ライフサイエンスコーパス: unrelated

1 rs, those between mothers and daughters were unrelated.

2 ng of alpha-synuclein pathologic changes was unrelated.

3 age-oriented approach, we have identified an unrelated Acr in a virulent phage of Streptococcus therm

4 In seven unrelated affected individuals, all suffering from devel

5 nally greater similarity (P value = 0.02) to unrelated affected individuals.

6 k if a test individual is more similar to an unrelated affected than to the unrelated unaffected sibl

7 mice retain immune competence to respond to unrelated Ags.

8 In the present work, 79 structurally unrelated analytes were taken into account and their chr

9 and FES systems through other preserved, but unrelated and limited in number, volitional movements (e

10 With the increasing use of mismatched, unrelated, and granulocyte colony-stimulating factor-mob

11 oinfecting pair, isolates were genotypically unrelated, and their genotypes were common among isolate

12 tibodies and antibody fragments specific for unrelated antigens suggest that the formation of the ant

13 n this process remain elusive due to a large unrelated background resulting from primary beam-induced

14 Top hits were structurally unrelated BETi, including JQ1, I-BET151, CPI-203, and BI

15 ionships between concentrations of seemingly unrelated biopolymers.

16 lymphoma [7.70, 7.20-8.23]), and some virus-unrelated cancers (eg, lung [1.97, 1.89-2.05]), but not

17 without carrier or linked to other allergen-unrelated carriers.

18 ation study of lean mass index (LMI) in 1000 unrelated Caucasian subjects, and replicated in 2283 unr

19 d Caucasian subjects, and replicated in 2283 unrelated Caucasians subjects.

20 ed function, and 5% of a second group of 170 unrelated CG patients carried rare variants in this gene

21 s, we performed whole-exome sequencing of 26 unrelated CG patients.

22 m observational studies can be confounded by unrelated changes in healthcare utilization, changes in

23 Eighty-five unrelated children with a diagnosis of isolated or syndr

24 We find striking similarities to the unrelated Chlamydiales, suggesting convergent adaptation

25 to several structurally and mechanistically unrelated classes of antibiotics and enhance survival fo

26 Their seemingly unrelated clinical presentations and pathologies share t

27 f these loci replicated at P < 0.00045 in an unrelated cohort (N = 122,867).

28 These results were validated in unrelated cohorts of early infected subjects as well as

29 Here we show in two large, unrelated cohorts that decline in kidney function associ

30 ns, whereas few strains occurred in multiple unrelated cohorts.

31 roteins involved in the various diseases are unrelated, common pathways appear to be used for their i

32 We now report a structurally unrelated compound, Photoregulin3 (PR3) that also inhibi

33 Only a few structurally unrelated compounds interfering with ELAV protein-mRNA c

34 In two unrelated consanguineous families, we identified three p

35 e, we employed whole-exome sequencing in two unrelated consanguineous kindreds with central nervous s

36 We found the same homozygous mutation in an unrelated consanguineous patient with diabetes and bone

37 rom the CD95 and CD95L mRNA sequences and an unrelated control gene, Venus, we have identified many t

38 d PD (mean disease duration 8 months) and 20 unrelated controls.

39 Other BMT options include unrelated cord blood or mismatched family donors.

40 cordingly, multiple mechanisms, which may be unrelated, could restore viability.IMPORTANCE Genetic an

41 Among 90 unrelated CS/CS-like individuals, 29% were found to have

42 This reaction is catalyzed by two unrelated cyclase enzymes using different chemistries.

43 Phenotyping of 137 unrelated deletion and reciprocal duplication carriers o

44 ck expression and disease outcome in CLL are unrelated despite observations that its inhibition produ

45 em, developed for human papillomavirus (HPV)-unrelated disease, discriminates poorly when applied to

46 In contrast to all of these observations, unrelated DNA-catalyzed radical DNA cleavage reactions r

47 ot available, a haploidentical or mismatched unrelated donor (mMUD) can be useful.

48 o hundred patients were grafted from matched unrelated donor (MUD), of these, 129 (64.5%) received an

49 al risk that use myeloablative conditioning, unrelated donor (URD), and methotrexate are not known.

50 identical sibling or a 10/10 allelic-matched unrelated donor in the same period.

