ライフサイエンスコーパス: unsuccessful

1 large), and reinforcing outcomes (successful/unsuccessful).

2 medium, large), and outcome (successful vs. unsuccessful).

3 y years, yet these efforts have been largely unsuccessful.

4 ron carbene intermediates have thus far been unsuccessful.

5 ashion via nickel catalysis has been largely unsuccessful.

6 o therapeutic benefit have also been largely unsuccessful.

7 resolution approaches is often difficult and unsuccessful.

8 dues of the amphipathic helical address were unsuccessful.

9 copy protein kinase C-encoding gene, proved unsuccessful.

10 cobacter pylori (H. pylori) are increasingly unsuccessful.

11 ared with communities where the invasion was unsuccessful.

12 s human trials of subunit vaccines have been unsuccessful.

13 nto proteins using the TM have thus far been unsuccessful.

14 PG from pathogenic Chlamydiae have remained unsuccessful.

15 ies to increase survival have proved largely unsuccessful.

16 while those that do not breed continue to be unsuccessful.

17 ects in non-human primates were surprisingly unsuccessful.

18 etion onto protoplanets have hitherto proven unsuccessful.

19 Previous treatment attempts have been unsuccessful.

20 uals with functional roles have been largely unsuccessful.

21 esigned to target CD8+ T cell responses were unsuccessful.

22 as its complete removal from the genome was unsuccessful.

23 these products were in the majority of cases unsuccessful.

24 at closure of the seven-membered D ring were unsuccessful.

25 omen with urgency UI if bladder training was unsuccessful.

26 ardizing ZAP-70 expression analysis has been unsuccessful.

27 macrocycle from these conjoined subunits was unsuccessful.

28 is is unclear and antiallergic therapy often unsuccessful.

29 tivation in oligodendrocytes in MS have been unsuccessful.

30 adjunctive interventions have been uniformly unsuccessful.

31 ious DNA aptamer selection efforts have been unsuccessful.

32 the full capacity using additives have been unsuccessful.

33 pneumococcus by generating a dpr mutant were unsuccessful.

34 cells while killing leukemic cells have been unsuccessful.

35 Sequencing of the discordant sample was unsuccessful.

36 areas, where other measures have so far been unsuccessful.

37 , antihistamines, and immunosuppressants was unsuccessful.

38 attempts to measure the dc Hall effect were unsuccessful.

39 ze this new thiophenic monomer have remained unsuccessful.

40 e quest to find effective therapies has been unsuccessful.

41 responsible for enhancing transfection were unsuccessful.

42 lable, and clinical trials have been largely unsuccessful.

43 ons to iodophenyl derivatives 1e and 5e were unsuccessful.

44 a (201 copies/mL); sequence confirmation was unsuccessful.

45 generally recommended when physiotherapy is unsuccessful.

46 s complex process have thus far been largely unsuccessful.

47 molecular cyclopropanation with styrene were unsuccessful.

48 to the E-containing sydnonate products were unsuccessful.

49 which vaccine development attempts have been unsuccessful.

50 n of NMSC in the general population has been unsuccessful.

51 ores >30 for whom conventional treatment was unsuccessful.

52 nturies, but these efforts have been largely unsuccessful.

53 r HIV-1 reactivation using single drugs were unsuccessful.

54 he membrane current of intact GUVs have been unsuccessful.

55 ogenetic manipulations of behavior have been unsuccessful.

56 tion underlying depression have largely been unsuccessful.

57 ed dimension of such defects has been so far unsuccessful.

58 general practitioner (GP) practice have been unsuccessful.

59 approach based on a late-stage oxidation was unsuccessful.

60 ers was performed as a comparison and deemed unsuccessful.

61 uman BCO2 expressed in Escherichia coli were unsuccessful.

62 th prior attempts at direct inhibition being unsuccessful.

63 of the threatened red-crowned crane has been unsuccessful.

64 linically useful inhibitors has been largely unsuccessful.

65 rystallization of the full-length enzyme was unsuccessful.

66 r patients has been inconsistent and largely unsuccessful.

67 ispose tumors to metastasis have been mostly unsuccessful.

