ライフサイエンスコーパス: unrestrained

1 and the rest of the ensemble are essentially unrestrained.

2 es in the AV3V and were tested conscious and unrestrained.

3 to activate the LE cells when the siphon is unrestrained.

4 t corresponding responses when the siphon is unrestrained.

5 efore proinflammatory effects of mCRP remain unrestrained.

6 of intermediate neural progenitors (INPs) is unrestrained.

7 mice that are conscious, unanesthetized, and unrestrained.

8 lick during the first day after a permitted, unrestrained 4.3 m(3) oil release conducted on the North

9 The unrestrained accumulation of Tfh cells in the absence of

10 important regulators of the cell cycle, and unrestrained activation of E2F-dependent transcription i

11 pivotal oncogenic mechanism responsible for unrestrained activation of ERK and AKT pathways in human

12 on Hippel-Lindau tumour suppressor (VHL) and unrestrained activation of hypoxia-inducible transcripti

13 Unrestrained activation of oncogenic kinases together wi

14 The resulting unrestrained activity of Ang II in brainstem regions neg

15 ody response to an organ transplant--despite unrestrained acute T cell-mediated allograft rejection.

16 initiated escalated aggression, a measure of unrestrained aggression that has a high probability of t

17 resents a vicious feedback loop that elicits unrestrained AKT signaling.

18 IP2 SAM-SAM domain heterodimer complex using unrestrained all-atom molecular-dynamics simulations.

19 rm of insulin degrading enzyme (IDE) through unrestrained, all-atom MD simulations have been investig

20 We report unrestrained, all-atom molecular dynamics simulations of

21 brain imaging with cellular resolution in an unrestrained and behaving animal.

22 Conversely, radiotelemetry systems allow unrestrained and continuous monitoring of blood pressure

23 er, when examining difference scores between unrestrained and restrained conditions, knockout mice ex

24 Ninety-five participants (unrestrained and restrained males and females) were test

25 nd GABA in rats under two conditions: awake, unrestrained and under chloral hydrate anesthesia.

26 terminal G.A pair; instead, G1 appears quite unrestrained, and A16 stacks on both C15 and G2.

27 10 transgenic mice, parasite replication was unrestrained, and except for antimony responsiveness, me

28 Their heads were unrestrained, and head position was tracked.

29 ied after overnight food deprivation, awake, unrestrained, and unstressed; all ICV infusion of L-NMMA

30 menting response was also observed in awake, unrestrained animals and was found to be dynamically mod

31 days and measured ventilation in conscious, unrestrained animals before and after microinjecting glu

32 il now, no technology compatible with use in unrestrained animals has combined high spatiotemporal re

33 nimals but was much less effective in awake, unrestrained animals in terms of both the number of sens

34 odulating the activity of defined neurons in unrestrained animals is a powerful approach in investiga

35 recordings of neuronal activity in awake and unrestrained animals is needed to provide new insights i

36 Neural imaging in unrestrained animals shows that URX and RMG encode O2 co

37 a seizure on unanesthetized freely behaving unrestrained animals.

38 tification of these cells in unanesthetized, unrestrained animals.

39 latency of response to a thermal stimulus in unrestrained animals.

40 have not been adequately explored in awake, unrestrained animals.

41 through active sampling movements with their unrestrained antennae.

42 simple forms of learning was carried out in unrestrained Aplysia in which the amplitude as well as t

43 loss of insulin response is associated with unrestrained apoC-III production and impaired triglyceri

44 In this study, we have carried out four unrestrained approximately 1 ns length MD trajectories i

45 Arg3.50(139) ionic bond would break, and the unrestrained Arg would be prevented from orienting itsel

46 Here we describe a simple, unrestrained associative place-conditioning paradigm.

47 Using unrestrained atomistic molecular dynamics simulations, w

48 This resulted in unrestrained autophagy in cardiomyocytes, which contribu

49 inant IFNgamma was sufficient to reverse the unrestrained bacterial growth and ultimately the lethal

50 In an unrestrained balance task in cats, we demonstrate that a

51 d to induce growth cone steering, but not at unrestrained bead binding sites.

