ライフサイエンスコーパス: unresolved (issue|problem|question)(|s)

1 minant of conformation is a long-running and unresolved issue.

2 out of alloimmunity has been a longstanding unresolved issue.

3 CENP-A (CID in Drosophila) is a fundamental, unresolved issue.

4 s exact role in this process has remained an unresolved issue.

5 established during development is a largely unresolved issue.

6 nteractions respond to mechanical cues is an unresolved issue.

7 ith aortic arch involvement (AAI) remains an unresolved issue.

8 ydrogen bonding in solution has long been an unresolved issue.

9 how the spirochetes cross the BBB remains an unresolved issue.

10 iming CD8(+) T cells has been a longstanding unresolved issue.

11 rdiovascular diseases has emerged as a major unresolved issue.

12 en spacing and size of such structures is an unresolved issue.

13 continents, to elucidate this long-standing unresolved issue.

14 silver ions (Ag(+)) in vivo has remained an unresolved issue.

15 data that throws light on several previously unresolved issues.

16 (BCP) method, which addresses some of these unresolved issues.

17 broad range of findings and raises important unresolved issues.

18 eck squamous cell carcinoma, and to describe unresolved issues.

19 a unique opportunity to shed light on these unresolved issues.

20 ents, whose organization in the Z-ring is an unresolved problem.

21 ting them from microscopy images in 3D is an unresolved problem.

22 ggested, it remains a challenging and as yet unresolved problem.

23 of these membranes to large-areas remains an unresolved problem.

24 tion of the toxic effects of OTA is still an unresolved problem.

25 atforms with the potential to face currently unresolved problems.

26 n homothallic fungal species in nature is an unresolved question.

27 chnique in diabetic patients is an important unresolved question.

28 ndent of stress response abnormalities is an unresolved question.

29 tains adipose tissue inflammation remains an unresolved question.

30 time of arrival of people in Australia is an unresolved question.

31 D8 T cell of the same specificity remains an unresolved question.

32 wound signals into regenerative growth is an unresolved question.

33 ry, how memory persists is a fundamental and unresolved question.

34 ction of the fetal primate brain is still an unresolved question.

35 rately through the receptor into cells is an unresolved question.

36 for biomass degradation is an intriguing yet unresolved question.

37 ocused to the volcanoes, however, remains an unresolved question.

38 cancer progression is a very important, yet unresolved question.

39 unterclockwise torque at high ATP is a major unresolved question.

40 ction in admixed populations is currently an unresolved question.

41 cessfully attached to the spindle remains an unresolved question.

42 tial advantages but also safety concerns and unresolved questions.

43 work remains to be done, and there are many unresolved questions.

44 ant antioxidative systems gives rise to many unresolved questions.

45 behavior and disease, and highlight critical unresolved questions.

46 o optimize transplant for MDS and identifies unresolved questions.

47 understanding of these events and highlight unresolved questions.

48 e required for any normal brain function are unresolved questions.

49 There are still, however, some unresolved questions.

50 where those have been examined, and outline unresolved questions.

51 his capacity is implemented in the brain are unresolved questions.

52 lective permeability and how this occurs are unresolved questions.

53 hing collaborative working groups to address unresolved questions.

54 An unresolved issue about many neurodegenerative diseases i

55 A critical unresolved issue about the genotoxic stress response is

56 y perspectives has contributed to addressing unresolved problems about the role of polyploidy.

57 global models and allows us now to focus on unresolved questions about carbon partitioning and reten

58 ugh information to unequivocally answer many unresolved questions about cause and effect of polyploid

59 nt of infection will be guided by answers to unresolved questions about interspecies transmission, mo

60 c studies have the potential to address many unresolved questions about microbial pathogens by facili

61 The authors investigated the following three unresolved questions about premorbid cognitive deficits:

62 lly, the report discusses limitations of and unresolved questions about SQUIRE; ancillary supporting

63 Key unresolved questions about the gp120-gp41 interface incl

64 Recently, several unresolved questions about the role of Treg in microbial

65 However, these studies have left many unresolved questions about underlying causality and orde

66 erature supporting its use and summarize the unresolved issues affecting broader application of this

67 An unresolved problem affecting the clinical use of PIs is

68 Unresolved issues and directions for future study are pr

69 In the process, we highlight some key unresolved issues and discuss how they might be addresse

70 We also discuss some of the unresolved issues and potential future directions.

71 We conclude by exploring unresolved questions and future directions for inquiry r

72 We also discuss some key unresolved questions and future prospects.

73 hat animate current scholarship and identify unresolved questions and new opportunities for research.

