ライフサイエンスコーパス: unnatural

1 Phosphorylation at natural (180) and unnatural (172) sites created two pure phospho-forms.

2 1-trihydroxyundecyl)-2H-pyran-2-one, and its unnatural 2R,4R-isomer starting from commercially availa

3 to the fact that this subfamily contains an unnatural 4,4-disubstitued glutamic acid, the synthesis

4 [3], mesocosms whose interior conditions are unnatural [4], and long-term correlation studies based o

5 ers were used in efficient syntheses of the "unnatural" 4aR,7aS,12bR-(+)-1) and its "natural" enantio

6 We also describe the synthesis of unnatural 6-O-sulfated CS pentasaccharides containing ei

7 the apparent free energy of partitioning of unnatural aliphatic amino acids on TM segments is propor

8 nthesis of a variety of types of natural and unnatural alpha-amino acid derivatives, with a wide rang

9 Unnatural alpha-amino acids form a family of essential m

10 to characterize the challenges attendant to unnatural alpha-amino amide synthesis.

11 plex peptides, particularly those containing unnatural alpha-amino amides.

12 ons, including both a canonical beta- and an unnatural alpha-anomeric configuration.

13 The unnatural alpha-Gal and beta-Man terminating antennae ca

14 aviolet irradiation of a photo-crosslinkable unnatural amino acid (UAA) cotranslationally incorporate

15 ally introduced into proteins by enabling an unnatural amino acid (Uaa) to selectively react with a p

16 ptor by genetically encoding a photoreactive unnatural amino acid (UAA).

17 essential HIV-1 protein biosynthesis through unnatural amino acid (UAA*)-mediated suppression of geno

18 onal aaRS to distinguish between a favorable unnatural amino acid (unAA) substrate from unfavorable n

19 ne WALP24 peptide labeled with the semirigid unnatural amino acid 4-(3,3,5,5-tetra-methyl-2,6-dioxo-4

20 CR1 (1-350) containing Mn(2+) chelated to an unnatural amino acid assists in the characterization of

21 eases the yield of protein, incorporating an unnatural amino acid at three sites, from unmeasurably l

22 improved second-generation synthesis of the unnatural amino acid components of the anticancer peptai

23 -linking coupled with mass spectrometry, and unnatural amino acid cross-linking.

24 2 substrate library, which also included the unnatural amino acid cyclohexylalanine (Cha) derivative

25 apoA-I specifically designed to include the unnatural amino acid exclusively at position 166.

26 As well, using a UV-crosslinking unnatural amino acid in KCNE1, we found EQQQQ and EQQ cr

27 arnessing proximity-enabled reactivity of an unnatural amino acid incorporated in the bait toward a t

28 Here, using unnatural amino acid incorporation and fluorine-19 nucle

29 ent advances are enhancing the efficiency of unnatural amino acid incorporation by creating and evolv

30 nstrate that tRNA levels can be limiting for unnatural amino acid incorporation efficiency, and we de

31 ns and highlight the exceptional capacity of unnatural amino acid incorporation for increasing our un

32 don suppression and related technologies for unnatural amino acid incorporation has greatly expanded

33 The efficiency of unnatural amino acid incorporation in response to the am

34 codons, to provide a substantial increase in unnatural amino acid incorporation in response to the UA

35 Unnatural amino acid incorporation into ion channels has

36 Improving the yield of unnatural amino acid incorporation is an important chall

37 ress in this area: (i) the low efficiency of unnatural amino acid incorporation that limits labeling

38 nstituted in vitro translation, quantitative unnatural amino acid incorporation via AUG codon reassig

39 Using unnatural amino acid incorporation, we demonstrate the r

40 transfer RNA (tRNA) synthetase/tRNA pair for unnatural amino acid incorporation.

41 pair enabling site-specific insertion of the unnatural amino acid into apoA-I.

42 ciently and site-specifically incorporate an unnatural amino acid into proteins.

43 In the present work, we incorporated an unnatural amino acid into the alpha-hemolysin (alphaHL)

44 We report a general unnatural amino acid mutagenesis approach to quantify th

45 ge-gated ion channels that have emerged from unnatural amino acid mutagenesis approaches.

