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1 gating residue, Glu(148), was protonated and unprotonated.
2 proteins would be expected to be completely unprotonated.
3 In two of these, C8 was left unprotonated.
4 y that the mouse UV chromophore is initially unprotonated.
5 analogues which were mostly diprotonated or unprotonated.
6 e that bonded to the p-nitrophenyl carbon is unprotonated.
7 pK(a) value of 7.4 for a group that must be unprotonated.
8 phenolic side chain of Tyr7 appearing to be unprotonated.
9 (2)/K(Sacc) pH-rate profiles and is required unprotonated.
10 de faster when a group with pK(a) of 6.8 was unprotonated.
11 loride, which implies that the amines remain unprotonated.
12 d an ionization (pKa = 7.6-7.8) that must be unprotonated.
13 nated to 2-3 protons and possibly when it is unprotonated.
14 and higher where the terminal amino group is unprotonated.
16 (A)(-)Q(B), one protonated (state A) and one unprotonated (alpha), and one state of the product, P(+)
19 hat, at least some of the time, it is in the unprotonated amine form and thus able to act as a base.
20 l evidence that it is carbamylated, since an unprotonated amine group is available to act as a Lewis
22 The strong directing effect of the free and unprotonated amino functionality leads to high regiosele
24 dine, leaving Nepsilon of the imidazole ring unprotonated and able to accept positive charge from the
25 is active when His-52 (pK(a) 3.8 +/- 0.1) is unprotonated and an unknown group with a pK(a) of 9.8 +/
27 l-shaped and indicate that one group must be unprotonated and another residue must be protonated for
28 e exhibiting a pK value of 6.7 which must be unprotonated and one exhibiting a pK value of 8.5 which
29 group with a pK(a) value of about 7 must be unprotonated and one with a pK(a) value of 9.5 must be p
30 sorbance bands suggests that these represent unprotonated and protonated Schiff base forms of the pig
32 -state NMR studies of the [2]rotaxane in its unprotonated and protonated states were carried out to l
33 nd releases metal cations, when respectively unprotonated and protonated, on effecting alternate pH c
38 thereby rendering the N(epsilon2) imidazole unprotonated and well positioned for accepting the ATP p
39 pKa = 8.3) and a second residue that must be unprotonated (apparent pKa = 7.7) for maximal catalytic
40 how the imidazole N epsilon of His-124 to be unprotonated, appropriate for general base catalysis.
42 in GtCCR2 requires the Asp-96 homolog to be unprotonated, as has been proposed for the BR cytoplasmi
43 cid and the symmetric carbonyl stretch of an unprotonated aspartate, respectively, and suggest that i
44 dazolylmethylene side chains that are mostly unprotonated at neutrality because of the nearby polycat
45 vely, leaving the fluorescein moiety largely unprotonated at physiological pH and thus limiting the s
47 e via effects on the open probability of the unprotonated channel and the pK of one of the inhibitory
49 ion (VCOP(D108A)) produced a pigment with an unprotonated chromophore (lambda(max) = 360 nm) and dram
51 HS)+ protonated species but are higher-order unprotonated clusters (M3S3, M4S6, M2S4), similar to tho
52 mulations of the system having protonated or unprotonated cytosines, mimicking the pH 5.0 and 8.0 con
53 ded by transient protonation of an initially unprotonated donor, which is probably the epsilon-amino
55 ilitated for states with protonated K362 and unprotonated E286, which would in principle allow proton
57 mechanism, with fumarate binding to the free unprotonated enzyme and a proton addition prior to malat
58 ll inhibitors bind faster and tighter to the unprotonated enzyme-NAD+ complex, which has a pK of abou
60 order, followed by the direct attack of the unprotonated epsilon-amino group on AcCoA, transferring
61 quadrupole splittings for the protonated and unprotonated ferryl forms of P450(BM3) are DeltaE(Q) = 2
62 of 5.3 for an enzymatic group required to be unprotonated for activity and a second pK of 6.3 that le
63 K199R, with a requirement for a group to be unprotonated for activity with a pK of 5.6 and a partial
66 residue with this pK(a) (betaLys-87) must be unprotonated for binding glycine or oxindolyl-L-alanine,
67 e exhibits the requirement for a group to be unprotonated for catalysis with a pK of 5.6 and also sho
68 yme ionization with a pKa value of 7 must be unprotonated for catalysis, and an enzyme ionization wit
69 group on the enzyme with a pK of 6.4 must be unprotonated for catalysis, and it is presumed that the
79 rotonated and two functional groups that are unprotonated for optimal substrate inhibition to occur.
81 t a pKa of 7.0-7.5 (for a group that must be unprotonated for optimum binding) with values, above pH
83 e phenolic hydroxyl of Tyr265, which must be unprotonated for reaction with either isomer of alanine.
84 up with a pK(a) value of ~7.5, which must be unprotonated for the catalytic phosphorylation of ACL to
86 ffects also indicate that sites that must be unprotonated for transport (apparent pK(a) approximately
87 icate that CH3-H4folate binds to MeTr in the unprotonated form and then undergoes rapid protonation.
