ライフサイエンスコーパス: unprecedented

1 lopment of Al(3+) selective nanobiosensor is unprecedented.

2 nanoparticle catalyst for water oxidation is unprecedented.

3 ditions of unactivated dialkylhydrazones are unprecedented.

4 s support a copper catalyzed formation of an unprecedented [10-S-4] sulfurane that reductively elimin

5 c skeleton, including an azocine ring and an unprecedented 2-dimethyl-3-methyl-azetidine ring.

6 mpounds, in up to 99 % yields, including the unprecedented 2-heteroarylethenesulfonyl fluorides and 1

7 We report efficient synthesis of a series of unprecedented [3]naphthylene regioisomers in high yields

8 This study demonstrates the unprecedented 3D printing of PMDA-ODA using mask-project

9 that produce a suite of sesterterpenes with unprecedented 6/11/5 and 6/6/7/5 fused ring systems when

10 This corresponds to an unprecedented 7.8-fold increase in crossover frequency.

11 report the synthesis and investigation of an unprecedented 8-heteroaryl-fused BODIPY 4.

12 ity ( approximately 4 x 10(14) cm(-3) ), and unprecedented 9 GHz charge-carrier mobility (71 cm(2) V(

13 HR-HDXMS provides the unprecedented ability to accurately assess protein stabi

14 oglycan and that, further, the PBPs have the unprecedented ability to transfer the primary epsilon-am

15 pathways are powerfully enabling and provide unprecedented access to materials far from equilibrium,

16 e antigen (PSMA)-ligand PET imaging provides unprecedented accuracy for whole-body staging of prostat

17 ng, and transcription termination sites with unprecedented accuracy.

18 e is the Tp-Bpy thin film, which displays an unprecedented acetonitrile permeance of 339 L m(-2) h(-1

19 neutral derivative captures fluoride with an unprecedented affinity for a neutral, water-compatible L

20 ic core structure associated with CmlI(P) is unprecedented among diiron cluster-containing enzymes an

21 is composed only of linear DNA molecules is unprecedented among eukaryotes, and highlights unexpecte

22 This development has generated an unprecedented amount of data that must be stored, proces

23 fer genome, the Ae. tauschii genome contains unprecedented amounts of very similar repeated sequences

24 a spatial axis within a single population is unprecedented and demonstrates that alliance complexity

25 These rich datasets offer unprecedented and exciting opportunities to address long

26 The Ir(IV,V) dimers are unprecedented and exhibit remarkable stability under amb

27 This unprecedented and not trivial transformation does not op

28 me-catalyzed 1,3 dipolar cyclo-additions are unprecedented and other mechanisms are plausible.

29 The new strategy constitutes an unprecedented application of Brook rearrangement, one wh

30 f these labile assemblies provides access to unprecedented architectures to be used as nanocarriers.

31 Paphia malabarica led to isolation of three unprecedented aryl polyketide derivatives, characterized

32 antibody domains, which assume a unique and unprecedented asymmetric structure within the homodimeri

33 The structures give unprecedented atomic details of the molecular interactio

34 the active-site zinc ion of CSN5 through an unprecedented binding mode.

35 odies and cytoskeletal structures in 3D with unprecedented biomolecular specificity for vibrational m

36 d fishing pressure had minimal effect on the unprecedented bleaching in 2016, suggesting that local p

37 cas and the Caribbean was associated with an unprecedented burden of neurological disease among adult

38 Ramanomics - an independent discipline with unprecedented capabilities to map the distribution of di

39 st decade, advanced cell imaging has enabled unprecedented capabilities to visualize individual TF mo

40 atalysts provide synthetic chemists with the unprecedented capability to harness reactive radicals th

41 es self-cleaning Cu catalyst electrodes with unprecedented catalytic stability toward CO2 reduction.

42 vant epitopes can be converted into mAb with unprecedented CDC activity.

