ライフサイエンスコーパス: unsolved

1 h, many basic epidemiologic questions remain unsolved.

2 ding, about half of our exome cases remained unsolved.

3 out the molecular mechanisms involved remain unsolved.

4 inal step of circularizing sequences remains unsolved.

5 he details of the enzymatic mechanism remain unsolved.

6 y influential spreaders, the problem remains unsolved.

7 ides before the emergence of enzymes remains unsolved.

8 enes have been implicated, many cases remain unsolved.

9 ns and their mechanistic interactions remain unsolved.

10 of the keratinocyte mild-cold sensor remains unsolved.

11 GC pairs function in this role, has remained unsolved.

12 quence for Ca(2+) release remained, however, unsolved.

13 pathogenesis of neonatal septicemia is still unsolved.

14 underlying SOX9 transcription remain largely unsolved.

15 s an effect on PAH biodegradation was so far unsolved.

16 inhibition to the plasticity, have remained unsolved.

17 re at the surface of the chromosomes remains unsolved.

18 ving tumor growth and ACTH secretion remains unsolved.

19 n of patients at risk of early sepsis remain unsolved.

20 their internal organization remains largely unsolved.

21 nd upon crossing the species barrier remains unsolved.

22 15 to 40 kDa, seven of which were previously unsolved.

23 ing to regulate its diverse functions remain unsolved.

24 e in shaping genomic patterns of CUB remains unsolved.

25 r switch have been elucidated, others remain unsolved.

26 How OS arises from synaptic circuits remains unsolved.

27 echanism of such nucleation activity remains unsolved.

28 The general off-lattice problem is still unsolved.

29 l tumor-specific cyclin D1b induction remain unsolved.

30 r complexity of this network remains largely unsolved.

31 regulation of this recruitment has remained unsolved.

32 eral pieces of this intriguing puzzle remain unsolved.

33 ding the details of macaque evolution remain unsolved.

34 such rearrangements lead to limping remains unsolved.

35 by these new complex datasets remain largely unsolved.

36 nism is necessary for this asymmetry remains unsolved.

37 een binding and translocation blocks remains unsolved.

38 this CD8(+) T-cell effector function remain unsolved.

39 ear mechanism for this reaction has remained unsolved.

40 the fine mechanisms that participate remain unsolved.

41 to highlight important problems that remain unsolved.

42 ut voltage-gated proton channels that remain unsolved.

43 ce and note some of the problems that remain unsolved.

44 between pairs of divergent sequence remains unsolved.

45 hanisms involved in their development remain unsolved.

46 nt Robinow syndrome cases remain molecularly unsolved.

47 (quaternary) derivatives remains essentially unsolved.

48 tion of candidate cancer genes (CCG) remains unsolved.

49 ported V2 variant (MCDR1), while five remain unsolved.

50 low confidence, while the remaining four are unsolved.

51 d its connection to CD3zeta signaling remain unsolved.

52 as a causal relationship to allodynia remain unsolved.

53 alized protein folding and design problem is unsolved.

54 musculature, but its evolutionary origin is unsolved.

55 rmines a specific cellular targeting remains unsolved.

56 m between TRIM24 and histone modification is unsolved.

57 unctional integration into the tissue remain unsolved.

58 lementation of skilled movement has remained unsolved.

59 roscience, many theoretical questions remain unsolved.

60 rst two issues, but the last is still mostly unsolved.

61 f expert crystallographers and that remained unsolved after application of an extensive array of alte

62 -Lam amination, overcoming long-standing and unsolved amine and organoboron limitations of this valua

63 e when it crystallizes out of solution is an unsolved and fundamental problem in materials synthesis,

64 ing Multituberculata and Haramiyida, remains unsolved and has generated contentious views on the orig

65 orts in the past decade, the problem remains unsolved and therefore still attracts a lot of attention

66 s bound to their effectors or regulators are unsolved, and it is unknown precisely how Ras proteins a

67 uctures and their ligand complexes are still unsolved, and no structures are known outside of family

68 We proof the strength of EnPEn for three yet unsolved architectures: (a) selective Na over Ca transpo

69 have been solved and providing an outlook on unsolved avenues.

70 ive in natural environments, remains a major unsolved biosafety problem.