46 nto AMPA receptors using genetically encoded unnatural amino acid mutagenesis in a mammalian cell lin

47 Further, unnatural amino acid mutagenesis is used to replace the

48 recision structural modifications enabled by unnatural amino acid mutagenesis on mammalian receptors

49 oteins expressed in Escherichia coli through unnatural amino acid mutagenesis using a Cnf-specific tR

50 ereoselective route to a masked form of this unnatural amino acid now enabled the synthesis of two of

51 For these studies, we have incorporated the unnatural amino acid p-acetyl-L-phenylalanine for specif

52 The unnatural amino acid p-acetylphenylalanine (pAcF) was si

53 By replacing LptD residues with an unnatural amino acid p-benzoyl-L-phenyalanine (pBPA) and

54 n suppression to introduce the photoreactive unnatural amino acid p-benzoyl-l-phenylalanine (BzF) at

55 By site-specific incorporation of the unnatural amino acid p-benzoyl-L-phenylalanine, a photor

56 incorporation of the UV photo-cross-linkable unnatural amino acid p-benzoyl-L-phenylalanine.

57 The unnatural amino acid p-Benzoylphenylalanine was successf

58 Here, we have used unnatural amino acid photo-cross-linking to investigate

59 not be feasible to separate the full-length unnatural amino acid protein from the truncated form.

60 mination of a chiral center derived from the unnatural amino acid R-alpha-methylcysteine makes the mo

61 gth overlap and highly selective natural and unnatural amino acid recognition sequences.

62 Many important and useful natural and unnatural amino acid salts can be produced in excellent

63 This approach provides hybrid natural and unnatural amino acid sequences, and thus we termed it th

64 This Perspective highlights the diversity of unnatural amino acid structures found in hit-to-lead and

65 ombination of self-labeling protein tags and unnatural amino acid technology permits the semisynthesi

66 Unnatural amino acid technology provides a degree of bio

67 he binding site of the binding protein using unnatural amino acid technology.

68 An unnatural amino acid termed a proline-templated glutamic

69 O-tert-Butyltyrosine (Tby) is an unnatural amino acid that can be site-specifically incor

70 Specifically, we report an unnatural amino acid that preferentially labels amine-pr

71 otein an appropriately "tuned" electrophilic unnatural amino acid that reacts with a native nucleophi

72 that binds to the hot spot, and selected an unnatural amino acid to incorporate, based on the struct

73 arget protein contains a genetically encoded unnatural amino acid with bioorthogonal reactivity and t

74 anted to report the utility of an unexplored unnatural amino acid, isothiocyanyl alanine ((NCS)Ala =

75 CLL1-alphaCD3, using the genetically encoded unnatural amino acid, p-acetylphenylalanine.

76 C identical withN stretching vibration of an unnatural amino acid, p-cyano-phenylalanine, to directly

77 We show, using a photoreactive, unnatural amino acid, that Asf1 tail residue 210 cross-l

78 addition, SIDEpro can accommodate any PTM or unnatural amino acid, thus providing a flexible predicti

79 Using next-generation sequencing and unnatural amino acid-mediated protein-DNA cross-linking,

80 age C-H oxidation to one containing a linear unnatural amino acid.

81 utilizing protein expressed with an alkynyl unnatural amino acid.

82 voltage-clamp fluorometry with a fluorescent unnatural amino acid.

83 Two stabilized derivatives incorporating unnatural amino acids ((68)Ga-SH01078 and (68)Ga-P03034)

84 The ability to incorporate unnatural amino acids (UAA) into proteins in a site spec

85 nsporter protein to encode photocrosslinking unnatural amino acids (UAAs) into 75 different positions

86 rm is reported that enables incorporation of unnatural amino acids (UAAs) into specific sites on the

87 combining mRNA display with incorporation of unnatural amino acids and "click" chemistry.

88 fted toward site-specific modification using unnatural amino acids and engineered site-selective amin

89 n reaction was applied to the preparation of unnatural amino acids and geometrically controlled tri-

90 on the in vivo incorporation of fluorescent unnatural amino acids and their analysis by steady-state

91 Methods for installing natural and unnatural amino acids and their modifications into prote

92 Among them, silicon-containing unnatural amino acids are becoming an interesting new cl

93 specifically incorporating multiple distinct unnatural amino acids are hampered by their low efficien

94 bility and unique conformational properties, unnatural amino acids are highly valued by pharmaceutica

95 In engineered systems, unnatural amino acids are incorporated into proteins to

96 F1, we increase the yield of protein bearing unnatural amino acids at a single site 17- to 20-fold.

97 r demonstrate that IQF substrates containing unnatural amino acids can be used to investigate proteas

98 sical properties of three of the fluorescent unnatural amino acids from two classes were also studied

99 elanogaster) and the incorporation of useful unnatural amino acids has been aided by the development

100 ally-encoded, site-specific incorporation of unnatural amino acids in regions essential for activatio

101 nd enables the preparation of Fmoc-protected unnatural amino acids in three steps.