88 ge interactions, whereas the T1 state of the unprotonated form does not experience any analogous stab
89 in determining the conformation of PrP; the unprotonated form favors native PrP(C), while the proton
92 y protonated forms of the inhibitors and the unprotonated form of an amino acid residue with a pK(a)
93 he enhancement factors (in log scale) of the unprotonated form of the imidazole compounds (B) and the
94 of log V vs pH indicated that at high pH an unprotonated form of the ternary enzyme complex was able
95 sts that the inhibitor binds as the neutral, unprotonated form that is subsequently protonated to gen
96 dicate that CH(3)-H(4)folate is bound in the unprotonated form throughout this pH range and that prot
103 the order Tg > Cg > Ts > Cs for the neutral (unprotonated) form of 1 and Ts > Tg > Cs > Cg for its pi
104 hydrylase are expected to maintain N1 in the unprotonated, formally neutral state for catalysis of ra
105 nger lifetime components originated from the unprotonated forms and the shorter components from the p
106 tion exchange behavior of the protonated and unprotonated forms as well as determination of the solid
109 c parameters for both the protonated and the unprotonated forms of each of these two entities as well
110 Raman bands belonging to the protonated and unprotonated forms of the isoquinoline ring of papaverin
113 tion results in reaction of the C-2 with the unprotonated fraction of the pyridine ring to form the r
114 ulations were done for both a protonated and unprotonated Glu and led to a proposed mechanism of prot
115 only at the 181-residue site-protonated and unprotonated Glu181-and calculate several experimentally
116 t lower pH, suggesting the involvement of an unprotonated group acting as a base in the chemical step
118 or wild-type and H187Q UDG indicates that an unprotonated group in the enzyme-substrate complex (pK(a
119 h pH consistent with the participation of an unprotonated group in the reductive half-reaction and th
121 ting for catalysis and with a model in which unprotonated imidazole accelerates the rate of isomeriza
122 d histidine show that His211 is neutral; the unprotonated imidazole nitrogen is not coordinated to zi
124 exen-1-one are consistent with His-186 being unprotonated in oxidized, reduced, and ligand-bound MR,
125 lu(232) in wild-type enzyme is protonated or unprotonated in the course of catalysis at neutral pH.
128 tional group binds to Na+, K+, Ca2+, and the unprotonated ionophore with binding constants of 10(3.5)
129 te of reorientation of the free carrier when unprotonated is predicted to be responsible for the coup
130 resulting intermediate, the dissociated but unprotonated leaving group forms an alkoxide coordinated
134 d that the underlying mechanism involves the unprotonated N atom acting as a H-bonding acceptor to fa
135 ound such that Asn-221 hydrogen bonds to the unprotonated N1 instead of the protonated N3 of the cofa
136 in their protonated cation form and in their unprotonated neutral form, but to date, tyrosyl radicals
137 te cavity, (3) the side chain of His64 being unprotonated (neutral) and predominantly in an inward co
139 or the binding of two gold(I) centers to the unprotonated nitrogen atoms, despite greater orbital den
143 ue in the peptide binding cleft that must be unprotonated (pK(a) = 5.8) for peptide binding and likel
144 tely 1 s time scale, which suggests that the unprotonated predecessor of Meta II in the native membra
145 s consistent with a covalent modification of unprotonated primary amines (i.e., N-terminus and epsilo
146 eactivity is analogous to that observed with unprotonated primary amines such as the N-terminus or ep
147 ves, an amide bond is formed between a free, unprotonated, primary amine group of a lysine side chain
148 yridoxal 5'-phosphate (PLP) with an unusual, unprotonated pyridine is mainly due to solvation effects
149 approximately equimolar amounts of an Ndelta-unprotonated (pyridine-like) form and an Ndelta-protonat
150 s rationalized by a greater abundance of the unprotonated radicals that preferentially abstract hydro
152 ->BR, where M(1), M(2), and M'(2) contain an unprotonated retinal Schiff base before and after a reor
154 ude that the MUV-visual pigment possesses an unprotonated retinylidene Schiff base in the dark state,
157 al and electrostatic effects surrounding the unprotonated Schiff base (USB) retinyl chromophore in th
159 e SWS1 pigments result from a protonated and unprotonated Schiff base chromophore, respectively.
162 form (pH 5.5, lambda(max) = 496 nm) and the unprotonated Schiff base form (pH 8.2, lambda(max) = 384
163 ment with opsin, through both protonated and unprotonated Schiff base linkages and likely within the
164 nist is rapidly converted to an agonist, the unprotonated Schiff base of all-trans retinal, upon ligh
165 C15=NZ-CE plane breaks the connection of the unprotonated Schiff base to the extracellular side and e
166 ut illumination and in the photocycle of the unprotonated Schiff base were measured in the visible an
167 by the deletion of Phe-86 that converted the unprotonated Schiff base-linked 11-cis-retinal to a prot
168 chemical calculations strongly suggest that unprotonated Schiff base-linked chromophore is responsib
171 ms shows that the photoproduct aniline, left unprotonated, serves as a poison for the QD catalyst by
172 guanidinium group, -NH-C(NH2)2+ and that the unprotonated side chain of these amino acids is responsi
174 ationship (QSAR) models for this data set as unprotonated species assuming the Tg, Cg, and Ts conform
177 The catalytic lysine may be returned to its unprotonated state using a rectifying proton tunnel driv
178 d reaction of thiols with H2O2 when in their unprotonated state would provide a potential mechanism f
181 g of serine is accompanied by a shift to the unprotonated tautomer of the external aldimine as well a
183 80 and 100 K, where the Schiff base remained unprotonated, the Wat85 pair stayed in similar states to
185 This suggests that the active site must be unprotonated to react with ascorbate and protonated to r
186 ur in molecules whose Schiff base linkage is unprotonated, we changed the pH of the solution bathing
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