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1 n thought to unwind structures formed in the untranslated 5' region via a nonprocessive mechanism.
2 ial lifestyle decisions by binding to the 5' untranslated and/or early coding regions of mRNA targets
4 cription of the first translated exon and an untranslated exon in hippocampus (P 1.3 x 10(-8)), front
7 n open reading frames, and fewer occurred in untranslated leader sequences, antisense strands, and in
9 tion via structural rearrangements in the 5' untranslated (leader) region of the mRNA in response to
11 step process initiated by stable assembly of untranslated mRNPs into core structures, which could pro
12 iculum stress and critically involved in the untranslated protein response, and Sec63, a heat shock p
17 nhibited the activity of a wild-type CCN2 3' untranslated region (3'-UTR) but not of a mutant CCN2 3'
18 th miR-195 and CUGBP1 interacted with the 3' untranslated region (3'-UTR) of Igf2r mRNA, and the asso
24 SN5 translation via direct binding to its 3' untranslated region (3'UTR) and 5'UTR, leading to tumor
25 nts of peripheral sensory neurons and the 3' untranslated region (3'UTR) landscapes after unilateral
26 Herein we show the importance of 3 prime untranslated region (3'UTR) non-coding regulatory varian
28 s via binding the AU-rich elements of the 3' untranslated region (3'UTR) of numerous pro-inflammatory
29 miR-365, a microRNA that targets the PDYN 3'-untranslated region (3'UTR), and is significantly associ
32 t the truncation of segments of the HIV-1 5'-untranslated region (5'-UTR) distinct from the core enca
33 om sequencing analysis of partial VP1 and 5' untranslated region (5'-UTR) sequences of the EV genome.
37 dcd4 regulates Sin1 translation, the SIN1 5' untranslated region (5'UTR) was fused with luciferase re
38 74 strain lacking 30 nucleotides from its 3' untranslated region (rDEN2Delta30) has previously been e
39 among which 23.5% and 5.4% were located in 5 untranslated region (uPSS) and intergenic region (iPSS),
40 ent, deep-sequencing method targeting the 5' untranslated region (UTR) and P1 genomic region to chara
41 TTP targets AU-rich elements in the NLRP3 3'-untranslated region (UTR) and represses NLRP3 expression
42 ated that MYF5 was capable of binding the 3' untranslated region (UTR) and the coding region (CR) of
43 SLA) and stem-loop B (SLB) located in the 5' untranslated region (UTR) are critical for binding the v
45 regulated by structural complexity of the 5'untranslated region (UTR) derives from bacterial and oth
46 of CaMKII mRNA, which consists of a short 3'-untranslated region (UTR) form lacking regulatory elemen
47 a common polymorphic variant in the ERCC5 5' untranslated region (UTR) generates an upstream ORF (uOR
48 tion in the asymmetric loop of a critical 3' untranslated region (UTR) hairpin that disrupts local hi
54 A nine-nucleotide motif located in the 5' untranslated region (UTR) is required for preferential a
55 in Seb1 resulted in widespread changes in 3' untranslated region (UTR) length as a consequence of inc
56 e subject to tissue-specific APA, such as 3' untranslated region (UTR) lengthening in head and 3' UTR
57 hnRNP E1 promotes its dissociation from a 3' untranslated region (UTR) nucleic acid regulatory motif,
58 her three variants are all located in the 5'-untranslated region (UTR) of an alternative spliced tran
60 inds to and translationally activates the 5' untranslated region (UTR) of G3BP1 mRNAs, thereby contro
62 at predicts the protein expression of the 5' untranslated region (UTR) of mRNAs in the yeast Saccharo
65 ecular level, CELF1 was found to bind the 3'-untranslated region (UTR) of Myc mRNA and repressed MYC
67 located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be assoc
68 esence of a G-quadruplex structure in the 5' untranslated region (UTR) of NRF2 mRNA, as measured by c
69 ation of the promotor region, the 5'- and 3'-untranslated region (UTR) of SAMHD1, and the mechanism r
70 terized SLC, a stem-loop structure in the 5' untranslated region (UTR) of the bean pod mottle comovir
72 erozygosity for a frequent variant in the 3' untranslated region (UTR) of the mutant allele, which di
76 criptional regulation of NR4A2, we used a 3' untranslated region (UTR) reporter screen and identified
77 selenoproteins by a mechanism involving a 3 untranslated region (UTR) selenocysteine insertion seque
79 acterial type I toxin mRNAs possess a long 5 untranslated region (UTR) that serves as the target site
82 ail in mRNAs influences the length of the 3'-untranslated region (UTR), a critical determinant of gen
83 , where auxin reduces PAC distribution in 5'-untranslated region (UTR), but increases in the 3'UTR.
