ライフサイエンスコーパス: unstructured

1 ereas the C-terminal of the molecule remains unstructured.

2 tion, despite being predicted to be natively unstructured.

3 tRNA-binding sites in this intermediate are unstructured.

4 if mRNA regions flanking the stop codon were unstructured.

5 viduals were highly irregular and temporally unstructured.

6 ies, and DMS/SHAPE-LMPCR determines it to be unstructured.

7 the outer membrane, is always intrinsically unstructured.

8 domain, in a region previously designated as unstructured.

9 he 'middle domain', previously thought to be unstructured.

10 n a DISC1 section previously predicted to be unstructured.

11 xible linker, whereas the N-terminus remains unstructured.

12 N-terminal region of CYP144A1-FLV is largely unstructured.

13 mRNAs with strong closed-loop potential and unstructured 5' UTRs, exactly the opposite features asso

14 uciferase mRNAs with stem-loop structured or unstructured 5'-UTR.

15 ucture in the 5'UTR and show that mRNAs with unstructured 5'UTRs are refractory to miRNA repression.

16 f Orai1 channels in puncta was substantially unstructured, a portion of channels were spaced at appro

17 d with metal-Abeta species and formed small, unstructured Abeta aggregates more noticeably than in me

18 Abeta42 monomers and its mature fibrils into unstructured Abeta aggregates with some beta-sheet struc

19 l unstructured tail of H3 and the C-terminal unstructured acidic tail of HMGB1, which are presumably

20 distinguished by displaying a structured or unstructured activation loop, respectively.

21 Our results point to the unstructured alphaC regions of the otherwise structured

22 lly located D'D3 domain through a relatively unstructured amino acid sequence, called here the N-term

23 ystal structures of actin complexes with the unstructured amino-terminal and the leucine-rich repeat

24 plexity region of Nab3 appears intrinsically unstructured and can form a hydrogel in vitro.

25 The N-terminal domain remains unstructured and does not interact with the C-terminal d

26 However, given the highly unstructured and dynamic nature of the SH2 domain, exper

27 ated data in particular are often completely unstructured and highly context dependent, posing essent

28 s the C-terminal segment (residues 13-17) is unstructured and highly flexible.

29 ce motif is found in regions predicted to be unstructured and is present in a number of zDHHC17 subst

30 The N-terminal chain is unstructured and leads the permeation process for the LF

31 ent length scale in PMEFs, although they are unstructured and longer ranged in ES cells.

32 s structured for RNA binding and one that is unstructured and low complexity that has no known functi

33 y and that the isolated subunit is partially unstructured and marginally stable.

34 ns or protein families and can process long, unstructured and multi-domain proteins thousands of resi

35 A relatively unstructured and negatively charged RAM binds to a posit

36 we have measured the absorbance of both the unstructured and structured nucleic acids to accurately

37 no terminus, whereas the carboxy terminus is unstructured and therefore may better tolerate fluoresce

38 tes initiated by hydrophobic collapse for an unstructured and two globular proteins while directly me

39 ratio by risk of readmission, and extracted unstructured and unconventional structured data from the

40 mentorship programs, and most are informal, unstructured, and do not involve all of the key stakehol

41 dative metabolism and that this requires the unstructured anionic C-terminal tail peptides found on b

42 a C-terminal kinase domain interposed by an unstructured approximately 80-residue interdomain linker

43 Average mRNAs tend to be unstructured around the ribosome binding site.

44 nant cytoplasmic domain of ADAM10 (A10Cp) is unstructured as judged by its susceptibility to limited

45 hip between the transformation from natively unstructured assembly to the beta-sheet oligomers to dis

46 x experts also provided a diagnosis based on unstructured assessment of the 80-scan subset.

47 tn to be alpha-helical at the N-terminus and unstructured at the C-terminus were matched by similar d

48 The partially unfolded species possess an unstructured beta-domain and C-helix with the rest of th

49 If it is unstructured (BEV), all ribosomes scan through dVI to th

50 for rare diseases summarize phenotypes with unstructured binary or quantitative variables.

51 g the release of cell clusters from a thick, unstructured biofilm.

