers (C-fibers) following noxious s
219 d objective measures of small myelinated and unmyelinated nerve fibers can improve in these diabetic
220 usor overactivity, there is up-regulation of unmyelinated nerve fibers expressing both the vanilloid
221 receptors are present on both myelinated and unmyelinated nerve fibers in human dental pulp and may p
222 d macrophages-preceded altered conduction of unmyelinated nerve fibers in SIV-infected macaques, sugg
223 and interweaving reported in humans and had unmyelinated nerve fibers within micrometers of the endo
225 By contrast, Pik3c3-deficient small-diameter unmyelinated neurons accumulated excessive numbers of ly
226 VGLUT3-persistent neurons are small-diameter unmyelinated neurons that are further divided into two s
227 mmetrical junction-like contacts between the unmyelinated neurons, 3) abnormal expression patterns fo
230 sitivity accompanied by marked neuropathy of unmyelinated nociceptive sensory axons terminating in th
231 ptic glomeruli, assumed to be the endings of unmyelinated nociceptive terminals, were found on these
232 ss MOR mRNA below this level, whereas small, unmyelinated nociceptors are likely to express above it.
237 ed receptor B4 marks a rare subpopulation of unmyelinated, nonpeptidergic sensory fibers that exclusi
238 le sources of the PERG bioelectric field are unmyelinated optic nerve axons adjacent to the sclera.
239 a clustering in the inner central retina and unmyelinated optic nerve regions, with microglia activat
244 iously reported findings, we also found that unmyelinated pathways contain only CB, whereas myelinate
245 , the vast majority of 5-HT1D-IR neurons are unmyelinated peptidergic afferents that distribute perip
246 sory neurons, slowing conduction velocity in unmyelinated peripheral nerve fibers, and stimulating re
247 on along the axonal membrane of nociceptive, unmyelinated peripheral nerve fibers, but clarifying the
250 scopic level, opsin labeling was confined to unmyelinated preterminal axons and small terminals that
252 mmunoelectron microscopy results, imply that unmyelinated primary afferent fibers terminating in the
253 mplicifolia (IB4) is selectively taken up by unmyelinated primary afferent fibers that terminate in t
254 L5 DRG that were labeled by IB4, a marker of unmyelinated primary afferent neurons, were largely abse
256 receive monosynaptic input from a subset of unmyelinated primary afferents and connect to other lami
260 of Wallerian and retrograde degeneration of unmyelinated retinal ganglion cell axons in living rats
261 de RGC dendrites, cell bodies and axons, the unmyelinated retinal nerve fiber layer and the myelinate
265 ament transport in contiguous myelinated and unmyelinated segments of axons in long-term myelinating
267 ger cross-sectional area than the contiguous unmyelinated segments, and this correlated with a local
270 pic analysis further revealed hypertrophy of unmyelinated sensory axons and a subset of myelinated ax
271 (>25 mm) regeneration of both myelinated and unmyelinated sensory axons with topographically correct
272 s is characterized by distal degeneration of unmyelinated sensory axons, similar to the "dying back"
274 anosensitive terminals of myelinated but not unmyelinated sensory fibers, whereas HCN2 and HCN4 were
275 ns between non-myelinating Schwann cells and unmyelinated sensory neuron axons that are critical for
280 eviously, we identified a rare population of unmyelinated sensory neurons in mice that express the G-
281 xpresser mice had increased numbers of small unmyelinated sensory neurons that express the tyrosine k
283 cteristics, including 1) large aggregates of unmyelinated SGNs in the apical and middle turns, 2) sym
284 a high degree of the "human-like" feature of unmyelinated SGNs that aggregate into neural clusters.
286 f axons in LKB1 mutants was most dramatic in unmyelinated small sensory fibers, whereas motor axons w
287 nitial myelinated part gives rise to several unmyelinated small-diameter branches that have a high nu
291 7.3 at heminodes, nodes, internodes, and the unmyelinated synaptic terminal segments beneath IHCs in
295 the possibility that glutamate release from unmyelinated vagal afferents may be regulated by a disti
297 provides excellent contrast visualization of unmyelinated white matter in the immature mouse brain.
298 is to functional electrical connectivity in unmyelinated WM fibers by conducting a longitudinal stud
300 In adult axons, Na(v)1.2 is localized to the unmyelinated zone, whereas Na(v)1.6 is specifically targ
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