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2 newly identified miR-9/TTP circuitry limits unscheduled accumulation of neuronal mRNAs in non-neuron
5 accumulation of DNA damage, together with an unscheduled activation of cytoplasmic CDK1/Cyclin A comp
6 rimary tumors and malignant cells, cause the unscheduled activation of EPAS1 in early dysplastic foci
7 crophthalmia (MiTF) through the cooperative, unscheduled activation of several stress-signaling pathw
8 whether rereplication stress induced by the unscheduled activation of the APC/C-CDH1 complex affects
9 resection on genomic instability and on the unscheduled activation of the interferon response under
10 nobyl carcinomas and that they often lead to unscheduled activation of the MAPK signaling pathway.
11 motif 1 (Hey1), down-regulation of Six2, and unscheduled activation of Wnt4-driven differentiation, r
12 , a nomadic egalitarian lifeway selected for unscheduled (ad hoc) ritual from which no one was exclud
14 .84; 95% confidence interval, 3.79-6.19) and unscheduled admission (odds ratio, 1.64; 95% confidence
15 utcomes in hospitalised older people with an unscheduled admission, by increasing hospital mortality,
18 the incidence of and factors associated with unscheduled aircraft diversion, transport to a hospital,
19 nd whether they used hospital, emergency, or unscheduled ambulatory care for pain on the previous day
20 inders ribosome recruitment and scanning via unscheduled and non-productive RNA clamping by the eukar
23 0.05) and on the first clinically performed (unscheduled) angiogram within 30 months (63% versus 50%,
26 egulated in A. nidulans and suggest that the unscheduled appearance of one or both of these activitie
27 ondary end points included repeat ablations, unscheduled arrhythmia-related visits, and quality of li
31 rents increased prescription uptake; reduced unscheduled care, and was cost saving to the health serv
32 aginal deliveries (1:1) and prelabor CD with unscheduled CD (1:1) and estimated associations with chi
34 d addressing the immunosuppressive nature of unscheduled cell death within the tumor microenvironment
37 disruption of CP110 phosphorylation leads to unscheduled centrosome separation and overt polyploidy.
38 gestation (0.546 +/- 0.146; P = 0.0002), and unscheduled cesarean delivery (0.387 +/- 0.162; P = 0.02
40 egnancy were compared with offspring born by unscheduled cesarean delivery and with offspring deliver
41 globally, with combined rates of planned and unscheduled cesarean delivery in a number of regions app
42 with vaginal delivery (but not compared with unscheduled cesarean delivery) was associated with a sma
45 ymptoms on standard therapy often leading to unscheduled clinic or emergency department visits or hos
46 of cardiovascular death, HF-related events (unscheduled clinic visit due to HF, ED revisit, or hospi
47 e frequency of hospitalizations (P = 0.047), unscheduled clinic visits (P = 0.019), and days of antib
48 ns (RR: 0.83; 95% CI: 0.62, 1.13; P = 0.23), unscheduled clinic visits (RR: 0.97; 95% CI: 0.85, 1.10;
51 sessed throughout the intervention period at unscheduled clinic visits whenever participants experien
52 ledermatologist assessment, and fast-tracked unscheduled clinic visits) or clinician-led surveillance
53 ximately 50 HF events, defined as an urgent, unscheduled clinic, emergency department, or hospitaliza
54 osis, bronchodilator or inhaled steroids, or unscheduled clinical evaluation for respiratory symptoms
55 (n = 5) of males maintained aviremia despite unscheduled complete discontinuation of cART lasting 3-1
57 was expanded during study conduct to include unscheduled coronary revascularization due to lower than
60 ns include the risk that women undergoing an unscheduled CS had intended to have a planned CS, and la
61 dle cell cycle checkpoint status and promote unscheduled cyclin B metabolism, cell cycle re-entry, an
62 ing RAD51 and BRCA2 in protecting forks from unscheduled degradation and preventing genome instabilit
63 argets and activates APC(Cdc20p), leading to unscheduled degradation of Pds1p/securin and Clb2p/cycli
64 mechanism by which APC/C(Cdh1) prevents the unscheduled degradation of SCF(Skp2-Cks1) substrates and
66 of APC/C(Cdc20) during interphase to prevent unscheduled degradation of specific APC/C substrates.
