ライフサイエンスコーパス: unsaturation

1 1 and AtSLD2 showed no detectable LCB Delta8 unsaturation.

2 es of natural lipids was set by the level of unsaturation.

3 nes that differ only in their position(s) of unsaturation.

4 ponent that expressed the variation in lipid unsaturation.

5 res that may have one or more sites of chain unsaturation.

6 onic radii and ancillary ligand coordinative unsaturation.

7 s was unaffected by the degree of acyl chain unsaturation.

8 PEs that vary in their degree of acyl chain unsaturation.

9 ng various acyl chain lengths and degrees of unsaturation.

10 conjugated double bonds, and trans-Delta(12) unsaturation.

11 higher than comparable compounds lacking 4,5-unsaturation.

12 damage is a consequence of altered membrane unsaturation.

13 function of their chain length and degree of unsaturation.

14 nt fatty acids differing in chain length and unsaturation.

15 characterized by a high level of fatty acid unsaturation.

16 opsis that have reduced levels of fatty acid unsaturation.

17 d with increasing chain length and degree of unsaturation.

18 e to net charge, chain length, and degree of unsaturation.

19 tructural changes associated with acyl chain unsaturation.

20 e C2-position and C2-substituents containing unsaturation.

21 utoxidation increased with the degree of oil unsaturation.

22 ion function f(theta) varied with acyl chain unsaturation.

23 r fatty acid/fatty acyl CoA chain length and unsaturation.

24 sociation in combination with fatty acyl cis-unsaturation.

25 nce supports the importance of the degree of unsaturation.

26 ition) and was proportional to the extent of unsaturation.

27 and hydroxy derivatives with conservation of unsaturation.

28 ficity for C18 fatty acids containing Delta9 unsaturation.

29 Humans also have increased distal marrow fat unsaturation.

30 lipid membranes bearing different degrees of unsaturation.

31 veal fatty acid chain lengths and degrees of unsaturation.

32 tionalization of C-H bonds with retention of unsaturation.

33 values depend on chain length and degree of unsaturation.

34 s AtSLD2 mutants showed little change in LCB unsaturation.

35 ing C14 and C16 chains with no more than two unsaturations.

36 so active on a C(22) substrate with multiple unsaturations, a result consistent with the role of pero

37 cytotoxic to CLL, and loss of the alpha-beta unsaturation abrogated Nrf2 activity and CLL toxicity.

38 d to be important for several compounds with unsaturation adjacent to the sulfate.

39 thanolamides that possess varying degrees of unsaturation also vary in their conformational mobility,

40 for the proposition that, in the absence of unsaturation, an acylium ion acts as a hydride acceptor,

41 ced LOOH transfer included (i) increasing PL unsaturation and (ii) increasing net negative charge imp

42 iophysical experiments have shown that lipid unsaturation and cholesterol both have significant effec

43 The roles of acyl chain unsaturation and curvature in the excimer formation effi

44 either SUV or LUV suggested that acyl chain unsaturation and high membrane curvature combine to favo

45 ts and chromatography unveiled the degree of unsaturation and hydroxylation in the ceramide lipid tai

46 sensitively dependent on the degree of chain unsaturation and on the presence of cholesterol.

47 number and size of lipid droplets, and lipid unsaturation and packing order of lipid droplets.

48 ease with the degree of lipid acyl chain cis-unsaturation and reach a plateau with 1-palmitoyl-2-arac

49 Unsaturation and shorter fatty acid length in phospholip

50 Specifically, alkyl chain length, degree of unsaturation and the head group to which the alkyl side

51 quantitative determination of the degree of unsaturation and transition temperatures of constituent

52 level, and there was a 19% increase in lipid unsaturation and triglyceride levels (P = .027 and P = .

53 unsaturated PCs and the total number of cis unsaturations and acyl chain length (18 to 22) of the un

54 cal stability as a function of the number of unsaturations and molecular branching in the chemical st

55 ber and location of cis and trans fatty acid unsaturations and the absolute stereochemistry of enanti

56 e, charge, reduction potential, coordination unsaturation, and coreactant selectivity.

57 g the PC acyl chain length and the degree of unsaturation, and examined domain formation upon additio

58 to obtain the number of carbons, degrees of unsaturation, and location of double bonds, as well as t

59 increasing acyl chain length independent of unsaturation, and modest discrimination between acyl pos

60 n terms of reduction potential, coordination unsaturation, and overall charge associated with the met

61 Quantitation of lipid storage, unsaturation, and oxidation in live C. elegans has been

62 rstand the effect of chain length, degree of unsaturation, and placement of the thia substituent on m

63 ermine the effect of chain length, degree of unsaturation, and stereoisomeric effects of unsaturation

64 on the lipid composition and extent of lipid unsaturation, and that sHsps can regulate membrane fluid

65 f pulmonary artery pressure, severe arterial unsaturation, and usually a low cardiac output.