84 (SbCAD2) that has an 8-bp deletion in its 5'-untranslated region (UTR), conferring the spontaneous br
85 Stem-loop A (SLA), a part of the viral 5' untranslated region (UTR), is critical for the initiatio
86 hat DDX3X specifically recognizes the HCV 3' untranslated region (UTR), leading to the activation of
87 rectly to an (AAN)3 motif within the mutS 5' untranslated region (UTR), repressing translation in the
88 hanged when the intron was located in the 5'-untranslated region (UTR), suggesting that the intron af
89 translation via two binding sites in its 3' untranslated region (UTR), thereby ensuring a dual contr
90 and miR-58 family miRNAs within the egl-1 3' untranslated region (UTR), which affect both mRNA copy n
96 ed from a leaderless transcript lacking a 5'-untranslated region and Shine-Dalgarno ribosome binding
97 RNAs containing AU-rich elements in their 3'-untranslated region and target them for degradation.
98 y stabilizing the interaction between the 3'-untranslated region and the RNA-induced silencing comple
99 work: both directly through targeting its 3' untranslated region at two distinct seed regions and ind
100 s at the CpG-island overlapping the first 5'-untranslated region exon, paralleling the increased PEAR
103 Additionally, inclusion of the CD40LG 3'-untranslated region in the transgene preserved posttrans
105 cis-acting sequence variants in the FAD2 5' untranslated region intron that determine the expression
106 tic production of CaMKII mRNA with a long 3'-untranslated region is necessary for modulating spontane
111 med by a dose-dependent reduction in HCN4 3'-untranslated region luciferase reporter activity on cotr
114 in a 38-base pair region of the PIM1 mRNA 3'-untranslated region mediate a regulatory interaction wit
115 fs, a miRNA collection, defined by shared 3' untranslated region motifs, and a molecular function col
117 ly repressed by p21, directly targets the 3' untranslated region of adenosine monophosphate-activated
121 1b-1, which we show directly binds to the 3' untranslated region of Bcl-2 mRNA leading to its transla
122 ture translation events from uORFs in the 5' untranslated region of binding immunoglobulin protein (B
123 The minor allele at rs1883832, in the 5'-untranslated region of CD40, was associated with earlier
124 miR-29 microRNA binding site, within the 3' untranslated region of COL4A1, was identified in the lar
128 dentified a G-quadruplex structure in the 5' untranslated region of Gap-43 mRNA that directly interac
132 iferase reporter assay confirmed that the 3'-untranslated region of IGFBP1 mRNA is targeted by miR-54
134 le-nucleotide polymorphisms (SNPs) in the 3' untranslated region of KCNQ1 were recently suggested to
137 y the translation of reporters containing 3' untranslated region of Mos or Ccnb1 and the accumulation
138 uR binding to AU-rich elements within the 3' untranslated region of mRNAs encoding oncogenes, growth
142 iferase reporter assay indicated that the 3' untranslated region of PTPRJ was targeted by this miR.