71 The CFTR structure is unsolved but homology models of the CFTR closed and open

72 tion (HCAI) in hospitals mainly results from unsolved but well-identified causes such as hand hygiene

73 oles overcome this Coulomb trapping is still unsolved, but increasing evidence points to the critical

74 nting 360 years ago that to this day remains unsolved, but still mystifies and intrigues.

75 iology in subjects from 20 families remained unsolved by WES.

76 ectron-phonon coupling, is a fascinating but unsolved case after decades of research.

77 The remaining samples were from unsolved cases that were biased toward more phenotypical

78 hed genetic diagnoses in 13 of 60 previously unsolved cases using confirmatory experiments, including

79 For the unsolved cases, our assay resulted in a molecular geneti

80 lic predicted protein-truncating variants in unsolved cases.

81 which explain the disease in several so far unsolved cases; and an intralocus OPA1 modifier, which e

82 g data from families affected by genetically unsolved CDGs and identified four individuals with diffe

83 offers an opportunity to objectively address unsolved cellular mechanisms, and has revealed emergent

84 variation among bacterial genomes remains an unsolved challenge in evolutionary biology, despite long

85 quence of its amino acid residues remains an unsolved challenge in modern structural biology.

86 hiles in cross-coupling reactions remains an unsolved challenge in organic chemistry.

87 ated, hindered halides persists as a largely unsolved challenge in organic synthesis.

88 A major unsolved challenge in the design of enantioselective cat

89 kind of data it is still a major and largely unsolved challenge to infer the topology and interaction

90 nymous, one-shot economic games has posed an unsolved challenge to models of economic and evolutionar

91 An unsolved challenge, however, is to quantify varying leve

92 ol over size and cluster geometry remains an unsolved challenge.

93 y evolving network topology remains to be an unsolved challenge.

94 e from spurious de novo mutations remains an unsolved challenge.

95 rammed by shape and composition, is still an unsolved challenge.

96 stochastic cellular fluctuations remains an unsolved challenge.

97 tructures and interactions is a critical but unsolved challenge.

98 logical functions of biomolecules remains an unsolved challenge.

99 probe with proteins in a proteome remains an unsolved challenge.

100 es into wild mosquito populations remains an unsolved challenge.

101 sphates in our bodies is critical and yet an unsolved challenge.

102 mations at a single-cell level is to date an unsolved challenge.

103 y and high electrical performance remains an unsolved challenge.

104 f cancer has led to a persistent, and as yet unsolved, challenge to develop cures for this disease.

105 ons about QMC developments, limitations, and unsolved challenges are discussed as well.

106 Finally, the remaining unsolved challenges are examined, and the potential dire

107 ays and interventions and highlight some key unsolved challenges that remain.

108 their production often suffers from multiple unsolved challenges.

109 rystal microbalance (QCM) sensors remains an unsolved challenging task.

110 on angioplasty and stenting (BAS) remains an unsolved clinical dilemma for patients with coronary art

111 However, restenosis remains an unsolved clinical problem after vascular interventions.

112 ludarabine refractoriness (FR) represents an unsolved clinical problem of chronic lymphocytic leukemi

113 reatment of complicated tissue defects is an unsolved clinical problem.

114 therapies targeting refractory NB remains an unsolved clinical problem.

115 Screening additional families and querying unsolved CMT2 exomes, we identified the p.R252W mutation

116 This new structure represents one of the key unsolved conformational states of SERCA and provides a s

117 rgent roles in transcriptional regulation of unsolved consequence.

118 rrival of colony-collapse disorder (CCD), an unsolved decline in bees from parts of the United States

119 ell form is a result of optimization remains unsolved despite previous attempts.

120 One unsolved difficulty with non-enzymatic RNA replication i

121 However, liposomes still present some unsolved drawbacks, such as poor colloidal stability, sh

122 er enzymes, the functional mechanisms remain unsolved due to a gap between static structural data and

123 exact and analytic broadband pulses remains unsolved due to the nonlinearity and complexity of the u

124 positional cloning, the causative genes for unsolved dystroglycanopathy cases have escaped discovery

125 This mismatch is an unsolved evolutionary paradox.

126 we provide evidence that a large fraction of unsolved exome cases have underlying structural mutation

127 The presence of unsolved families after highly parallel sequencing strat

128 problem in visual neuroscience has remained unsolved for 50 years.