66 ts arising from the presence of the Delta(5)-unsaturation are key controlling elements for the format

67 company changes in the degree of lipid chain unsaturation, are entirely confined to the disordered ph

68 zed amino acids, especially amino acids with unsaturation, are important, demanding building blocks i

69 w field of research, but the large degree of unsaturation as isomers of alkynes (as well as residual

70 egrees C) and also an increased phospholipid unsaturation, as in higher animal models.

71 e more inhibitory than those with alpha,beta-unsaturation, as indicated by the k(inact) values, and p

72 The new complex shows coordinative unsaturation at one of the Fe(II) centers as the result

73 and fatty acids of various chain lengths and unsaturation at sn-1.

74 us dimer 4 (DSB-120) that lacks substitution/unsaturation at the C2 position elevates melting by only

75 ing structure, and in particular exo or endo unsaturation at the C2-position and C2-substituents cont

76 l compounds, that systematically removed the unsaturation at the N and the chelate character of the l

77 roximately 16% of the energy difference, the unsaturation at the nitrogens accounts for approximately

78 stion generates disaccharides with Delta-4,5-unsaturation at the nonreducing end.

79 a M-C sigma bond and creates a coordination unsaturation at the other metal atom.

80 troduced at position 5, as well as a unit of unsaturation between positions 3 and 4, with benzoyl or

81 ylene group (i.e., a homologue) or exocyclic unsaturation between the thiazolidine ring and the C3 ca

82 reaction was observed with aldehydes having unsaturation both at terminal and internal positions.

83 ature was increased at lower levels of lipid unsaturation, but the highest temperature was detected f

84 of mixed-chain PE with increasing degree of unsaturation can be interpreted in terms of structural c

85 d acyl chain length and extent of acyl chain unsaturation can now be probed by monitoring the conform

86 icroalgal oils, depending on their degree of unsaturation, can be utilized as either nutritional supp

87 d bilayer properties and composition such as unsaturation, charge, and the presence of reaction produ

88 The degree of acyl chain unsaturation contributed positively to binding strength.

89 the headgroups supports a mechanism by which unsaturation contributes to reduced transition temperatu

90 On the other hand, higher levels of unsaturation decreased bioaccessibility.

91 h the presence of triacylglycerols and their unsaturation degree inhibited cholesterol thermooxidatio

92 The influence of the unsaturation degree of different fatty acids methyl este

93 The influence of the unsaturation degree of different triacylglycerols (trist

94 ffect was further promoted by increasing the unsaturation degree of FAME.

95 tivity largely depends on the length and the unsaturation degree of the hydrocarbon chain.

96 fatty acids with different chain lengths or unsaturation degree on anhydrous milk fat (AMF) crystall

97 The effects of the acyl moiety and its unsaturation degree, and of the sterol structure were in

98 yl groups and this depends not only on their unsaturation degree, but also on the concentration of th

99 m the triacylglycerol was independent on the unsaturation degree.

100 ximum amount decreased with increasing their unsaturation degree.

101 disappearance rate of the groups with higher unsaturation degree.

102 chemical compositions and different varying unsaturation degrees and carbon-chain lengths, together

103 ipid microdomains with a headgroup and chain unsaturation-dependent lipid composition.

104 chain length, and/or increased level of cis unsaturation) destabilize lipoproteins and accelerate th

105 size increases with the extent of acyl chain unsaturation (DOPC:POPC ratio).

106 e phospholipid composition (headgroup, chain unsaturation, etc.), whereas inclusion of 33-50% cholest

107 synthesis (SQLE), regulation of fatty acids unsaturation (FADS1), cellular cholesterol uptake (LDLR)

108 ion of lipid acyl chain length and degree of unsaturation for a series of phosphatidylcholines.

109 classical concepts that require coordinative unsaturation for catalytic reactions to occur on such su

110 this ratio can be a measure of the degree of unsaturation for fatty acyl chains of lipids.

111 On the basis of the effect of unsaturation for other potent PKC ligands, we would pred

112 energetics of alpha,beta- versus beta,gamma-unsaturation for some common organic functional groups.

113 ions were used to determine the position of unsaturation for some of these species.