43 outbreak in west Africa was associated with unprecedented challenges in the provision of care to pat

44 These comprehensive analyses enable unprecedented characterization of the complex network of

45 In addition, unprecedented charge-assisted ChB-mediated anion binding

46 s new degree of freedom has enabled reaching unprecedented CHF levels and revealed new details about

47 inum(I) compound NacNacAl (1) results in the unprecedented cleavage of the C-N multiple bond to give,

48 of MsbA with ADP-vanadate and ADP reveal an unprecedented closed and an inward-facing conformation,

49 An unprecedented combination of high proton conductivity (3

50 orption, optoelectricity, etc. owning to the unprecedented combination of large surface area, high cr

51 ically insulating composite that exhibits an unprecedented combination of metal-like thermal conducti

52 edral and diamond quaternary topologies with unprecedented complexity.

53 sis of flow cytometric data, resulting in an unprecedented concordance of 98% (97% for samples with M

54 crystal structure of EcAGPase-R130A revealed unprecedented conformational changes in structural eleme

55 ocal-earthquake seismic tomography to derive unprecedented constraints on multi-stage fluid release f

56 Most importantly, this work makes an unprecedented contribution to Ras research in inhibitor

57 ange of molecular ions could be studied with unprecedented control and precision.

58 sional van der Waals ferromagnet, we achieve unprecedented control of the transition temperature (bet

59 abrication of hollow self-folding tubes with unprecedented control over their diameters and architect

60 The heteroporphyrins provide unique and unprecedented coordination environments for metals.

61 omplex biological samples, thus achieving an unprecedented coverage of system-wide, native biomolecul

62 Here we analyse an unprecedented data set derived from 274 rod surface-elev

63 derive the velocities and densities provided unprecedented data to document the evolution of the bulk

64 lization of deep anatomical features with an unprecedented degree of clarity.

65 ten billion people within the next century, unprecedented demands will be placed on food, energy and

66 unctional imaging of biological specimens at unprecedented depth and resolution.

67 from noisy and impure bulk tumour samples at unprecedented depth.

68 work explores Plasmodium DNA replication in unprecedented detail and opens up tremendous scope for a

69 ying ATP hydrolysis has been investigated in unprecedented detail over an aggregate simulation time o

70 nsition state effects in enzyme catalysis in unprecedented detail, providing a molecular description

71 etic and epigenetic evolution over time with unprecedented detail.

72 landscape of common forms of human cancer in unprecedented detail.

73 imental data reveal the unfolding pathway in unprecedented detail.

74 and calibrated molecular phylogeny that has unprecedented detail.

75 reconstructed in 3-D from confocal scans in unprecedented detail.

76 to reconstruct human evolutionary history in unprecedented detail.

77 s is analyzed within surface structures with unprecedented detail.

78 ation can uncover past population history in unprecedented detail.

79 Our study revealed unprecedented details of glomerular abnormalities in Col

80 The unprecedented deterioration rate of the environmental qu

81 h a monodentate phosphine ligand enables the unprecedented direct and alpha-stereoselective catalytic

82 search focus on these species has spawned an unprecedented diversity of complementary methodological

83 h in vivo experiments allows us to access an unprecedented diversity of genomes, the content of which

84 ransposable elements, which likely cause the unprecedented diversity that we observe in the sequence

85 We describe an unprecedented DNA-catalyzed DNA cleavage process in whic

86 we investigated D477G missense mutation, an unprecedented dominant-acting mutation of RPE65 identifi

87 In addition, our results support an unprecedented 'double K-turn' module in type A and type

88 downstream signaling, and (iii) undergoes an unprecedented dysfunction in Huntington's disease, an ar

89 uccius productus (Pacific hake) exhibited an unprecedented early and northward spawning expansion dur

90 mic lesions could be introduced in vivo with unprecedented ease.

91 rect-acting antivirals (DAAs), which have an unprecedented efficacy to clear the virus, and establish

92 r extraction for the C-exciton state with an unprecedented efficiency of 80%, accompanied by a twofol

93 vatives with an in-ring quaternary carbon in unprecedented enantioselectivity, offering valuable mate

94 Electron waves give an unprecedented enhancement to the field of microscopy by

95 We report the discovery of a hitherto unprecedented enzyme-promoted alpha-hydroxyketone rearra

96 An unprecedented epidemic of Zika virus (ZIKV) infection ha

97 This study provides unprecedented evidence and tools to assess the local str

98 f benzo-15-crown-5 ether (B15C5) afforded an unprecedented example (outside of matrix isolation) of a

99 Compounds 4 and 7 are unprecedented examples of uranium phosphido complexes ou

100 Combining these tools facilitated an unprecedented exploration of the kinetics of Cas9-mediat

101 rom the Lifshitz-Slyozov-Wagner theory to an unprecedented extent, thereby establishing a new paradig

102 This diversity is unprecedented for any Hirnantian fossil group, and the f

103 hways, including several that are completely unprecedented for bacteria or any organism.

