ライフサイエンスコーパス: unscheduled

1 Loss-of-function mutations in rap cause unscheduled accumulation of cyclin B in the developing e

2 newly identified miR-9/TTP circuitry limits unscheduled accumulation of neuronal mRNAs in non-neuron

3 Unscheduled activation of APC(Cdc20) by Tax provides an

4 rimary tumors and malignant cells, cause the unscheduled activation of EPAS1 in early dysplastic foci

5 resection on genomic instability and on the unscheduled activation of the interferon response under

6 nobyl carcinomas and that they often lead to unscheduled activation of the MAPK signaling pathway.

7 , a nomadic egalitarian lifeway selected for unscheduled (ad hoc) ritual from which no one was exclud

8 Unscheduled adhesive-SBO admissions in NY State from 200

9 .84; 95% confidence interval, 3.79-6.19) and unscheduled admission (odds ratio, 1.64; 95% confidence

10 For 6-month unscheduled admissions, discrimination was good with all

11 Outcomes were 1-year mortality and 6-month unscheduled admissions.

12 the incidence of and factors associated with unscheduled aircraft diversion, transport to a hospital,

13 nd whether they used hospital, emergency, or unscheduled ambulatory care for pain on the previous day

14 0.05) and on the first clinically performed (unscheduled) angiogram within 30 months (63% versus 50%,

15 ssing autoactivating stromelysin-1 underwent unscheduled apoptosis during late pregnancy.

16 Although Str1 has been shown to induce unscheduled apoptosis when expressed ectopically during

17 egulated in A. nidulans and suggest that the unscheduled appearance of one or both of these activitie

18 d addressing the immunosuppressive nature of unscheduled cell death within the tumor microenvironment

19 Inactivation of Rb in mice results in unscheduled cell proliferation, apoptosis and widespread

20 ull mice die in midgestation with widespread unscheduled cell proliferation.

21 disruption of CP110 phosphorylation leads to unscheduled centrosome separation and overt polyploidy.

22 gestation (0.546 +/- 0.146; P = 0.0002), and unscheduled cesarean delivery (0.387 +/- 0.162; P = 0.02

23 Compared with offspring born by unscheduled cesarean delivery (n = 56,015 [17.4%]), thos

24 egnancy were compared with offspring born by unscheduled cesarean delivery and with offspring deliver

25 globally, with combined rates of planned and unscheduled cesarean delivery in a number of regions app

26 with vaginal delivery (but not compared with unscheduled cesarean delivery) was associated with a sma

27 This cohesion fatigue, resulting in unscheduled chromatid separation in cells delayed at met

28 ymptoms on standard therapy often leading to unscheduled clinic or emergency department visits or hos

29 e frequency of hospitalizations (P = 0.047), unscheduled clinic visits (P = 0.019), and days of antib

30 ns (RR: 0.83; 95% CI: 0.62, 1.13; P = 0.23), unscheduled clinic visits (RR: 0.97; 95% CI: 0.85, 1.10;

31 All-cause mortality, hospitalizations, and unscheduled clinic visits were recorded.

32 e ubiquitin-related modifier (SUMO) prevents unscheduled crossover events during S phase.

33 ns include the risk that women undergoing an unscheduled CS had intended to have a planned CS, and la

34 dle cell cycle checkpoint status and promote unscheduled cyclin B metabolism, cell cycle re-entry, an

35 argets and activates APC(Cdc20p), leading to unscheduled degradation of Pds1p/securin and Clb2p/cycli

36 mechanism by which APC/C(Cdh1) prevents the unscheduled degradation of SCF(Skp2-Cks1) substrates and

37 C(Cdh1) that maintain euploidy by preventing unscheduled degradation of securin.

38 of APC/C(Cdc20) during interphase to prevent unscheduled degradation of specific APC/C substrates.

39 nd interactions with RAS2-Val19 suggest that unscheduled derepression of IME1 is probably due to a de

40 keletal muscle progenitors, EZH2 prevents an unscheduled differentiation by repressing muscle-specifi

41 bed growth conditions to prevent unwanted or unscheduled DNA recombination.

42 Together, these data indicate that unscheduled DNA replication and failed cell cycle progre

43 ggest that CF formation is the product of an unscheduled DNA replication event initiated by the free

44 ties of LR and HR HPV E7 proteins to promote unscheduled DNA replication in organotypic raft cultures

45 to UV irradiation and show reduced levels of unscheduled DNA synthesis (UDS).