52 Unrestrained bead propulsion matched or exceeded rates o

53 bjects are scanned awake and their heads are unrestrained, because the NHPs move their heads faster a

54 developed methods for chronic recordings in unrestrained, behaving bats reveal two consistent bouts

55 activity of small subsets of neurons during unrestrained behavior.

56 y and smoothly released for recording during unrestrained behavior.

57 l of pRb from the beta-cell should result in unrestrained beta-cell replication, increased beta-cell

58 pression, tethers formed from undulations of unrestrained bilayer area.

59 responses to the same stimulus in the awake, unrestrained bird.

60 This report shows that wild, unrestrained bottlenose dolphins use their learned whist

61 a tight control of LytB activity to prevent unrestrained breakdown of the cell wall.

62 s exhibit high rates of proteolysis that are unrestrained by physiologic increases in insulin, intrav

63 diminish potentially deleterious effects of unrestrained calcineurin activity in cardiac and skeleta

64 estraints are lower than models generated in unrestrained calculations and (ii) the low-energy struct

65 "motor" compartment of the RE in the awake, unrestrained cat during simple locomotion on a flat surf

66 ent in both pRb and p130, beta-cells undergo unrestrained cell cycle reentry and activation of apopto

67 te activation of Shh target genes results in unrestrained cell division and eventually medulloblastom

68 enhancing cell growth to levels required for unrestrained cell division.

69 driven by oncogenic lesions that facilitate unrestrained cell expansion and resistance to antiprolif

70 tiating cells (CICs) are responsible for the unrestrained cell growth and chemoresistance of malignan

71 feature constitutive hormone production and unrestrained cell proliferation; the mechanisms linking

72 Zinc deficiency alone induced unrestrained cellular proliferation in the esophagus and

73 clin/Cdk function, loss of p27 may result in unrestrained cellular proliferation.

74 ical measures can be obtained for physically unrestrained cetaceans.

75 nto the rat lateral cerebral ventricle under unrestrained condition.

76 e (GLU), and dopamine (DA) in rats in awake, unrestrained conditions and during chloral hydrate anest

77 s were tested under head-restrained and head-unrestrained conditions.

78 st and after pharmacological manipulation in unrestrained conscious mice using electrocardiogram (ECG

79 The measurement of AR in unrestrained, conscious animals provides new opportuniti

80 eic acid were made into area infraradiata of unrestrained, conscious rats (n = 10) and the responses

81 major determinant of nuclear shape and that unrestrained contractility causes nuclear dysmorphia, nu

82 ransmitters in spinal dialysates from awake, unrestrained control and diabetic rats under resting con

83 evalent forms of the disease is complex, but unrestrained de-novo lipogenesis driven by hyperinsulina

84 rway basal stem cells are lost through their unrestrained differentiation, resulting in the simplific

85 Unrestrained DNA supercoiling and the number of topologi

86 Unrestrained DNA supercoiling was measured using a Me3-p

87 enuated BRCA1-A functions at DSBs and led to unrestrained DSB end resection and hyperactive DNA repai

88 Because unrestrained E2F activity in the absence of Rb function

89 rs, are a hallmark of most cancers and allow unrestrained E2F-1 transcription factor activity, which

90 was not significantly different from 100% in unrestrained eaters (99 +/- 6.8%) but was lower in restr

91 +/- SEM) and weighing 63.8 +/- 1.7 kg and 34 unrestrained eaters aged 59.4 +/- 0.6 y and weighing 64.

92 ence in 100 x rEI:TEE between restrained and unrestrained eaters by any of the dietary assessment met

93 a second study consisting of restrained and unrestrained eaters.

94 an antagonizes blockade of CTLA-4, promoting unrestrained effector function and proliferation, and an

95 This, in turn, may contribute to unrestrained epithelial cell proliferation and carcinoge

96 einvasive method to measure and study IOP in unrestrained experimental animals.

97 ccRCC cells, JARID1C inactivation led to the unrestrained expression of heterochromatic noncoding RNA

98 to TLR activation and produce TNFalpha in an unrestrained fashion.

