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1 domains represents a highly interesting and unsolved problem.
2 s based on EEG and MEG data alone remains an unsolved problem.
3 f [2,3]- and [1,2]-rearrangements remains an unsolved problem.
4 nt in preparation and measurement is a major unsolved problem.
5 d carbon and energy source, is an important, unsolved problem.
6 rdinates is an extensively studied but still unsolved problem.
7 rocess; however, their synthesis is still an unsolved problem.
8 ostly low-quality models, is still a largely unsolved problem.
9 tive reactions of natural proteins remain an unsolved problem.
10 but the nature of this signal remains a key unsolved problem.
11 of more oxidizable functionality) remains an unsolved problem.
12 the resulting models has largely remained an unsolved problem.
13 terial strains or viruses, remains a largely unsolved problem.
14 y of these transformations is also a largely unsolved problem.
15 ations in a typical tumor is a difficult and unsolved problem.
16 e arose from the 'prebiotic soup' remains an unsolved problem.
17 protein-small-molecule interfaces remains an unsolved problem.
18 ds) from the measured time series is a major unsolved problem.
19 s a major diagnostically and therapeutically unsolved problem.
20 defense upon effector perception remains an unsolved problem.
21 ge of protein folding remains an interesting unsolved problem.
22 the transcription of genes is an important, unsolved problem.
23 ulate transcriptional specificity remains an unsolved problem.
24 sents the correct structure, has remained an unsolved problem.
25 distantly related proteins remains a largely unsolved problem.
26 gene models from genome sequence remains an unsolved problem.
27 for coordinating these activities remains an unsolved problem.
28 ds with chiral phosphorus centers remains an unsolved problem.
29 s levels of torsional stress is an important unsolved problem.
30 rization of phosphorylation sites remains an unsolved problem.
31 alidity of psychiatric diagnoses is still an unsolved problem.
32 six-membered ring to form ring D remains an unsolved problem.
33 of investigation, remains a challenging and unsolved problem.
34 members of a receptor family, is largely an unsolved problem.
35 ineers for over 100 years, yet it remains an unsolved problem.
36 esponsible for this behavior present a major unsolved problem.
37 gagement by small-molecule inhibitors remain unsolved problems.
38 detection and assay design remain important unsolved problems.
39 which this lesion is repaired in vivo remain unsolved problems.
40 , discuss their complementarity, and outline unsolved problems.
41 tinguishes hot spots from cold regions is an unsolved problem, although transcription factors determi
42 y of Sciences, "Frontiers in Bioinformatics: Unsolved Problems and Challenges," organized by David Ei
43 rgetic changes and conclude by commenting on unsolved problems and opportunities for future basic and
45 evolution of QSAR; (ii) the current trends, unsolved problems, and pressing challenges; and (iii) se
46 heoretical contributions to this classic but unsolved problem are presented here: a method to determi
47 ughput RNA-seq data is a challenging and yet unsolved problem because of the non-contiguous transcrip
48 her, their key applications, and the various unsolved problems, closing with a perspective on the pro
49 ctions with electron-rich anilines remain an unsolved problem due to catalyst deactivation and delete
50 on of the shape skeleton remains a notorious unsolved problem; existing approaches are extremely sens
53 ination of the precise dopant location is an unsolved problem in applications from channel doping in
61 ecules having many molecular skeletons is an unsolved problem in diversity-oriented synthesis (DOS).
64 tive contributions of these properties is an unsolved problem in molecular evolution with broad impli
69 , to aldehydes and ketones remains a largely unsolved problem in organic synthesis, despite the wide
71 e of Mott insulators continues to be a major unsolved problem in physics despite more than 50 years o
82 ese ideas have been proposed for significant unsolved problems in condensed-matter physics, such as n
83 e are hidden intermediates are the two major unsolved problems in defining the folding pathway of bar
84 self-renewal and differentiation are central unsolved problems in developmental biology with potentia
86 e, it is widely recognized as one of the key unsolved problems in modern physics, representing a para
87 n in the form of results, chemical tools, or unsolved problems in return for valuable insights and id
88 turies, and is regarded as among the deepest unsolved problems in science, with wide-ranging theoreti
94 ly has proved difficult, and one of the main unsolved problems is finding what determines the tempera
95 ong the approximately 43 superfamilies, with unsolved problems now yielding to much larger data sets
99 py-induced alopecia - one of the fundamental unsolved problems of clinical oncology - is driven in pa
103 n of planetary rings is one of the prominent unsolved problems of planetary sciences, with direct imp
105 of HCN and chromophores are two of the major unsolved problems of the atmospheric chemistry of Jupite
107 er of homologs of a gene is a very important unsolved problem that has broad implications for researc
109 rough sustained antibiotic release have some unsolved problems which include short life-span, narrowe
110 multiple DCs at each position, a heretofore unsolved problem, while adhering to a constraint on the
112 nces, including nitric oxide, CDH remains an unsolved problem with a mortality rate of 35% to 50%.
113 ature compensation of circadian clocks is an unsolved problem with relevance to the general phenomeno
114 basis of translocation is the most important unsolved problem with respect to ribosome function.
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