52 sidues 80-88, 108-110, and 129-131 represent unstructured breaks between the helices.

53 eptide (pHLIP) binds to a membrane at pH 7.4 unstructured but folds across the bilayer as a transmemb

54 s) are generally thought to be intrinsically unstructured, but capable of adopting limited secondary

55 The unstructured C terminus gradually threads through the su

56 Furthermore, the unstructured C terminus is able to facilitate contacts b

57 we report that phosphorylation of the DUE-B unstructured C-terminal domain unique to higher organism

58 e comprising N-terminal, globular, and long, unstructured C-terminal domains.

59 In yeast and humans, the unstructured C-terminal region of alpha7 contains an aci

60 segment having a role of membrane anchor, an unstructured C-terminal region that is weakly associated

61 aA in complex with a portion of the natively unstructured C-terminal tail of RhlB at 2.8-A resolution

62 sts of a pentameric N-terminal domain and an unstructured C-terminal tail.

63 ethering the two G domains together at their unstructured C-terminal tails.

64 end of binding pocket and (ii) switch of the unstructured C-terminus at the other end of the binding

65 proximal and distal faces of Ec Hfq and the unstructured C-terminus.

66 ing polymerase-RNP complex and may rearrange unstructured central tail sections to facilitate polymer

67 ically by the rate of reconfiguration of the unstructured chain, such that the faster the reconfigura

68 Strikingly, the short, unstructured, charged transmembrane domain is threaded t

69 ke cancer recurrence, that are documented in unstructured clinical text, such as progress notes, radi

70 ne blue (MB)-modified probe assumes a linear unstructured conformation in the absence of the target;

71 ndergoing transitions between structured and unstructured conformations.

72 kle fold, whereas the human sequence remains unstructured, consistent with the mutation of one of the

73 ated measures with a random intercept and an unstructured covariance matrix.Short-term changes in ene

74 In contrast, unstructured Ctn[15-34] replicated the activity of paren

75 The MD data identify an intrinsically unstructured cytoplasmic loop region connecting transmem

76 Temporally unstructured daily routines (e.g., not dominated by a si

77 More automated means of leveraging unstructured data from daily clinical practice is crucia

78 rn to examples of synthesizing more complex, unstructured data sets through a range of data-mining ap

79 bles superior classifier design using small, unstructured data sets.

80 chine-learning approach using structured and unstructured data.

81 tion of GroES and ATP, the more expanded and unstructured denatured cyclophilin A is not encapsulated

82 tructure leading to a random distribution of unstructured, denatured forms, the results provide evide

83 of the transition state (TS), structured or unstructured, determines the binding mechanism.

84 serine/threonine residues at the N-terminal unstructured domain of ORF57 prevents its digestion by c

85 e this intrinsic timescale at the N-terminal unstructured domain of the prion protein.

86 We show that the TubZ C-terminal tail is an unstructured domain that fulfills multiple functions con

87 intrinsically disordered regions, uncovering unstructured domains as prevalent partners in protein-RN

88 dy by computer simulation the dynamics of an unstructured droplet of chiral active fluid in three dim

89 Thus, distinct DPF-based codes within the unstructured Eps15/R C terminus direct the assembly of t

90 Unstructured family interviews were conducted with adult

91 t territories where there is only low-level, unstructured firing.

92 due to the distinct character of these more unstructured, flexible segments of the RNA that emanate

93 86-mer polypeptide, "Bbk32," comprising the unstructured FN-binding region of BBK32.

94 animal screening data are only accessible in unstructured free-text format, which hinders computation

95 In the complex, the prion protein is unstructured from residue 23 to 116.

96 hain-reconfiguration motions expected for an unstructured, fully unfolded chain.

97 ure that are composed of a rigid core and an unstructured fuzzy coat.

98 is results in improved accuracy, relative to unstructured gene copy number data, at predicting tumor

99 More flexible methods like the use of unstructured grids can significantly increase the comput

100 ation of meteorological data, and the use of unstructured-grids to better resolve nearshore features.

101 o apical domains, as well as to the normally unstructured GroEL C-terminal tails.