74 e-molecule studies, highlighting some of the unresolved questions and ongoing debates.

75 nd summarizes subsequent progress, promises, unresolved issues, and challenges of the field.

76 ndings and some of the unanswered questions, unresolved issues, and controversies that remain.

77 Important unresolved issues are addressed, including the mechanism

78 A number of unresolved issues are outlined and discussed, including

79 These unresolved issues are risk prediction models to identify

80 purposes, further progress has been mired by unresolved questions around the definition and the mecha

81 diagnosis for the clinician and to identify unresolved issues as a stimulus to future work.

82 ure, discuss recent progress, and raise some unresolved questions awaiting the field.

83 We also provide our perspective on unresolved issues, both conceptual and technical, that w

84 Here, we show that these unresolved issues can be explained through analysis of t

85 evels, and to discuss current controversies, unresolved issues, challenges, and future directions.

86 element for energy transduction and a major unresolved question common for all motor proteins is the

87 nitrogenase remains enigmatic, with a major unresolved issue concerning how inhibitors and substrate

88 A key unresolved issue concerning SOC function is their spatia

89 A major unresolved question concerning the synthesis of starch i

90 intends to stimulate new studies on the many unresolved questions concerning the chemical ecology of

91 An unresolved question concerns the mechanisms by which act

92 Two unresolved issues could better illuminate the mechanisti

93 the development of socioemotional skills are unresolved issues destined to attract future research.

94 m these field synopses and discuss remaining unresolved issues -- especially in the light of evidence

95 elation to the martensitic phase is still an unresolved issue, even though it is critical to the unde

96 detection of tumorous tissue is an important unresolved issue for cancer surgery.

97 tion of nitroaromatic explosives has been an unresolved issue for over a decade.

98 cipitation interactions represent important, unresolved questions for biological and atmospheric scie

99 ADHF patients and identifies challenges and unresolved questions for each approach.

100 search for greener primary explosives, this unresolved problem has become a "holy grail" of energeti

101 i is the prototype of such pathways, several unresolved issues have accumulated over the years.

102 An unresolved issue, however, is the role of stable inherit

103 An unresolved issue in chronic lymphocytic leukemia (CLL) i

104 A key unresolved issue in cuprates is the relationship between

105 neous natural environments remains a largely unresolved issue in ecology.

106 A central unresolved issue in evolutionary biology is how metaboli

107 herbivore dietary specialization has been an unresolved issue in evolutionary ecology.

108 One unresolved issue in gut immunity is how mucosal T lympho

109 One unresolved issue in immune tolerance is what prevents se

110 An important unresolved issue in microbial secondary metabolite produ

111 An unresolved issue in ocean and climate sciences is whethe

112 An unresolved issue in ocean science is the discrepancy bet

113 es an enduring yet dynamic memory remains an unresolved issue in studies of memory.

114 lfur clusters as they exist in vivo, a major unresolved issue in studies of Wbl proteins.

115 A major unresolved issue in the cloning of mammals by somatic ce

116 's disease (PD) is the single most important unresolved issue in the management of this disorder.

117 ons perturbed by TorsinA[DeltaE] are a major unresolved issue in understanding the pathophysiology of

118 There are many unresolved issues in adults and children with PN depende

119 Progress on several unresolved issues in cancer epigenetics will benefit fro

120 There are a number of unresolved issues in EoE, including phenotypes, optimal

121 slands' can improve our understanding of two unresolved issues in evolutionary genetics: the likely l

122 erism of ligands and receptors is one of the unresolved issues in structure-based prediction of bindi

123 Unresolved issues in the field are outlined.

124 Key unresolved issues in the field of emotional memory inclu

125 nderstanding of STING and highlight the many unresolved issues in the field.

