ライフサイエンスコーパス: unresolved issue

1 nteractions respond to mechanical cues is an unresolved issue.

2 ith aortic arch involvement (AAI) remains an unresolved issue.

3 ydrogen bonding in solution has long been an unresolved issue.

4 how the spirochetes cross the BBB remains an unresolved issue.

5 iming CD8(+) T cells has been a longstanding unresolved issue.

6 rdiovascular diseases has emerged as a major unresolved issue.

7 es to this compound remains an important and unresolved issue.

8 the vertebral column remains a fundamental, unresolved issue.

9 c dermatitis and asthma, is an important but unresolved issue.

10 e Ca(2+) spark terminates remains a central, unresolved issue.

11 D4 T cells to allograft rejection remains an unresolved issue.

12 tal influences on structure remains a major, unresolved issue.

13 stant metastases remains a controversial and unresolved issue.

14 en spacing and size of such structures is an unresolved issue.

15 silver ions (Ag(+)) in vivo has remained an unresolved issue.

16 continents, to elucidate this long-standing unresolved issue.

17 minant of conformation is a long-running and unresolved issue.

18 out of alloimmunity has been a longstanding unresolved issue.

19 CENP-A (CID in Drosophila) is a fundamental, unresolved issue.

20 s exact role in this process has remained an unresolved issue.

21 established during development is a largely unresolved issue.

22 data that throws light on several previously unresolved issues.

23 ins diverts attention from these fundamental unresolved issues.

24 t developments relevant to several important unresolved issues.

25 ized and experiments designed to address its unresolved issues.

26 (BCP) method, which addresses some of these unresolved issues.

27 broad range of findings and raises important unresolved issues.

28 eck squamous cell carcinoma, and to describe unresolved issues.

29 a unique opportunity to shed light on these unresolved issues.

30 materials remain fundamental, yet presently unresolved, issues.

31 Further research is critical to answer three unresolved issues: (1) What are the equivalent doses for

32 An unresolved issue about many neurodegenerative diseases i

33 A critical unresolved issue about the genotoxic stress response is

34 erature supporting its use and summarize the unresolved issues affecting broader application of this

35 Unresolved issues and directions for future study are pr

36 In the process, we highlight some key unresolved issues and discuss how they might be addresse

37 We also discuss some of the unresolved issues and potential future directions.

38 nd summarizes subsequent progress, promises, unresolved issues, and challenges of the field.

39 ndings and some of the unanswered questions, unresolved issues, and controversies that remain.

40 Important unresolved issues are addressed, including the mechanism

41 s to clinical trials, many new and presently unresolved issues are coming into focus.

42 However, several unresolved issues are difficult to address using current

43 A number of unresolved issues are outlined and discussed, including

44 These unresolved issues are risk prediction models to identify

45 diagnosis for the clinician and to identify unresolved issues as a stimulus to future work.

46 There remain, however, many unresolved issues before such therapy can become a part

47 We also provide our perspective on unresolved issues, both conceptual and technical, that w

48 Here, we show that these unresolved issues can be explained through analysis of t

49 evels, and to discuss current controversies, unresolved issues, challenges, and future directions.

50 One unresolved issue concerning cecropins and other antibiot

51 nitrogenase remains enigmatic, with a major unresolved issue concerning how inhibitors and substrate

52 A key unresolved issue concerning SOC function is their spatia

53 allowed us to address several important, yet unresolved, issues concerning the biological activity of

54 An unresolved issue concerns the consequences for visuomoto

55 Two unresolved issues could better illuminate the mechanisti

56 the development of socioemotional skills are unresolved issues destined to attract future research.

57 m these field synopses and discuss remaining unresolved issues -- especially in the light of evidence

58 elation to the martensitic phase is still an unresolved issue, even though it is critical to the unde

59 detection of tumorous tissue is an important unresolved issue for cancer surgery.

60 tion of nitroaromatic explosives has been an unresolved issue for over a decade.