102 XTEN is a class of unstructured hydrophilic, biodegradable protein polymers

103 The peptide was unstructured in aqueous buffer and dimyristoylphosphatid

104 We also found that PEP87 is unstructured in isolation but tends to form a helix as e

105 peptide corresponding to the C terminus was unstructured in solution and only folded into an alpha-h

106 lthough almost half of the capsid protein is unstructured in solution, this unstructured region folds

107 zetacyt is unstructured in solution.

108 d (25/76 amino acid residues) and inherently unstructured in solution.

109 in loops because natural sequences are often unstructured in solution.

110 e FATC domains of the other PIKKs are rather unstructured in the isolated form and only significantly

111 The C-terminal domain is relatively unstructured in the monomeric state but forms an alpha-h

112 Diagnostic radiologists generally produce unstructured information in the form of images and narra

113 faster than the reduced monomer because the unstructured intermediate of oxidized ClyA is less stabl

114 Unstructured interviews and field observations were cond

115 approach data were collected using in depth unstructured interviews, with nine purposively recruited

116 e able to show that despite the region being unstructured, it nevertheless is resistant to general pr

117 stally and dynamically because of a natively unstructured linker connecting the dimerization domain a

118 We discovered a role for the unstructured linker region connecting the N-terminal oli

119 autoinhibited in a manner dependent upon the unstructured linker region joining the amino-terminal mi

120 ent upon the presence of the matrix-exposed, unstructured linker region of Cox15 needed for Cox15 oli

121 It is positionally analogous to an unstructured linker that becomes helical and membrane-fa

122 nconserved region thought to function as an "unstructured" linker also abrogated polymerase activity

123 standing of the allosteric role of partially unstructured linkers flanking globular domains is limite

124 ended C-terminal alpha-helical domain and an unstructured loop in the putative substrate binding doma

125 ts intermembrane space (IMS)-exposed charged unstructured loop region.

126 In striking contrast, deletion of the unstructured loop results in increased binding to substr

127 hat the N-terminal region and the C-terminal unstructured loop undergo conformational changes when as

128 We identified mutations in an unstructured loop within the MSP that uncoupled VAPB-reg

129 d (unfolded) via the introduction of a long, unstructured loop.

130 and, induces structural perturbations on two unstructured loops that are distally located beyond the

131 ucture, where it folds into alpha helices or unstructured loops.

132 , from Pro-405 to Phe-431, and is flanked by unstructured loops.

133 Unstructured low complexity domains (LCDs) in proteins a

134 gions on the autosomes also replicated in an unstructured manner, similar to the Xi.

135 complex and induces refolding of the short, unstructured MDM2 N-terminal region to achieve its high

136 is modified compared with the emissivity of unstructured metals, resulting in an emission spectrum u

137 gation: a slow, structured mode, and a fast, unstructured mode sustained by wind-fire coupling.

138 points) warn of impending transitions to the unstructured mode.

139 ranscripts-confers the ability of relatively unstructured model RNA transcripts to activate PKR to in

140 coarse-grained MD of several structured and unstructured models that indicate that coupled folding a

141 ay in the presence of detergent, in which an unstructured, monomeric intermediate is transiently popu

142 Mutations (W128A and Y130A) in the unstructured N terminus of Dna2 abrogate its checkpoint

143 products are not known, cleavage between the unstructured N-terminal domain and the structured C-term

144 ed finding that in isolation, the 90-residue unstructured N-terminal domain of colicin N is cytotoxic

145 This effect is specific to the unstructured N-terminal domain of PrP(C).

146 Formation of the translocon involved ColE9's unstructured N-terminal domain threading in opposite dir

147 is a 109-amino acid protein with a natively unstructured N-terminal domain.