104 ht-binding mechanism of inhibition, which is unprecedented for SIRT5.

105 ctamate, the reaction pathway switched to an unprecedented formal [5 + 1]-cyclization that provided m

106 The unprecedented formation of unsymmetrical alkenes from th

107 This one-pot transformation allows unprecedented functional group tolerance and it is well-

108 n govern physical properties and may lead to unprecedented functionalities and novel devices.

109 late light at the subwavelength scale offers unprecedented functionalities for passive and active las

110 ghtweight, and flat lenses (metalenses) with unprecedented functionalities.

111 he platform for tunable optical devices with unprecedented functionality and performance characterist

112 ased on a simple coordination process has an unprecedented general character in terms of substrate sc

113 advances in genome sequencing have provided unprecedented glimpses into the virosphere.

114 Unprecedented global climate change and increasing rates

115 Unprecedented global effort is under way to facilitate t

116 challenges in successfully implementing this unprecedented global initiative, including (1) coordinat

117 R-1 immobilized on an ITO electrode displays unprecedented H2O2 reduction activity.

118 The solid-state structure shows an unprecedented helicoidal tubular chain resulting from th

119 approach that has the prospect of furnishing unprecedented heterometallic bicyclic architectures with

120 Ce4Li3P18N35 consists of an unprecedented hexagonal framework of PN4 tetrahedra and

121 tructured artificial receptor materials with unprecedented hierarchical structure for determination o

122 This method allows an unprecedented high precision of detection, quantitative

123 lower-than-average rates before 1990 toward unprecedented high rates in recent decades.

124 ces to these peatlands that are experiencing unprecedented high rates of land use and land cover chan

125 zed conformation and of 2-oxoglutarate in an unprecedented high-energy conformation that favors ethyl

126 Together, these observations provide unprecedented high-resolution molecular portraits of mut

127 The sample quality allows for unprecedented high-resolution spectroscopy, which offers

128 nges and future directions in the context of unprecedented human-mediated environmental change.

129 Here we document an unprecedented hypoxic event on the Caribbean coast of Pa

130 This unprecedented imaging speed was achieved by concurrent i

131 ology laboratories (PHLs) are on the cusp of unprecedented improvements in pathogen identification, a

132 This mechanism appears unprecedented in asymmetric catalysis.

133 nase-like reaction by a monocopper enzyme is unprecedented in nature and opens new avenues in chemist

134 mics code, which is capable of performing an unprecedented in silico experiment-simulating an entire

135 on, something, to the best of our knowledge, unprecedented in TCBD-based conjugates.

136 ep-wise increase from 1910 to present levels-unprecedented in the last 363 years.

137 espite substantial progress, events that are unprecedented in the local observational record remain a

138 Herein, we disclose an unprecedented in vivo reduction process that affords Mei

139 istic improvements in motor function with an unprecedented increase in life span.

140 Despite the recent unprecedented increase in the power conversion efficienc

141 This increase represents an unprecedented input of nitrogen (N) to African ecosystem

142 perties and relaxation pathways, and give an unprecedented insight into the interpretation of the spe

143 stology analysis of the dodo and provides an unprecedented insight into the life history of this icon

144 These results provide unprecedented insights into molecular recognition with h

145 particle behavior to infectivity, providing unprecedented insights into the biology of HIV infection

146 Metagenomics provide unprecedented insights into the genetic diversity of unc

147 lms by varying growth temperature, affording unprecedented insights into the origin of the resistivit

148 onal (3D) configuration of DNA have provided unprecedented insights into the relationship between DNA

149 emonstrates the power of MALDI-MSI to reveal unprecedented insights on metabolic outcomes in multicel

