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1 of stress (rendering aggression risky and/or unnecessary).
2 agments, for site-directed mutagenesis it is unnecessary.
3 reshold currents or synaptic facilitation is unnecessary.
4 ge change in albuminuria from baseline seems unnecessary.
5 ose, thus indicating that multiple doses are unnecessary.
6 ns, since time-consuming culturing steps are unnecessary.
7 oups directly, rendering community detection unnecessary.
8 e GAS detection, making culture confirmation unnecessary.
9 g wakefulness, even when hypocapnia makes it unnecessary.
10 d dose has limited benefit and appears to be unnecessary.
11  on the use of repackaged bevacizumab may be unnecessary.
12 ining anti-HCV therapy is discriminatory and unnecessary.
13 y was confirmed and intestinal biopsies were unnecessary.
14  be computationally prohibitive and is often unnecessary.
15 king preoperative common duct investigations unnecessary.
16 ime of conception are likely unwarranted and unnecessary.
17 lth regarded specialist follow-up as largely unnecessary.
18  employ tools, using them even when they are unnecessary.
19 (HBED), making subsequent purification steps unnecessary.
20 licitly, thus rendering such transformations unnecessary.
21 ll-cohort estimates were similar, making IPW unnecessary.
22 sk and hopefully make implantation of an ICD unnecessary.
23 n in controls, where getting off the mat was unnecessary.
24                                  Because the unnecessary activation of a defense is costly, the shame
25 ecrease turnaround times and the duration of unnecessary acyclovir therapy.
26 ate aRT might reduce overtreatment, decrease unnecessary adverse effects, and reduce risk of CR in th
27 f random Raman lasing renders directionality unnecessary, allowing for the detection and identificati
28  stronger recognition tag, the E-tags become unnecessary and ClpX's preference for the complex over M
29    In the latter case, compensation would be unnecessary and even deleterious.
30  as dichotomous even when dichotomization is unnecessary and misleading, as in inferences based on wh
31 sion on when to start antiretroviral therapy unnecessary and that, instead, efforts should be aimed a
32 ly stable patients was that a sternotomy was unnecessary and the cardiac injury, if present, had seal
33                                Study-defined unnecessary angiography occurred in 69 (28.8%) in the NI
34 on by CMR resulted in a lower probability of unnecessary angiography within 12 months than NICE guide
35 1%) in the MPS group; adjusted odds ratio of unnecessary angiography: CMR group vs NICE guidelines gr
36 nosis of UTI were common and associated with unnecessary antibiotic exposure and missed STI diagnoses
37                                              Unnecessary antibiotic prescribing contributes to antimi
38 l infection, many children worldwide receive unnecessary antibiotic treatment, while bacterial infect
39  hospitals is 2.9%, potentially resulting in unnecessary antibiotic use and excessive therapy costs.
40 ibiotics with the highest risks and reducing unnecessary antibiotic use are important strategies for
41 uses might improve clinical care by reducing unnecessary antibiotic use, shortening length of hospita
42 l to identify non-influenza viruses to avoid unnecessary antibiotic use.
43                                              Unnecessary antibiotics and hospitalization for misdiagn
44  ultimate diagnosis, and 48 (92.3%) received unnecessary antibiotics.
45 nd Clostridium difficile infections, halting unnecessary antimicrobial use has become one of the larg
46 hods, eliciting risk awareness, and avoiding unnecessary anxiety among the public.
47   The primary outcome was the elimination of unnecessary appointments with a dermatologist.
48 cne by primary care clinicians may eliminate unnecessary appointments, reduce wait time for treatment
49                         Savings from averted unnecessary ART costs were greater than retesting costs
50                                   To prevent unnecessary attendance at the cooperatives, physicians a
51 D1 axis maintains homeostasis by suppressing unnecessary autophagic breakdown of cellular components,
52 tam antibiotics is common and often leads to unnecessary avoidance in patients who could tolerate the
53  The exoribonuclease activity of RNase BN is unnecessary because all its action on 6S RNA is due to e
54 screening for extensive hip osteonecrosis is unnecessary because their risk is low and lesions tend t
55                     Moreover, it can prevent unnecessary biopsies and orchidectomies, and can maintai
56  Due to its 100 % NPV, Simtomax could reduce unnecessary biopsies by 66 % if only those with a positi
57 t before first prostate biopsy, could reduce unnecessary biopsies by a quarter.