102 er RNAs to encode numerous pairs of distinct unnatural amino acids into a single protein expressed in

103 However, the efficient incorporation of unnatural amino acids into proteins and the specific, fl

104 The efficient, site-specific introduction of unnatural amino acids into proteins in mammalian cells i

105 Site-specific incorporation of unnatural amino acids into proteins provides a powerful

106 principles and methods for incorporation of unnatural amino acids into proteins.

107 bles efficient, homogeneous incorporation of unnatural amino acids into target proteins in diverse ma

108 e basis for ion selectivity by incorporating unnatural amino acids into the channel, engineering chan

109 urements, because efficient incorporation of unnatural amino acids is limited to transient expression

110 Genetically encoded unnatural amino acids provide powerful strategies for mo

111 o acids are transformed to twenty-one chiral unnatural amino acids representing seven distinct functi

112 achieved using peptide libraries containing unnatural amino acids such as the hybrid combinatorial s

113 eted cellular proteins with versions bearing unnatural amino acids that allow imaging or synthetic re

114 The expression of proteins containing unnatural amino acids through suppression of a stop codo

115 tantially enhanced this by incorporating 102 unnatural amino acids to explore the S1-S4 pockets of hu

116 This method entails the incorporation of unnatural amino acids to site-specifically label protein

117 We genetically encoded four unnatural amino acids with a diverse set of functional g

118 mized system, we produce proteins containing unnatural amino acids with comparable yields to a protei

119 eral strategy for labelling pairs of encoded unnatural amino acids with different probes via rapid an

120 labeling of proteins at genetically encoded unnatural amino acids with distinct small molecules at p

121 The synthesis of unnatural amino acids with small side-chain functionalit

122 The synthesis of a third class of unnatural amino acids, amino tetrazolyl alanines ((ATz)A

123 ing novel self-associating peptides based on unnatural amino acids, and inhibitor peptides of detrime

124 the amino acid sequence, the introduction of unnatural amino acids, and labeling with stable isotopes

125 ry is applied to the gram-scale syntheses of unnatural amino acids, bioactive molecules, and chiral b

126 sters, which may be regarded as novel hybrid unnatural amino acids, during the peptide synthesis itse

127 Receptors rescued by incorporation of unnatural amino acids, including p-benzoyl-l-phenylalani

128 or labeling through genetic incorporation of unnatural amino acids, lanthanide resonance energy trans

129 es rely mainly on traditional coupling using unnatural amino acids, postsynthetic modification of pep

130 Ita), for the synthesis of another class of unnatural amino acids, thioureayl alanines ((TU)Ala = Tu

131 s-linking experiments with photo-activatable unnatural amino acids, we show that full-length BACE1, i

132 g selective modification of both natural and unnatural amino acids--each with merits and limitations-

133 n through the site-directed incorporation of unnatural amino acids.

134 photostabilizer and biomolecular target via unnatural amino acids.

135 ish eight tripeptides, each having different unnatural amino acids.

136 nalogues in which Phe(13) was substituted by unnatural amino acids.

137 ent structure (7) was replaced by natural or unnatural amino acids.

138 or efficiently designing peptides containing unnatural amino acids.

139 post-translational modifications (PTMs) and unnatural amino acids.

140 brary (HyCoSuL), which uses both natural and unnatural amino acids.

141 Using unnatural amino-acid mutagenesis, we subtly altered the

142 usly provided farnesol, geranylgeraniol, and unnatural analogs of these isoprenols containing an anil

143 e triphosphates enforces initiation with the unnatural analogue, yielding 5'-end modified transcripts

144 elective mutasynthesis lead to production of unnatural analogues cahuitamycins D and E of increased p

145 using the azumamides along with a series of unnatural analogues obtained through chemical synthesis.

146 Further modifications with unnatural and modified amino acids resulted in novel met

147 for all-cause mortality and for an array of unnatural and natural causes of death among patients rec

148 ray dried betanin samples were described as 'unnatural' and 'artificial' whereas the colour of beetro

149 rent unnatural codons and tRNAs with cognate unnatural anticodons, and their efficient decoding at th

150 Herein, we use two unnatural aromatic amino acids and several spectroscopic

151 exchange of the Tyr9 residue with different unnatural aromatic amino acids.