61 tes and involve some distinct components, an unresolved issue has been whether multiple pathways conv

62 i is the prototype of such pathways, several unresolved issues have accumulated over the years.

63 Unfortunately, several unresolved issues have seriously hampered quantitative d

64 One important unresolved issue, however, is the mechanism through whic

65 An unresolved issue, however, is the role of stable inherit

66 An important, unresolved issue, however, is whether this integrin can

67 An unresolved issue in chronic lymphocytic leukemia (CLL) i

68 An unresolved issue in cortical development concerns the re

69 osses the blood-brain barrier (BBB) is a key unresolved issue in cryptococcosis.

70 A key unresolved issue in cuprates is the relationship between

71 neous natural environments remains a largely unresolved issue in ecology.

72 A central unresolved issue in evolutionary biology is how metaboli

73 herbivore dietary specialization has been an unresolved issue in evolutionary ecology.

74 One unresolved issue in gut immunity is how mucosal T lympho

75 One unresolved issue in immune tolerance is what prevents se

76 An important unresolved issue in microbial secondary metabolite produ

77 An important, unresolved issue in mononegavirus biology is whether or

78 An unresolved issue in ocean and climate sciences is whethe

79 An unresolved issue in ocean science is the discrepancy bet

80 An unresolved issue in preventive cardiology is whether the

81 An unresolved issue in structural biology concerns the rela

82 es an enduring yet dynamic memory remains an unresolved issue in studies of memory.

83 lfur clusters as they exist in vivo, a major unresolved issue in studies of Wbl proteins.

84 A major unresolved issue in the cloning of mammals by somatic ce

85 A major unresolved issue in the field of secretory granule bioge

86 An unresolved issue in the field of T helper (Th) cell deve

87 's disease (PD) is the single most important unresolved issue in the management of this disorder.

88 A major unresolved issue in the pathogenesis of HIVAN is whether

89 ons perturbed by TorsinA[DeltaE] are a major unresolved issue in understanding the pathophysiology of

90 There are many unresolved issues in adults and children with PN depende

91 Progress on several unresolved issues in cancer epigenetics will benefit fro

92 There are a number of unresolved issues in EoE, including phenotypes, optimal

93 slands' can improve our understanding of two unresolved issues in evolutionary genetics: the likely l

94 erism of ligands and receptors is one of the unresolved issues in structure-based prediction of bindi

95 y activity in the cortex are among the major unresolved issues in systems neurobiology.

96 Unresolved issues in the field are outlined.

97 Key unresolved issues in the field of emotional memory inclu

98 nderstanding of STING and highlight the many unresolved issues in the field.

99 To investigate two unresolved issues in the initiation of signaling, the ro

100 One of the central, unresolved issues in the pathogenesis of acute pancreati

101 t results and discuss some controversies and unresolved issues in this field.

102 This review highlights recent progress and unresolved issues in understanding the function and regu

103 ent one of the most fundamental, yet largely unresolved, issues in evolutionary biology.