126 t results and discuss some controversies and unresolved issues in this field.

127 A fundamental and unresolved problem in animal development is the question

128 ve rise to functional innovations is a major unresolved problem in biology.

129 Ischemia/reperfusion injury (IRI) remains unresolved problem in clinical organ transplantation.

130 reakdown in pipe transition is a century-old unresolved problem in fluid mechanics.

131 the genome are inherited-is still mostly an unresolved problem in genomics.

132 ificity during positive selection remains an unresolved problem in immunology.

133 his energy conversion occurs remains a major unresolved problem in plasma physics.

134 An unresolved problem in population genetics lies in unders

135 A central unresolved problem in research on Alzheimer disease is t

136 electron tomography to address long-standing unresolved problems in the physical sciences.

137 One unresolved question in ApoE biology is whether ApoE is n

138 a million-fold excess of undamaged DNA is an unresolved question in biology.

139 their characteristic shape is a fundamental unresolved question in biology.

140 size with growth and development is a major, unresolved question in cell biology.

141 ans reach their final shape is a central yet unresolved question in developmental biology.

142 r versus CD8 cytotoxic lineages is a central unresolved question in developmental immunology.

143 eta cells of pancreatic islets, an important unresolved question in diabetes research.

144 A central and largely unresolved question in drug discovery, which is especial

145 An unresolved question in ecology concerns why the ecologic

146 The root of the eukaryotic tree is a major unresolved question in evolutionary biology.

147 es into biochemical signals is a crucial yet unresolved question in mechanobiology.

148 However, an unresolved question in molecular evolution is how often

149 An unresolved question in neuroscience relates to the exten

150 An unresolved question in our understanding of the medial t

151 A key unresolved question in population ecology concerns the r

152 tinct brain regions still are a fundamental, unresolved question in prion research.

153 An important unresolved question in skeletal muscle plasticity is whe

154 One major unresolved question in the field of pancreas biology is

155 lomorpha in the tree of life remains a major unresolved question in the study of deep animal relation

156 An unresolved question in the study of the polyglutamine ne

157 before v after surgery) remains an important unresolved question in this subgroup.

158 An unresolved question in vasculogenesis is how mammalian e

159 continued promise for unlocking many of the unresolved questions in evolutionary biology and biogeog

160 Finally, we review unresolved questions in gene regulation as it pertains t

161 ch it causes Ca(2+) entry remain fundamental unresolved questions in human reproduction.

162 One of the major unresolved questions in influenza A virus (IAV) ecology

163 RT is demonstrated for shedding new light on unresolved questions in intracellular transport.

164 owering immunologists to answer longstanding unresolved questions in living animals.

165 We also put forward two major unresolved questions in the field and propose future ave

166 One of the unresolved questions in the field of cell division is ho

167 th increasing risk, this study addressed two unresolved questions in the field of decision-making: Fi

168 as regulators of cardiac form and function, unresolved questions in the field, and issues for the fu

169 ecades of research and formulate the central unresolved questions in the field.

170 ar protein quality control, and identify the unresolved questions in the field.

171 tiple surprises, seeming contradictions, and unresolved questions in the long-term record of ecosyste

172 e also discuss future aspirations to address unresolved questions in this exciting area of research.