99 tery flow and PP were measured in conscious, unrestrained, fasted partial portal vein-ligated rats wi

100 edical education (GME)-principally fueled by unrestrained federal support-will lead to a physician su

101 s this inactivation mechanism and results in unrestrained FGFR1 ubiquitylation in cells.

102 acute infarct size but were associated with unrestrained fibroblast proliferation, impaired scar rem

103 ectious pathogens, chronic inflammation, and unrestrained fibroproliferation are likely to be part of

104 tations affecting fork reversal also induced unrestrained fork progression and chromosomal breakage,

105 to analyze the muscle patterns of intact and unrestrained frogs during kicking, a natural defensive b

106 and 0.5 degrees for bond angles based on an unrestrained full-matrix least-squares refinement.

107 Twenty-five 10 ns unrestrained fully solvated molecular dynamics simulatio

108 stimate the coupling term as a biophysically unrestrained function of the presynaptic inter-spike int

109 d or acquired ADAMTS13 deficiency allows the unrestrained growth of microthrombi that are composed of

110 al problems with mixed cultures on scale are unrestrained growth of one bacterium, which leads to sub

111 The unrestrained growth of tumor cells is generally attribut

112 rates detrimental long-term consequences for unrestrained growth.

113 to sustain sufficient protein synthesis for unrestrained growth.

114 etion, their lymphadenopathy may result from unrestrained homeostatic proliferation.

115 ctivity must be tightly regulated in vivo as unrestrained HR can cause genomic instability.

116 e state, with membrane-anchored farnesyl and unrestrained HVR, the catalytic domain fluctuates reinle

117 We suggest that unrestrained IFN-gamma synthesis is one key immunobiolog

118 -17 are key to its host-protective capacity, unrestrained IL-17 signaling is associated with immunopa

119 kines, is essential to prevent initiation of unrestrained immune activation.

120 s IDO-dependent mechanism to limit otherwise unrestrained immune responses, inhibition of this counte

121 basalis, and infection by Listeria remained unrestrained in its absence.

122 Thereafter, infection was unrestrained in mice lacking iNOS but was fully controll

123 in the United States involve a child riding unrestrained in the same vehicle with a drinking driver.

124 the spread of new technologies is relatively unrestrained in the United States, many of these technol

125 teraction with like types, whereas it is the unrestrained individuals that must face the negative lon

126 ion of BACH2 and its phosphorylation enabled unrestrained induction of TCR-driven effector programs.

127 as mediating pathways that lead to further, unrestrained inflammation and depression.

128 mmatory phenotype, establishing a pattern of unrestrained inflammation associated with nonhealing wou

129 rotecting tissues from injury and infection, unrestrained inflammation can cause chronic inflammatory

130 Crohn's disease is characterized by unrestrained inflammation with a genetic component.

131 However, brains from ASC(-/-) mice displayed unrestrained inflammation, including elevated levels of

132 erminate immune responses as a check against unrestrained inflammation.

133 This unrestrained inflammatory response may cause tissue dama

134 ematopoietic phenotypes seem to be driven by unrestrained inflammatory signaling that leads to the ex

135 cyclitolic ceramide analog designed to avoid unrestrained iNKT cell activation.

136 ystal conformation exhibits low conductance; unrestrained it increases the channel radius upon applic

137 When inactive, unrestrained kinesin movement generates flows that wash

138 Unrestrained Kit signalling leads to the transformation

139 Unrestrained KO mice exhibited significantly lower c-Fos

140 long-term 2-photon intravital microscopy of unrestrained large arteries in live CX3CR1-GFP (green fl

141 or clinical decay, chronic stabilization, or unrestrained lethal growth of the pathogen; the response

142 red adipose tissue insulin action results in unrestrained lipolysis and lipotoxicity, which are hallm

143 amic insulin action, which may contribute to unrestrained lipolysis seen in human obesity and type 2

144 n contrast, systemic disease, in the form of unrestrained lymphoproliferation, continued unabated.

145 ithout lipid/heparin were performed in alert unrestrained male rats.

146 Here, we show that in conscious, unrestrained male Sprague Dawley rats the infusion of in

147 ay be driving a speciation event, by a live, unrestrained male.