58 arm clearly exists, including a high rate of unnecessary biopsies, possibly resulting in cosmetic or,
59  levels and could reduce the total number of unnecessary biopsies.
60  mammography or US and can help avoid 92% of unnecessary biopsies.
61 tiate normal from abnormal growth and reduce unnecessary biopsies.
62 rinary testing for T2:ERG and PCA3 can avert unnecessary biopsy while retaining robust sensitivity fo
63 y to increase screening rates, thus reducing unnecessary blindness.
64 ] and platelet count), and its use may avoid unnecessary blood product transfusion in patients with c
65 ric MR imaging may have potentially obviated unnecessary breast biopsies in six of eight lesions (P =
66 atients with high PSA levels have to undergo unnecessary but physically painful and expensive procedu
67 se of the hierarchic data structure to avoid unnecessary calculation, especially for collision detect
68  should be interpreted with caution to avoid unnecessary cardiac interventions.
69  for a tumor or abscess, which may result in unnecessary cardiac surgery.
70 rove quality and reduce costs by eliminating unnecessary care.
71 ncludes, sperm are streamlined by discarding unnecessary cellular components into cellular wastebags
72 alidated with additional procedures to avoid unnecessary cessation of valuable medication.
73 s can result in either cancer progression or unnecessary chemotherapy.
74 a safe reduction of approximately 25%-37% of unnecessary chest CTs.
75 and implement programmes at scale to prevent unnecessary child deaths.
76                      To reduce the burden of unnecessary colonoscopies and alleviate colonoscopy capa
77 individuals required at least one additional unnecessary computed tomography scan or magnetic resonan
78                     In turn, this has caused unnecessary concern among patients and prescribers.
79 enclature for atopic dermatitis (AD) creates unnecessary confusion for patients, healthcare providers
80 nders hospital improvement efforts by adding unnecessary confusion to the already complex arena of pe
81         Exosomes likely remove excess and/or unnecessary constituents from the cells, functioning lik
82 sed healthcare costs, longer hospital stays, unnecessary consultations, and inappropriate use of anti
83  of this policy commitment would also render unnecessary continued substantial expenditure on fossil
84   The primary end point was protocol-defined unnecessary coronary angiography (normal fractional flow
85 nts represents a substantial and potentially unnecessary cost for state-funded systems.
86 cols that incorporate these DIs may decrease unnecessary costs and radiation exposure in the dispropo
87 SNP-CROP maximizes data usage by eliminating unnecessary data culling due to imposed read-length unif
88  vision will prevent hundreds of millions of unnecessary deaths during the remainder of this century
89 relaxation, poor ventilator synchronization, unnecessary deep sedation, agitation, and an overall opt
90 quires the avoidance of pain, agitation, and unnecessary deep sedation, but these outcomes are challe
91 tects the discontinuous daughter strand from unnecessary degradation by MMR machinery.
92        In addition, we have established that unnecessary degradation of the discontinuous strand that
93 P folding flux and minimizes aggregation and unnecessary degradation.
94                           The elimination of unnecessary degrees of freedom has opened up large-scale
95      Reaction times thus include a seemingly unnecessary delay that accounts for approximately one-th
96 ood functional outcome remains uncertain and unnecessary delays to treatment may be faced while monit
97 in 36% of all referred patients), and avoids unnecessary desensitizations in nonhypersensitive patien
98                                              Unnecessary diagnostic imaging leads to higher costs, lo
99 mpiric diet with few food triggers, avoiding unnecessary dietary restrictions, saving endoscopies, an
100 inology that may cause confusion and lead to unnecessary dietary restrictions.
101 hould be performed safely and early to avoid unnecessary diets.
102 lly avoidable risk factors continue to cause unnecessary disability and premature death in older peop
103  of discard may contribute to minimizing the unnecessary discard of organs.