51 Matched unrelated donor recipients showed a 3.8-fold elevated ri

52 were matched unrelated donors or mismatched unrelated donors (n = 18) and matched related donors (n

53 ematopoietic cell transplantation (HCT) from unrelated donors as compared with related donors.

54 Stem cell donors were matched unrelated donors or mismatched unrelated donors (n = 18)

55 followed by HCT from HLA-matched related or unrelated donors.

56 underwent HCT from 9/10 or 10/10 HLA-matched unrelated donors.

57 h revealed another three micromolar agonists unrelated either to 28 or known muscarinics.

58 ions to experienced and described offers are unrelated even though they predict the same outcomes.

59 It is not known whether unrelated expenditures resulting from this "broad" defin

60 tion of proteins associated with eHAV versus unrelated extracellular vesicles with similar buoyant de

61 dentified 3 mutations in exon 7 of NTN1 in 2 unrelated families and 1 sporadic case with isolated con

62 ndrome, we identified four children from two unrelated families carrying homozygous missense variants

63 Whole-exome analysis across 3 unrelated families found no pathogenic variants in known

64 We report that patients from three unrelated families harbor either of two missense mutatio

65 Here, we have identified 2 unrelated families in the BRIDGE Bleeding and Platelet D

66 C1D23 mutations in six individuals from four unrelated families manifesting a non-degenerative form o

67 322-10G>A in affected sibling pairs from two unrelated families of Puerto Rican descent.

68 ese disorders (HIPKD) in 17 children from 11 unrelated families suggested an unrecognized genetic dis

69 cesses, we report here four individuals from unrelated families where biallelic mutations in C1QBP ca

70 homozygous truncating mutations in MYPN in 2 unrelated families with a slowly progressive congenital

71 Seven patients from 4 unrelated families with arRP, among whom 3 patients had

72 ATAD3A fusion genes in individuals from four unrelated families with fatal congenital pontocerebellar

73 Here we report six individuals from four unrelated families with HPA who exhibited progressive ne

74 esults of 467 index patients from apparently unrelated families with hypertrophic cardiomyopathy were

75 t protein, MRPS34, in six subjects from four unrelated families with Leigh syndrome and combined OXPH

76 argeted sequencing of 13 individuals from 10 unrelated families with overlapping clinical manifestati

77 We report 5 individuals in 3 unrelated families with severe thrombocytopenia progress

78 Five affected subjects (three unrelated families) were documented to share biallelic i

79 putative myosin adaptors that belong to two unrelated families, with four members each (MadA and Mad

80 x lethal encephalopathic patients from three unrelated families.

81 Thirty-six affected individuals from 23 unrelated families.

82 bands and 2 unaffected family members from 4 unrelated families.

83 61Leu) in four affected individuals from two unrelated families.

84 l-dominant sensorineural hearing loss in two unrelated families.

85 we report 11 individuals with HGF from three unrelated families.

86 sought to identify the cause of disease in 3 unrelated Finnish kindreds with variable symptoms of imm

87 oning and mobilized peripheral blood HSCT in unrelated, fully MHC-matched Mauritian-origin cynomolgus

88 to determine whether FMRP has a multitude of unrelated functions or whether combinatorial mechanisms

89 essary for the activity of diverse Trxs with unrelated functions.

90 th certain chromosomes combining up to eight unrelated gene fragments.

91 cted with control complexes that targeted an unrelated gene.

92 BRD2-occupied element positioned between two unrelated genes enables regulatory influence to spread f

93 eviously annotated promoters of functionally unrelated genes, and like typical enhancers, they form e

94 inal repeat (LTR) retrotransposons and other unrelated genes.

95 ding, and the challenge is to winnow out the unrelated genetic factors to identify those related spec

96 n for mutations in cadherin 2 (CDH2) gene in unrelated genotype-negative patients with ARVC.

97 ree of natural variation in large samples of unrelated great apes.

98 apten inhibition and the use of structurally unrelated hapten-BSA adducts confirmed antigen specifici

99 s suggest that the increased GVHD risk after unrelated HCT is predominantly an effect of HLA-mismatch

100 y and 25 had a non-BD mood disorder), and 80 unrelated healthy individuals.

