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1 gating residue, Glu(148), was protonated and unprotonated.
2  proteins would be expected to be completely unprotonated.
3                 In two of these, C8 was left unprotonated.
4 y that the mouse UV chromophore is initially unprotonated.
5  analogues which were mostly diprotonated or unprotonated.
6 e that bonded to the p-nitrophenyl carbon is unprotonated.
7  pK(a) value of 7.4 for a group that must be unprotonated.
8  phenolic side chain of Tyr7 appearing to be unprotonated.
9 (2)/K(Sacc) pH-rate profiles and is required unprotonated.
10 de faster when a group with pK(a) of 6.8 was unprotonated.
11 loride, which implies that the amines remain unprotonated.
12 d an ionization (pKa = 7.6-7.8) that must be unprotonated.
13 nated to 2-3 protons and possibly when it is unprotonated.
14 and higher where the terminal amino group is unprotonated.
15       Moreover, we found that when Asp103 is unprotonated, a rigid Zn1-OH-Zn2 bridge results, while f
16 (A)(-)Q(B), one protonated (state A) and one unprotonated (alpha), and one state of the product, P(+)
17                                              Unprotonated amelogenins can bind protons, suggesting th
18                     The results suggest that unprotonated amelogenins may regulate the pH of forming
19 hat, at least some of the time, it is in the unprotonated amine form and thus able to act as a base.
20 l evidence that it is carbamylated, since an unprotonated amine group is available to act as a Lewis
21 e and anthracene are known to be quenched by unprotonated amines by the PET mechanism.
22  The strong directing effect of the free and unprotonated amino functionality leads to high regiosele
23 ly with amino acid residues bearing thiol or unprotonated amino groups.
24 dine, leaving Nepsilon of the imidazole ring unprotonated and able to accept positive charge from the
25 is active when His-52 (pK(a) 3.8 +/- 0.1) is unprotonated and an unknown group with a pK(a) of 9.8 +/
26 is singly protonated, and the semiquinone is unprotonated and anionic.
27 l-shaped and indicate that one group must be unprotonated and another residue must be protonated for
28 e exhibiting a pK value of 6.7 which must be unprotonated and one exhibiting a pK value of 8.5 which
29  group with a pK(a) value of about 7 must be unprotonated and one with a pK(a) value of 9.5 must be p
30 sorbance bands suggests that these represent unprotonated and protonated Schiff base forms of the pig
31 rate CoMFA models were built for the AAIs as unprotonated and protonated species.
32 -state NMR studies of the [2]rotaxane in its unprotonated and protonated states were carried out to l
33 nd releases metal cations, when respectively unprotonated and protonated, on effecting alternate pH c
34 s of 5.65 +/- 0.25 and 8.75 +/- 0.05 must be unprotonated and protonated, respectively.
35 residues, while leaving the N-terminal amine unprotonated and therefore reactive.
36 ee functional groups in the free enzyme, one unprotonated and two protonated.
37 itively charged at acidic and neutral pH and unprotonated and uncharged at alkaline pH.
38  thereby rendering the N(epsilon2) imidazole unprotonated and well positioned for accepting the ATP p
39 pKa = 8.3) and a second residue that must be unprotonated (apparent pKa = 7.7) for maximal catalytic
40 how the imidazole N epsilon of His-124 to be unprotonated, appropriate for general base catalysis.
41                     Gas-phase conjugation to unprotonated arginine side-chains via N-hydroxysuccinimi
42  in GtCCR2 requires the Asp-96 homolog to be unprotonated, as has been proposed for the BR cytoplasmi
43 cid and the symmetric carbonyl stretch of an unprotonated aspartate, respectively, and suggest that i
44 dazolylmethylene side chains that are mostly unprotonated at neutrality because of the nearby polycat
45 vely, leaving the fluorescein moiety largely unprotonated at physiological pH and thus limiting the s
46  changes the base triple to one involving an unprotonated C41.
47 e via effects on the open probability of the unprotonated channel and the pK of one of the inhibitory
48 ening but with a lower open probability than unprotonated channels.