69 nd interactions with RAS2-Val19 suggest that unscheduled derepression of IME1 is probably due to a de
70 keletal muscle progenitors, EZH2 prevents an unscheduled differentiation by repressing muscle-specifi
75 ggest that CF formation is the product of an unscheduled DNA replication event initiated by the free
76 ties of LR and HR HPV E7 proteins to promote unscheduled DNA replication in organotypic raft cultures
78 vity compared with wild-type, as assessed by unscheduled DNA synthesis after UV irradiation (10J/m2)
79 53-deficient hepatocytes also showed reduced unscheduled DNA synthesis after UV, but there was no imp
80 ion in G1, as measured by RAD51 recruitment, unscheduled DNA synthesis and a CRISPR-Cas9-based gene-t
81 ed a reduced capacity for NER as measured by unscheduled DNA synthesis and host cell reactivation ass
82 in two independent assays that measure NER (unscheduled DNA synthesis and host cell reactivation), t
83 lobutane pyrimidine dimers from bulk DNA, or unscheduled DNA synthesis and, therefore, do not involve
84 orporating 5'-bromodeoxyuridine, a marker of unscheduled DNA synthesis and/or cell proliferation.
85 e I breast tumors tested with the functional unscheduled DNA synthesis assay exhibited a significant
86 1 (CDK1) activity, DNA damage responses, or unscheduled DNA synthesis but to loss of an ATR function
87 vation of u.v.-damaged reporter plasmids and unscheduled DNA synthesis experiments in transiently-tra
88 tion and defective DNA repair (16% of normal unscheduled DNA synthesis in intact cells and undetectab
89 to be deficient in their ability to conduct unscheduled DNA synthesis in response to UV-induced DNA
90 n was maximum with the drug combination, and unscheduled DNA synthesis induced by bendamustine was bl
92 splatin or doxorubicin led to an increase in unscheduled DNA synthesis that was reduced by combined t
95 ermined by measurements of repair synthesis (unscheduled DNA synthesis), by immunoassays to detect re
96 (2-4 Gy) alone provokes a marked increase in unscheduled DNA synthesis, a measure of DNA repair, but
97 es promote cell cycle progression, stimulate unscheduled DNA synthesis, and present the cell with an
98 a included increased cellular proliferation, unscheduled DNA synthesis, increased E2F-responsive gene
99 a pigmentosum variant cells exhibited normal unscheduled DNA synthesis, normal recovery of RNA synthe
100 eterozygotic parents showed normal levels of unscheduled DNA synthesis, recovery of RNA synthesis, an
101 or DNA repair after ultraviolet irradiation: unscheduled DNA synthesis, recovery of RNA synthesis, an
103 eotide excision repair (NER), as measured by unscheduled DNA synthesis, was accelerated by PAF and 5-
108 cells have developed a strategy to conduct 'unscheduled' DNA synthesis in mitosis (termed MiDAS) tha
109 outcomes were controller use, reliever use, unscheduled doctor visits, emergency department (ED) vis
110 n gaps could prevent as many as nine million unscheduled doctor visits, four million emergency depart
111 for the maintenance of genome stability when unscheduled DSBs occur in the vicinity of DNA replicatio
112 s independent analyses for all scheduled and unscheduled duplex ultrasound examinations and angiograp
114 achycardia), detected by either scheduled or unscheduled electrocardiogram, Holter, transtelephonic m
116 opose that replication inhibitors can induce unscheduled encounters between replication and transcrip
119 romote lytic viral nucleic acid synthesis by unscheduled entry into the S phase of the cell cycle.
120 trix metalloproteinases (MMPs) do not induce unscheduled epithelial cell death after weaning, but ins
125 ization therapy often visit the hospital for unscheduled examinations, placing a great burden on heal
126 erence has a destabilizing effect, likely by unscheduled exposure of underlying chromatin to modifyin
127 ety of activating genes, which contribute to unscheduled expression and constitutive dimerization of
131 of these genes in leukemia, and suggest that unscheduled expression of Hex and mEg5 contributes to th
133 ls of IME1 even in vegetative cells and this unscheduled expression results in premature sporulation.
136 bitory effect of TLS-CHOP is attributable to unscheduled gene expression resulting from TLS-CHOP's pu
137 inhalations per week, respectively; P=0.69), unscheduled health care utilization for asthma (0.75 and
138 n control homes had more asthma symptoms and unscheduled health care utilization in the previous 2 we
140 f postnatal age included in-hospital safety, unscheduled health care visits, and nonaccidental trauma
141 rent smokers had poorer asthma control, more unscheduled health care visits, more rescue courses of o
142 ons, annualized exacerbation rates prompting unscheduled health care were also higher in children wit
148 (new onset or worsening of HF leading to an unscheduled hospital admission or an urgent visit, with
149 dverse Events 3), treatment discontinuation, unscheduled hospital admission, and death was 0.48 (95%
150 p=0.84), and the number of patients who had unscheduled hospital admissions were 13 (18%) of 73 vers
153 rately estimates relative risk of mortality, unscheduled hospitalisation, and MACE associated with LT
159 2000 to 2006 and 2007 to 2013, the number of unscheduled IBD-related admissions increased by 50% for
162 e nightshifts, especially combined with more unscheduled in-house nightshifts, experienced significan
163 ions (adjusted odds ratio, 1.72; p < 0.001), unscheduled index admission (adjusted odds ratio, 1.37;
166 esolution of the gestation, while minimizing unscheduled interventions, are important priorities.