104 utilization and develop strategies to reduce unnecessary discard.
105 port includes a treatment plan that prevents unnecessary discontinuation of therapy.
106 ack and believes that this tool may decrease unnecessary download requests, while still facilitating
107 tem planning and implementation should avoid unnecessary duplication of services.
108  (eg, pulmonary visit) or when follow-up was unnecessary (eg, in patients with a terminal illness).
109                       US diagnosis can avoid unnecessary emergency surgical treatment, required in ca
110 gorithm was similar and would have spared 19 unnecessary esophagectomies and 16 explorative laparotom
111 e performed in cirrhosis patients to prevent unnecessary esophagogastroduodenoscopy.
112 ation of the CDV FAT to these samples avoids unnecessary euthanasia of dogs with suspected CDV.
113 inician and radiologist leads to innumerable unnecessary examinations in the developed world, includi
114 ss," and "burnout"), and the health system ("unnecessary, excessive, and inefficient resource utiliza
115 elanoma improves early detection and reduces unnecessary excisions; however, a cost analysis of this
116 n critical care supply and demand without an unnecessary expansion of the intensivist supply.
117 hile potentially leading to patient harm and unnecessary expense.
118 d to inappropriate removal from exposure and unnecessary financial and social consequences.
119 the primary mode of diagnosis, thus avoiding unnecessary fine needle aspiration cytologies.
120 uld enable timely re-interventions and avoid unnecessary follow up studies of lost transplants.
121 %] in PR peer review ), such as recommending unnecessary follow-up imaging or radiation exposure in p
122 g conjugates concluded that drug release was unnecessary for activity, highlighting the importance of
123 structures, lead to over fit models, and are unnecessary for an efficient, accurate predictive model
124 xification mechanisms likely render microbes unnecessary for caterpillar herbivory.
125  functional (uridylylating) CRE(2C) would be unnecessary for CVB-TD replication.
126              Routine potassium monitoring is unnecessary for healthy women taking spironolactone for
127                  3D chirality is shown to be unnecessary for introducing strong circular dichroism fo
128  In light of recent observations that Myc is unnecessary for long-term hepatocyte proliferation, we h
129  Surprisingly, in our system fork restart is unnecessary for maintaining cell viability.
130   However, such lifelong surveillance may be unnecessary for most patients, thereby contributing to o
131                        Restrictive advice is unnecessary for NET patients being discharged from the d
132             Additionally, antibiotics may be unnecessary for physiologic tachypnea in otherwise well
133       Here we report that patching an eye is unnecessary for producing this paradoxical deprivation e
134     Correction for dead time was found to be unnecessary for small-animal experiments, whereas propag
135 also show that a high electrolyte modulus is unnecessary for stable electrodeposition of lithium.
136 ting that glutamatergic neurotransmission is unnecessary for synapse assembly and maintenance.
137 esults indicated that nontreponemal assay is unnecessary for syphilis diagnosis but can be recommende
138                 Continuation of dim light is unnecessary for T15/30 behavioral entrainment following
139 hese results indicate that Hcrt signaling is unnecessary for the activation of Hcrt, HA, or ACh wake-
140       As sophisticated exercise equipment is unnecessary for this measurement, our extremely simple d
141           This approach renders peak picking unnecessary for tracking population changes.
142                HDAC4 was found to be largely unnecessary for transcriptional regulation of naive sens
143 enes and facilitates their repression but is unnecessary for ZNF750-driven differentiation.
144 emblies, and conservative approaches lead to unnecessary fragmentation.
145 ed process rather than the simple removal of unnecessary genes.
146 rity, there is the additional need to reduce unnecessary healthcare costs and radiation exposure.
147 ppropriate resource utilization and reducing unnecessary healthcare costs.
148 nts, having a medical home, and avoidance of unnecessary hospitalization), and a social outcome (havi
149                           Policies to reduce unnecessary hospitalizations after percutaneous coronary
150 ulitis misdiagnosis leads to 50000 to 130000 unnecessary hospitalizations and $195 million to $515 mi
151 uideline-recommended management might reduce unnecessary hospitalizations.