68 ately, targeted therapies thus far have been unsuccessful.

69 efforts to transmit GSS to rodents have been unsuccessful.

70 ioral therapy for insomnia (CBT-I) alone was unsuccessful.

71 del-Crafts cyclization as the last step, was unsuccessful.

72 targeting the KRAS protein has thus far been unsuccessful.

73 95%CI, 3-10) patients fundus photography was unsuccessful.

74 rosine phosphatases (PTPs), nearly all of it unsuccessful.

75 ctic processing was ultimately successful or unsuccessful.

76 r mitigate its neurotoxicity has so far been unsuccessful.

77 y testing examples of one successful and one unsuccessful 2D combination experimentally.

78 aration of 2 corneas from a single donor was unsuccessful; 48 corneas were clear at 2 months and 47 a

79 One placement was unsuccessful (abdominal wall not breached), two patients

80 entation for mapping and ablation because of unsuccessful ablation from the coronary venous system an

81 tion is associated with better outcomes than unsuccessful ablation.

82 However, ACT against large tumor burdens was unsuccessful, accompanied by CTL deletion and functional

83 Vitamin D deficiency seems to predict the unsuccessful achievement of sustained viral response (SV

84 Across outcomes (ie, successful and unsuccessful) activity in the right habenula decreased i

85 onships between CMV, immune dysfunction, and unsuccessful aging during chronic HIV infection is warra

86 vant concentrations of artemisinic acid were unsuccessful, allowing production of only 1.6 grams per

87 a single crystal of Li(2)TCNQF(4) have been unsuccessful, although air-stable (Pr(4)N)(2)TCNQF(4) wa

88 attempts to obtain knock-out parasites were unsuccessful, although the locus of PfI3 is accessible.

89 ods of dendrite suppression have been mainly unsuccessful and have significant implications for pract

90 e TBDPS with tetrabutylammonium fluoride was unsuccessful and led to a complex mixture of compounds t

91 nted when nonpharmacological intervention is unsuccessful and neuropsychiatric symptoms or associated

92 ivacy attacks are theoretically possible but unsuccessful and unconvincing in real settings.

93 chemotherapy (one docetaxel based) had been unsuccessful and who had Eastern Cooperative Oncology Gr

94 re for topologies where design was initially unsuccessful, and revealed subtle contributions to stabi

95 ain with both TK1413 and TK2289 deleted were unsuccessful, arguing that a histone-mediated event(s) i

96 d with mitochondrially-targeted lipoate were unsuccessful at correcting the deficiency.

97 s extremely inefficient and to date has been unsuccessful at differentiating iPS into hematopoietic s

98 f mPV IgG into wild-type (WT) mice have been unsuccessful at inducing disease.

99 ches into thermally stable photoisomers were unsuccessful at photogenerating macroscopic shapes that

100 egrated stress response and autophagy, in an unsuccessful attempt to replenish the pool of intracellu

101 After early unsuccessful attempts at cell-associated transmission in

102 of a 2-deoxy-2-fluoro-substrate, and several unsuccessful attempts at confirmation of a simpler mecha

103 Our unsuccessful attempts at intramolecular carboacylation o

104 Numerous unsuccessful attempts have been made to identify specifi

105 The unsuccessful attempts often result in dissociation of BL

106 Following unsuccessful attempts to express functional myosin 15-S1

107 During unsuccessful attempts to make optically pure starting ma

108 After numerous unsuccessful attempts to prepare these compounds by ther

109 t difference we found between successful and unsuccessful attempts was the reduction in the frequency

110 f the five actions, whether in successful or unsuccessful attempts.

111 to MFI via direct hydrothermal syntheses was unsuccessful because metal precursors precipitated prema

112 ves using the Sc(3)N@I(h)-C(80) dianion were unsuccessful because of its low nucleophilicity.