173 Unresolved issues include a means for rapid identificati

174 Unresolved issues include optimal patient selection crit

175 Unresolved issues include psychology's neglect of levels

176 However, unresolved issues include the astonishing complexity of

177 Unresolved issues include the most critical groups to va

178 The many unresolved issues include the role of the amino-terminal

179 Unresolved issues include to what degree, when, and how

180 We focus on unresolved issues including phenotypic and genetic heter

181 There are several unresolved issues, including the following.

182 tively resistant to HIV-1, and a fundamental unresolved question involves deciphering restriction fac

183 One unresolved issue is how infection or vaccination with se

184 A key unresolved issue is how ions gain access to the pore, be

185 An important and unresolved issue is how T cells discriminate between pot

186 A central unresolved issue is how the Cdc45-MCM-GINS helicase is l

187 A key unresolved issue is how the highly complex adaptor-clath

188 A major unresolved issue is how these different populations of T

189 A major unresolved issue is how transcription factors find their

190 An unresolved issue is the degree to which the fate of NCCs

191 One unresolved issue is the duration and significance of the

192 An important unresolved issue is the extent to which incompatibility

193 One unresolved issue is the extent to which the loop bundle

194 A crucial unresolved issue is the extent to which this organizatio

195 A major unresolved issue is the relative timing of CAI and chond

196 A major unresolved issue is the role of Cdc20 autoubiquitination

197 The most important unresolved issue is understanding the evolutionary cause

198 A key unresolved issue is whether astrocyte [Ca(2+)](i) elevat

199 An unresolved issue is whether power-law scaling on differe

200 However, an important but unresolved issue is whether this forebrain structure als

201 An important but unresolved issue is why this occurs.

202 ted with activities of neuronal networks, an unresolved problem is how the brain assembles these acti

203 An interesting unresolved question is how additional copies of FliM mig

204 An important but unresolved question is how direction selectivity is impl

205 An outstanding unresolved question is how does the mitotic spindle util

206 An important unresolved question is how four different EBNAs (EBNA2,

207 An unresolved question is how HIV-1 achieves efficient repl

208 A central unresolved question is how its many substrates bind and

209 An unresolved question is how neural systems for reinforcem

210 A fundamental and still largely unresolved question is how neurons achieve rapid deliver

211 An important and unresolved question is how orientation tuning emerges du

212 An important unresolved question is how populations of coldwater-depe

213 One unresolved question is how RLRs interact with each other

214 An open and unresolved question is how STRF maturation affects stimu

215 A major unresolved question is how the combined allelic variatio

216 A major, unresolved question is how the disruption of specific ac

217 An important and unresolved question is how the human brain processes spe

218 tch signalling is not activated in veins; an unresolved question is how vein identity is regulated.

219 A significant unresolved question is how vitamin A deprivation causes,

220 A major unresolved question is the extent of functional specific

221 An unresolved question is the involvement of chromatin mark

222 A major unresolved question is the mechanism in which the intera

223 An unresolved question is whether clamp loaders capture cla

224 An unresolved question is whether each SV protein is sorted

225 An unresolved question is whether En plays intrinsic roles

226 Moreover, an important but unresolved question is whether hippocampal mismatch sign

227 An unresolved question is whether NK1.1(+) CD8(+) cells are

228 An unresolved question is whether PKA is sufficient to init

229 An important and yet unresolved question is whether shape information from ar

230 A fundamental unresolved question is whether terminally differentiated

231 However, one major unresolved question is whether the neonatal mouse heart

232 A hitherto unresolved question is whether the structure of the land

233 An unresolved question is which steps in the process requir

234 Among the many unresolved questions is the difference between GR regula

235 One of the major unresolved questions is the location, morphology, and ne

236 e results hold the promise of answering many unresolved questions linking structural diversity of vir

237 This study investigated the unresolved issue of antigen-dependency and antigen-speci

238 ct and indirect mechanisms contribute to the unresolved issue of CD4(+) T-cell depletion that results

239 er or not bacterial species exist remains an unresolved issue of paramount theoretical as well as pra

240 offer significant advantages for addressing unresolved issues of neuronal development.

241 A central, unresolved problem of DNA microarray technology is the i

242 induced alopecia represents one of the major unresolved problems of clinical oncology.