148 Arg80 and that loss of HAI-2 in IECs led to unrestrained matriptase activity and efficient cleavage

149 Unrestrained MD calculations indicate that DAOTA-M2 disp

150 a modern force field, we performed a 200 mus unrestrained MD simulation of the acid-unfolded state of

151 ocking these structures to B-DNA followed by unrestrained MD simulations led to a stable complex in w

152 Unrestrained MD simulations suggest that the conversion

153 Dynamics in unrestrained MD trajectories were in poor agreement with

154 valuated luciferase bioimaging in conscious, unrestrained mice after neonatal intracranial or intrava

155 ponses to inhaled methacholine in conscious, unrestrained mice after sensitization and airway challen

156 ) and heart rate were measured in conscious, unrestrained mice after they were instrumented with intr

157 We monitored breathing patterns of unrestrained mice during wake-sleep states and while alt

158 ) injection of human REN (hREN) in conscious unrestrained mice elicited a pressor response, which was

159 weights to lightly anesthetized, completely unrestrained mice established a paradigm that simulates

160 mps were performed on 5-h-fasted, conscious, unrestrained mice using an arterial catheter for samplin

161 eely controllable virtual reality system for unrestrained mice.

162 ctroacupuncture in conscious, freely moving, unrestrained mice.

163 mechanism at atomic resolution, revealed by unrestrained microsecond equilibrium molecular dynamics

164 is in differentiated Colo-205 cells involves unrestrained mitochondrial proliferation and progressive

165 Taken together, our data demonstrate that unrestrained MK growth and proliferation results in rapi

166 tensive NMR data set and performed the first unrestrained molecular dynamics (MD) simulation in water

167 and-protein complex we report 10 ns of fully unrestrained molecular dynamics (MD) simulations with ex

168 Unrestrained molecular dynamics calculations showed that

169 a closed-pore conformation that results from unrestrained molecular dynamics equilibration of the str

170 With a total of more than 43 mus of unrestrained molecular dynamics simulation, this study i

171 Extensive unrestrained molecular dynamics simulations (accumulativ

172 The model was refined in light of unrestrained molecular dynamics simulations conducted in

173 We performed unrestrained molecular dynamics simulations for several

174 eport on the results of five independent and unrestrained molecular dynamics simulations of an RNA te

175 e carried out molecular modeling and 1.25 ns unrestrained molecular dynamics simulations of the adduc

176 Unrestrained molecular dynamics simulations of the dimer

177 Here we present unrestrained molecular dynamics simulations of the DNA a

178 Unrestrained molecular dynamics simulations of unfolding

179 Unrestrained molecular dynamics simulations predicted th

180 We have carried out fully unrestrained molecular dynamics simulations starting fro

181 In the present study, restrained and unrestrained molecular dynamics simulations, carried out

182 In this work, we generate several unrestrained molecular dynamics trajectories of its isol

183 Using unrestrained molecular dynamics, it was shown that for t

184 the incorrect to the correct structure using unrestrained molecular dynamics.

185 in then relaxed the complex by a 100-ns long unrestrained molecular dynamics.

186 old and refine structures, as well as to run unrestrained molecular-dynamics simulations.

187 perinsulinaemic conditions in the conscious, unrestrained mouse.

188 studies on discrete object manipulation and unrestrained movements.

189 modeled androgen receptor was refined using unrestrained multiple molecular dynamics simulations in

190 cal data and TIRF microscopy show that NEDD4 unrestrained mutant constitutively downregulates the IKS

191 trophysiological activity of NAcc neurons in unrestrained, naive Sprague-Dawley rats.