49 ion (VCOP(D108A)) produced a pigment with an unprotonated chromophore (lambda(max) = 360 nm) and dram
50          However, when the glutamate gate is unprotonated, Cl(-) cannot occupy this site nor, consequ
51 HS)+ protonated species but are higher-order unprotonated clusters (M3S3, M4S6, M2S4), similar to tho
52 mulations of the system having protonated or unprotonated cytosines, mimicking the pH 5.0 and 8.0 con
53 ded by transient protonation of an initially unprotonated donor, which is probably the epsilon-amino
54 facial sites between DLPC and protonated and unprotonated dye I.
55 ilitated for states with protonated K362 and unprotonated E286, which would in principle allow proton
56 ilitated for states with protonated K362 and unprotonated E286.
57 mechanism, with fumarate binding to the free unprotonated enzyme and a proton addition prior to malat
58 ll inhibitors bind faster and tighter to the unprotonated enzyme-NAD+ complex, which has a pK of abou
59 hich must be protonated to react with Tyr265-unprotonated enzyme.
60  order, followed by the direct attack of the unprotonated epsilon-amino group on AcCoA, transferring
61 quadrupole splittings for the protonated and unprotonated ferryl forms of P450(BM3) are DeltaE(Q) = 2
62 of 5.3 for an enzymatic group required to be unprotonated for activity and a second pK of 6.3 that le
63  K199R, with a requirement for a group to be unprotonated for activity with a pK of 5.6 and a partial
64 s (pK(a) values of 6.9 and 7.5) that must be unprotonated for activity.
65  of 7.0 and 6.1, respectively, which must be unprotonated for activity.
66 residue with this pK(a) (betaLys-87) must be unprotonated for binding glycine or oxindolyl-L-alanine,
67 e exhibits the requirement for a group to be unprotonated for catalysis with a pK of 5.6 and also sho
68 yme ionization with a pKa value of 7 must be unprotonated for catalysis, and an enzyme ionization wit
69 group on the enzyme with a pK of 6.4 must be unprotonated for catalysis, and it is presumed that the
70 tin profile and 7.5 in the V profile must be unprotonated for catalysis.
71  ionization with a pK(a) of 8.5 that must be unprotonated for catalysis.
72  pK(a) value of 9.1 for a group that must be unprotonated for catalysis.
73          The pK(a) of the group that must be unprotonated for catalytic activity varied according to
74            The pKa of the group that must be unprotonated for catalytic activity was consistent with
75       The identity of the group that must be unprotonated for catalytic activity was consistent with
76 ox).L-proline complex (pK(a) = 8.02) must be unprotonated for conversion to E(red).P.
77  that a single group from the enzyme must be unprotonated for maximal catalytic activity.
78 oup with a p K a of 8.1 +/- 0.1 that must be unprotonated for nitronate formation.
79 rotonated and two functional groups that are unprotonated for optimal substrate inhibition to occur.
80 y 7 for a single enzyme residue that must be unprotonated for optimum activity.
81 t a pKa of 7.0-7.5 (for a group that must be unprotonated for optimum binding) with values, above pH
82 te having a pKa of approximately 6.6 must be unprotonated for reaction to take place.
83 e phenolic hydroxyl of Tyr265, which must be unprotonated for reaction with either isomer of alanine.
84 up with a pK(a) value of ~7.5, which must be unprotonated for the catalytic phosphorylation of ACL to
85 ith a pK of approximately 6.2, which must be unprotonated for the catalytic reaction to occur.
86 ffects also indicate that sites that must be unprotonated for transport (apparent pK(a) approximately
87 icate that CH3-H4folate binds to MeTr in the unprotonated form and then undergoes rapid protonation.
88 ge interactions, whereas the T1 state of the unprotonated form does not experience any analogous stab
89  in determining the conformation of PrP; the unprotonated form favors native PrP(C), while the proton
90                                          The unprotonated form of 5-HT shows the opposite orientation
91          These results implicate the neutral unprotonated form of A38 in a transition state that invo
92 y protonated forms of the inhibitors and the unprotonated form of an amino acid residue with a pK(a)
93 he enhancement factors (in log scale) of the unprotonated form of the imidazole compounds (B) and the
94  of log V vs pH indicated that at high pH an unprotonated form of the ternary enzyme complex was able
95 sts that the inhibitor binds as the neutral, unprotonated form that is subsequently protonated to gen
96 dicate that CH(3)-H(4)folate is bound in the unprotonated form throughout this pH range and that prot
97                                       In its unprotonated form, Lys-52 acts as a base catalyst facili
98 ar substrate entering the active site in its unprotonated form.