243 sh by discussing current models to the still unresolved question of how piRNA precursors are selected

244 pproach to gain insight into the fundamental unresolved question of what makes the Tm coiled coil an

245 cell hypothesis has the potential to explain unresolved questions of tumorigenesis, tumor heterogenei

246 ific deletion of SCL and CXCL12, we focus on unresolved issues on HSC niches, framed around some very

247 With regard to earlier unresolved issues on the macaque evolution, the topology

248 Unresolved issues on the role of RNA silencing in virus-

249 gene-targeted mice can be used to elucidate unresolved questions on the occurrence, distribution and

250 to the interchain hopping energy remains an unresolved issue, one that is central to many organic an

251 To discuss unresolved issues pertaining to aetiology and diagnosis

252 till unknown, in this study we address other unresolved questions pertaining to the molecular mechani

253 affects microvascular obstruction in SCD, an unresolved issue pivotal to understanding its clinical e

254 The last section summarizes some critical unresolved issues, possible challenges/obstacles and als

255 One of the key unresolved issues regarding proton pumping in cytochrome

256 Here, we address the unresolved question regarding a possible zebrafish homol

257 A key unresolved question regarding the basic function of volt

258 A central, yet unresolved question regarding the function of integrins

259 Here, the latest information and unresolved questions regarding capsule synthesis, struct

260 in this field and discuss several important, unresolved questions regarding the roles and mechanisms

261 That uncertainty relates to unresolved questions regarding the supramolecular nature

262 conclude by exploring overarching themes and unresolved questions regarding unconventional interactio

263 will be placed in the context of previously unresolved issues related to BDNF biology, as well as ho

264 Three unresolved issues related to cortical activity in subjec

265 ned studies are necessary to address several unresolved issues related to PFO stroke and PFO migraine

266 Last, unresolved issues related to the duration of use of para

267 However, unresolved issues related to the spatial, spectral, and

268 a timely and invaluable resource to explore unresolved questions related to stem/progenitor origin o

269 important insights and highlight significant unresolved questions related to ZIKV and other emerging

270 A critical unresolved question relates to how these gradients can b

271 A major unresolved issue relating to internal climate dynamics i

272 er vaccines hold much promise; however, many unresolved questions remain in the effort to generate a

273 Important unresolved questions remain in these areas, promising ex

274 However, unresolved questions remain regarding the potential olig

275 Moreover, some of the unresolved issues revolving around the suboptimal positi

276 Nonetheless, many unresolved questions still remain.

277 stent embodied energy calculation, there are unresolved issues, such as an overdependence on price da

278 An unresolved issue surrounding self-antigens as immunother

279 There are a number of unresolved issues surrounding this illness, which are th

280 briefly review the evidence and some of the unresolved questions surrounding a causative role for ac

281 The traceability of olive oil is an unresolved issue that remains a challenge.

282 Here, we define the previously unresolved issues that are now better understood for the

283 controls pluripotent identity and highlight unresolved issues that arise from these studies.

284 in the immune system, as well as some of the unresolved issues that remain on the road to eventually

285 Other unresolved problems that are discussed include prioritie

286 We conclude by presenting some unresolved problems that require the attention of biophy

287 tal unit in visual search, we point out some unresolved problems that their account will have to solv

288 The unresolved question that has been asked for more than 50

289 n polyamide binding in live cells remains an unresolved question that impedes their deployment in viv

290 tween fact and fiction, and to formulate the unresolved questions that need further attention.

291 work on APS has revolved around a series of unresolved questions: the actual incidence of conversion

292 on current understanding and a discussion of unresolved issues, we propose a molecular model for init

293 orm of the dimer remains a controversial and unresolved question, we addressed this matter by enginee

294 However, it remains an unresolved issue whether beat-to-beat alternations in in

295 However, it remained an unresolved issue whether differences in Aux/IAA turnover

296 rrent sensor technologies still exhibit some unresolved issues which hampers their direct application

297 between homologous Rab GTPases represents an unresolved problem with respect to the specificity of ve

298 An important unresolved question with regard to T regulatory (Treg) c

299 An unresolved question with regard to this property is whet

300 s here on work that strives to address these unresolved questions, with emphasis on fate mapping and