171 1 for the other children (P=0.001), and 2.56 unscheduled medical visits for asthma per year, as compa
172 There were 23 of 108 (21.3%) subsequent unscheduled medical visits for bronchiolitis in the true
174 ssociation with death, rehospitalization, or unscheduled medical visits through 60 days was assessed.
175 m 20 to 28 (+/- 2) in the expected number of unscheduled medications administered/day, and from 29 to
176 auses DNA replication stress, DNA damage and unscheduled mitotic entry due to elevated CDK activity.
177 n induces mitotic catastrophe resulting from unscheduled mitotic entry in the presence of DNA damage.
178 plex native tissue extract and quantified by unscheduled multiple reaction monitoring on a TSQ Vantag
179 h factors are required for cells to tolerate unscheduled MYCN overexpression during early malignant t
180 livers from animals that recovered and from unscheduled necropsies of those that succumbed to toxici
181 ns increasingly use community EDs for acute, unscheduled needs, attention to factors associated with
182 xisting NOTCH1 inhibitors, and indicate that unscheduled Notch signalling may be a disease-defining f
183 l to elucidate the oncogenic consequences of unscheduled NUT expression and altered BRD4 function.
186 ra-S-phase checkpoint, by which MDM2 induces unscheduled origin firing and accelerates S-phase entry
188 stall, and they exhibit reduced fork rates, unscheduled origin firing, and increased replication for
189 delivery, and reviews of medical records of unscheduled outpatient visits and all hospitalizations.
191 that some methylation loss may occur during unscheduled, oxidative damage repair-associated DNA synt
192 ins unknown how this ssDNA is prevented from unscheduled pairing with the template, which can lead to
194 ous rehydration, hospitalization, subsequent unscheduled physician encounter, protracted symptoms, cr
195 be associated with reductions in anxiety and unscheduled physician visits and increases in self-effic
197 g episodes within 48 hours after enrollment, unscheduled physician visits within 7 days after enrollm
198 ence for an impact on hospital admissions or unscheduled physician visits, and increased ICS dose inc
199 uced beneficial effects in terms of reducing unscheduled physician visits, lowering patients' anxiety
201 results may have important implications for unscheduled polyploidization that frequently occurs in h
204 cerbations requiring oral corticosteroid and unscheduled primary care attendances for exacerbations.
208 ls in normal blood vessels might prevent the unscheduled proliferation of smooth muscle cells (SMCs)
209 ays mitigate the detrimental consequences of unscheduled promiscuous initiation occurring at hundreds
211 Pol-dependent repriming limits the extent of unscheduled R-loop formation at these sequences, mitigat
212 n addition, the SF3B1 K700E mutation induced unscheduled R-loop formation, replication fork stalling,
215 PAF1 promotes Pol II elongation, preventing unscheduled R-loops that hyper-restrain IGS Pol I-associ
217 difference, 2.1% [95% CI, -15.5% to 19.8%]), unscheduled readmission (14.3% vs 15.7%; adjusted differ
218 e setting, is an independent risk factor for unscheduled readmission or death, which may have value b
219 mortality, 30-day cardiovascular mortality, unscheduled readmission, length of hospital stay, and ki
222 chemical assays, we show that PARI restricts unscheduled recombination by interfering with the format
224 a (13.3% vs. 19.6%, p = 0.08) and subsequent unscheduled repeat catheterization (7.6% vs. 13.3%, p =
225 ation with asthma was greater following both unscheduled repeat CS (3.7% versus 3.3%, adjusted hazard
226 following planned repeat CS (n = 17,919) and unscheduled repeat CS (n = 8,847) with those following V
228 k of death and learning disability following unscheduled repeat CS compared to VBAC may reflect compl
229 ability and death were more common following unscheduled repeat CS compared with VBAC (3.7% versus 2.