46 vity compared with wild-type, as assessed by unscheduled DNA synthesis after UV irradiation (10J/m2)

47 53-deficient hepatocytes also showed reduced unscheduled DNA synthesis after UV, but there was no imp

48 ion in G1, as measured by RAD51 recruitment, unscheduled DNA synthesis and a CRISPR-Cas9-based gene-t

49 ed a reduced capacity for NER as measured by unscheduled DNA synthesis and host cell reactivation ass

50 in two independent assays that measure NER (unscheduled DNA synthesis and host cell reactivation), t

51 lobutane pyrimidine dimers from bulk DNA, or unscheduled DNA synthesis and, therefore, do not involve

52 orporating 5'-bromodeoxyuridine, a marker of unscheduled DNA synthesis and/or cell proliferation.

53 e I breast tumors tested with the functional unscheduled DNA synthesis assay exhibited a significant

54 1 (CDK1) activity, DNA damage responses, or unscheduled DNA synthesis but to loss of an ATR function

55 vation of u.v.-damaged reporter plasmids and unscheduled DNA synthesis experiments in transiently-tra

56 tion and defective DNA repair (16% of normal unscheduled DNA synthesis in intact cells and undetectab

57 to be deficient in their ability to conduct unscheduled DNA synthesis in response to UV-induced DNA

58 n was maximum with the drug combination, and unscheduled DNA synthesis induced by bendamustine was bl

59 st that p21cip1 induction effectively blocks unscheduled DNA synthesis reactivated by E7.

60 splatin or doxorubicin led to an increase in unscheduled DNA synthesis that was reduced by combined t

61 ER-2 and radiation demonstrate a decrease of unscheduled DNA synthesis to 25-44% of controls.

62 The level of ultraviolet (UV)-induced unscheduled DNA synthesis was less than 5% of normal, ch

63 ermined by measurements of repair synthesis (unscheduled DNA synthesis), by immunoassays to detect re

64 (2-4 Gy) alone provokes a marked increase in unscheduled DNA synthesis, a measure of DNA repair, but

65 es promote cell cycle progression, stimulate unscheduled DNA synthesis, and present the cell with an

66 a included increased cellular proliferation, unscheduled DNA synthesis, increased E2F-responsive gene

67 a pigmentosum variant cells exhibited normal unscheduled DNA synthesis, normal recovery of RNA synthe

68 eterozygotic parents showed normal levels of unscheduled DNA synthesis, recovery of RNA synthesis, an

69 or DNA repair after ultraviolet irradiation: unscheduled DNA synthesis, recovery of RNA synthesis, an

70 Two commonly used assays are UDS (unscheduled DNA synthesis, requiring a precise measureme

71 eotide excision repair (NER), as measured by unscheduled DNA synthesis, was accelerated by PAF and 5-

72 An alternative measure of DNA repair, unscheduled DNA synthesis, was also assessed.

73 mitosis, TopBP1 marks sites of and promotes unscheduled DNA synthesis.

74 atin recruitment of SLX4 and by facilitating unscheduled DNA synthesis.

75 as determined by phosphorylation of H2AX and unscheduled DNA synthesis.

76 outcomes were controller use, reliever use, unscheduled doctor visits, emergency department (ED) vis

77 n gaps could prevent as many as nine million unscheduled doctor visits, four million emergency depart

78 for the maintenance of genome stability when unscheduled DSBs occur in the vicinity of DNA replicatio

79 achycardia), detected by either scheduled or unscheduled electrocardiogram, Holter, transtelephonic m

80 s included symptom days, medication use, and unscheduled emergency department or clinic visits.

81 opose that replication inhibitors can induce unscheduled encounters between replication and transcrip

82 In tumors, unscheduled EndMT generates cancer-associated myofibrobl

83 Thus, unscheduled entry into S phase directly mediates activat

84 romote lytic viral nucleic acid synthesis by unscheduled entry into the S phase of the cell cycle.

85 trix metalloproteinases (MMPs) do not induce unscheduled epithelial cell death after weaning, but ins

86 ontemplate DNA strand to mutagens and primes unscheduled error-prone DNA synthesis.

87 Scheduled office visits and unscheduled evaluations, incidence of morbidity, and tim

88 on and replication, this also holds true for unscheduled events, such as repair of DNA damage.

89 ization therapy often visit the hospital for unscheduled examinations, placing a great burden on heal

90 ety of activating genes, which contribute to unscheduled expression and constitutive dimerization of

91 TLS-CHOP thus leads to the unscheduled expression of a gene that is normally associ

92 Unscheduled expression of cyclin A in the sub-G0/G1 peak

93 of these genes in leukemia, and suggest that unscheduled expression of Hex and mEg5 contributes to th

94 Unscheduled expression of SKP2 promoted marked overproli

95 ls of IME1 even in vegetative cells and this unscheduled expression results in premature sporulation.