129 y other objects, but this leaves the problem unsolved for other categories.

130 bing complex reaction networks have remained unsolved for over 70 years.

131 the absence of therapy remain important but unsolved goals of HIV-1 cure research.

132 ductal adenocarcinoma (PDAC) remains a major unsolved health problem.

133 However, it remains unsolved how the interplay between TFs and chromatin env

134 verse problem, however, has remained largely unsolved: How to reconstruct the underlying reactions de

135 ctivity challenge that remains intrinsically unsolved in aldol-type reactions is the suppression of s

136 ion, the problem for large networks is still unsolved in general.

137 ructure of the eukaryotic nucleosome remains unsolved, in part due to limited information regarding t

138 ease in a substantial share of families with unsolved inherited optic neuropathies.

139 he etiology of seizures in R6/2 mice remains unsolved, involvement of the hippocampus is suggested by

140 of the most important problems that remains unsolved is sampling high-dimensional free-energy landsc

141 One unsolved issue in brain development is how interneurons

142 y, data also definitively settle a currently unsolved issue on the capacity of human neutrophils to p

143 erify such an accuracy remains a crucial but unsolved issue until now.

144 -like transcriptional responses is a central unsolved issue.

145 eported to occur in food products is a major unsolved issue.

146 us system (CNS) diseases, remains a critical unsolved issue.

147 To reach this goal, a number of unsolved issues have to be addressed and consensually ac

148 individuals with MAE, accounting for ~4% of unsolved MAE cases.

149 and produced a nearly complete model for an unsolved map containing a 660-residue heterodimeric prot

150 althcare concern, obesity remains largely an unsolved medical problem.

151 les in 1,929 human exomes from families with unsolved Mendelian disease.

152 We also describe unsolved mysteries and new technologies that could help

153 le progression are coordinated is one of the unsolved mysteries of cell biology.

154 eveloping human brain remains one of the few unsolved mysteries of science.

155 An unsolved mystery in cell biology is how unusually large

156 ctive and sterile castes, represents a major unsolved mystery in evolution.

157 metal distribution that to date have been an unsolved mystery in magnesium biology.

158 One major unsolved mystery is how the feathers of a single bird ca

159 type 2 diabetes mellitus, cancer) remains an unsolved mystery of current biology and medicine.

160 left the identity of the feedback signal an unsolved mystery.

161 to tumorigenesis has remained a decades-long unsolved mystery.

162 ells collaborate to make a tissue remains an unsolved mystery.

163 nalgesia, amnesia, and immobility) remain an unsolved mystery.

164 ith histologically confirmed but genetically unsolved NM.

165 There exist unsolved, open statistical questions about the inaccurat

166 ecruited to specific targets remains largely unsolved, particularly in plants.

167 ly with respect to Hexapoda remain the major unsolved phylogenetic problems.

168 ughput RNA-seq data is a challenging and yet unsolved problem because of the non-contiguous transcrip

169 ctions with electron-rich anilines remain an unsolved problem due to catalyst deactivation and delete

170 enting the material explored-is an important unsolved problem for disordered materials.

171 ination of the precise dopant location is an unsolved problem in applications from channel doping in

172 However, it remains an unsolved problem in catalysis, as typically it involves

173 trol of organelle abundance is a fundamental unsolved problem in cell biology.

174 high-temperature superconductors is a major unsolved problem in condensed matter physics.

175 An unsolved problem in cryptococcal biology is whether the

176 Finally we used our model to test an unsolved problem in dinosaur biomechanics: how fast a hu

177 A largely unsolved problem in eukaryotic gene regulation focuses o

178 tive contributions of these properties is an unsolved problem in molecular evolution with broad impli

179 A fundamental but unsolved problem in neuroscience is how connections betw

180 to behavioural action selection, remains an unsolved problem in neuroscience.

181 , to aldehydes and ketones remains a largely unsolved problem in organic synthesis, despite the wide

182 lkenes with simple dialkyl amines remains an unsolved problem in organic synthesis.

