ライフサイエンスコーパス: unreactive

1 AGPA (it is assumed that the D-enantiomer is unreactive).

2 aromatic structure and are stable in air and unreactive.

3 ty, with the Mn(IV)(3)CaO(4) OEC model being unreactive.

4 ental P resides, is relatively insoluble and unreactive.

5 ation was attained, while anhydrite remained unreactive.

6 ive, whereas the beta-anomer was found to be unreactive.

7 of DTT thiol groups are protonated and thus unreactive.

8 ht that the interior surface of nanotubes is unreactive.

9 , which are dominant in marine systems, were unreactive.

10 alpha,beta-Unsaturated esters were unreactive.

11 ly functionalized ceramides were found to be unreactive.

12 e unable to adopt the S-cis conformation are unreactive.

13 ophiles, whereas constrained nucleotides are unreactive.

14 e spin transfer cannot occur, the species is unreactive.

15 onyl functionalities at nitrogen, are rather unreactive.

16 Esters were unfortunately found to be unreactive.

17 The other altered state is unreactive.

18 reduced form of Cys 266, which is otherwise unreactive.

19 like, acceptors were found to be essentially unreactive.

20 ntal phospholipids and alcohol analogues are unreactive.

21 e reactive than TCEP, and DTT is essentially unreactive.

22 Disulfides (cystine) are unreactive.

23 Cystine and histidine derivatives are unreactive.

24 is constrained trans to the 2'-amine is also unreactive.

25 isubstituted and trisubstituted alkenes were unreactive.

26 in, whereas the anti-beta-silyl alkoxide was unreactive.

27 lkylidenes that bear a boron substituent are unreactive.

28 ant is so far from optimal that it is almost unreactive.

29 Adenine is essentially unreactive.

30 Of the 268 OFSs, 266 were unreactive.

31 mbranes; however, their matrices were mostly unreactive.

32 actions of G217B; cytoplasmic fractions were unreactive.

33 consequence of which renders both chemically unreactive.

34 s, which in its oxidized state is relatively unreactive.

35 owed by the 3,5-positions, while the 2,6 are unreactive.

36 to oxidative addition, rendering the system unreactive.

37 Hexafluorobenzene proves unreactive.

38 Aliphatic amines were unreactive.

39 ronates for reaction that would otherwise be unreactive.

40 t gas phase basicities being, in large part, unreactive.

41 eas more substituted secondary alcohols were unreactive.

42 n the C-H bonds, previously considered to be unreactive.

43 d probe based on a warhead so far considered unreactive.

44 4.9 x 10(4) M(-1) x s(-1)) of the relatively unreactive (1)HNO into the extremely reactive (3)NO(-).

45 Inversely, with unreactive 2'-fluoro-RNA substrates, AID's deaminase act

46 tructures of these mutants complexed with an unreactive abasic site in DNA reveal these residues to a

47 ading to productive glycosylations even with unreactive acceptors.

48 rawing groups failed to glycosylate hindered unreactive acceptors.

49 formation with a reactive chiral face and an unreactive achiral face.

50 actions involving challenging and relatively unreactive acyclic diene substrates.

51 phene acryloyl HAV 3C (C24S) is a relatively unreactive acyl enzyme, deacylating with a pKa of 7.1 an

52 When the pupils remained dilated and unreactive after 6 mins of CPR, resuscitation efforts we

53 ading to higher reactivity for the otherwise unreactive aldehydes.

54 e the substitution of sulfur for hydrogen at unreactive aliphatic or electron-rich aromatic carbon at

55 for the alkylation of amides with relatively unreactive alkyl halides (i.e., poor substrates for SN2

56 The AGP-unreactive alpha-galactosyl Yariv reagent (alpha GalY) h

57 te that N-alkylation activates the otherwise unreactive amide bond towards sigma N-C cleavage by swit

58 in the presence of dihydroNADPH (NADPH3, an unreactive analogue lacking the 5,6-double bond in the n

59 nding experiments with dGCVIA peptide and an unreactive analogue of FPP, (E,E)-2-[2-oxo-2-[[(3,7,11-t

60 ynthetase, was determined in complex with an unreactive analogue of its acyl-adenylate and CoA.