104 However, many unresolved issues, in particular the possibility of othe

105 Unresolved issues include a means for rapid identificati

106 Unresolved issues include optimal patient selection crit

107 Unresolved issues include psychology's neglect of levels

108 However, unresolved issues include the astonishing complexity of

109 Unresolved issues include the most critical groups to va

110 The many unresolved issues include the role of the amino-terminal

111 Unresolved issues include the timing, content, and scope

112 Unresolved issues include to what degree, when, and how

113 We focus on unresolved issues including phenotypic and genetic heter

114 Despite these results, there are many unresolved issues, including no defined standard techniq

115 There are several unresolved issues, including the following.

116 One unresolved issue is how infection or vaccination with se

117 A key unresolved issue is how ions gain access to the pore, be

118 An important and unresolved issue is how T cells discriminate between pot

119 A central unresolved issue is how the Cdc45-MCM-GINS helicase is l

120 A key unresolved issue is how the highly complex adaptor-clath

121 A major unresolved issue is how these different populations of T

122 A major unresolved issue is how transcription factors find their

123 An unresolved issue is the degree to which the fate of NCCs

124 One unresolved issue is the duration and significance of the

125 An important unresolved issue is the extent to which incompatibility

126 One unresolved issue is the extent to which the loop bundle

127 A crucial unresolved issue is the extent to which this organizatio

128 A major unresolved issue is the mechanism by which the tyrosyl r

129 A major unresolved issue is the relative timing of CAI and chond

130 A major unresolved issue is the role of Cdc20 autoubiquitination

131 A major unresolved issue is the type strain of N. asteroides, as

132 The most important unresolved issue is understanding the evolutionary cause

133 An important unresolved issue is whether and to what extent LTP and L

134 A key unresolved issue is whether astrocyte [Ca(2+)](i) elevat

135 An important unresolved issue is whether covert attention can also sp

136 An unresolved issue is whether power-law scaling on differe

137 However, an important but unresolved issue is whether this forebrain structure als

138 An important but unresolved issue is why this occurs.

139 An important unresolved issue of AIDS pathogenesis is the mechanism o

140 This study investigated the unresolved issue of antigen-dependency and antigen-speci

141 ct and indirect mechanisms contribute to the unresolved issue of CD4(+) T-cell depletion that results

142 A central, yet unresolved issue of HIV disease is the mechanism for thi

143 Here we address the unresolved issue of how many Hox target genes are suffic

144 er or not bacterial species exist remains an unresolved issue of paramount theoretical as well as pra

145 offer significant advantages for addressing unresolved issues of neuronal development.

146 ific deletion of SCL and CXCL12, we focus on unresolved issues on HSC niches, framed around some very

147 With regard to earlier unresolved issues on the macaque evolution, the topology

148 Unresolved issues on the role of RNA silencing in virus-

149 to the interchain hopping energy remains an unresolved issue, one that is central to many organic an

150 To discuss unresolved issues pertaining to aetiology and diagnosis

151 affects microvascular obstruction in SCD, an unresolved issue pivotal to understanding its clinical e

152 The last section summarizes some critical unresolved issues, possible challenges/obstacles and als

153 One of the key unresolved issues regarding proton pumping in cytochrome

154 Two unresolved issues regarding the identification and chara

155 In this study, we address two previously unresolved issues regarding the requirement for perforin

156 will be placed in the context of previously unresolved issues related to BDNF biology, as well as ho

157 Three unresolved issues related to cortical activity in subjec

158 ned studies are necessary to address several unresolved issues related to PFO stroke and PFO migraine

159 Last, unresolved issues related to the duration of use of para

160 However, unresolved issues related to the spatial, spectral, and

161 A major unresolved issue relating to internal climate dynamics i

162 Moreover, some of the unresolved issues revolving around the suboptimal positi

163 f nuclear import and export as well as major unresolved issues such as how directionality is conferre

164 stent embodied energy calculation, there are unresolved issues, such as an overdependence on price da

165 An unresolved issue surrounding self-antigens as immunother

166 There are a number of unresolved issues surrounding this illness, which are th

167 rome c peroxidase has been an intriguing but unresolved issue that impacts our understanding of the r

168 The traceability of olive oil is an unresolved issue that remains a challenge.

169 Here, we define the previously unresolved issues that are now better understood for the

170 controls pluripotent identity and highlight unresolved issues that arise from these studies.

171 in the immune system, as well as some of the unresolved issues that remain on the road to eventually

172 To address these unresolved issues, the American Society of Hematology es

173 in viability assessment is complex with many unresolved issues to be considered in the design and imp

174 on current understanding and a discussion of unresolved issues, we propose a molecular model for init

175 However, it remains an unresolved issue whether beat-to-beat alternations in in

176 However, it remained an unresolved issue whether differences in Aux/IAA turnover

177 rrent sensor technologies still exhibit some unresolved issues which hampers their direct application

178 due to HIV-1 infection remains a pivotal but unresolved issue with important implications for vaccine