152 The synthesis of bioinspired unnatural backbones leading to foldamers can provide eff

153 g., helices, sheets) have been produced from unnatural backbones, yet examples of tertiary folds comb

154 S techniques often lead to quick fatigue and unnatural ballistic movements.

155 NAPII) to transcribe across many natural and unnatural barriers, and this transcription across barrie

156 We demonstrate that the unnatural base analogue 7-deazaguanine (7dG) will suppre

157 We have developed an unnatural base pair (UBP) and a semisynthetic organism (

158 two synthetic nucleotides that form a third, unnatural base pair (UBP) have recently yielded three pr

159 s them to replicate a plasmid containing the unnatural base pair dNaM-dTPT3.

160 ts significant progress toward developing an unnatural base pair for the in vivo expansion of an orga

161 ino acid, and efficient participation of the unnatural base pair in decoding at the ribosome.

162 mation requires in vivo transcription of the unnatural base pair into mRNA and tRNA, aminoacylation o

163 These marker nucleotides constitute an unnatural base pair, allowing large quantities of marked

164 rs two additional letters that form a third, unnatural base pair.

165 increased information, we have developed the unnatural base pairs (UBPs) dNaM and d5SICS or dTPT3 (dN

166 We have developed a family of unnatural base pairs (UBPs), which rely on hydrophobic a

167 lphabet has been expanded to include several unnatural base pairs (UBPs).

168 We synthesized a panel of unnatural base pairs whose pairing depends on hydrophobi

169 ini-hairpin DNA provides robust stability to unnatural-base DNA aptamers generated by SELEX using gen

170 resent a remodeling method for high-affinity unnatural-base DNA aptamers to augment their thermal sta

171 ever, this minimal model tends to produce an unnatural behaviour where several smaller aggregates eme

172 ows for the direct formation of a variety of unnatural biaryl-containing amino acids in good to excel

173 Two unnatural bromo-chloro-malbrancheamide analogues were ge

174 of the native side chains is displayed on an unnatural building block to generate a heterogeneous bac

175 diversity of chemically plausible (including unnatural but functionally relevant) side chains is not

176 ng a logical, synthetic array of natural and unnatural C10, C20, C30, and C40 polyisoprenol sugar pyr

177 ifferently access to the natural C20-(R) and unnatural C20-(S) configurations.

178 mbers of organic compounds, both natural and unnatural, cannot be overstated.

179 ications for the biosynthesis of natural and unnatural carbohydrates.

180 Unnatural cause of death represented 40.6% of fatalities

181 of child, sibling or spouse, and loss due to unnatural cause were analyzed separately (P for trend or

182 and sub-hazard ratios for natural-cause and unnatural-cause mortality were lower in most ethnic mino

183 icides (7.65, 95% CI 6.43-9.04), non-suicide unnatural causes (4.01, 3.34-4.78), respiratory disease

184 causes (diseases and medical conditions) or unnatural causes (suicides, accidents, and homicides).

185 Similar patterns were found for natural and unnatural causes of death.

186 pool mortality ratios for all, natural, and unnatural causes of death.

187 The risk of death by natural or unnatural causes was significantly higher among persons

188 al causes; MRR, 2.61 [95% CI, 1.91-3.47] for unnatural causes) than among the general population.

189 sorders were due to natural causes, 17.5% to unnatural causes, and the remainder to other or unknown

190 ity in ADHD was mainly driven by deaths from unnatural causes, especially accidents.

191 -risk group (5.5% compared with 2.5%) due to unnatural causes, with a nearly 8-year difference in the

192 Unnatural chemically modified nucleotide sugars UDP-4-N3

193 dNaM and dTPT3 into mRNAs with two different unnatural codons and tRNAs with cognate unnatural antico

194 c "chemical transducer" that can generate an unnatural communication channel between two proteins is

195 bility to cross-communicate with natural and unnatural complements in both enantiomeric forms.

196 stereocenters are found in many natural and unnatural compounds.

197 ile stereoselective syntheses of natural and unnatural conjugated alkenyl(methyl)maleic anhydrides ha

198 termine this key interaction, we designed an unnatural d-amino acid dipeptide that is metabolically i

199 ying a potential primary PBP responsible for unnatural D-amino acid incorporation and gaining insight

200 omprehensively establish the tolerability of unnatural D-amino acids by PBPs in both Gram-positive an

201 Metabolic peptidoglycan remodeling via unnatural D-amino acids has provided unique insights int

202 s that govern the metabolic incorporation of unnatural D-amino acids into bacterial peptidoglycan.