61 Formamides are unreactive analogues of aldehydes and bind to the enzyme

62 Formamides are unreactive analogues of the aldehyde substrates of alcoh

63 resulting Au99(SPh)42 compound, however, is unreactive and highly stable in the presence of excess a

64 metals other than palladium were completely unreactive and led to recovered starting material.

65 molecule (4 or CDNB) leading to formation of unreactive and reactive complexes, respectively.

66 -1 (ET-1) and endothelin-3 (ET-3) relatively unreactive and resistant to proteolytic cleavage.

67 hydrogen bonds to the O2' atom, rendering it unreactive and thus explaining the specificity for 2'-de

68 on paths associated with other h-e pairs are unreactive, and the moderate experimental efficiency is

69 literature but whose protons were considered unreactive are also shown for the first time to react wi

70 may be synthetically useful when relatively unreactive arene substrates such as benzene, toluene, an

71 this approach to monofluorobenzenes, highly unreactive arenes, which upon complexation become nearly

72 Secondary amines are unreactive, as is a catalyst with a single aminolyzable

73 l back to its parent molecule, it formed the unreactive ascorbate anion radical.

74 ue-like profiles but was weakly localized to unreactive astrocytes; weak HLA-DR and GFAP immunoreacti

75 ages in [4 + 2] cycloadditions with normally unreactive azadienophiles including unactivated cyano gr

76 Using saposin B as a unreactive backbone, chimeric saposins containing variou

77 s the most favored one thermodynamically, is unreactive because of a high propensity for charge recom

78 e Mabs that recognized residues 141-164 were unreactive because of the 146-160 deletion; in addition,

79 tive of MDH.PQQ(NH2(+).methanol structure is unreactive because of the nonproductive means of methano

80 s for the Michael reactions of traditionally unreactive beta,beta'-enones and substituted beta,beta'-

81 also the subsequent functionalization of the unreactive beta-methylene group in an unprecedented tand

82 a powerful tool with which to convert these unreactive bonds into carbon-carbon and carbon-heteroato

83 Unreactive by itself, the Mo-dimethyl catecholate analog

84 The amination of nominally unreactive C(aryl)-H bonds via a sequential directed ort

85 one step, and in the process transforms the unreactive C-3 position to the reactive C-5 position.

86 ) may be a general strategy for cleaving the unreactive C-C bonds between adjacent sp(2)-hybridized c

87 nctionalize molecules directly at ostensibly unreactive C-H bonds, chemists have discovered reaction

88 t catalytic methods to cleave the relatively unreactive C-O bonds of ethers remains an important chal

89 e reaction is based on the activation of the unreactive C-OMe bond by the proximate amide directing g

90 diates capable of abstracting a hydride from unreactive carbon centers, including benzyl-, allyl-, an

91 f methane through the cleavage of the highly unreactive carbon-phosphorus bond in methyl phosphonate

92 ctivation catalysis) is employed to activate unreactive carbonyl substrates.

93 ) to undergo oxidation to Tl(III) due to the unreactive character of the 6s(2) electrons.

94 at could allow delineation of the active and unreactive clones, the sequences identified in five of t

95 a mechanism in which each nucleotide samples unreactive (closed) and reactive (open) states.

96 teraction with the reduced Fd present in the unreactive complex.

97 predominates in the presence of practically unreactive compounds (acetone, butanol, propionic, and b

98 f the triphosphate of GTP, destabilizing the unreactive conformation and thereby allowing thermal flu

99 rate processes, (b) alternative reactive and unreactive conformations, and (c) mutations within the c

100 3)Bi-7.16.4, (c) 120 muCi (213)Bi-Rituximab (unreactive control), and (d) unlabeled 7.16.4.

101 but now new substrates that were previously unreactive could be employed.

102 We conclude that Cys-41 is the unreactive cysteine in PLB and is located at a crucial s

103 acylcarbohydrazides represent a new class of unreactive cysteine protease inhibitors that share a com

104 ting increased accessibility of a previously unreactive cysteine residue.

105 map to putative loops and turns whereas the unreactive cysteines lie within the predicted interior o

106 ust the ratio between fast reactive and slow unreactive decay channels.

107 Formation of this unreactive dimer is an important step in the mechanism o

108 rception of the reaction by the formation of unreactive (E)-phosphazides.