183 ate method that overcomes this longstanding, unsolved problem in radiative transport.

184 nucleic acid template replication is a major unsolved problem in science.

185 cial injuries with bone loss is an important unsolved problem in surgery.

186 strong Bronsted acids to alkenes remains an unsolved problem in synthetic chemistry.

187 or of thermodynamic response functions is an unsolved problem in the physics of water.

188 An unsolved problem in this context is how to systematicall

189 One unsolved problem is whether such response allows coming

190 Another unsolved problem is whether these CTL can then patrol an

191 l trial designs, alternative targets and the unsolved problem of bilateral lesional treatment.

192 A solution to the classic unsolved problem of olefin hydromethylation is presented

193 ature compensation of circadian clocks is an unsolved problem with relevance to the general phenomeno

194 tinguishes hot spots from cold regions is an unsolved problem, although transcription factors determi

195 To address this important unsolved problem, we develop a generalized orientation a

196 multiple DCs at each position, a heretofore unsolved problem, while adhering to a constraint on the

197 but the nature of this signal remains a key unsolved problem.

198 of more oxidizable functionality) remains an unsolved problem.

199 the resulting models has largely remained an unsolved problem.

200 terial strains or viruses, remains a largely unsolved problem.

201 y of these transformations is also a largely unsolved problem.

202 ations in a typical tumor is a difficult and unsolved problem.

203 e arose from the 'prebiotic soup' remains an unsolved problem.

204 protein-small-molecule interfaces remains an unsolved problem.

205 ds) from the measured time series is a major unsolved problem.

206 s a major diagnostically and therapeutically unsolved problem.

207 defense upon effector perception remains an unsolved problem.

208 ge of protein folding remains an interesting unsolved problem.

209 ulate transcriptional specificity remains an unsolved problem.

210 the transcription of genes is an important, unsolved problem.

211 sents the correct structure, has remained an unsolved problem.

212 distantly related proteins remains a largely unsolved problem.

213 gene models from genome sequence remains an unsolved problem.

214 for coordinating these activities remains an unsolved problem.

215 ds with chiral phosphorus centers remains an unsolved problem.

216 s levels of torsional stress is an important unsolved problem.

217 f [2,3]- and [1,2]-rearrangements remains an unsolved problem.

218 rdinates is an extensively studied but still unsolved problem.

219 rocess; however, their synthesis is still an unsolved problem.

220 ostly low-quality models, is still a largely unsolved problem.

221 tive reactions of natural proteins remain an unsolved problem.

222 on of the shape skeleton remains a notorious unsolved problem; existing approaches are extremely sens

223 We discuss major unsolved problems and suggest areas that may be particul

224 tructure prediction remains one of the major unsolved problems in computational biology.

225 ss transition still remains one of the great unsolved problems in condensed matter physics.

226 ation of body size is one of the fundamental unsolved problems in developmental biology.

227 e, it is widely recognized as one of the key unsolved problems in modern physics, representing a para

228 n in the form of results, chemical tools, or unsolved problems in return for valuable insights and id

229 turies, and is regarded as among the deepest unsolved problems in science, with wide-ranging theoreti

230 ly has proved difficult, and one of the main unsolved problems is finding what determines the tempera

231 ong the approximately 43 superfamilies, with unsolved problems now yielding to much larger data sets

232 ics researchers about the pressing needs and unsolved problems of computational virology.

233 One of the major unsolved problems of modern biology is deep understandin

234 n of planetary rings is one of the prominent unsolved problems of planetary sciences, with direct imp

235 polyketide synthases remains one of the key unsolved problems of secondary metabolism.

236 ncy (C1-INH-HAE) represent one of the oldest unsolved problems of the disease.

237 rough sustained antibiotic release have some unsolved problems which include short life-span, narrowe

238 Moreover, novel trends and unsolved problems will be introduced.

239 evolution of QSAR; (ii) the current trends, unsolved problems, and pressing challenges; and (iii) se

240 her, their key applications, and the various unsolved problems, closing with a perspective on the pro

241 gagement by small-molecule inhibitors remain unsolved problems.

242 detection and assay design remain important unsolved problems.