101 on, we analyzed a cohort of 2530 related and unrelated hematologically normal individuals (ages 55 to

102 rome who underwent myeloablative HLA-matched unrelated hematopoietic cell transplantation (HCT) were

103 Furthermore, an unrelated herpes simplex virus-thymidine kinase (HSV-TK)

104 ions were generally rare, we identified five unrelated hES cell lines that carried six mutations in t

105 ither closely related (homotypic defence) or unrelated (heterotypic defence) to the prophage.

106 ical to that found over many years in other, unrelated, hyperinvasive meningococci, suggesting that t

107 opoI-CTDs in mycobacteria are evolutionarily unrelated in amino acid sequence and three-dimensional s

108 Although unrelated in sequence, the mode of c-di-GMP binding to C

109 Here, we identified seven unrelated individuals affected with an apparent dominant

110 The BPTF variants were found in unrelated individuals aged between 2.1 and 13 years, who

111 Any two unrelated individuals differ by about 10,000 single amin

112 eritability, h(2)g ) using data from 120 286 unrelated individuals of European ancestry (2987 with AF

113 ritable and expressed in whole blood in 1748 unrelated individuals of European ancestry.

114 in the gene KMT2B (also known as MLL4) in 27 unrelated individuals with a complex progressive childho

115 ent detailed phenotypic information on seven unrelated individuals with a recurrent de novo nonsense

116 19S regulator of 26S proteasome complex, in unrelated individuals with intellectual disability, cong

117 rare de novo CAMK2A or CAMK2B variants in 24 unrelated individuals with intellectual disability.

118 etected heterozygous in 2 subjects among 100 unrelated individuals with KA who never relapsed after c

119 e, which codes for uS12, are reported in two unrelated individuals with microcephaly, hearing loss, a

120 exome-wide collapsing analysis including 262 unrelated individuals with pulmonary fibrosis clinically

121 ncing of 18 153 genes in a population of 391 unrelated individuals.

122 rience can persist in time and bias how new, unrelated information is encoded and recollected.

123 mutation enhances block by the structurally unrelated inhibitor VU714 but not by a higher-affinity a

124 be bound not only by CSF-1, but also by the unrelated interleukin-34 (IL-34) cytokine.

125 They also can be used as a bridge to allow unrelated interventions that are unable to be performed

126 In the present study, we identified four unrelated IRD families with the HK1 p.E851K variant, whi

127 (p.V984L) affecting protein stability in an unrelated isolated case with LVNC.

128 ophila wing disc cells carrying functionally unrelated loser mutations (Minute and mahjong) display t

129 e investigated the mechanism of action of an unrelated lysis protein, Lys(M), of the Escherichia coli

130 ed in the ICU were found to have genetically unrelated M. hominis isolates, excluding patient-to-pati

131 urethritis outbreak among epidemiologically unrelated men in Columbus, Ohio, are linked to increased

132 a large set of structurally and functionally unrelated mitochondrial proteins as substrates of the SU

133 eath regulators from different kingdoms with unrelated modes of action (i.e. caspases vs metacaspases

134 rationalize how a multitude of structurally unrelated molecular patterns can activate C1 and suggest

135 e, HLA-matched related (MRD), or HLA-matched unrelated (MUD) donor T-cell-replete bone marrow allogra

136 ease loci and whole-exome sequencing in four unrelated multiplex families presenting with severe AMC,

137 EFC proteins had previously been found with unrelated mutants blocked earlier in morphogenesis that

138 this mutation in an additional two of seven unrelated mutation-negative Saudi USH1 patients.

139 atched unrelated (n = 25, 55.5%), mismatched unrelated (n = 14, 31.1%), or mismatched related donors

140 plastic syndrome underwent HCT using matched unrelated (n = 25, 55.5%), mismatched unrelated (n = 14,

141 LA-matched unrelated (n = 9), HLA-mismatched unrelated (n = 3), and HLA haploidentical sibling (n = 1

142 ere HLA-matched sibling (n = 1), HLA-matched unrelated (n = 9), HLA-mismatched unrelated (n = 3), and

143 sense mutations affect approximately 0.8% of unrelated NF1 mutation-positive probands in the Universi

144 The gene PSD2, for which multiple unrelated NHW cases had rare missense variants, was sign

145 and suspected AD genes, variants in multiple unrelated NHW patients, variants present in 19 Hispanic

146 amilies, and genes with variants in multiple unrelated NHW patients.