203 ngly, bacteria can metabolically incorporate unnatural D-amino acids into the peptidoglycan stem pept

204 Incorporation of the unnatural d-proline ((D)P) stereoisomer into a polypepti

205 The relative risk for unnatural death (IRR, 25.0; 95% CI, 22.0-28.4) was much

206 selected cases of natural and non-suspicious unnatural death referred to Her Majesty's (HM) Coroners.

207 Parental unnatural death was associated with a higher mortality r

208 X-ray diffraction structure of one of these unnatural derivatives complexed to an anti-MUC1 monoclon

209 he stereochemistry of the title compound, an unnatural diastereomer, and of a decalin building block

210 ay crystal structure analysis of natural and unnatural diastereomers of polyhalogenated stereohexads.

211 f the discharge, although streamflow came in unnatural diurnal pulses.

212 The correct function of this unnatural DNA linker in human cells is demonstrated here

213 controlled de novo synthesis of l-NBDNJ (the unnatural enantiomer of the iminosugar drug Miglustat) a

214 al synthesis of both (-)-mitragynine and its unnatural enantiomer, (+)-mitragynine, employing a proli

215 A range of unnatural enantiopure fluorinated alpha-amino acids were

216 netics and gain-of-function processing of an unnatural, epimerized hexaketide.

217 stigations and methods, many of which create unnatural experimental conditions.

218 roism spectra which are mirror imaged if the unnatural FDFD-analogue is used.

219 ded genetic information systems (AEGISs) are unnatural forms of DNA that increase the number of indep

220 chemical properties of glycans or introduce unnatural functional groups through metabolic labeling a

221 e would enable the selective introduction of unnatural functionality.

222 (GlcNAc), N-acetyllactosamine (LacNAc), and unnatural Galalpha(1,4)-GlcNAc and Manbeta(1,4)-GlcNAc a

223 ith both, the natural (Gb3-R) as well as the unnatural (Gb3-S) configuration of the 2OH group.

224 Threose nucleic acid (TNA) is an unnatural genetic polymer capable of undergoing Darwinia

225 engineering natural polymerases to replicate unnatural genetic polymers is a challenging problem.

226 Moreover, unnatural glycans on the tumor cell surface were conjuga

227 cific metabolic precursors that can generate unnatural glycans on the tumor-cell surface.

228 developed to enable tumor cells to generate unnatural glycans that contain azide groups.

229 ial lack of immune suppression, render these unnatural glycopeptides promising candidates for designi

230 ersensitive to IFN-alpha in lymphocytes from unnatural hosts, indicating that the antiviral state can

231 oach might lead to artificial results due to unnatural hydrophobic interactions.

232 The resulting "unnatural killer cells" hold promise as an effective mea

233 d methodology also provides direct access to unnatural L-carbohydrates from the (S)-glyceraldehyde pr

234 rably binding and incorporating D-dNTPs over unnatural L-dNTPs during DNA synthesis.

235 alian cells with exogenous lipids, including unnatural lipids.

236 oorganism tolerance and enzyme processing of unnatural malonyl-ACP analogues, as well as on the amena

237 ediates, and their prevalence in natural and unnatural materials.

238 r type I polyketide synthases (PKSs) to make unnatural metabolites commonly results in attenuated yie

239 biosynthetic gene clusters (BGCs) to produce unnatural metabolites with improved properties are often

240 le combinations of PIX-protein scaffolds and unnatural metal cofactors to catalyse a wide range of ab

241 erials based on coiled-coil peptides bearing unnatural metal-chelating terpyridine moieties.

242 side chains are constructed chemically, many unnatural modifications can also be directly introduced

243 the cell wall polymer lignin to incorporate unnatural monomer units.

244 ether activation responses to natural versus unnatural motion in primary dystonia differ from normal,

245 s during the perception of 'natural' versus 'unnatural' motion (defined respectively as trajectories

246 ver, in their responses to 'natural' versus 'unnatural' motion in these regions.

247 and during the perception of 'natural' and 'unnatural' motion.

248 ter during the perception of natural (versus unnatural) motion (P < 0.05).