148 Here we demonstrate that the unstructured N-terminal extension (NTE) of ClpS enters t

149 onical human PrP(C) (HuPrP) fold features an unstructured N-terminal part (residues 23-124) and a wel

150 a8 was fused with a 600-residue hydrophilic, unstructured N-terminal polypeptide chain comprising pro

151 The protein is composed of a largely unstructured N-terminal region (residues 1-71) and a wel

152 CaBP4 contains an unstructured N-terminal region (residues 1-99) and four

153 NMR structure shows that AGR2 consists of an unstructured N-terminal region followed by a thioredoxin

154 An unstructured N-terminal region of Tim10 is necessary and

155 This enables CH1 to bind actin aided by an unstructured N-terminal region that becomes alpha-helica

156 immunity depends on the presence of a basic unstructured N-terminal region that tethers SpaI to the

157 The unstructured N-terminal tail (NTT) of yeast eIF1A deploy

158 Finally, we implicate the unstructured N-terminal tail of eIF1 in blocking rearran

159 the resulting excited state ensemble was an unstructured N-terminus stabilized by non-native contact

160 nds and beta-strands formed in the initially unstructured N-terminus.

161 data, incorrect data, and vast quantities of unstructured narrative text data.

162 nantly alpha-helical, in contrast to largely unstructured native omega, and then studied its assembly

163 to infection by Chrysomyxa rhododendri in an unstructured natural population of Norway spruce.

164 preferences from RNAcompete data due to the unstructured nature of the data, as noted by its develop

165 The transient, dynamic, and unstructured nature of this protein-protein interaction

166 he same techniques, we show that despite its unstructured nature, the addition of trifluoroethanol ex

167 urred more often than would be expected from unstructured network activity (e.g., by chance).

168 ces may emerge through learning from largely unstructured network architectures.

169 ndent plasticity rule acts upon an initially unstructured network of spiking neurons that receive inp

170 In our model, unstructured neural noise, after passing through the rec

171 We analyzed the biogenesis of three unstructured neuropeptide hormones and observed that tra

172 sttranslational modifications in their long, unstructured, NH2- and COOH-terminal tails.

173 lements; (4) machine-learning approach using unstructured notes; and (5) machine-learning approach us

174 channel of the NPC and depends critically on unstructured nuclear pore proteins, and is therefore not

175 ivator-3 (SRC-3 or AIB1), a large and mostly unstructured nuclear protein.

176 method that takes advantage of intrinsically unstructured nucleic acid sequences to achieve exception

177 Specifically, RNAs with less than three unstructured nucleotides at the 3'-end and RNAs that are

178 Assembly of one bPNA strand with two unstructured oligo T/U strands enables facile insertion

179 flicted by replacement of a duplex stem with unstructured oligo-T/U strands, which are bPNA binding s

180 beta(17-36) from a fibrillar aggregate to an unstructured oligomer.

181 the formation of off-pathway, highly stable unstructured oligomers, supporting the SPRi results.

182 and eliminate annealing of natural sRNAs or unstructured oligonucleotides, without preventing bindin

183 In the absence of unstructured omega, the association of sigma-factors to

184 that in contrast to omega, which is largely unstructured, omega mutants display substantial acquisit

185 and internal loops are often represented as unstructured on secondary structure diagrams, but RNA 3D

186 tured group psychoeducation versus optimised unstructured peer support for patients with remitted bip

187 this intervention are unclear compared with unstructured peer support matched for delivery and aim o

188 linically effective than similarly intensive unstructured peer support, but was more acceptable and i

189 tructured group psychoeducation or optimised unstructured peer support.

190 N- and C-terminal domains; insertions of an unstructured peptide between these domains and the trans

191 C-36 converts from an unstructured peptide to mature amyloid twisted-ribbon fi

192 Promoter B encodes a charged, unstructured peptide, whereas promoter C encodes an amph

193 Towards this goal, here we have combined unstructured peptide-insertion screening (UPS) with elec

194 We show that unstructured peptides containing alternating N--trifluor

195 Control HX-MS experiments using unstructured peptides labeled at pD 4.0 under crowded an

196 n and in a proof-of-concept experiment using unstructured peptides under slow-exchange conditions (pD

197 ore variability altogether or only model its unstructured Poisson-like aspects.

198 relatively slow but eventually surpasses the unstructured population (hare) in average fitness.

199 a structured population only lags behind an unstructured population in average fitness (ultimately c

200 In an unstructured population, a lineage with selective access

201 In particular, all assume a single, unstructured population, and none has been evaluated for

202 At pH 6.4, for the major unstructured population, the peptide sinks deeper into t

203 recent changes in effective size compared to unstructured populations.