143 found that miR-376c-3p encoded within the 3'-untranslated region of RUNX2 played a pivotal role in re
144 at direct interaction of miR-124 with the 3'-untranslated region of SMOX mRNA contributes to this neg
145 Our results show that HuR binds to the 3'-untranslated region of SOX2 mRNA together with the RNA-i
146 n Escherichia coli), or by binding to the 5' untranslated region of target mRNAs (in mammalian cells)
151 Expansion of a CGG-repeat tract in the 5'-untranslated region of the FMR1 gene to >200 repeats res
153 capitulate the selective packaging of the 5' untranslated region of the HIV-1 genome in the presence
154 d significantly less 5-hmC binding in the 3' untranslated region of the nestin gene in melanoma compa
155 etically by TET2 via 5-hmC binding at the 3' untranslated region of the nestin gene, providing one po
156 e evasion factors, including CssA, in the 5'-untranslated region of the operon for capsule biosynthes
161 DENV RT-iiPCR assay targeting a conserved 3' untranslated region of the viral genome was evaluated.
162 ne candidates containing deletions in the 3' untranslated region of the Zika virus genome (ZIKV-3'UTR
163 contains a 10-nucleotide deletion in the 3' untranslated region of the ZIKV genome (10-del ZIKV).
165 t by binding to specific sequences in the 3' untranslated region of their target genes and causing th
167 eracted with a stem-loop structure in the 3' untranslated region of these transcripts through its PIN
171 effects, including direct binding to the 3' untranslated region of VWF and targeting FURIN and the h
173 ificant association between 2 SNPs in the 3' untranslated region or within the adjacent region just 3
174 iotic transcript isoform with an extended 5'-untranslated region predicted to impair protein translat
175 n an 250 kb haplotype block spanning the 5' untranslated region region of insulin-degrading enzyme i
177 deletion polymorphism (rs3045215) in the 3' untranslated region sequence of human IRF2BP2 mRNA had a
179 nd CSP41a had been shown to cleave within 3'-untranslated region stem-loop structures, which contain
180 e and structural elements in the SMN mRNA 3'-untranslated region that are reminiscent of the snRNP co
181 al design, we engineered a cis-repressing 5' untranslated region that can be activated by this new ri
182 r(CGG) repeat (r(CGG)(exp)) present in a 5' untranslated region that causes fragile X-associated tre
183 ependent translation element (BTE) in the 3'-untranslated region that interacts with host translation
184 P2 exons 6 to 11, 1 a PKP2 duplication of 5' untranslated region till exon 1, 1 the desmocollin-2 (DS
185 identified a novel intron within the LANA 5' untranslated region using a splice acceptor at 127888.
186 ignificant interaction between rs3744165 (5'-untranslated region variant of exon 2 of zinc finger pro
187 etween miR-650 and its target site in the 3' untranslated region was validated through luciferase rep
189 of additional genes, predominantly in the 5' untranslated region, and has global effects on the expre
192 alternative splicing of its terminal exon 3' untranslated region, generating an oncogenic, C-terminal
193 -5p, which directly targeted IkappaBalpha 3' untranslated region, leading to NF-kappaB activation.
194 of the miR-223 binding site in the NLRP3 3' untranslated region, phenocopied the characteristics of
195 d not bind with high affinity to the ndhA 5' untranslated region, suggesting that PPR53's RNA-stabili
211 ate that, through an interaction with the 3' untranslated regions (3' UTRs) of BCL2 and BIK, LARP1 st
213 cripts that differ in the length of their 3' untranslated regions (3' UTRs) while producing the same
215 ng reporter assays have demonstrated that 3' untranslated regions (3'-UTRs) regulate gene expression
216 transcripts via targeting elements within 3' untranslated regions (3'UTR), and enforced IGF2BP3 expre
217 A) generates mRNA isoforms with different 3' untranslated regions (3'UTRs) and/or coding sequences.
219 ate-uridylate-rich elements (AREs) in the 3'-untranslated regions (3'UTRs) of specific mRNAs, such as
223 d repeated Alu elements (IRAlus) in their 3' untranslated regions (UTRs) are inefficiently exported t
224 Each EBOV gene contains exceptionally long untranslated regions (UTRs) flanking the open reading fr
225 ed 3' ends, and genes possessing multiple 3'-untranslated regions (UTRs) generated by alternative cle
227 we show that WT1 binds preferentially to 3' untranslated regions (UTRs) of developmental targets.