249 ification of peptide nucleic acid (PNA) with unnatural nucleobases enables the formation of PNA-RNA t

250 organism (SSO) that imports the constituent unnatural nucleoside triphosphates and uses them to repl

251 esents new and unprecedented challenges: the unnatural nucleoside triphosphates must be available ins

252 l products were prepared along with numerous unnatural oligomeric congeners to provide rapid access t

253 egradation, and when properly designed these unnatural oligomers can mimic the protein-recognition pr

254 enantioselectivity observed with these novel unnatural organocatalysts is opposite to that obtained w

255 3 to 1.2%) of the same genotypes indicate an unnatural origin.

256 A short total synthesis of the novel unnatural parthenolide diastereomer (+/-)-4,5-dia-parthe

257 irections are seen also in helices formed by unnatural peptidic backbones, e.g., those containing bet

258 hesis of (+/-)-phaeosphaeride B (1d) and the unnatural phaeosphaeride 1b is reported.

259 The unnatural phosphinic dipeptide analogs exhibited a high

260 Using an unnatural, photocross-linkable amino acid, azidophenylal

261 er, many of these methods require the use of unnatural PLA2 substrates that may alter enzyme kinetics

262 HVD, we have substituted this region with an unnatural polyethylenglycol (PEG) linker by using oxime

263 presence of the probes generated a range of unnatural polyketide derivatives, including novel putati

264 analogues, as well as on the amenability of unnatural polyketides to further structural modification

265 cluding the peptidyl-transferase center, for unnatural polymer synthesis in cells.

266 facilitate the encoded cellular synthesis of unnatural polymers by orthogonal translation systems.

267 rmations enable a wide diversity of natural, unnatural, posttranslationally modified (methylated, gly

268 t from other related prodigiosin natural and unnatural products and is even more intriguing in the ab

269 t may have significance in context of fixing unnatural pyranoside conformation with the help of silyl

270 mance of natural protein structures with the unnatural reactivity of transition-metal catalytic cente

271 ed a dependence on the position at which the unnatural residue was incorporated.

272 stem also allows the facile incorporation of unnatural side chains to improve activity and probe the

273 ity displayed by PBPs in tolerating entirely unnatural side chains.

274 e of externalization; when spectral cues are unnatural, sounds are perceived as closer to the listene

275 ectrical microstimulation resulted in highly unnatural spatial activation of cortex, whereas optical

276 However, RBC storage is an unnatural state, resulting in complicated biological cha

277 ascade reactions resulting in the natural or unnatural steroid skeletons.

278 4000-fold increase in the specificity for an unnatural substrate.

279 ivator than any other known ASCT2 natural or unnatural substrate.

280 (TE) domain catalytic bottleneck processing unnatural substrates in the pikromycin (Pik) system, pre

281 nctions as a gatekeeper in the processing of unnatural substrates.

282 esigner glycans in bacteria, some containing unnatural sugars, and techniques for evolving glycosylat

283 rse thiolactomycin analogues and prepared an unnatural thiotetroamide C analogue with potentiated bio

284 Both the natural cis and unnatural trans 6,6-membered ring systems proved accessi

285 This generates ssDNA molecules containing an unnatural triazole-linked DNA backbone that is sufficien

286 y, bound to an siRNA guide strand bearing an unnatural triazolyl nucleotide at position 1 (g1).

287 odactylum tricornutum, imports the requisite unnatural triphosphates from its medium and then uses th

288 Neither the presence of the unnatural triphosphates nor the replication of the UBP i

289 dogenous polymerases must be able to use the unnatural triphosphates to faithfully replicate DNA cont

290 e now report the synthesis and evaluation of unnatural triphosphates with their beta,gamma-bridging o

291 east in part limited by the stability of the unnatural triphosphates, which are degraded by cellular

292 nding energies of tyrosine (Tyr) and several unnatural Tyr analogs, to several orthogonal aaRSes deri

293 bserved using site specifically incorporated unnatural tyrosine analogs; however, equilibration betwe

294 These unnatural UDP sugar products were then tested for incorp

295 the natural substrate, UDP-GlcNAc, over the unnatural UDP-GlcNDAz.

296 The resulting unnatural UDP-sugar donors were then tested as substrate

297 Unnatural uridine diphosphate (UDP)-sugar donors, UDP-4-

298 Homogeneous PAR oligomers and unnatural variants produced from chemical synthesis will

299 relatively greater during the perception of unnatural (versus natural) motion (P < 0.01).

300 tegy for accessing peptide chains containing unnatural vinyl glycine amino acid residues.