192 When uninduced, unrestrained negative supercoiling was organized into 32

193 protect T cells from adverse consequences of unrestrained NF-kappaB activation, such as cellular sene

194 Striatal [GABA](ecf) was determined in unrestrained, non-hibernating ground squirrels (T(b) ran

195 10 mm Hg from day to day and hour to hour in unrestrained nonhuman primates, which indicates that sna

196 trained front target occupant in front of an unrestrained occupant compared with a restrained front t

197 a restrained rear target occupant behind an unrestrained occupant compared with a restrained rear ta

198 ined side target occupant sitting next to an unrestrained occupant compared with a restrained side ta

199 s were randomized into two groups--awake and unrestrained or treated with intensive care medicine the

200 At the cellular level, unrestrained p38 MAPK activity diminished cardiac contra

201 cts, combined disruption of Dusp1/4 promoted unrestrained p38 MAPK activity in both mouse embryonic f

202 ring becomes severe and unacceptable despite unrestrained palliative efforts; some of these patients

203 Tracheally intubated, awake, and unrestrained patients (group 1, n = 54; mean age, 113 +/

204 Unrestrained phosphorylation by JNK, as obtained by a ce

205 Unrestrained PKA activity is pathological, and an enduri

206 ut (KO) mice (i) initial liver infection was unrestrained, plateaued, and then declined somewhat by w

207 assessed by using invasive tracheostomy and unrestrained plethysmography.

208 age-depleted dermal cells confirmed that the unrestrained proliferating cells contain procollagen I+

209 The consequent unrestrained proliferation allows the glycolytic phenoty

210 enetic and epigenetic alterations that allow unrestrained proliferation and increased survival.

211 n self-renewing multiple myeloma cells begin unrestrained proliferation by unknown mechanisms.

212 athway overcomes cellular protection against unrestrained proliferation in cancer.

213 The mechanism for intermittent, unrestrained proliferation of myeloma cells is unknown,

214 To determine the factors responsible for the unrestrained proliferation of PEL, we have studied the g

215 However, the risk of triggering unrestrained proliferation of permanently engineered T c

216 l cell suspensions essentially abrogated the unrestrained proliferation of the CD11b- dermal cells.

217 The growth factors responsible for the unrestrained proliferation of these lymphomas have not y

218 fe mechanism for the cell to protect against unrestrained proliferation.

219 Concomitant loss of p53, which causes unrestrained propagation of tetraploids into aneuploid c

220 Comparison of torsionally restrained and unrestrained protein dynamics simulated at three levels

221 he earliest stages of development in living, unrestrained pups.

222 re transducer to measure IOP continuously in unrestrained rabbits.

223 tenin to cell/cell contacts, indicating that unrestrained Rap activity underlies the alterations in c

224 p66(Shc) in normal epithelial cells leads to unrestrained Ras activation, preventing anoikis through

225 matosensory cortex of the unanesthetized and unrestrained rat.

226 rgic agonist, were administered to conscious unrestrained rats 24 hr later to elicit the cardiac resp

227 d mean arterial blood pressure in conscious, unrestrained rats [peak elevations vs. baseline: PrRP-20

228 all relevant muscles in both head-fixed and unrestrained rats and two-dimensional imaging to monitor

229 d with fluorescent microspheres in conscious unrestrained rats before and 2, 4, and 6 hours after lip

230 ere recorded in the dorsolateral striatum of unrestrained rats before and after amphetamine injection

231 Unrestrained rats chronically implanted with electrodes

232 Single unit recordings in awake, unrestrained rats confirmed and extended previous findin

233 (250 microg/kg over 30 min) into conscious, unrestrained rats prevented LPS-induced hyperdynamic and

234 rt-1 and Hcrt-2 given i.c.v. into conscious, unrestrained rats stimulated significant elevations in m

235 activity (SP-LI) in spinal CSF of conscious, unrestrained rats using microdialysis techniques followi

236 excitations induced by bicuculline in awake, unrestrained rats, suggest that modulation of GABA inhib

237 We demonstrate, in unrestrained rats, that the discharge activity of a homo

238 ssure of oxygen (PO2) in the renal cortex of unrestrained rats, which might in turn contribute to the

239 ses to subsequent hypoglycemia in conscious, unrestrained rats.

240 le neurons in the lateral striatum of awake, unrestrained rats.

241 he medial preoptic area (mPOA) of conscious, unrestrained rats.

242 s combined with microiontophoresis in awake, unrestrained rats.

243 ng was combined with iontophoresis in awake, unrestrained rats.