96 bitory effect of TLS-CHOP is attributable to unscheduled gene expression resulting from TLS-CHOP's pu

97 inhalations per week, respectively; P=0.69), unscheduled health care utilization for asthma (0.75 and

98 n control homes had more asthma symptoms and unscheduled health care utilization in the previous 2 we

99 rent smokers had poorer asthma control, more unscheduled health care visits, more rescue courses of o

100 irometry) and morbidity (school absences and unscheduled healthcare visits).

101 r model for the evaluation of the effects of unscheduled HGF expression in breast cancer.

102 Unscheduled homologous recombination (HR) can lead to ge

103 hich affects genome stability by suppressing unscheduled homologous recombination.

104 p=0.84), and the number of patients who had unscheduled hospital admissions were 13 (18%) of 73 vers

105 disorder of grade 4 severity, that required unscheduled hospital admissions, or caused death.

106 ilar in the two groups, as were the risks of unscheduled hospital admissions.

107 mortality and the composite of mortality or unscheduled hospitalizations for HF.

108 Unscheduled hospitalizations occurred significantly less

109 romised in AGS patients and may be linked to unscheduled immune responses.

110 ions (adjusted odds ratio, 1.72; p < 0.001), unscheduled index admission (adjusted odds ratio, 1.37;

111 Risk factors for unscheduled interruptions in radiotherapy courses comple

112 There was no difference in unscheduled medical attendances for wheezing episodes be

113 Compared with placebo, unscheduled medical attendances for wheezing episodes we

114 The primary outcome was number of unscheduled medical attendances for wheezing episodes.

115 1 for the other children (P=0.001), and 2.56 unscheduled medical visits for asthma per year, as compa

116 There were 23 of 108 (21.3%) subsequent unscheduled medical visits for bronchiolitis in the true

117 The primary outcome was unscheduled medical visits for bronchiolitis, including

118 ssociation with death, rehospitalization, or unscheduled medical visits through 60 days was assessed.

119 m 20 to 28 (+/- 2) in the expected number of unscheduled medications administered/day, and from 29 to

120 auses DNA replication stress, DNA damage and unscheduled mitotic entry due to elevated CDK activity.

121 plex native tissue extract and quantified by unscheduled multiple reaction monitoring on a TSQ Vantag

122 l to elucidate the oncogenic consequences of unscheduled NUT expression and altered BRD4 function.

123 A model is proposed in which unscheduled or aberrant DNA replication is a critical st

124 NCOA4(-/-) MEFs display unscheduled origin activation and reduced interorigin di

125 ra-S-phase checkpoint, by which MDM2 induces unscheduled origin firing and accelerates S-phase entry

126 s through which ATR kinase inhibitors induce unscheduled origin firing in undamaged cells.

127 stall, and they exhibit reduced fork rates, unscheduled origin firing, and increased replication for

128 delivery, and reviews of medical records of unscheduled outpatient visits and all hospitalizations.

129 ortality, syncope, emergency room visits, or unscheduled outpatient visits.

130 ins unknown how this ssDNA is prevented from unscheduled pairing with the template, which can lead to

131 The tertiary outcome was the number of unscheduled physician appointments for concerning lesion

132 ous rehydration, hospitalization, subsequent unscheduled physician encounter, protracted symptoms, cr

133 be associated with reductions in anxiety and unscheduled physician visits and increases in self-effic

134 uced beneficial effects in terms of reducing unscheduled physician visits, lowering patients' anxiety

135 Unscheduled Plk1 activity, either in cycling or interpha

136 There were more complications and unscheduled postoperative events in the Doppler group (P

137 The ability to sustain unscheduled proliferation is a hallmark of cancer.

138 Nevertheless, unscheduled proliferation of SCs in the adult p130(-/-)

139 ls in normal blood vessels might prevent the unscheduled proliferation of smooth muscle cells (SMCs)

140 ontrolled ubiquitylation is crucial to avoid unscheduled proteolysis of essential proteins.

141 e setting, is an independent risk factor for unscheduled readmission or death, which may have value b

142 erstage mortality was 8.1%, and 47% had >/=1 unscheduled readmission.

143 We compared interstage mortality, unscheduled readmissions, and change in weight-for-age Z

144 chemical assays, we show that PARI restricts unscheduled recombination by interfering with the format

145 The unscheduled relocalization of this large a pool of PP1 s

146 a (13.3% vs. 19.6%, p = 0.08) and subsequent unscheduled repeat catheterization (7.6% vs. 13.3%, p =

147 ation with asthma was greater following both unscheduled repeat CS (3.7% versus 3.3%, adjusted hazard

148 following planned repeat CS (n = 17,919) and unscheduled repeat CS (n = 8,847) with those following V

149 sy were similar between planned repeat CS or unscheduled repeat CS and VBAC.