113 mal in these mice; however, pregnancies were unsuccessful because of retarded fetal growth and miscar

114 orts to develop selective M4 activators were unsuccessful because of the lack of M4 mAChR subtype spe

115 to target this pathway therapeutically were unsuccessful because of toxicity, lack of efficacy, or b

116 erapies to induce a hypoestrogenic state are unsuccessful because of undesirable side effects, reprod

117 he creation of 'universal' vaccines has been unsuccessful because the immunological mechanisms that p

118 rmediates using a 1,1-difluoro-substrate was unsuccessful because the probe was too deactivated to be

119 Available drug therapies are unsuccessful because they fail to penetrate through the

120 So far, drug discovery strategies have been unsuccessful, because of a lack of suitable screening me

121 Predictors for unsuccessful bidirectional mitral isthmus blockade were

122 oupling with naphthoquinone fragments proved unsuccessful, both amidation and C-N bond formation tact

123 criminate between these hypotheses have been unsuccessful but here a new test is presented based on t

124 assemble complete environmental genomes were unsuccessful, but analysis of scaffolds revealed two div

125 owed greater activation than the rIFC during Unsuccessful, but not Successful, Stop trials, and multi

126 Effective vaccine development has been unsuccessful, but surveillance data suggest that outer m

127 Specular microscopy was unsuccessful, but the fellow untreated eyes had normal e

128 These kindreds had earlier unsuccessful candidate gene testing and five probands we

129 ded the majority of those who died following unsuccessful cardiopulmonary resuscitation attempts or b

130 performed multiple short, high-speed, mostly unsuccessful chases to capture prey, while cheetahs (Aci

131 experimentally adapted prions led to several unsuccessful clinical studies in patients with prion dis

132 The unsuccessful clinical trials of proteasome inhibitor PS-

133 Despite unsuccessful clinical trials using anti-IL-1beta monothe

134 0 orthologue in Mycobacterium smegmatis were unsuccessful, consistent with previous studies indicatin

135 sequence variation leading to successful and unsuccessful copulation attempts was similar.

136 Patients with unsuccessful CTO PCIs had significantly higher 2.5-year

137 roved survival compared with procedures with unsuccessful CTO, and higher-volume CTO operators are mo

138 r body mass index (BMI) were associated with unsuccessful culture in scalp (all p<0.05), but not in d

139 bers (N = 15) who had direct experience with unsuccessful DCD and 5 focus groups with professionals i

140 bdominal transplants are not possible due to unsuccessful DCD organ donation.

141 experimental results for both successful and unsuccessful dechlorination, suggesting the model is a v

142 manipulation for nutrient acquisition and/or unsuccessful defence responses, such as kauralexin produ

143 g these activation patterns in LDVF and that unsuccessful defibrillation shocks may alter activation

144 All unsuccessful direct laryngoscopy patients were successfu

145 ul discharges was significantly shorter than unsuccessful discharges (168 [152-184] ms versus 245 [22

146 DMEK and whole donor corneas obtained after unsuccessful DM stripping were examined by transmission

147 Were unsuccessful donations converted to successful donations

148 m withdrawal of support to patient death for unsuccessful donations was 33 hours, 37 minutes (range,

149 UPR attempts to restore proteostasis but if unsuccessful drives affected cells towards apoptosis.

150 e colonoscopy, cecal intubation is sometimes unsuccessful due to a redundant or tortuous colon.

151 Earlier attempts to produce MH were unsuccessful due to diamond failure before the required

152 The first attempt was unsuccessful due to problems with inefficient cannulatio

153 maguchi macrolactonization reaction that was unsuccessful due to steric hindrance of the oxygen at th

154 of CA IX inhibitors so far has been largely unsuccessful due to technical difficulties regarding the

155 This attempt was unsuccessful due to the chemical instability of the bis-

156 Unsuccessful eculizumab treatment has only been reported

157 Although the oxidants tested were unsuccessful, electrophiles, particularly NBS, enabled t

158 was greater during successful compared with unsuccessful encoding, and that this alignment was corre

159 During successful, but not unsuccessful, encoding of the images there was a signifi

160 controlled under antiarrhythmic drugs after unsuccessful endocardial/epicardial ablation.

161 Reasons for failed or limited ablation were unsuccessful epicardial access (6%), failure to identify

162 t placement indicated after a total of three unsuccessful EVD clamping attempts or need for CSF drain

163 rous theoretical investigations and hitherto unsuccessful experimental searches have followed Dirac's

164 ect on extinction when administered after an unsuccessful exposure session.