152  have the potential to prevent SCD and avoid unnecessary ICD implantations.
153  the need for neurosurgical consultation and unnecessary imaging.
154  appears to be safe and avoids prolonged and unnecessary immobilization.
155 ts activity and limiting the fitness cost of unnecessary immune responses.
156                  These procedures may become unnecessary in single-polar-domain crystals of polar mag
157 ed resources on restricting dog movements is unnecessary in this endemic setting.
158 often suffer from philosopher's disease: the unnecessary, inappropriate, theoretically driven explana
159 s or with an indication that prophylaxis was unnecessary increased from approximately 40% in 2005 to
160 hat is proportionate to the threat, to avoid unnecessary inflammation.
161 les with a self-limiting response to prevent unnecessary inflammatory responses harmful to the organi
162   Use of the Bazett correction may result in unnecessary interruptions in ATO therapy, and alternativ
163 nature of these events is important to avoid unnecessary intervention, including the cessation of a p
164 ant women, leading to emotional distress and unnecessary interventions, including termination of preg
165 sing them as malignancies, which can lead to unnecessary interventions.
166                                Limitation of unnecessary intravascular neutrophil activation is also
167 logical examination inevitably leads to many unnecessary invasive excisions.
168 s well as strategic location would eliminate unnecessary invasive manipulations.
169       The method has the potential to reduce unnecessary invasive procedures and emotional distress f
170 ckness and shrinking lung, and might obviate unnecessary invasive procedures for MPM.
171 nd reducing health-care costs by eliminating unnecessary invasive procedures.
172  false positive findings, overdiagnosis, and unnecessary invasive testing is real.
173 ports, and because hardware modification was unnecessary, it was convenient to frequently switch amon
174             If one or more of these steps is unnecessary, it would significantly decrease compute tim
175 p, there were 56 (6.7%) deaths and 29 (3.5%) unnecessary laparotomies, whereas in the latter NOM grou
176 iampullary cancer, but many patients undergo unnecessary laparotomy because tumours can be understage
177 py costs ( pound995) were offset by avoiding unnecessary laparotomy costs.
178                      Secondary outcomes were unnecessary laparotomy rates and mortality.
179 ew found diagnostic laparoscopy can decrease unnecessary laparotomy.
180 An accurate early diagnosis should forestall unnecessary later surgery.
181 ect-size distribution, which is a severe and unnecessary limitation.
182 agnetic resonance imaging and 39 required an unnecessary liver biopsy according to the recall policy.
183 mendations is predicted to reduce harms from unnecessary liver biopsy.
184 timated by unsupervised training which makes unnecessary manually curated preparation of training set
185 essed (blood pressure control, discontinuing unnecessary medications such as aspirin or nonsteroidal
186 points (14.2%) but did not affect the use of unnecessary medicines and antibiotics.
187 markers can therefore potentially help avoid unnecessary morbidity from high-dose corticosteroid ther
188 ely supported and simple proposal to prevent unnecessary nomenclatural instability.
189              We evaluated criteria to reduce unnecessary nucleic acid amplification testing (NAAT) fo
190 icantly reduced fouling, resulting in either unnecessary or approximately 10-15 times shorter and les
191 ic pathway by which eukaryotic cells deliver unnecessary or damaged cytoplasmic material to the vacuo
192 useful, whereas others perceive epidurals as unnecessary or even deleterious.
193 roperly with a risk of patient harm, costly, unnecessary or inappropriate investigations, or delayed
194 gh extrusion, preventing the accumulation of unnecessary or pathological cells.
195 ular fibrous pseudotumor may eventuate in an unnecessary orchiectomy.
196 nalysis of discarded kidneys to determine if unnecessary organ discard was still occurring since the
197 measles cases and vaccine reactions to avoid unnecessary outbreak response measures such as case isol
198  screening as well as possible ways to avoid unnecessary overdiagnosis.