109 On addition of HMBPP to an (unreactive) E126A IspH mutant, a reaction intermediate f

110 les enantioselective reactions of relatively unreactive electrophiles.

111 a new capacity, to incorporate two otherwise unreactive elements, Re and Zn, in the same structure wh

112 tially stabilize the reactive imine over the unreactive enamine tautomer.

113 ing the tandem oxidation and amidation of an unreactive ethyl group.

114 active headgroup and a matrix-silane with an unreactive ethylene glycol group.

115 Thus, ostensibly unreactive excipients under certain conditions may incre

116 ys265 is absent in the homologous but oxygen-unreactive FAD site in heterotetrameric sarcosine oxidas

117 ow yield; additionally, the lactones are too unreactive for solid-phase applications.

118 fic for the Mycobacterium avium complex were unreactive for these strains.

119 cases, catalyze oxidation of the thiol to an unreactive form such as a sulfinic or sulfonic acid.

120 The manipulation of traditionally unreactive functional groups is of paramount importance

121 Carbon-fluorine bonds are among the most unreactive functionalities in chemistry.

122 ctions is particularly pronounced in case of unreactive glycosyl donors and/or glycosyl acceptors.

123 sulted in the precipitation of insoluble and unreactive group 2 acetylides.

124 cture of RtcB in complex with Mn(II) and the unreactive GTP analogue guanosine 5'-(alpha-thio)triphos

125 The facile formation of the remarkably unreactive hemiketal 16 thwarted attempts to elaborate 1

126 generally thermodynamically and kinetically unreactive; however, we recently discovered that the tri

127 The triose binds to XI as the unreactive hydrate, but ligand binding induces metal cof

128 The selective activation of unreactive hydrocarbons by biosynthetic enzymes has insp

129 the formation of covalent bonds by oxidizing unreactive hydroquinone moieties in LHA to reactive, ele

130 plexation of an activator species to form an unreactive, immobile complex reduces the effective diffu

131 and excels at the introduction of relatively unreactive impurity ions that have not been previously a

132 Four AIDS-KS sera were unreactive in both assays.

133 Other types of cells were unreactive in both groups.

134 gh proliferative responses but are virtually unreactive in certain other assays, e.g., skin graft rej

135 Amide N-C(O) bonds are generally unreactive in cross-coupling reactions employing low-val

136 enders the antigen-antibody-HRPase complexes unreactive in subsequent reprobings of the same membrane

137 All dyes were unreactive in the 8-position.

138 and also that fully saturated compounds are unreactive in the catalytic system.

139 or and a second oxidant (Ox2 ) that would be unreactive in the primary reaction.

140 mplex whereas those with KSPXXX repeats were unreactive in this system.

141 eplacement for Asn245, which is inaccessible/unreactive in WT LacY, alkylates readily in the Gly-->Tr

142 coli RNAP, forming the closed, permanganate-unreactive intermediate I(1).

143 products occurs due to the epimerization of unreactive intermediates from the other two pathways, as

144 n framework confers activity on an otherwise unreactive iron-haem cofactor.

145 ssary recognition elements into an otherwise unreactive junction resulted in specific strand scission

146 the chemoselective reduction of an extremely unreactive lactam in the presence of a readily reduced l

147 ppears to be critical for inhibition because unreactive lipids, e.g. PGB1, PGE2, PGF2alpha, and TxB2,

148 The ratio of unreactive lithium-cationized hexose to total lithium-ca

149 zyne moiety, thereby generating a relatively unreactive meta-benzyne analogue.

150 owing to its sequestration by calcium in the unreactive mineral hydroxyapatite.

151 revealed that fungi recruit and redistribute unreactive Mn(2+) provided by fresh plant litter to prod

152 on reveals that absorption by high-frequency unreactive modes (e.g., C[double bond]C stretches) incre

153 heated in the presence of a noble gas or an unreactive molecule at 650 degrees C and 3000 atm pressu

154 reaction that consumed small amounts of the unreactive monoacetate (-)-9.

155 ds to accelerate C-H activation of otherwise unreactive monodentate substrates is crucial for outcomp

156 er reactions for a number of substituted and unreactive N-allyl-2-furfurylamines under biomimetic con

157 For example, in reaction with highly unreactive n-butyl acrylate and using only 2 equiv of MD

158 cess to reactive sites, promote formation of unreactive NH4(+), and reduce oxidant levels due to high

159 t methanol and dimethyl ether are apparently unreactive on the two most important methanol-to-hydroca

160 cyclopropane bond to give a lower energy and unreactive open triplet, has been suggested.