243 arrest (SCA) in the young remains a largely unsolved public health problem, and sports activity is a

244 region of the phase diagram is an important unsolved puzzle in the field of high-transition-temperat

245 It has been an old unsolved puzzle to evolutionary theorists on which mecha

246 f this ancient enzymatic system are still an unsolved puzzle.

247 maintenance of T cell repertoire remains an unsolved puzzle.

248 s such as SQUIDs and qubits is still a major unsolved puzzle.

249 odes of reproduction evolve remain important unsolved puzzles in evolutionary biology.

250 One of water's unsolved puzzles is the question of what determines the

251 echanism of action of VAs remains one of the unsolved puzzles of neuroscience [1, 2].

252 arian syndrome is one of the most intriguing unsolved puzzles related to the origins of modern humans

253 nfluence is one of social science's greatest unsolved puzzles: Do people befriend others who are simi

254 rete surrounding matter is a fundamental yet unsolved question in astrophysics.

255 ion is well developed in human society is an unsolved question in biological and human sciences.

256 echanism of unconsciousness has been a major unsolved question in neuroscience despite its vital role

257 A key unsolved question regarding the developmental origin of

258 An essential unsolved question regarding this prebiotic set is whethe

259 These observations pose a general unsolved question that is relevant to all nervous system

260 ersible defect accumulation is a fundamental unsolved question.

261 us cell carcinoma, remains a fundamental yet unsolved question.

262 pulation of epithelial stem cells is a major unsolved question.

263 itors exist in the adult pancreas is a major unsolved question.

264 ne and then to the cell cytoplasm remains an unsolved question.

265 random or specific but flexible sites is an unsolved question.

266 al subtype-specific targets exist remains an unsolved question.

267 e germline-soma distinction is a fundamental unsolved question.

268 of Hox proteins in vivo remains an important unsolved question.

269 of evolutionary patterns is an important and unsolved question.

270 is of Alzheimer's disease (AD) is a critical unsolved question; and although recent studies have demo

271 One central, and yet unsolved, question in evolutionary biology is the relati

272 recent molecular advances and some remaining unsolved questions and discuss the possible implications

273 The main unsolved questions are (i) What are the respective roles

274 p in cell division, remains one of the major unsolved questions in basic cell biology.

275 ous valve leaflets remains one of the major, unsolved questions in heart development.

276 rated solutions remains one of the last deep unsolved questions in polymer physics.

277 We also discuss some unsolved questions in the field and how they might be ad

278 is usually restricted to the macula are two unsolved questions in the pathogenesis of this disorder.

279 ernal immune system remains one of the major unsolved questions in transplantation immunology.

280 erspectives on future experiments to address unsolved questions related to the EC.

281 omoting and anti-tumor effectors, as well as unsolved questions such as DAMP release from non-tumor c

282 merging or future research opportunities and unsolved questions.

283 positively select them within the thymus are unsolved questions.

284 in mouse and rat models, interacting with an unsolved receptor, while peptides smaller than eight ami

285 Applying this database to unsolved recessive conditions in the GME population redu

286 tensive research, important questions remain unsolved regarding the molecular and cellular mechanisms

287 need for vascular imaging at the RHs remains unsolved, resulting in an important amount of futile tra

288 reviously generated exome sequencing data in unsolved retinal dystrophy cases identified a homozygous

289 the eye, which is crucial for sight, are an unsolved riddle.

290 with other methods, as well applications to unsolved RNAs, are also presented.

291 a large cohort of patients with genetically unsolved RP.

292 lular basis of the magnetic sense remains an unsolved scientific mystery.

293 reate Roger Sperry in 1968, and has remained unsolved since then.

294 as a special [4Fe-4S](2+) cluster with a yet unsolved structure.

295 erotetrameric maize endosperm AGPase remains unsolved, structures of a nonnative, low-activity form o

296 Nevertheless, major issues remain unsolved, such as the origin of a genetic code.

297 rbon-oxygen (C-O) bonds in aryl ethers is an unsolved synthetic problem important for the generation

298 ave shown great promise against high-impact, unsolved vaccine targets ranging from bacterial and vira

299 However, it has remained unsolved whether the oligomers are a necessary step in t

300 A long-standing puzzle remains unsolved: why the Au surfaces with {100} sub-facets were