199 des 2, beyond simple isolation, proved to be unnecessary owing to the impurity rejection afforded by
200 the absence of results from clinical trials, unnecessary oxygen delivery should be avoided in critica
201 the absence of results from clinical trials, unnecessary oxygen delivery should be avoided in ventila
202 : Despite suggestions of potential harm from unnecessary oxygen therapy, critically ill patients spen
203 men, -4 days for women), which was driven by unnecessary pancreatic surgeries associated with false-p
204 tremity cellulitis is common and may lead to unnecessary patient morbidity and considerable health ca
205 tremity cellulitis is common and may lead to unnecessary patient morbidity and considerable health ca
206 re efficient patient encounter and alleviate unnecessary patient stress.
207  critically, typical carpet cloaks introduce unnecessary phase shifts in the reflected light, making
208 exposure prophylaxis (PrEP) while minimizing unnecessary PrEP exposure.
209            In this trial, we aimed to reduce unnecessary prescriptions of antibiotics by general prac
210 cedure should include avoidance of medically unnecessary primary caesarean section.
211  important, because misdiagnosis may lead to unnecessary procedures and prolonged morbidity.
212 but tertiary coverage would require avoiding unnecessary procedures to remain cost-effective.
213 neal LN dissection revealed a high number of unnecessary procedures, but patients with positive LN ha
214                         Forty-two percent of unnecessary prostate biopsies would have been averted by
215 al due to the high rate of overdiagnosis and unnecessary prostate biopsies, despite evidence that it
216 prostate cancer are undermined by harms from unnecessary prostate biopsy and overdiagnosis of indolen
217 naccurate perceptions of cancer risk, and an unnecessary psychological burden.
218                 This new method reduces this unnecessary quantification variability and increases pow
219 compared with administration of lower doses; unnecessary radiation exposure can be avoided by adminis
220 esearch, suggesting that patients exposed to unnecessary radiation.
221  scrotal lesions and consequently can reduce unnecessary radical surgical procedures in these patient
222 ify risk factors and strategies for reducing unnecessary readmissions among this patient population.
223 uality improvement interventions that reduce unnecessary readmissions, even if the rates of transplan
224 s with suspected mastocytosis and help avoid unnecessary referrals and investigations.
225 eview process, editors can potentially avoid unnecessary rejections, identify key areas for improveme
226             The misdiagnosis perpetuated the unnecessary removal of trees and exacerbated economic lo
227 ons targeting infected animals might lead to unnecessary removal of young animals that carry pathogen
228 or population-based CRC screening and reduce unnecessary repeat tests.
229 , that valuable research is being subject to unnecessary requirements and limitations.
230    Using this information, we identified the unnecessary resistance marker NeoR to be a highly transc
231 lprit fish or other nonrelated fish to avoid unnecessary restricted diets.
232 y in screening out low risk individuals from unnecessary restrictive interventions; very low positive
233 I is essential to prevent adverse effects or unnecessary risk of treatment failure.
234 tients does not improve outcomes and creates unnecessary risks.
235 h, minimizing regulatory burden-particularly unnecessary, self-imposed burden-in the ACUP is particul
236 dless of its temporal position, resulting in unnecessary sequence errors, that they later try to corr
237 tiemetic overuse is prevalent and results in unnecessary spending associated with systemic chemothera
238                              To avoid firing unnecessary spikes, neurons need to share information ab
239               Elimination of this apparently unnecessary step will make this potent antimalarial drug
240 upport tool (CDST) to decrease the number of unnecessary stool cultures (STCUL), ova/parasite (O&P) e
241 a global burden that promotes disability and unnecessary suffering.
242 patients with thyroid nodules while reducing unnecessary surgery and social costs.
243             Use of this model could decrease unnecessary surgery by nearly one-third and could help g
244  real-world effectiveness of PET in avoiding unnecessary surgery for newly diagnosed patients with no
245 represent an additional financial burden and unnecessary surgery on individual patients.
246  often mistaken for acute abdomen leading to unnecessary surgery.
247 ity and appears to be beneficial in avoiding unnecessary surgery.
248 ssessment could lead to some patients having unnecessary surgery.