150 An unprecedented intermolecular aliphatic C-F...H-C interac

151 d morphological characterization revealed an unprecedented intrinsic sensitivity of AL PCs to PIs, ev

152 ive elimination of the entire PCO group, the unprecedented [L2 Ge-GeL2 ] complex 3 in 54 % yields bea

153 s that spatial modes can be controlled to an unprecedented level and have the potential to enable pra

154 hree-dimensional (3D) ultrastructure with an unprecedented level of 3D information using electron tom

155 tic architecture of complex phenotypes at an unprecedented level of detail using genome-wide associat

156 and engineering technologies have enabled an unprecedented level of interrogation into the impact of

157 uid flow, known as flow sculpting, offers an unprecedented level of passive fluid flow control, with

158 ot development in Arabidopsis thaliana at an unprecedented level of temporal detail.

159 de expression data production has reached an unprecedented level.

160 conomic development are forecasted to impose unprecedented levels of extinction risk on many more spe

161 Unprecedented levels of habitat transformation and rapid

162 However, despite unprecedented levels of intervention, postnatal growth f

163 of the world are experiencing evolutionarily unprecedented levels of light at night.

164 ensor exhibits two wide linear ranges and an unprecedented LOD compared with previously reported anal

165 (demonstrated at 7.0 and 9.9 Wh/L) exhibited unprecedented long cycling performance, 700 cycles at 60

166 Additional benefits of the unprecedented low relative density (68-77 %) are the lar

167 d at atmosphere pressure by SIFSIX-1-Cu, and unprecedented low-pressure SO2 capacity is obtained in S

168 al cell-cycle progression is regulated by an unprecedented mechanism involving parallel adders (i.e.,

169 The biochemical basis for this unprecedented mechanism of signal transduction suggests

170 We have uncovered an unprecedented mechanism of viral replication: Kaposi's s

171 This study provides an unprecedented methodology to label, retain, and image sm

172 that these miniprotein dimers bind Ras in an unprecedented mode in which the Ras effector domain is r

173 containing materials through utilization of unprecedented MOF modularity, which cannot be replicated

174 roteomics to study ADP-mediated signaling at unprecedented molecular resolution.

175 a compound containing the PCO(-) anion in an unprecedented mu(2) :eta(2) ,eta(2) -binding mode.

176 eses and preliminary mechanistic research of unprecedented multitargeting heterocyclic ferrociphenols

177 The key step was an unprecedented NaBH4-promoted one-pot reductive cyclizati

178 Our unprecedented new mechanism may have relevance to biolog

179 Here, we discovered an unprecedented nonribosomal peptide synthetase-like-pteri

180 In particular, the unprecedented nucleophilic reactivity of the symmetric [

181 affords the resolving power to determine an unprecedented number of components in complex mixtures,

182 An unprecedented number of trials have been done, initiated

183 molecular form of cadmium chalcogenides with unprecedented one-dimensional bonding motifs.

184 The UK Biobank will allow unprecedented opportunities for analysis of further phen

185 -derived retinal organoids has brought forth unprecedented opportunities for developmental and physio

186 duced pluripotent stem cells (hiPSCs) offers unprecedented opportunities for in vitro disease modelin

187 peritoneal and uterine lavage fluid provide unprecedented opportunities to dissect the earliest phas

188 gnetic resonance spectroscopy (MRS) provides unprecedented opportunities to obtain clinical diagnosti

189 exist for prevention of hearing loss, as do unprecedented opportunities to reduce the generally high

190 ferent types of biological data that provide unprecedented opportunities to unravel molecular heterog

191 This Protocol Review discusses the unprecedented opportunity that CRISPR/Cas9 technology of

192 molecular profiling technologies provide an unprecedented opportunity to apply precision medicine st

193 ation within the tumor, thereby providing an unprecedented opportunity to study T cell FA metabolism

194 n DNA sequencing technology have provided an unprecedented opportunity to study the human virome.

195 nt areas of the immune system has offered an unprecedented opportunity to understand the complexity o

196 rence to existing studies carried out during unprecedented outbreaks of bluetongue virus in Europe, a

197 Simultaneously, China launched an unprecedented overseas intervention against Ebola virus

198 new information and tools materialize at an unprecedented pace, the field is now ripe for systematic

199 red by radiation exposure, recently produced unprecedented patterning performance in EUV lithography.