114 ecedented influence of the bicyclic backbone unsaturation for the preparation of the corresponding di

115 r ion m/z ratios, chain length and degree of unsaturation for these fatty acids were determined.

116 Increasing acyl chain unsaturation from 18:0,18:1PC to 18:0,22:6PC resulted in

117 Chain unsaturation has only a minor influence on the ethanol d

118 n chain length, degree and position of chain unsaturation, head group repulsion, and incorporation of

119 bon chains caused by changes of temperature, unsaturation, headgroups, and ethanol.

120 h affinity for fluoride and its coordination unsaturation in aqueous media, which play a key role in

121 cholesterol concentration and increased tail unsaturation in brain PM) appear to have opposite, yet c

122 nside a mass spectrometer to assign sites of unsaturation in complex lipids.

123 Increasing the degree of unsaturation in either the sn-1 or sn-2 aliphatic chains

124 d is a guanosine analogue containing a 2',3'-unsaturation in its planar carbocyclic deoxyribose ring

125 ew silicon species with different degrees of unsaturation in petroleum products.

126 mechanism governing the degree of fatty acid unsaturation in Saccharomyces cerevisiae.

127 ture over the past 5,600 y based on alkenone unsaturation in sediments of two lakes in West Greenland

128 ts are consistent with a role for LCB Delta8 unsaturation in selective channeling of ceramides for th

129 at NIVS can determine the relative degree of unsaturation in six different lipid samples as accuratel

130 Unsaturation in the acyl chains leads to a greater reduc

131 Results showed that lipid unsaturation in the axonal layer was significantly incre

132 The presence of unsaturation in the center of the C(10)-alkyl linker pro

133 as expected based on the decreasing level of unsaturation in the fatty acyl chains.

134 s indicative of chain lengths and degrees of unsaturation in the fatty acyl moieties.

135 use is made of the capacity for introducing unsaturation in the furanose sector via phenylsulfenylat

136 adgroup steric bulk and the inclusion of cis-unsaturation in the hydrophobic domain led to greater li

137 lity has a 'propargylic' relationship to the unsaturation in the linker.

138 group, but also by increasing the degree of unsaturation in the lipid tails.

139 he value of the integer being the degrees of unsaturation in the lipid.

140 ositions of the piperidino ring, (2) varying unsaturation in the piperidino C-2 and C-6 substituents,

141 We found that the trans 4,5-unsaturation in the sphingosine backbone promoted closer

142 Yappert and co-workers that trans unsaturation in the vicinity of C4 of the sphingoid back

143 intramolecular hydroamination of diverse C-C unsaturations, including terminal and internal aminoalke

144 ned with lipid species of varying degrees of unsaturation incorporated into either SUV or LUV suggest

145 ymerization (excluding decrease of degree of unsaturation) increased significantly as a function of f

146 rd by combining measurements of the alkenone unsaturation index (U37(K)) with non-destructive scannin

147 r temperatures, as observed by a decrease in unsaturation index and 20:5n-3.

148 es to ESI/MS/MS analyses correlated with the unsaturation index and inversely correlated with total a

149 olae/lipid rafts, causing an increase in the unsaturation index in the membrane microdomain.

150 Furthermore, unsaturation index of individuals from the two coldest s

151 The 15.99% increase in the level of unsaturation indicated elevated lipid peroxidation.

152 Time series of alkenone unsaturation indices gathered along the California margi

153 ouble bonds per lipid molecule, we find that unsaturations influence mainly the order of the bottom h

154 implicate turnover-limiting insertion of C-C unsaturation into the Ln-O bond, involving a highly orga

155 ytic cycle is insertion of the carbon-carbon unsaturation into the Ln-P bond, followed by rapid proto

156 no C-2 and C-6 substituents, (3) introducing unsaturation into the piperidine ring, (4) ring-opening

157 features-an optimal C12-C8 chain length, pi-unsaturation introduction at the corresponding arachidon

158 ly, our findings reveal that increased lipid unsaturation is a metabolic marker for ovarian CSCs and

159 high membrane curvature and extensive chain unsaturation is an enhanced rate of lipid motion in the

160 h genetically designed and tunable degree of unsaturation is desirable to maximize process efficiency

161 nyl beta-amino ketones possessing alpha,beta-unsaturation is exemplified in the total synthesis of th

162 In particular, alpha,beta-unsaturation is favored by less than 1 kcal/mol for the

163 itration at the 9 or 10 olefinic carbon, and unsaturation is required for XOR inhibition.