165 l effects when administered after inadequate/unsuccessful exposure sessions.

166 ose undergoing technically successful versus unsuccessful FCI (63.6% vs. 46.7%, respectively), althou

167 Of the unsuccessful first-time applications, 24 (15.9%) include

168 n testing-guided elimination diet has proved unsuccessful for adult eosinophilic oesophagitis (EoE),

169 to apply next-generation platforms have been unsuccessful for detecting diabetes biomarkers.

170 this translational attenuation strategy was unsuccessful for enhancing the secretion deficiencies of

171 rotoxic Abeta peptides, have thus far proven unsuccessful for improving cognitive function.

172 ructural characterization that proved mostly unsuccessful for this peptide.

173 area index were significantly smaller in the unsuccessful group (P = 0.004 and 0.003, respectively).

174 n the successful group versus 2 (11%) in the unsuccessful group (P = 0.008).

175 R/S ratio of > 2 in V1 versus 5 (28%) in the unsuccessful group (P = 0.056).

176 ave in lead V1, as opposed to 6 (33%) in the unsuccessful group.

177 d set of genes, in the analysis of otherwise unsuccessful GWAS data, to identify gene-gene interactio

178 uent attempts to disrupt rrp2 have also been unsuccessful has led investigators to hypothesize that R

179 ies to limit or reverse fibrosis have proven unsuccessful, highlighting the need for a greater unders

180 or patients in whom it is contraindicated or unsuccessful, hydromorphone could be offered as an alter

181 d information on 'dark' reactions--failed or unsuccessful hydrothermal syntheses--collected from arch

182 patient was cured or completed treatment and unsuccessful if the patient died or defaulted from treat

183 as inducible at the end of the procedure and unsuccessful if VT remained inducible or if programmed s

184 image of one or both eyes was gradable, and "unsuccessful" if neither macula-centered image was grada

185 Regardless of group, 71.4% of the unsuccessful implants failed before the end of the first

186 nt percutaneous drainage, and aspiration was unsuccessful in 2.

187 e negative for infection, and aspiration was unsuccessful in 4.

188 cefixime-resistant strains with cefixime was unsuccessful in 83% (95% CrI 53%-99%) of cases, represen

189 tiology but endoscopic intervention is often unsuccessful in achieving durable hemostasis with surger

190 s targeted toward these type 2 pathways were unsuccessful in all patients.

191 ctor A and lipoteichoic acid have all proven unsuccessful in clinical trials.

192 mall, inconsistent in their formulations, or unsuccessful in controlling for total supplement calorie

193 MALDI MSI was unsuccessful in detecting all of the target compounds; t

194 sive disorder in particular have so far been unsuccessful in detecting genome-wide significant single

195 WAS) of chronic periodontitis (CP) have been unsuccessful in discovering susceptibility factors.

196 ariant association studies have been largely unsuccessful in identifying common breast cancer suscept

197 dered in patients with obesity who have been unsuccessful in losing or maintaining weight loss with l

198 of ZD strategies, and have found them to be unsuccessful in populations.

199 els during treatment, GTVSBR and GTV50% were unsuccessful in segmenting primary tumor volume.

200 of HGF-targeting therapies have been largely unsuccessful in several different cancers (e.g., gastric

201 mechanistic insight as to why surgery may be unsuccessful in some patients.

202 require an HR defect for efficacy, have been unsuccessful in sporadic BLCs, unlike cisplatin, which e

203 ting them pharmacologically has largely been unsuccessful in the clinic because of their functional p

204 Furthermore, those who are unsuccessful in their cessation attempt can safely re-es

205 rivatives which are commercially limited and unsuccessful in traditional condensation chemistry.

206 sis factor (TNF)inhibitors have been largely unsuccessful in treating AA and have been reported to in

207 IL-6 inhibition has been unsuccessful in treating psoriasis, despite high levels

208 und reaction in a synthetic system have been unsuccessful, in part because of the challenge in prepar

209 preclinical models, but have been clinically unsuccessful, in part due to side effects.