204 ased systems that help decision makers solve unstructured problems under complex, uncertain condition

205 d among individuals, and resembled a random, unstructured process.

206 ify the search; these include the removal of unstructured protein regions, application of attraction

207 Numerous biomolecular interactions involve unstructured protein regions, but how to exploit such in

208 an alpha-synuclein (alpha-Syn) is a natively unstructured protein whose aggregation into amyloid fibr

209 globule structures ( approximately 0.33) and unstructured proteins ( approximately 0.50).

210 cytoplasmic transport via their affinity for unstructured proteins (polymers) in the nuclear pore com

211 nal distributions, many of the properties of unstructured proteins are difficult to describe with the

212 Single-molecule pulling experiments on unstructured proteins linked to neurodegenerative diseas

213 r by forming a cross-linked network with the unstructured proteins stretching across the pore.

214 asis for relating the physical properties of unstructured proteins to folding and function.

215 A class of naturally unstructured proteins, termed intrinsically disordered p

216 ion of hydrophobic residues in intrinsically unstructured proteins, the distortion of bond geometry b

217 onformation, for some of these conditionally unstructured proteins, the opposite applies: Their activ

218 losis ClpP1P2 to degrade larger peptides and unstructured proteins, this effect is weaker than for Cl

219 ve hydrogels are designed with intrinsically unstructured proteins.

220 use/dependence (n = 2797) and (2) data from unstructured qualitative interviews with a subset of pat

221 unting for 44.3% of the total variance in an unstructured random-effects model.

222 ven though RNAcompete data is designed to be unstructured, RCK can still learn structural preferences

223 s substitutions at residues 95 and 96 in the unstructured region affected CWD propagation, their prot

224 component, and is instead determined by the unstructured region flanking AUG828.

225 id protein is unstructured in solution, this unstructured region folds in the virion into a single ex

226 solved crystal structure of ToxT revealed an unstructured region in the N-terminal domain between res

227 These results suggest that a small unstructured region in the ToxT N-terminal domain is inv

228 the contiguous alpha-helix of the C-terminal unstructured region is included.

229 The unstructured region is primarily responsible for the abi

230 eptide sequence of the exposed extracellular unstructured region linking the S5-S6 transmembrane segm

231 We found that an unstructured region of anamorsin is essential for the fo

232 f specific sequence features in the normally unstructured region of PrP that influence the infectious

233 Ser1232 is located in an unstructured region of the C-terminal portion of eIF4G1

234 main and a conserved peptide motif within an unstructured region of the molecule, partly occludes the

235 Proteases initially bind an unstructured region on a substrate and then translocate

236 ong single-stranded areas and a large A-rich unstructured region surrounding the initiation codon AUG

237 is identified specific mutations within this unstructured region that prevent ToxT proteolysis and ot

238 The Q-rich domain is part of the unstructured region, which becomes increasingly dynamic

239 LV] and S[AV]F[SA]FLN, within its C-terminal unstructured region, which interact with the C-terminal

240 ally from the Bcl-2 fold is an intrinsically unstructured region.

241 obile part is flanked by two highly dynamic, unstructured regions (loops) that cover residues 10-22 a

242 he Ypp1 C-terminal lobe, which also binds to unstructured regions in the Efr3 C terminus.

243 malian eIF4G contains three HEAT domains and unstructured regions involved in protein-protein interac

244 Moreover, docking peptides arise in unstructured regions of proteins that are probably alrea

245 COP subunits bind Wxn(1-6)[WF] motifs within unstructured regions of proteins that influence the life

246 flanking the cytosine dinucleotide target in unstructured regions of ssDNA.

247 Recently, the surprising prevalence of unstructured regions or entirely disordered proteins und

248 signal and local conformational bias within unstructured regions raises a question: can phosphorylat

249 chondroitin attachment sites are located in unstructured regions.

250 Mcm4, a helicase subunit, possesses an unstructured regulatory domain that mediates control fro

251 ng pathways in a manner reminiscent of other unstructured regulatory elements commonly found in mamma

252 cal exchange rates are measured by use of an unstructured reporter peptide, YPI.