161 s were also easily obtained but showed to be unreactive or rearranged under these cyclization conditi

162 und for incubations of DNA/enzyme films with unreactive organic controls or hydrogen peroxide.

163 in a mixture of precursors that would remain unreactive otherwise.

164 The resting state Fe(III) is unreactive oxidatively.

165 re treated soils were dominated by dissolved unreactive P (DUP), mainly originating from manure.

166 ene (NHC)-induced activation of an otherwise unreactive Pd/Al2O3 catalyst.

167 ther cleaved from iridium by water or formed unreactive, phenoxide-bridged iridium dimers.

168 Because hydrotalcites do not have an unreactive polymer as a structural core, their aqueous s

169 interesting biofunctionalization approach of unreactive polymers with applications in immunosensing a

170 cterized by changing the relative amounts of unreactive polymorphic lipid and reactive lamellar lipid

171 this radical can abstract hydrogen atoms at unreactive positions, facilitating the introduction of a

172 etal complexes cleave C-H bonds at typically unreactive positions.

173 of the water adduction reaction rate or the unreactive ratio provides two separate methods for confi

174 he equilibrium constant for the formation of unreactive reactant dimers.

175 The use of well-controlled fabrics, unreactive reference materials, and a life-cycle based e

176 ted: three Ag variants and one Au used as an unreactive reference to separate mechanical from chemica

177 F3)4](-) and [(bpy)Cu(CF3)3], are stable and unreactive, remaining dead-end spectators throughout the

178 ydrogen binding of the Asp side chain of the unreactive residue may be the constraint that prevents i

179 duct yield and rate of oxidation of formerly unreactive Rieske clusters.

180 flexibility in the number and structures of unreactive rings, since both Tcm and B3 and DMAC are goo

181 ease of tethered molecules, while generating unreactive side products.

182 These thioalkyl esters are rather unreactive so the ligation reaction is catalyzed by in s

183 both catalyzing mineralization in otherwise unreactive solution and of templating nanocrystal growth

184 be fit to a model that assumed a protonated unreactive species A, a major reactive species B, and a

185 , like those obtained from biomass or highly unreactive species, such as CO2 should be transformed in

186 on of the binuclear center was trapped in an unreactive, spectrally distinct form which is most likel

187 the open conformation possibly represents an unreactive state with Glu-288 positioned away from the c

188 of TUNEL-reactive DNA to a subsequent TUNEL-unreactive state.

189 from two MAb 10F3-reactive and two MAb 10F3-unreactive strains of M. catarrhalis revealed that the d

190 ure of its complex with three Mg(2+) and the unreactive substrate analogue dimethylallyl-S-thiolodiph

191 ase complexed with three Mg(2+) ions and the unreactive substrate analogue farnesyl-S-thiolodiphospha

192 mide displacement reactions, carba-NAD is an unreactive substrate analogue for NAD-consuming enzymes.

193 The unreactive substrate analogue, maleate, is used to induc

194 ohol dehydrogenase complexed with NAD(+) and unreactive substrate analogues, 2,2,2-trifluoroethanol o

195 sing highly modified, severely minimized, or unreactive substrate analogues.

196 , which was associated with the formation of unreactive surface carbonato complexes.

197 oach can be employed for a range of normally unreactive systems.

198 d to a protein target, changing an initially unreactive terminus into one that could be modified in h

199 of the approaching SO2 and makes a normally unreactive tertiary carbenium carbon susceptible to addi

200 KO(t)Bu by the selective C-C coupling of an unreactive tertiary sp(3) C-H bond.

201 t peptides of each of the three proteins are unreactive, that the length at which they become accessi

202 in that its electrophilic carbon is rendered unreactive through steric hindrance.