210 ut in only 6% initial fundus photography was unsuccessful, indicating its value in assessing retinopa

211 We quantified host behaviour, successful and unsuccessful infections, and each species' reaction norm

212 trigger repair mechanisms, or, if repair is unsuccessful, initiate apoptosis.

213 The long-term consequences of unsuccessful interferon-alpha based hepatitis C treatmen

214 he uterine cavity and history of two to four unsuccessful IVF cycles.

215 sound of the uterine cavity and a history of unsuccessful IVF treatment cycles does not improve the l

216 Pharmacological inhibition of KRAS has been unsuccessful, leading to a focus on downstream effectors

217 g the dopaminergic system have thus far been unsuccessful, leading to alternative strategies aimed at

218 tested a lineage rank approach, but this was unsuccessful, likely because VRC01 class antibody sequen

219 eractive in major depressive disorder during unsuccessful loss-avoidance although the median raphe nu

220 in emergency departments, yet traumatic and unsuccessful lumbar punctures occur 30% to 50% of the ti

221 Dehydration may be a risk factor for unsuccessful lumbar punctures, but to our knowledge, no

222 lity to extract useful information even from unsuccessful metadynamics runs.

223 s motor behavior is shaped by successful and unsuccessful movements.

224 and retinal vein occlusion the procedure was unsuccessful, necessitating pars plana vitrectomy, while

225 ion rates among trials of new successful and unsuccessful neurological drugs.

226 Six of 171 (3.5%) other patients received unsuccessful nonsurgical treatment with SAE.

227 Four patients underwent SAE after unsuccessful observation.

228 Since they are associated with unsuccessful ocriplasmin treatment, presence and topogra

229 ts, and in the remaining 39 patients, it was unsuccessful or had to be abandoned because of anatomic

230 iological measure of idiopathic LVOT VAs was unsuccessful or had to be abandoned because of anatomic

231 ficult, and clonality analysis may be either unsuccessful or misleading.

232 ) is recommended when a single medication is unsuccessful or produces side effects at higher dosages;

233 MTBDRplus at 2 months was associated with an unsuccessful outcome (aOR 2.87; 95% CI, 1.11 to 7.42).

234 had a successful outcome, and 222 (56.5%) an unsuccessful outcome: 39 (9.9%) died, 56 (14.3%) had fai

235 Intriguingly, in patients with unsuccessful outcomes, the proposed computational approa

236 Extubation is often unsuccessful owing to lung disease or inadequate respira

237 outcomes of patients with successful versus unsuccessful PCI to a CTO.

238 These results demonstrate that the risk of unsuccessful periodontal treatment is associated with ta

239 damage of the vitreoretinal interface after unsuccessful pharmacologic vitreolysis compared to untre

240 ng recently been validated using data from 3 unsuccessful phase 3 trials.

241 een promising but are frequently followed by unsuccessful phase III studies, highlighting a disconnec

242 y assigned; one was not immunised because of unsuccessful phlebotomy.

243 Successful and unsuccessful predictions by PFP and ESG are also discuss

244 ncy to prey attack, number of successful and unsuccessful prey attacks was measured during the presen

245 Approaches using ancient DNA have also been unsuccessful, probably because of rapid DNA degradation

246 n rush protocols; however, underreporting of unsuccessful procedures is very probable.

247 Several unsuccessful recapturing attempts occurred once the doma

248 series correlations during successful versus unsuccessful recollection in three separate experiments,

249 to understand the dynamics of successful and unsuccessful reductive dechlorination of chlorinated eth

250 function, and age (all p < 0.001) along with unsuccessful reperfusion (p = 0.25) were independently p

251 le paralysis may be a contributing factor to unsuccessful respiratory support.

252 -wide association studies, have been largely unsuccessful, resulting in limited knowledge as to the c

253 sults of tarsoaponeurectomy in patients with unsuccessful results after repetitive surgery or who dev

254 s brain dead, and 26 (14%) died following an unsuccessful resuscitation attempt.

255 ression (intentional forgetting) than during unsuccessful retrieval (unintentional forgetting).