253 s of a specific protein to more than 240 000 unstructured RNA probes in one experiment.

254 ified the impact of spatially and temporally unstructured routines on the dynamics of transmission of

255 Our model shows a transition from an unstructured salt-and-pepper organization to a pinwheel

256 andem pair of dsRBDs separated by a natively unstructured segment confers dsRNA binding activity.

257 we identify a conserved patch that binds an unstructured segment in Nup53 and show that a C-terminal

258 RNase E cleavage in an unstructured segment located immediately upstream from t

259 cally contain higher-order RNA structure, an unstructured sequence of about 84 nucleotides (nt) immed

260 on the presence of an intact, intrinsically unstructured SF3b155 domain containing seven ULM-like mo

261 olyelectrolyte brush, which is formed by the unstructured short C-terminal and long N-terminal Tau do

262 ly stimulated by duplex or branched DNA, but unstructured single-stranded DNA or chromatinized DNA is

263 red by the nanopore can freely fold from the unstructured state without constraint and can be program

264 retches that become available because of the unstructured states of targeting-competent preproteins.

265 atically identifying the features present in unstructured stimuli based solely on neuronal responses.

266 te state for folding and aggregation with an unstructured strand A and a native-like core.

267 electron microscopy images revealed that an unstructured substance accumulated on nongroomed antenna

268 while the N-terminal helix remained largely unstructured, suggesting that proximity in the primary s

269 orders of magnitude higher than that from an unstructured surface, and vortex beams with topological

270 the light of previous work on intrinsically unstructured systems are discussed.

271 Unstructured T-rich DNAs cooperatively fold with the tre

272 tional modifications that lie outside of the unstructured tail domains of histones.

273 at the interaction is between the N-terminal unstructured tail of H3 and the C-terminal unstructured

274 from multiple phosphorylation events on the unstructured tail of its Hec1 subunit are additively int

275 cular dynamics simulations, suggest that the unstructured tail plays a double role in the reaction me

276 erminal three-helix bundle and a lysine-rich unstructured tail, which has been shown to be necessary

277 s an SH3 domain fold flanked by a C-terminal unstructured tail.

278 The use of the unstructured tails of gammaretroviral INs to direct asso

279 ce or post-translational modification of the unstructured tails of tubulin result in substantial chan

280 a-strands, the properties of the much longer unstructured Tau domains protruding from the fibril core

281 ibuted interactions mediated by the natively unstructured termini of Hfq.

282 of this information remains 'locked' in the unstructured text of biomedical publications.

283 is information is distributed throughout the unstructured text of over 23 million articles.

284 Combinations of structured and unstructured textual data can be mined to generate high-

285 ral pH both N17 and the polyQ become largely unstructured-thereby suggesting a mechanism for how N17

286 nsically disordered proteins even though the unstructured, thus generally variable regions in protein

287 GORS extended to downstream differences from unstructured transcripts in expression of TNF-alpha, oth

288 unusual bacteriocin lacks the intrinsically unstructured translocation domain that usually mediates

289 ocess can proceed through both structured or unstructured TS's with similar probabilities.

290 ned with both pre-structured (adenosine) and unstructured (tyrosinamide) aptamers and with dyes of di

291 ivity in Xanthomonas XopD, contributed by an unstructured ubiquitin binding region.

292 y functional sites of the 50S subunit remain unstructured until late stages of maturation, preventing

293 domain in dynamin, however, Drp1 contains an unstructured variable domain, whose function is not yet

294 roteins contain polypeptide domains that are unstructured when analyzed in cell lysates.

295 N-terminal 12 residues, which are mobile and unstructured when the protein is solubilized in micelles

296 se that the amino-terminal portion of p33 is unstructured when VacA is in a monomeric form and that i

297 nal alpha6/alpha7/alpha8-helices are largely unstructured, whereas the apo-PhuS H212R variant showed

298 pe with time (in months) was assumed with an unstructured within subject correlation structure for re

299 Unstructured XTEN polypeptides have hydrodynamic volumes

300 Chaperone-bound SH3 is largely unstructured yet distinct from the unfolded state in the