99 he other amines remain in their noncompeting unprotonated form.
100 oup that facilitates flavin reduction in the unprotonated form.
101 se enzymes are expected to use PLP in the N1-unprotonated form.
102 yl radicals have only been observed in their unprotonated form.
103 the order Tg > Cg > Ts > Cs for the neutral (unprotonated) form of 1 and Ts > Tg > Cs > Cg for its pi
104 hydrylase are expected to maintain N1 in the unprotonated, formally neutral state for catalysis of ra
105 nger lifetime components originated from the unprotonated forms and the shorter components from the p
106 tion exchange behavior of the protonated and unprotonated forms as well as determination of the solid
107 esonance (EPR) frequencies of protonated and unprotonated forms of a pH-sensitive probe.
108         The properties of the protonated and unprotonated forms of dIII are consistent with those exp
109 c parameters for both the protonated and the unprotonated forms of each of these two entities as well
110  Raman bands belonging to the protonated and unprotonated forms of the isoquinoline ring of papaverin
111 ectra is the presence of both protonated and unprotonated forms of these compounds.
112 he doubly protonated, singly protonated, and unprotonated forms.
113 tion results in reaction of the C-2 with the unprotonated fraction of the pyridine ring to form the r
114 ulations were done for both a protonated and unprotonated Glu and led to a proposed mechanism of prot
115  only at the 181-residue site-protonated and unprotonated Glu181-and calculate several experimentally
116 t lower pH, suggesting the involvement of an unprotonated group acting as a base in the chemical step
117                                         This unprotonated group has a small DeltaH of ionization (-0.
118 or wild-type and H187Q UDG indicates that an unprotonated group in the enzyme-substrate complex (pK(a
119 h pH consistent with the participation of an unprotonated group in the reductive half-reaction and th
120                                          The unprotonated guanidino group of arginine can serve as a
121 ting for catalysis and with a model in which unprotonated imidazole accelerates the rate of isomeriza
122 d histidine show that His211 is neutral; the unprotonated imidazole nitrogen is not coordinated to zi
123                                  Addition of unprotonated imidazole results in a 5-fold increase in t
124 exen-1-one are consistent with His-186 being unprotonated in oxidized, reduced, and ligand-bound MR,
125 lu(232) in wild-type enzyme is protonated or unprotonated in the course of catalysis at neutral pH.
126  UV-sensitive cone pigments have this moiety unprotonated in the dark.
127 hat the nonbridge phosphate oxygen atoms are unprotonated in the transition state.
128 tional group binds to Na+, K+, Ca2+, and the unprotonated ionophore with binding constants of 10(3.5)
129 te of reorientation of the free carrier when unprotonated is predicted to be responsible for the coup
130  resulting intermediate, the dissociated but unprotonated leaving group forms an alkoxide coordinated
131                                     As such, unprotonated Lys-73 could promote serine for acylation,
132 ld reconfigure to the protonated Glu-166 and unprotonated Lys-73.
133                                   This gives unprotonated Lys73 and protonated Glu166.
134 d that the underlying mechanism involves the unprotonated N atom acting as a H-bonding acceptor to fa
135 ound such that Asn-221 hydrogen bonds to the unprotonated N1 instead of the protonated N3 of the cofa
136 in their protonated cation form and in their unprotonated neutral form, but to date, tyrosyl radicals
137 te cavity, (3) the side chain of His64 being unprotonated (neutral) and predominantly in an inward co
138 of 14 kcal/mol for the formation of .NO from unprotonated nitrite substrate.
139 or the binding of two gold(I) centers to the unprotonated nitrogen atoms, despite greater orbital den
140 ring can be either protonated (pAPIRH(+)) or unprotonated (pAPIR).
141                                          The unprotonated peroxohemiacetal provides a branch point fo
142 roup as the 2-hydroxyl of ribose attacks the unprotonated phosphate.