164 The degree of unsaturation is unified by selective heterogeneous hydro

165 The N-acyl heterogeneity, including unsaturation, is localized mainly to the proximal glucos

166 on rate and selectivity vary with substrate unsaturation: larger metal ions and more open ligand sys

167 the substrate by incorporating an alpha,beta-unsaturation led to the discovery of a tandem cyclizatio

168 licable to many natural fats and oils of low unsaturation level assisting advanced investigation of l

169 The unsaturation level of the fluid-phase component was vari

170 Higher lipid unsaturation levels were also detected in CSC-enriched s

171 e mapping of fat distribution, degree of fat unsaturation, lipid oxidation, and cholesterol storage i

172 Unsaturation lowers chain order, mostly in the lower thi

173 for leiomyosarcoma, the degree of fatty acyl unsaturation may be an important determinant of the meta

174 sible, despite the latter having a degree of unsaturation more similar to olive oil than to sunflower

175 levels in the BRCA2 cohort showed increased unsaturation of 21% (P = .030) relative to triglycerides

176 ying the number of carbons and the degree of unsaturation of any acyl-chain substituents.

177 f this study was to examine how the enhanced unsaturation of CH2=C=X compared to that of CH3CH=X may

178 om which the carbon number and the degree of unsaturation of each acyl group are obtained.

179 es in both carbon chain length and degree of unsaturation of fatty acid substituents, particularly in

180 Degree of unsaturation of fatty acids affects physical properties

181 r high antioxidant capacity and the level of unsaturation of fatty acids.

182 ependent on their composition instead of the unsaturation of fatty acids.

183 d as being causally linked to changes in the unsaturation of membrane phospholipids, yet in animals t

184 Unsaturation of one PC acyl chain greatly increased tran

185 presence of both the PE headgroup per se and unsaturation of the 1,2 fatty acids.

186 Increased unsaturation of the acyl or steryl moiety of steryl este

187 or zeta-aryl carbonyl compounds, because the unsaturation of the alkene is relayed to the alcohol, re

188 membrane bilayer including (1) the degree of unsaturation of the fatty acid guest and the regiospecif

189 rbate/Fe(III)/O(2)] depends on the degree of unsaturation of the fatty acid.

190 duct ion ratio is dependent on the extent of unsaturation of the fatty acyl group at sn-2 as well as

191 Coordinative unsaturation of the Fe(II) in the presence of both cosub

192 f the cationic head group, (2) the degree of unsaturation of the hydrophobic tail, and (3) the presen

193 weight reduction with no change in the total unsaturation of the molecule (or Z-number as in chemical

194 r whereby cis-double bond geometry and alpha-unsaturation of the native substrate are important featu

195 ntibiotic activity on the size and degree of unsaturation of the precursor.

196 sidic linkage of the substrate chain and the unsaturation of the product.

197 trometry, there was no compensatory shift in unsaturation of the PtdEtn and PtdPrn toward more bilaye

198 torsional angles between different planes of unsaturation of the retinal chromophore.

199 uded removal of C-19 (19-nor); each also had unsaturation of the side chain.

200 mics increased in mixed-chain species as the unsaturation of the sn-2 chain was increased.

201 s coupled with a 33% decrease in the average unsaturation of the sphingolipids resulted in a phosphol

202 e fashion, despite the significant degree of unsaturation of the substrates.

203 servations highlight the dramatic effects of unsaturation on bilayer structure.

204 inds with a superior affinity to lipids with unsaturation on both alkyl chains.

205 The influence of hydrocarbon chain unsaturation on Ca(2+) binding is secondary compared to

206 ly relate our results to the impact of chain unsaturation on the interaction of the fluid-phase lipid

207 unsaturation, and stereoisomeric effects of unsaturation on the oxidation of individual fatty acids

208 The effects of membrane lipid unsaturation on the partitioning of alamethicin were als

209 Varied degrees of unsaturation (one double bond, NSenB; two double bonds,

210 lipid isomers that differ only in site(s) of unsaturation or geometric configuration of the carbon-ca

211 ycloaddition reaction, the overall degree of unsaturation (or oxidation state) of the 4pi (diene) and

212 3 fatty acid metabolism, including degree of unsaturation (P=1.16x10(-)(34)), levels of polyunsaturat

213 lability of appropriate levels of fatty acid unsaturation, partially compensating the antilipogenic e

214 significant promise for facile profiling of unsaturation patterns within complex lipidomes including

215 s composed of phospholipids containing a cis unsaturation per acyl chain (DO and DPe), while transbil

216 PC), a lipid possessing a single acyl chain unsaturation point, yields the highest abundance of the

217 The unsaturation present in the (E)-methyl-pent-3-enoate sid

218 The utility of the 2,3-unsaturation present in the resulting glycoside is demon

219 ond one was highly affected by the degree of unsaturation, PUFA being the fatty acids that showed the

220 of sea surface temperature based on alkenone unsaturation ratios in sediments of the Bermuda Rise pro

221 The compounds lack the olefin unsaturation required for potency in the natural ligand

222 dramatically with chain length and degree of unsaturation, respectively.