230 outcomes after (1) planned repeat CS and (2) unscheduled repeat CS with those that follow vaginal bir
231 controlled during each cell cycle to prevent unscheduled replication and ensure proper genome mainten
232 racting chromatin compaction associated with unscheduled replication fork stalling and restart, and s
233 r genetic systems in budding yeast to induce unscheduled replication in a G1-like cell cycle state.
235 PRC2-mediated gene repression in preventing unscheduled reprogramming of fully differentiated plant
238 es of return for care, with no difference in unscheduled return medical visits and delayed hospitaliz
239 o [HR], 1.25; 95% CI, 0.89-1.76; P = .20) or unscheduled revascularization (HR, 0.98; 95% CI, 0.64-1.
240 rdiovascular death, acute coronary syndrome, unscheduled revascularization or hospital admission for
241 site of death, recurrent MI, ischemia-driven unscheduled revascularization, or readmission for ischem
242 ry endpoint was a composite of nonfatal AMI, unscheduled revascularization, stroke, all-cause death,
243 was additional resource use, a composite of unscheduled revisits for bronchiolitis or use of additio
245 sion of Ime2 in vegetative cells leads to an unscheduled RPA phosphorylation reaction that does not r
249 verexpression of kinase-inactive Nek5 caused unscheduled separation of centrosomes in interphase, a p
253 ated during projection neuron migration, and unscheduled SOCS7 expression stops migration prematurely
254 fect in chromosome separation accompanied by unscheduled spindle elongation before the completion of
255 stained periods of instrumental response and unscheduled spontaneous behavior, task-induced decreases
257 of proliferation of primitive HPCs and that unscheduled stimulation of CD34+ cells residing in G0 ma
258 d scheduled surgical admissions, and 27% had unscheduled surgical admissions; 73% had severe sepsis w
259 f patients dying in the hospital, percent of unscheduled surgical patients, percent of patients on me
260 rogression of DNA replication forks, causing unscheduled termination events with a frequency similar
261 work shows that within a single interphase, unscheduled tetraploid cells can acquire highly abnormal
262 ed high transgene transcript levels at early unscheduled timepoints that subsequently decreased.
264 damage whereby reducing the H1 pool triggers unscheduled TOP2 substrate formation in low-accessibilit
265 efore sets a threshold that prevents random, unscheduled transcription all over the genome and even l
266 ain stable throughout the cell cycle, induce unscheduled transcription in G2 and mitosis, and promote
267 eviously published microarray data indicated unscheduled transcription of a large number of Snf1- and
268 accelerates SMC differentiation and promotes unscheduled transcription of developmental regulators in
270 participants, supported by receipt of fewer unscheduled treatments versus aflibercept (6 vs. 15) and
272 ore stable CSFT reductions, receipt of fewer unscheduled treatments, and higher rates of fluid resolu
273 r, however, it frequently causes episodes of unscheduled uterine bleeding, which could be associated
274 infants with desaturations, 18 (24%) had an unscheduled visit for bronchiolitis as compared with 11
275 and a composite of death, rehospitalization, unscheduled visit for HF, or > or =50% increase in oral
277 vs. 3.8 +/- 8.5; p = 0.022) per patient, and unscheduled visits (14 of 65 [21%] vs. 29 of 66 [44%]; p
278 60-day rates of death, rehospitalization, or unscheduled visits (50%) compared with those with low-gr
279 nt, length of emergency department stay, and unscheduled visits for bronchiolitis within 72 hours.
280 ilure (defined as death, hospitalization, or unscheduled visits for heart failure) at 60 days after r
282 the likelihood of SMM, those with 4 or more unscheduled visits had an adjusted OR of 1.46 (95% CI, 1
284 clinics every 2 weeks for 24 weeks and made unscheduled visits in the case of febrile illness in the
285 of symptomatic patients who experienced 4.6 unscheduled visits per year to an emergency department o
286 ndard GEE model including both scheduled and unscheduled visits predicted a pneumonia prevalence of 2
287 More children in the non-malaria group made unscheduled visits than children in the malaria group (1
289 , clinically significant worsening of HF, or unscheduled visits to a clinician for treatment intensif
290 he 2 weeks before baseline, and had frequent unscheduled visits to clinics or emergency departments (
291 ct with a nurse increased the mean number of unscheduled visits to obstetricians (1.2 in the weekly-c
294 nces in exacerbations, hospitalizations, and unscheduled visits, all of which were markedly higher in
295 yed better disease control, fewer numbers of unscheduled visits, and being followed by a gastroentero
299 B expression was not only increased but also unscheduled with respect to its usual cell cycle pattern
300 , Scotland, and Wales who had been admitted, unscheduled, with severe ulcerative colitis and failed t