256 behaviorally and neurally: successful versus unsuccessful retrieval was associated with hippocampal a

257 that GBA patterns during successful (but not unsuccessful) retrieval of one sequence were more simila

258 ese highly favorable conditions, the risk of unsuccessful search remains significant.

259 tants in the presence of A4(1) or E5(1) were unsuccessful, showing that effective broad-spectrum anti

260 his early oligomeric region has largely been unsuccessful since traditional techniques measure only e

261 rately differentiated between Successful and Unsuccessful Stop trials.

262 text, large-scale CCS is a risky, and likely unsuccessful, strategy for significantly reducing greenh

263 ul strikes where the tongue hit the fly, and unsuccessful strikes where the fly turned and the tongue

264 to approval of 435 days following the first unsuccessful submission.

265 us in cell cultures and chicken embryos were unsuccessful, suggesting distinct requirements compared

266 activity using straight-chain analogues were unsuccessful, suggesting that Chp2 has specificity for n

267 trate its CTD phosphatase activity have been unsuccessful, suggesting that Rtr1 has a non-catalytic r

268 ect PG in any chlamydial species have proven unsuccessful (the 'chlamydial anomaly').

269 rts to generate an rrp2 deletion strain were unsuccessful, the role of Rrp2 in the activation of the

270 When the first ablation was unsuccessful, the second ablation was delivered on the o

271 If unsuccessful, the UPR initiates a proapoptotic program t

272 patients eligible for a targeted therapy was unsuccessful; the role of clonal populations in cancer b

273 d perception that such initiatives have been unsuccessful, there are few quantitative tests of this p

274 targeting EGFR in glioma has been relatively unsuccessful, this study suggests that IGFBP2 may be a n

275 from shore and within the water column were unsuccessful; this was identified as a key bottleneck to

276 GBM in mice using wild-type EGFR have proven unsuccessful to date, hampering endeavors at understandi

277 id tumors using CAR T cells has been largely unsuccessful to date, partly because of tumor-induced im

278 ect their HSC initiating potential have been unsuccessful to date.

279 biomarkers of aging (BoAs) has been largely unsuccessful to-date and there is widespread skepticism

280 mote wound healing in diseases heightened by unsuccessful transition from M1 to M2 phenotypes.

281 anges associated with EF-G dissociation upon unsuccessful translocation attempts of the second slippa

282 al benefit of achieving an SVR compared with unsuccessful treatment in a range of populations infecte

283 ear was not significantly associated with an unsuccessful treatment outcome (adjusted odds ratio [aOR

284 -8.81) were independently associated with an unsuccessful treatment outcome.

285 ing encephalopathy at a neuroscience center, unsuccessful treatment with immunosuppression based on t

286 direct MTBDRplus at 2 months with subsequent unsuccessful tuberculosis treatment outcome (failure/dea

287 ve immune reconstitution have until now been unsuccessful, underscoring the need for better insight i

288 otent and durable B-cell responses have been unsuccessful until now.

289 tihyperglycemic therapies, however, has been unsuccessful until recently.

290 el approach to the berkelic acid core proved unsuccessful upon translation to the natural product its

291 es from 2200 patients for whom treatment was unsuccessful (viremia >50 copies/mL) by considering the

292 nti-Abeta immunotherapy clinical trials were unsuccessful was due to this high percentage of VCID com

293 ium-mediated transformation of epicotyls was unsuccessful when a constitutive promoter (2x CaMV 35S)

294 of ventricular tachycardia (VT) is sometimes unsuccessful when ablation lesions are of insufficient d

295 In mammals complete regeneration is often unsuccessful, while most of the low phyla animals can re

296 ng of an adsorbed magnetic molecule has been unsuccessful with single-molecule magnets.

297 ombination antiretroviral therapy (cART) was unsuccessful with viremia levels 50-1000 copies/mL, for

298 attempts were made into the sternum; 54 were unsuccessful, with an overall success rate of 76%.

299 to either the tibia or the humerus; 192 were unsuccessful, with an overall success rate of 91%.

300 ive pharmacotherapies for patients have been unsuccessful, with the exception of riluzole, the only F