249 sion procedures, which expose the patient to unnecessary surgical procedures and inappropriate antibi
250                                 Early and/or unnecessary tapering or treatment discontinuation for dr
251   Their intervention significantly decreased unnecessary test orders and saved their laboratory over
252 tal information system (HIS) alerts to deter unnecessary test orders for ovum and parasite (O&P) exam
253 line, estimate expenditures from potentially unnecessary testing, and identify patient and health car
254 n of adaptive testing strategies that reduce unnecessary testing, while ensuring that patient deterio
255 at computerized order sets may contribute to unnecessary testing.
256  characteristics associated with potentially unnecessary testing.
257        Use of pretest probability can reduce unnecessary testing.
258 them in line with current practice and avoid unnecessary testing.
259 use they can lead to subsequent, potentially unnecessary tests and procedures.
260 eached clinical significance, while avoiding unnecessary tests and surgery in patients with benign no
261 enotypes at the point of care, thus reducing unnecessary therapy and cost in these contexts.
262 ), including faster detection rates, reduces unnecessary therapy but permits therapy for ventricular
263                   While this modification is unnecessary to cause pneumonic plague, the substitution
264 new paradigm for regeneration in which it is unnecessary to invoke special damage-resistant cell type
265 ailable, it is computationally expensive and unnecessary to study combinatorial patterns of all modif
266 t selection could improve outcomes and spare unnecessary toxicity.
267 should be used to improve quality and reduce unnecessary transfusions.
268 ndle of care that aim to reduce or eliminate unnecessary transfusions.
269                         To determine whether unnecessary transport can be avoided.
270 ervices, redundancy of specialist attention, unnecessary travel), empowerment for health (self-preser
271  diagnosed as past or not syphilis, avoiding unnecessary treatment compared with other POC tests.
272 ing bad outcomes from disease progression or unnecessary treatment side effects.
273 of Xpert, and the hypothetical reductions in unnecessary treatment, contact investigation, and housin
274 despite no active infection, and can lead to unnecessary treatment.
275 mbocytopenia remain unclear, contributing to unnecessary treatment.
276 uish PTNFL from typical FL in order to avoid unnecessary treatment; however, this distinction relies
277 ertainty range [UR]: 0, 1.3) and generate 18 unnecessary treatments (95% UR: 10, 29) per 1,000 indivi
278 esulting in a median ratio of 38 incremental unnecessary treatments added by Ultra per incremental de
279 tic and management decisions, while limiting unnecessary treatments and costs.
280  deaths averted, and the projected number of unnecessary treatments generated per TB death averted, i
281 omes were the projected number of additional unnecessary treatments generated, the projected number o
282 er absolute benefit-this ratio improved to 7 unnecessary treatments per TB death averted (95% UR: 2,
283 , this ratio was much less favorable, at 372 unnecessary treatments per TB death averted (95% UR: 75,
284 per bound), although the projected number of unnecessary treatments using Xpert Ultra was lower (with
285                                   To prevent unnecessary treatments, they should be distinguished fro
286 are expected to benefit from PRRT, and avoid unnecessary treatments.
287 ed as a triage test might allow men to avoid unnecessary TRUS-biopsy and improve diagnostic accuracy.
288 he need for other diagnostic tests, reducing unnecessary use of antibiotics, and leading to a reducti
289                                 Reduction of unnecessary use of antifungals via antifungal stewardshi
290 n improve clinical outcomes while minimizing unnecessary use of broad-spectrum antibiotics, including
291 mpliance with the protocol, and avoiding the unnecessary use of intravenous and urinary tract cathete
292                                TMTS includes unnecessary use of non-evidence-based interventions, as
293 radiograph after this common procedure is an unnecessary use of resources and may delay resuscitation
294 ow that this preprocessing approach leads to unnecessary variability in peak quantifications that adv
295              Clinical protocols may decrease unnecessary variation in care and improve compliance wit
296 tion of preschool children from experiencing unnecessary VI and associated developmental delays.
297  proportion of individuals from experiencing unnecessary vision loss and blindness, decrease associat
298 otherapy was not performed so as to avoid an unnecessary wash out to the non-targeted duodenum.
299          Workup should consider reduction in unnecessary workup in addition to cancer diagnosis.
300               This recommendation results in unnecessary Xpert MTB/RIF testing in many individuals li

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