200 This discovery reveals an unprecedented pharmacological approach to MMP inhibition

201 in the prevalence of adolescent obesity, an unprecedented phenomenon of type 2 diabetes has emerged

202 iority of our design concept by achieving an unprecedented photocurrent density in PEC water splittin

203 are two-dimensional (2D) nanomaterials with unprecedented physical, optical, and electronic properti

204 -F bond functionalization path that provides unprecedented possibilities for the stereoselective gene

205 arch, carbon nanomaterials have demonstrated unprecedented potential for a variety of regenerative me

206 presented active Huygens' metalens may offer unprecedented potentials for real-time, fast, and sophis

207 dsourcing" approach to team neuroscience has unprecedented power for advancing our understanding of b

208 Whole-genome sequencing gives unprecedented power to detect three categories of pathog

209 d chemical properties of rhodamine dyes with unprecedented precision.

210 rlap on existing transcriptional classes and unprecedented predictive and prognostic performances.

211 The last decade has seen unprecedented progress in understanding the molecular bi

212 design of functional molecular machines with unprecedented properties.

213 structure, often inducing exotic phases with unprecedented properties.

214 superconducting state, being associated with unprecedented quantum Little-Parks oscillations originat

215 thout any additional plasmonic layer exhibit unprecedented Raman signal enhancements up to 3.4 x 10(3

216 tune the Fermi level of the graphene over an unprecedented range at the interface with WS2 .

217 Here, the authors measured an unprecedented range of apolipoproteins in a prospective,

218 chiral active stresses, yet this leads to an unprecedented range of complex motilities, including osc

219 Species are being lost at an unprecedented rate due to human-driven environmental cha

220 Humans are altering global environment at an unprecedented rate through changes in biodiversity, clim

221 umber and are spreading to new regions at an unprecedented rate.

222 This unprecedented reaction represents an interesting and com

223 An unprecedented reactivity of 3-aminoquinoline-2,4-diones

224 and the human microbiome have resulted in an unprecedented recognition of new bacterial genus/species

225 The data represent unprecedented recovery of inner ear function and suggest

226 Our investigations unveil an unprecedented regulatory use of an evolutionarily conser

227 he tropospheric warming from 1979 to 2016 is unprecedented relative to internally generated temperatu

228 nformation about tsetse tissue topology with unprecedented resolution and allowed the first 3D analys

229 the potential of the OCO-2 sensor, with its unprecedented resolution and sensitivity, to detect loca

230 allows to easily explore the yeast genome at unprecedented resolution and throughput.

231 he present study uses confocal microscopy at unprecedented resolution for direct observation of oil d

232 The unprecedented resolution of cold-ion spectroscopy couple

233 This unprecedented resolution showed major advantages in comp

234 ombined with clustering analysis to study at unprecedented resolution the distribution of the inhibit

235 has enabled its functional dissection at an unprecedented resolution.

236 mapping the human brain pathways in vivo at unprecedented resolution.

237 bes, it can provide images of nuclear DNA at unprecedented resolution.

238 The Connectivity Map (CMAP) represents an unprecedented resource to study the gene expression cons

239 This unprecedented result shows that the combination of a con

240 Following the unprecedented rise in photovoltaic power conversion effi

241 novel regulatory mechanism and identifies an unprecedented role for ACT.

242 Together, the study provides a previously unprecedented role of Golgi-derived secretory vesicles i

243 een adhesion and contractility and reveal an unprecedented role of N-cadherin on cell shapes and cell

244 an archaeological radiocarbon date series of unprecedented sampling density and detail.

245 e global coordination during 2015-2016 on an unprecedented scale among global public health technical

246 Evidence shows use of this strategy on an unprecedented scale by the Syrian Government and allied

247 global communications and coordination on an unprecedented scale from 2014 to 2016, involving global

248 ls around the world and to collaborate on an unprecedented scale in large international trials.

249 ow us to explore patterns of diversity at an unprecedented scale.

250 sation product indolocarbazole, it undergoes unprecedented selective pseudo-four-component tandem oxi

251 ically separate ethylene from ethane with an unprecedented selectivity of 100, owing to its distinct

252 = 7 and 2.3 nM, respectively), exhibiting an unprecedented selectivity over Dyrk1A.