223 eral domains, which are cholesterol-rich and unsaturation-rich, respectively.

224 In all cell lines, pentamines that had unsaturation(s) at the end of the chain showed the highe

225 The pentamines with unsaturation(s) at the end of the chain were once again

226 However, the unsaturation seems to be compensated by a weak M-C(arene

227 ta-XCH2, where X is Cl, Br, or I or contains unsaturation, show limited efficacy in inhibiting [35S]T

228 atty acid chain lengths and degrees of chain unsaturation showed a range of membrane affinities (5.8

229 separation allowed assignment of the native unsaturation sites.

230 Fatty acid desaturases regulate the unsaturation status of cellular lipids.

231 sight into the interplay of fatty acid chain unsaturation, sterol concentration, and lipid hydrophobi

232 lic and physiological significance of Delta8 unsaturation, studies were performed using mutants of th

233 ted lipids or lipids with a modest degree of unsaturation, substantially larger pK(a) shifts are obse

234 g acyl chain length and decreasing degree of unsaturation, such that N-lauroylethanolamine and N-myri

235 r of potency correlated with their degree of unsaturation, suggesting that AA directly stimulates the

236 ylcholine had a significantly lower level of unsaturation than phosphatidylcholine in the remainder o

237 Waals contact, and the degree of acyl chain unsaturation, than a function of electrostatics.

238 Notably, this approach tolerates substrate unsaturation that normally poses major challenges in che

239 chosen with 18 carbon chains and degrees of unsaturation that ranged from one double bond (C18:0/1,

240 The degree of fatty acid unsaturation, that is, the ratio of unsaturated versus s

241 spholipids differ significantly in length or unsaturation, the behavior is markedly different.

242 pending on temperature and hydrocarbon chain unsaturation, the lipid with the highest chain melting t

243 lysed strongly depended on the degree of oil unsaturation; the two least unsaturated oils with low co

244 h an acetate ester functional group, and 1-3 unsaturations, there are 1039 isomers.

245 a pathway for the generation of coordinative unsaturation, thereby enabling ligand substitution and/o

246 up, but differ in their alkyl tail length or unsaturation; these differences are expected to affect t

247 chronic cold by increasing phosphoglyceride unsaturation to restore the fluidity of cold-rigidified

248 on of the importance of chloroplast membrane unsaturation to the proper growth and development of pla

249 n and promotes the migration of the alkene's unsaturation toward the alcohol to ultimately form the k

250 ig1/SREBP1 and preserves the degree of lipid unsaturation under conditions of obesity-induced insulin

251 g substantially increased metal coordinative unsaturation vs the corresponding Me2SiCp' '2AnR2 (Cp' '

252 Barton-McCombie reaction, and the alpha,beta-unsaturation was achieved through selenylation and oxida

253 Finally, the position of unsaturation was determined using reactive paper spray i

254 The C14,15 unsaturation was installed late in the synthesis by an o

255 Unsaturation was introduced at Delta(4,6) and Delta(6) o

256 aturated rhodium complexes; the coordinative unsaturation was stabilized by the site isolation of the

257 el production with a wide range of degree of unsaturation were created, in which proportion of SFAs,

258 y acid chain lengths with varying degrees of unsaturation were found to support binding to radiolabel

259 differing in acyl chain length and degree of unsaturation were potent inhibitors of the well-characte

260 imido-substituted furans containing tethered unsaturation were prepared by the addition of the lithiu

261 ethylthio)-5-amidofurans containing tethered unsaturation were prepared via the reaction of dimethyl(

262 ethylthio)-5-amidofurans containing tethered unsaturation were prepared via the reaction of dimethyl(

263 lipids, varying in headgroup and acyl chain unsaturation, were studied by measuring the partition co

264 llustrating the effect of introducing C2-exo-unsaturation which serves to flatten the C-rings and ach

265 hospholipid vesicles with varying acyl chain unsaturation, with and without cholesterol.

266 size, the effect of methyl substitution, and unsaturation within the macrocyclic ring structure were