203 The mutants F56C to L59C and I75C were unreactive to 4-PDS under the conditions used, suggestin

204 illar inclusion pathology was diminished and unreactive to antibodies specific for the C terminus of

205 MAb 4A4-2 was unreactive to antigens of two closely related apicomplex

206 Ala and Gly are far too unreactive to be useful probes in typical experiments an

207 free drug, yet remain essentially stable and unreactive to in vitro DNA alkylation conditions (<0.1-0

208 Cys-87 was unreactive to maleimides under all conditions in wild-ty

209 cids and esters, the chromophore of pnGFP is unreactive to millimolar concentrations of hydrogen pero

210 in the presence of B(C6 F5 )3 , a Lewis acid unreactive to O2 , to generate bis(borane) peroxide.

211 fine stable DNA hairpins that are relatively unreactive to single strand-specific probes.

212 ackground, the T cells mediating lesions are unreactive to viral Ags.

213 ctional state, in which the active sites are unreactive, to the functional proteolytic conformation.

214 s-DNA treated in buffer or buffer containing unreactive toluene resulted in no significant changes in

215 onyls and imines (pi-electrophiles), but are unreactive toward a range of other electrophiles.

216 mocysteine and methyltetrahydrofolate but is unreactive toward adenosylmethionine and flavodoxin.

217 The D-isomer of Ser is unreactive toward alpha 2 beta 2, and therefore, D,L-Ser

218 nce model studies showed that lactone 13 was unreactive toward amines.

219 One-electron oxidized 2'-FdC is unreactive toward C3'* or C2'* formation.

220 In contrast, [Zn3(OH)3L] (4) was found to be unreactive toward CO2 over the course of several days at

221 Molecular oxygen is generally unreactive toward covalent bonds, due to spin conservati

222 F; R = H, 1-H) were prepared and shown to be unreactive toward D(2) and alpha-olefins, leading to the

223 a high-spin, five-coordinate complex and is unreactive toward dioxygen.

224 ing to [Ar*SnH2 (PtBu3 )](+) which is rather unreactive toward further dehydrogenation.

225 While unreactive toward further oxidation, Compound RH can be

226 n CHCl3 and other nonpolar solvents, OsO4 is unreactive toward H2 over a week at ambient temperatures

227 as pi-activated alcohols, which are normally unreactive toward HCl catalysis.

228 lates that form on warming the solutions are unreactive toward isobutyraldehyde and undergo retroaldo

229 However, the silicon reagent is completely unreactive toward many sulfones, the tin reagent typical

230 toward adenosylmethionine and flavodoxin but unreactive toward methyltetrahydrofolate.

231 with azide, thiocyanate, and ammonia, but is unreactive toward nitriles, NO, and butyrate.

232 Moreover, the CDO active site is essentially unreactive toward NO in the absence of substrate, sugges

233 ply that the metal centers of the oxides are unreactive toward NO(2).

234 l changes that render the trinuclear cluster unreactive toward O(2), demonstrating a structural role

235 (4), was prepared and found to be completely unreactive toward O(2), suggesting a critical role for F

236 rimary N-oxides, and secondary N-oxides, are unreactive toward or react predominantly by proton trans

237 by allylic oxygenation of linoleic acid, are unreactive toward oxidative fragmentation.

238 e semiquinone is highly stabilized making it unreactive toward oxygen; and 3) the Q(o) site catalyzes

239 ol(2)(eta(4)-C(4)CO)Ru(CO)(2)H](-) (13) were unreactive toward PhCHO under conditions where facile Ph

240 hough B(C(6)F(5))(3) has been reported to be unreactive toward silica in the absence of a Bronsted ba

241 CsoR is unreactive toward sulfite under the same conditions.

242 otonation renders basic sites (nucleophiles) unreactive toward the N-hydroxysuccinimide ester reagent

243 alue (10.5) that makes this thiol relatively unreactive toward the target disulfide in nDsbD.

244 hat Mn(IV)(3)CaO(4) and Mn(IV)(3)ScO(4) were unreactive toward trimethylphosphine (PMe(3)).

245 odeled after the p53 acetylation site but is unreactive toward trypsin because all other lysine and a

246 The diradical is unreactive toward water, methanol, and chloroform; upon

247 LS-3DCHIm is resistant to reduction, is unreactive toward weakly acidic 4-NO2-phenol, and strong

248 y to cleave carbon-heteroatom bonds that are unreactive towards other transition metals.