147 d States from 2008 to 2015, compared to 4800 unrelated, nonshipped, non-KPD LDKTs.

148 niscent of Chd1 even though Chd1 contains an unrelated NTR.

149 in bone marrow transplant patients that are unrelated or that are siblings of the donors, using a hi

150 g the central nervous system or the lungs in unrelated, otherwise healthy children who are heterozygo

151 Participants included 1415 unrelated outpatients diagnosed with schizophrenia or sc

152 2 (20%) FMT participants with SAEs (both FMT unrelated; P = 0.02).

153 cally 1) exposing cells to four structurally unrelated PAK inhibitors (PF-3758309, FRAX486, FRAX597,

154 not been deployed to study large cohorts of unrelated participants.

155 ty of NB-LRR genes to generate resistance to unrelated pathogens with completely different lifestyles

156 cantly increased resistance to infections by unrelated pathogens, such as pseudorabies virus.

157 tance specificities between phylogenetically unrelated pathogens.

158 encoding presenilin enhancer protein 2, in 6 unrelated patients and families with DDD in whom mutatio

159 luding the promoter and 3'UTR regions, in 49 unrelated patients diagnosed with episodic ataxia.

160 We found an excess of 138 VOIs in 102 (59%) unrelated patients in 54 previously identified LVNC or o

161 Isolates from other HCUs and unrelated patients were more widely distributed in the p

162 and a case-control cohort consisting of 1831 unrelated patients with AMD and 1367 control individuals

163 The 1831 unrelated patients with AMD had a mean (SD) age of 75.0

164 chniques and GeneMatcher, we identified four unrelated patients with brain hypomyelination, all with

165 AKUT and candidate genes, in a cohort of 204 unrelated patients with CAKUT; 45% of the patients were

166 Five new unrelated patients with CMT carrying the NEFL mutations

167 In this report, we describe two unrelated patients with complex medical histories consis

168 Whole-exome sequencing of 33 unrelated patients with EoE revealed 39 rare mutations i

169 rtebral, and renal defects, among others, in unrelated patients.

170 two coding indels, one of them found in two unrelated patients.

171 Studying patients from three unrelated pedigrees characterized by neutropenia, specif

172 performed next-generation sequencing for 82 unrelated PFAPA patients and identified a frameshift var

173 y in another S. thermophilus strain, against unrelated phages, and in another bacterial genus immuniz

174 provide unexpected insights into apparently unrelated phenomena.

175 ature is rare and scattered in taxonomically unrelated plants.

176 We performed whole-exome sequencing of 43 unrelated probands affected by severe specific language

177 Here, we report 162 individuals (129 unrelated probands and 33 affected relatives) heterozygo

178 Twenty unrelated probands or families from Greece have been ana

179 METHODS AND Four hundred and thirteen unrelated probands with HCM seen in a specialized HCM ce

180 olecular diagnosis was achieved in 110 (40%) unrelated probands.

181 en genotyped in the co-affected siblings and unrelated probands.

182 s with multiple de novo damaging variants in unrelated probands: WWC1 (WW and C2 domain containing 1)

183 I consider what it means for two ostensibly unrelated problems to be the same, and how such sameness

184 face, cross-react with a number of seemingly unrelated proteins expressed on the vegetative cell surf

185 acquired different domains to interact with unrelated proteins, encoded by different phages, but in

186 to numerous genetic mutations in apparently unrelated proteins.

187 c prenyl and glycosyl transfer are seemingly unrelated reactions that yield molecules and protein mod

188 lated outcomes in HLA-phenotypically matched unrelated recipients were low, relative to the large dif

189 QA1, DQB1, DPA1, DPB1-phenotypically matched unrelated recipients, the average recipient mismatching

190 Of 972 unrelated registrants without mutations in the classic p

191 tively, and 13 of 60 (22%) made a neutral or unrelated response.

192 ide substrates, which are cleaved by several unrelated rhomboid proteases, can be used both in deterg

193 ntracellular trafficking of HCV and multiple unrelated RNA viruses with a high barrier to resistance.

194 vior of similarity metrics for identical and unrelated samples.

195 LM) to address case-control ascertainment in unrelated samples.

196 tion in a DNA mixture composed of different, unrelated samples.