253 genide clusters and this approach allows for unprecedented selectivity over the metal and chalcogen i

254 solution structures can be written that show unprecedented selectivity when exposed to etching condit

255 Significantly, at high I2 loading an unprecedented self-aggregation of I2 molecules into trip

256 It exhibited unprecedented sensitivity of 37.66 Hz/mM.cm(2) and a lin

257 ed very valuable for the detection of PPi in unprecedented sensitivity over other competing ions.

258 , methanogenesis, and acetate oxidation with unprecedented sensitivity throughout Holocene sediment c

259 nses and informing strategies to extend such unprecedented sensitivity to broader molecularly defined

260 d sensitivity paves the way for sensors with unprecedented sensitivity.

261 or 2 equiv) of Lewis acids (LA's) to form an unprecedented series of O-type species (O(MeAN)-LA) able

262 iogeochemical cycles are currently facing an unprecedented set of comprehensive anthropogenic changes

263 ure decrease in local populations at a scale unprecedented since the last glacial maximum.

264 psychiatrically well-characterized sample of unprecedented size (n=1616) that informs the neurobehavi

265 livestock disease event in the country, with unprecedented socioeconomic and commercial consequences.

266 Importantly, unprecedented solvent-dependent and anion-binding-induce

267 An unprecedented solvent-directed "switch" both in helical

268 These results introduce an unprecedented source of pigmentation in amphibians and h

269 and phase transformation, can be probed with unprecedented spatial and temporal resolutions.

270 analysis technology, we generated herein an unprecedented spatial transcriptome map of the mature in

271 f genetically defined neuronal circuits with unprecedented specificity and precision has been paramou

272 es is fundamentally interesting and promises unprecedented speed for magnetic data storage that is th

273 ced to the stage of clinical evaluation with unprecedented speed.

274 y SmI2-H2O-LiBr, provide efficient access to unprecedented spirocyclic scaffolds containing up to fiv

275 ions was used to assess the influence of the unprecedented strained cis configuration on the optical

276 ysis of chemical shift anisotropy, providing unprecedented structural information about a broad range

277 vitro, providing additional support for this unprecedented structure.

278 and in vivo, culminating in the discovery of unprecedented substituents able to interact with conserv

279 e of lipid bicontinuous single crystals with unprecedented swelling capacity.

280 ecific antisense oligonucleotides allows the unprecedented telomere-specific DDR inactivation in cult

281 ible analysis of the functional network with unprecedented temporal precision.

282 Our approach offers unprecedented temporal resolution and, uniquely, physica

283 tenance of mitotic chromosome structure with unprecedented temporal resolution.

284 Targeting of the human ribosome is an unprecedented therapeutic modality with a genome-wide se

285 o permits single-step deposition of films of unprecedented thickness via continuous processing techni

286 An unprecedented three consecutive C-H functionalizations o

287 key regulatory drivers of this process with unprecedented tissue and temporal resolution.

288 We report an unprecedented transition metal-free coupling of indoles

289 can also enable mode-locked lasers to attain unprecedented tunable spectral reach for spectroscopy, b

290 e highly activated magnesium alkyls and show unprecedented, uncatalyzed reactivity toward H2, CO, and

291 ly undergoing rapid economic development and unprecedented urbanization.

292 These results offer an unprecedented view of how a glycan modification influenc

293 These results provide an unprecedented view of how albumin interacts with Abeta a

294 ation of mixing and T-jump results yields an unprecedented view of lactate dehydrogenase enzymology,

295 etastasis in two CRC patients and provide an unprecedented view of metastasis at single-cell genomic

296 High throughout sequencing has provided an unprecedented view of the circulating diversity of all c

297 Recently, Wallace et al. (2017) provide an unprecedented view of the layers of molecular, cellular

298 This enables an unprecedented way of tailoring the blazing operation, fo

299 at, upon NIR excitation at 980 nm, showed an unprecedented Yb to Tb upconversion sensitization phenom

300 m triphenyldicarboxylic acid (H2TPDC) and an unprecedented Zr12 secondary building unit (SBU): Zr12(m