249 Carboxamide-ligated 8 is shown to be unreactive towards oxo atom donors, in contrast to imine

250 The complex 2 was air-stable and unreactive towards water, methanol, and other substrates

251 eful for separation of microliter amounts of unreactive trace volatile compounds from large-volume ga

252 ithin a series of g-C3N4, the yield of these unreactive trapped electrons correlates inversely with H

253 As a result, the unreactive triplet state nitrene undergoes delayed, ther

254 c acid, a compound previously reported to be unreactive under Dakin-West conditions, forms 4-phenyl-2

255 On the other hand, SA is singularly unreactive under identical reaction conditions, except f

256 hindered alpha-quaternary lactams which are unreactive under known conditions for similar transforma

257 alyzed rearrangement of precursors that were unreactive under simple thermal instigation.

258 erization into alpha-bromide that is totally unreactive under the established reaction conditions.

259 yl chlorides and aryl and vinyl halides were unreactive under the reaction conditions.

260 ng, while the 5-alkyl isomers are completely unreactive under the same conditions.

261 Although 1,5-dienes with this skeleton were unreactive under thermal conditions, they were photochem

262 ethyl, and isopropyl esters are essentially unreactive under these conditions, allowing for the sele

263 atic aldehydes, as an aliphatic aldehyde was unreactive under these conditions, and other reactive fu

264 ss of sulfur(VI) halides, that are generally unreactive unless activated by protein binding.

265 ur) is suggested to be largely insoluble and unreactive until it reacts with hydrogen sulfide.

266 were found in occluded positions, while some unreactive uracils were found in exposed positions.

267 Interestingly, trans-vinylsilanes are unreactive, whereas allylic oxidations of cis-vinylsilan

268 in the acrosomal process, C837 is completely unreactive while the other cysteines become less reactiv

269 In this series, sulfanyl derivatives were unreactive, while sulfoxide and sulfone analogues provid

270 Sera from women and men that were unreactive with alpha-actinin (negative control sera) fa

271 M. capricolum EIIA was unreactive with antibodies directed against the correspo

272 Lycopene has previously been reported to be unreactive with BCO1, and our findings warrant a fresh l

273 xy analog of the natural substrate, normally unreactive with cAOS, was thereby epoxidized stereospeci

274 Other hedgehog point mutants at D303, also unreactive with cholesterol, accepted 3HPC as a substrat

275 ree, extruded mast cell granules was largely unreactive with DAO-gold.

276 e, the full- and half-resonance lactams, are unreactive with DMDO.

277 4-Hydroxyphenyl isopropyl sulfone (6) is unreactive with either CCl4 or CBrCl3 in KOH-t-BuOH, its

278 ere we show that antithrombin is essentially unreactive with factor IXa in the absence of heparin (k(

279 m) of 7 microm; k(cat)) of 14 min(-1) but is unreactive with GDP, GTP, GpppA, ATP, CTP, or UTP.

280 o methylates the cap analog m(7)GpppA but is unreactive with GTP, GDP, GpppA, m2,2,7GTP, m2,2,7GDP, A

281 .26(+) OVA-specific CD4(+) T cells that were unreactive with HSV.

282 enide (TOPSe)) were surprisingly found to be unreactive with metal carboxylates and incapable of yiel

283 S esters, which would render them relatively unreactive with NHS esters.

284 This form of NDO is unreactive with O2.

285 This conformation of the enzyme is unreactive with oxygen.

286 d that while carboxylated SWCNTs were rather unreactive with respect to direct solar photolysis, they

287 In contrast, uracil is completely unreactive with ribose under these conditions.

288 rapidly with carbon-centered radicals but is unreactive with superoxide and lipid peroxidation produc

289 ated iron(II)-SciOPP species was found to be unreactive with the cycloheptyl bromide electrophile ove

290 Except for strains unreactive with the Fluo-card (8%), all S. anginosus and

291 d analogue of 1, [(bppppa)Ni](ClO4)2 (2), is unreactive with the hemithioacetal, thus indicating the

292 omplete V(H) and V(L )germline revertant was unreactive with the human ILD and didomain, the Escheric

293 Clones reactive with this pool but unreactive with the pool of pony antisera to organisms c

294 ) mice in which all CD4(+) T lymphocytes are unreactive with the protozoan.

295 Complex 1 is unreactive with the thioester product, PhCH(OH)C(O)SCD3,

296 ata demonstrate that 19-substituted BQAs are unreactive with thiols, display reduced hepatotoxicity,