244 easurement of renal tissue oxygen tension in unrestrained rats.

245 spatial and temporal characteristics of free unrestrained reaching movements of the arm were examined

246 Unrestrained recombination causes undesired endpoints (t

247 Unrestrained reconsolidation may have the opposite effec

248 hese observations, we also found patterns of unrestrained retrotransposons in p53-driven mouse and hu

249 al homeostasis is reflected in the fact that unrestrained signaling activity in mammals is associated

250 ich acts as a Rheb GAP, yields constitutive, unrestrained signaling from the cell growth machinery co

251 tructure factors and those derived from this unrestrained simulation is 23% to 1.0 A resolution.

252 A 30 ns unrestrained simulation reveals dynamic partitioning of

253 The simulations were compared to unrestrained simulations of the EPSP synthase tetrahedra

254 Comparisons with unrestrained simulations show that internal and global m

255 of these interactions using microsecond-long unrestrained simulations shows that urea-aromatic stacki

256 In unrestrained simulations, the cellulose diffuses into th

257 In another set of 10 unrestrained simulations, the dominant growth mode was d

258 Unlike the unrestrained simulations, the resulting sarcolipin struc

259 gy profile of the gating transition and from unrestrained simulations, we conclude that the pore of t

260 onsistent with the observed behaviors of the unrestrained simulations.

261 describe and discuss a series of long-time, unrestrained, solution molecular dynamic runs for this s

262 Unrestrained spider dragline 'super-contracts' when it i

263 at another potential negative consequence of unrestrained spontaneous LIP is constriction of the tota

264 A total of 41 conscious unrestrained Sprague-Dawley rats were studied during 2-d

265 ular brain imaging of mice in the conscious, unrestrained state and demonstrate the effects of isoflu

266 Three unrestrained stochastic dynamics simulations have been c

267 in, which can inhibit transcription, reduced unrestrained supercoiling by 75% at one chromosomal loca

268 The level of unrestrained supercoiling in the hph gene varied, from h

269 ing should be enhanced transiently until the unrestrained supercoiling is removed by diffusion or top

270 elated with their effects on either total or unrestrained supercoiling.

271 In one cell line, the hph gene contained no unrestrained supercoiling.

272 n inexpensive chicken blood extract to relax unrestrained superhelical tension.

273 required to effectively eliminate pathogens, unrestrained T(H) activity also contributes to tissue in

274 om the miR-29ab1 genomic cluster, results in unrestrained T-bet expression and IFN-gamma production.

275 Among unrestrained target occupants, the adjusted RRs were, fo

276 Prior research indicates that unrestrained TGF-beta1 and/or type 2 cytokine-driven imm

277 Consequently, absence of T-bet leads to unrestrained Th17 cell differentiation and activation ch

278 s response must be tightly regulated because unrestrained TLR signaling generates a chronic inflammat

279 e (EA) on persistent inflammatory pain in an unrestrained, unsedated, and conscious rat model.

280 likelihood refinement with stereochemically unrestrained updating of the model, proved to be of cruc

281 Unrestrained use of blood cultures has serious implicati

282 ing of dentate granule neurons with a novel, unrestrained virtual reality system for rodents, we disc

283 ical microstimulation (ICMS) during hours of unrestrained volitional behavior.

284 methacholine was measured by use of a Buxco unrestrained whole-body plethysmograph.

285 Unrestrained whole-body plethysmography measurement of e

286 This was done by subjecting unrestrained wild-type, cryophilic, or thermophilic worm

287 tracking microscope records the motion of an unrestrained worm expressing channelrhodopsin-2 or halor

288 Because each cell in an unrestrained worm is a rapidly moving target, our system

289 re, by using fluorescent biosensors in live, unrestrained worms, we show that intestinal pH also osci

290 c molecules and drive redox chemistry, which unrestrained would be destructive.

291 er chronic inflammation is the key driver of unrestrained wound healing (i.e., the fibrotic response)

292 significantly lower c-Fos levels relative to unrestrained WT mice in 9 regions, including lateral sep

293 d potency observed with the conformationally unrestrained Xaa-boroPro class of inhibitors, the L-L di