143 ue in the peptide binding cleft that must be unprotonated (pK(a) = 5.8) for peptide binding and likel
144 tely 1 s time scale, which suggests that the unprotonated predecessor of Meta II in the native membra
145 s consistent with a covalent modification of unprotonated primary amines (i.e., N-terminus and epsilo
146 eactivity is analogous to that observed with unprotonated primary amines such as the N-terminus or ep
147 ves, an amide bond is formed between a free, unprotonated, primary amine group of a lysine side chain
148 yridoxal 5'-phosphate (PLP) with an unusual, unprotonated pyridine is mainly due to solvation effects
149 approximately equimolar amounts of an Ndelta-unprotonated (pyridine-like) form and an Ndelta-protonat
150 s rationalized by a greater abundance of the unprotonated radicals that preferentially abstract hydro
151 l-trans-retinal Schiff base is protonated or unprotonated, respectively.
152 ->BR, where M(1), M(2), and M'(2) contain an unprotonated retinal Schiff base before and after a reor
153 ater 402 moves also, nearly 1A away from the unprotonated retinal Schiff base nitrogen.
154 ude that the MUV-visual pigment possesses an unprotonated retinylidene Schiff base in the dark state,
155                                  Conversely, unprotonated Sap C (initially dissolved in a neutral buf
156         In the dark state, VCOP-D108A has an unprotonated Schiff base (SB) chromophore (lambdamax = 3
157 al and electrostatic effects surrounding the unprotonated Schiff base (USB) retinyl chromophore in th
158  the wild-type protein, no intermediate with unprotonated Schiff base accumulated.
159 e SWS1 pigments result from a protonated and unprotonated Schiff base chromophore, respectively.
160         These results are consistent with an unprotonated Schiff base chromophore.
161                                          The unprotonated Schiff base contribution (approximately 16
162  form (pH 5.5, lambda(max) = 496 nm) and the unprotonated Schiff base form (pH 8.2, lambda(max) = 384
163 ment with opsin, through both protonated and unprotonated Schiff base linkages and likely within the
164 nist is rapidly converted to an agonist, the unprotonated Schiff base of all-trans retinal, upon ligh
165 C15=NZ-CE plane breaks the connection of the unprotonated Schiff base to the extracellular side and e
166 ut illumination and in the photocycle of the unprotonated Schiff base were measured in the visible an
167 by the deletion of Phe-86 that converted the unprotonated Schiff base-linked 11-cis-retinal to a prot
168  chemical calculations strongly suggest that unprotonated Schiff base-linked chromophore is responsib
169 port the hypothesis that UV pigments have an unprotonated Schiff base-linked chromophore.
170 ase (PSB11), UV pigments uniquely contain an unprotonated Schiff-base (USB11).
171 ms shows that the photoproduct aniline, left unprotonated, serves as a poison for the QD catalyst by
172 guanidinium group, -NH-C(NH2)2+ and that the unprotonated side chain of these amino acids is responsi
173      (1) The ascorbate monoanion binds to an unprotonated site (histidine) on cytochrome b(561).
174 ationship (QSAR) models for this data set as unprotonated species assuming the Tg, Cg, and Ts conform
175 side and having that nitrogen largely in the unprotonated state facilitates its formation.
176                                     Only the unprotonated state of Myosin A-H810 is compatible with t
177  The catalytic lysine may be returned to its unprotonated state using a rectifying proton tunnel driv
178 d reaction of thiols with H2O2 when in their unprotonated state would provide a potential mechanism f
179 f the imidazole (15)N between protonated and unprotonated states.
180 e increasing concentration of the inhibitory unprotonated substrate.
181 g of serine is accompanied by a shift to the unprotonated tautomer of the external aldimine as well a
182 nd exists as a mixture of the protonated and unprotonated tautomers.
183 80 and 100 K, where the Schiff base remained unprotonated, the Wat85 pair stayed in similar states to
184 Schiff base counterion Asp-75, which remains unprotonated throughout the photocycle.
185   This suggests that the active site must be unprotonated to react with ascorbate and protonated to r
186 ur in molecules whose Schiff base linkage is unprotonated, we changed the pH of the solution bathing

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