197 models are subject to contamination; once an unrelated sequence has been added to the model, homologs

198 has been added to the model, homologs of the unrelated sequence will also produce high scores, and th

199 tive trait, chill coma recovery time, in the unrelated, sequenced inbred lines of the Drosophila mela

200 s alignment over-extensions or alignments to unrelated sequences.

201 76 NG-STAR STs (n = 109) were identified as unrelated singletons.

202 sequencing of LAMB4 in 148 non-familial and unrelated sporadic diverticulitis patients identified tw

203 d absent in non-affected members, and in one unrelated sporadic patient with type 1 painless diabetic

204 three outbreak strains and epidemiologically unrelated ST382 isolates, which were indistinguishable b

205 guish the outbreak strains from the outbreak-unrelated strains, thereby demonstrating that WGS is val

206 llelic pathogenic mutations in MDH2 in three unrelated subjects presenting with early-onset generaliz

207 panels show many of these compounds modulate unrelated targets in vitro, while several also demonstra

208 rimination can be explained by selection for unrelated targets to invest more effort in resisting evi

209 Birth weight was also unrelated to academic performance in adolescents (per 10

210 ion paradigm may cause additional phenotypes unrelated to AD Second-generation mouse models contain h

211 ave surfing varied among individuals and was unrelated to age or energetic state.

212 Risk of non-major bleeding was unrelated to age, but major bleeding increased steeply w

213 est set of 43 additional compounds that were unrelated to amino acids.

214 This modulatory property of hBD2, unrelated to antibacterial effects, gives new significan

215 the healthy volunteers, a condition that was unrelated to antipsychotic and/or anxiolytic medication.

216 in farm children Moraxella colonization was unrelated to asthma.

217 CS was unrelated to behavior, self-esteem and depressive sympto

218 ubtedly resulted in genetic changes that are unrelated to blood feeding, and the challenge is to winn

219 Socioeconomic status was unrelated to BMIz (95% CI, -0.21 to 0.26) or skinfold th

220 'Exploration behaviour' was unrelated to both measures of daily foraging behaviour.

221 n resulted from C1 neuron inhibition and was unrelated to breathing changes.

222 These reductions were unrelated to change in body weight, but correlated with

223 Change in depression was unrelated to change in neuropsychological measures.

224 in MT behavior and describe a syndromic LCA unrelated to ciliary dysfunction.

225 isopods it appeared to be a symplesiomorphy unrelated to colonization of subterranean habitats.

226 Dietary niche breadth was unrelated to competitor and predator richness, on both i

227 bserved also for agents that were presumably unrelated to diarrhea.

228 Population density was unrelated to dietary niche breadth across island and mai

229 contact with seed nodes while centrality is unrelated to diffusion.

230 ing through mechanisms that appeared largely unrelated to DJ-1 antioxidant activity.

231 schizophrenia-related polygenic effects were unrelated to each other and changes in trait-disorder li

232 passenger alterations on cancer fitness were unrelated to enhanced immunity, as our tests were perfor

233 Short sleep was unrelated to epigenetic age and late differentiated cell

234 Brain-to-brain synchrony was unrelated to episodes of speech/no-speech or general con

235 ers, risk was associated with low SA but was unrelated to FCA.

236 A hybrid exists at the repressed loci but is unrelated to gene suppression by the sac3b mutation.

237 nd reflect instead voluntary rodent behavior unrelated to genetic manipulation or to brain trauma.SIG

238 -translationally stabilizes the SMN protein, unrelated to global proteasome or autophagy inhibition,

239 nd of treatment for reasons determined to be unrelated to HCV treatment.

240 l annual number of US VTE events related and unrelated to hospitalization using Rochester Epidemiolog

241 r of US VTE events was 495 669 per year (48% unrelated to hospitalization).

242 inhibited As biomethylation, this effect was unrelated to its inhibition of sulfate reduction and ins

243 airing cell, and this function appears to be unrelated to its role in forming gap junction channels.

244 a higher risk of dying as a result of causes unrelated to lymphoma progression with R-FM versus R-CVP

245 clean and undergoing no secondary procedures unrelated to mastectomy were included.

246 acellular and extracellular signaling events unrelated to metabolism.