150 k of death and learning disability following unscheduled repeat CS compared to VBAC may reflect compl

151 ability and death were more common following unscheduled repeat CS compared with VBAC (3.7% versus 2.

152 outcomes after (1) planned repeat CS and (2) unscheduled repeat CS with those that follow vaginal bir

153 controlled during each cell cycle to prevent unscheduled replication and ensure proper genome mainten

154 racting chromatin compaction associated with unscheduled replication fork stalling and restart, and s

155 PRC2-mediated gene repression in preventing unscheduled reprogramming of fully differentiated plant

156 POT1b represses unscheduled resection of the 5'-ended telomeric DNA stra

157 es of return for care, with no difference in unscheduled return medical visits and delayed hospitaliz

158 rdiovascular death, acute coronary syndrome, unscheduled revascularization or hospital admission for

159 sion of Ime2 in vegetative cells leads to an unscheduled RPA phosphorylation reaction that does not r

160 verexpression of kinase-inactive Nek5 caused unscheduled separation of centrosomes in interphase, a p

161 Unscheduled short-term return visits to the emergency de

162 ated during projection neuron migration, and unscheduled SOCS7 expression stops migration prematurely

163 fect in chromosome separation accompanied by unscheduled spindle elongation before the completion of

164 stained periods of instrumental response and unscheduled spontaneous behavior, task-induced decreases

165 e expression and ST accumulation, as well as unscheduled sporulation.

166 of proliferation of primitive HPCs and that unscheduled stimulation of CD34+ cells residing in G0 ma

167 d scheduled surgical admissions, and 27% had unscheduled surgical admissions; 73% had severe sepsis w

168 f patients dying in the hospital, percent of unscheduled surgical patients, percent of patients on me

169 rogression of DNA replication forks, causing unscheduled termination events with a frequency similar

170 aving missed blood samples or blood drawn at unscheduled times (group 2).

171 efore sets a threshold that prevents random, unscheduled transcription all over the genome and even l

172 eviously published microarray data indicated unscheduled transcription of a large number of Snf1- and

173 accelerates SMC differentiation and promotes unscheduled transcription of developmental regulators in

174 participants, supported by receipt of fewer unscheduled treatments versus aflibercept (6 vs. 15) and

175 Unscheduled treatments were allowed at the investigator'

176 ore stable CSFT reductions, receipt of fewer unscheduled treatments, and higher rates of fluid resolu

177 r, however, it frequently causes episodes of unscheduled uterine bleeding, which could be associated

178 infants with desaturations, 18 (24%) had an unscheduled visit for bronchiolitis as compared with 11

179 and a composite of death, rehospitalization, unscheduled visit for HF, or > or =50% increase in oral

180 emergency departments (76% had at least one unscheduled visit in the preceding 3 months).

181 vs. 3.8 +/- 8.5; p = 0.022) per patient, and unscheduled visits (14 of 65 [21%] vs. 29 of 66 [44%]; p

182 60-day rates of death, rehospitalization, or unscheduled visits (50%) compared with those with low-gr

183 nt, length of emergency department stay, and unscheduled visits for bronchiolitis within 72 hours.

184 ilure (defined as death, hospitalization, or unscheduled visits for heart failure) at 60 days after r

185 e frequency of subsequent fever, otalgia, or unscheduled visits for medical care.

186 ctional capacity, HF rehospitalizations, and unscheduled visits in 90 days.

187 of symptomatic patients who experienced 4.6 unscheduled visits per year to an emergency department o

188 ndard GEE model including both scheduled and unscheduled visits predicted a pneumonia prevalence of 2

189 More children in the non-malaria group made unscheduled visits than children in the malaria group (1

190 he 2 weeks before baseline, and had frequent unscheduled visits to clinics or emergency departments (

191 ct with a nurse increased the mean number of unscheduled visits to obstetricians (1.2 in the weekly-c

192 nces in exacerbations, hospitalizations, and unscheduled visits, all of which were markedly higher in

193 re uploaded every approximately 3 months, at unscheduled visits, exit, and death.

194 Birth by repeat CS, whether planned or unscheduled, was associated with an increased risk of ho

195 B expression was not only increased but also unscheduled with respect to its usual cell cycle pattern

196 , Scotland, and Wales who had been admitted, unscheduled, with severe ulcerative colitis and failed t