247 low time to disengage from ongoing behaviors unrelated to micturition and initiate specific voiding b

248 Received social support was unrelated to mortality across all groups.

249 Resting-state functional connectivity was unrelated to motor performance (r = 0.182; P = .184) and

250 e to mild and severe physical aggression was unrelated to nurses' emotions.

251 et Clostridium difficile infection (CDI) are unrelated to other cases of active disease in the hospit

252 all ( approximately 27-kDa) secreted protein unrelated to other cytokine families, suggesting a funct

253 fungi were largely comparable and generally unrelated to phylogenetic distance among hosts.

254 nary artery disease; never smoking; symptoms unrelated to physical or mental stress; and higher high-

255 patients with follow-up >/=12 months, OH was unrelated to previous ocular surgery: risk factors at ba

256 o 0.12, 90% CI 0.04-0.37; p=0.0007), but was unrelated to previous TKI or TKI therapy duration.

257 system uses a type I secretion system and is unrelated to previously described contact-dependent inhi

258 ZIKV-specific antibody titers in cases were unrelated to prior dengue virus infection.

259 a effects on host growth and physiology, was unrelated to resistance, implying that any combination o

260 rmed that their spatial firing patterns were unrelated to running speed and highly reproducible withi

261 an also arise through evolutionary processes unrelated to speciation, and examination of their proper

262 ed with an early increase in MI risk, mainly unrelated to stent thrombosis; the magnitude of risk is

263 One adverse event unrelated to study devices occurred during the study (ga

264 nown cause); all four deaths were considered unrelated to study drugs.

265 rious adverse event, which was considered as unrelated to study medication.

266 One fatal serious adverse event deemed unrelated to study treatment was reported (cardiorespira

267 One patient in the placebo group died (unrelated to study treatment).

268 inogenic processes across its subtypes, some unrelated to sun exposure, and extends potential involve

269 ransfected and infected cell lines that were unrelated to the binding of the MAb to the target cells.

270 CXCL-8 production in DLBCL was unrelated to the cell of origin, as APRIL-producing neut

271 tion in accessibility of RBC cholesterol was unrelated to the cholesterol content of RBCs or plasma,

272 One patient could not be tested for reasons unrelated to the device.

273 indicates that the beta-band modulation was unrelated to the execution of the motor act associated w

274 t to limited proteinase K digestion, but was unrelated to the expression of host prion protein or its

275 Current clinical signs and AD symptoms were unrelated to the level of ADHD symptoms.

276 inct from strains recovered from individuals unrelated to the outbreak.

277 ease severity and tissue IL-5 expression but unrelated to the patients' atopy status.

278 However, the detection is unrelated to the radius of an AFM tip and, in fact, a ma

279 ee serious adverse events occurred that were unrelated to the vaccine.

280 er partly correlated with the cell cycle but unrelated to the yeast ultradian metabolic cycle.

281 an overall increase in response variability unrelated to threat-related biases in spatial attention,

282 es branching MT nucleation, which we find is unrelated to TPX2's ability to nucleate MTs in vitro.

283 d possibly related to treatment) were deemed unrelated to treatment.

284 isperidone group died of a cause regarded as unrelated to treatment.

285 e reported, all assessed by investigators as unrelated to vaccine.

286 Fruit color, however, was unrelated to vertebrate diversity or to the representati

287 al indicators of drought stress, they can be unrelated to visible metrics of mortality, i.e. lack of

288 synaptic transmission, various structurally unrelated transmembrane auxiliary subunits control the f

289 The standard for selecting unrelated umbilical cord blood units for transplantation

290 e from current practice in that selection of unrelated umbilical cord blood units for transplantation

291 similar to an unrelated affected than to the unrelated unaffected sibling from the CDS and then, sum

292 oimmune lymphoproliferative syndrome and his unrelated, unaffected parents and identified compound he

293 formed exome sequencing in a patient and his unrelated, unaffected parents to identify the genetic et

294 with acute or persistent infections with an unrelated virus.

295 pathology associated with infections with an unrelated virus.

296 orresponding dynamics in perception, for two unrelated visual and motor tasks.

297 A-DRB1, which is the standard used for adult unrelated volunteer donor transplantation for non-malign

298 Systematic infanticide of unrelated young has been reported in several animal taxa

299 by suggesting that selective infanticide of unrelated young may generally become adaptive when the r

300 iding their own offspring and targeting only unrelated young.