228 stream open reading frames (uORFs) across 5'-untranslated regions (UTRs) of key signalling components
230 to unwind RNA secondary structure in the 5'-untranslated regions (UTRs) of mRNAs to promote their re
231 ed the specific binding of miR-224 to the 3' untranslated regions (UTRs) of SLC4A4 and CFTR mRNAs, th
233 to all validated human microRNAs and the 3' untranslated regions (UTRs) of ~6000 cancer-associated g
235 e RNA regulons embedded in homeobox (Hox) 5' untranslated regions (UTRs) that confer ribosome-mediate
236 reporters, we show that miR-J8 can target 3' untranslated regions (UTRs) with miR-17-5p or miR-20a co
237 s with polyadenylated 3' ends that map to 5'-untranslated regions (UTRs), introns, and protein-coding
238 ee major domains loosely corresponding to 5' untranslated regions (UTRs), open reading frames, and 3'
239 otide-containing sequences in introns and 3' untranslated regions (UTRs), promotes exon inclusion or
245 ntragenic transcripts, leaderless RNAs, long untranslated regions and a unique nucleotide frequency f
246 . vivax genes tend to have unusually long 5' untranslated regions and also present multiple transcrip
247 ding patterns in introns, are enriched in 3' untranslated regions and alter genes distinct from TDP-4
248 t HNRNPR binds MHC class I mRNAs in their 3' untranslated regions and enhances their stability and co
249 insertion sites are within genes (including untranslated regions and introns) and 28% (7217) are wit
250 mRNA-specific activators that bind to the 5' untranslated regions and promote translation on mitochon
251 oplast mRNAs harbor putative SDs in their 5' untranslated regions and the aSD displays strong conserv
252 ational control between cell lines, while 3' untranslated regions can confer cell type-specific expre
253 gnition sequence and specific introns and 3' untranslated regions each increased protein expression b
255 ings unveil a role for the translation of 5' untranslated regions in cancer, and expose new targets f
256 Here we show that secondary structure in 5' untranslated regions is only a minor determinant for Roc
257 uding transcription factor binding sites and untranslated regions mutated in up to approximately 15%
258 revealed that PSPC1 binds to intronic and 3'-untranslated regions of a number of adipocyte RNAs, incl
263 find potential G-quadruplexes located in the untranslated regions of human mRNAs (i.e. in the 5' and
264 rden of rare variants in patients within the untranslated regions of known disease-causing genes, dri
265 inds in a sequence-specific manner to the 3' untranslated regions of many proinflammatory mRNAs and r
266 anscriptional riboswitches located in the 5'-untranslated regions of messenger RNA requires the tempo
267 trinucleotide motif predominantly in the 3' untranslated regions of mRNA, and destabilizes target mR
269 by direct functional interaction with the 3'-untranslated regions of proinvasive alphav- and alpha6-i
270 ers identified so far include elements in 3' untranslated regions of specific mRNAs and several non-c
271 entary sequences and binding affinity for 3' untranslated regions of the Fas ligand (FasL) and Fas, r
272 ent translation enhancers (3'CITE) in the 3' untranslated regions of their genomic (g)RNAs to compete
273 ened for variations in the entire coding and untranslated regions of these 3 genes by resequencing.
275 binds to AU-rich elements present in the 3' untranslated regions of transcripts that mainly encode p
276 ative nuclear processing within noncoding 3'-untranslated regions of VEGF and CPEB4 messenger RNAs in
277 anslation of viral or reporter mRNAs with 5' untranslated regions that contain adenosine repeats, so-
279 is proposed to reflect highly structured 5' untranslated regions that depend strongly on eIF4A-media
280 n the 5b+ annotation build, added additional untranslated regions to 1,393 5b+ gene models, identifie
281 iridae use RNA structures in their 5'- or 3'-untranslated regions to stall and repress XRN1, effectiv
282 tion initiation sites (uTISs) at the mRNA 5' untranslated regions was strongly associated with improv
283 The large majority of TISs that mapped to 5' untranslated regions were noncanonical and led to N-term
284 ence, modified NS5B consensus sequence, pS52 untranslated regions, and coding mutations from a cultur
285 revealed the landscapes of gene structures, untranslated regions, and splicing activities to be more
287 tly improve the annotations of P. vivax gene untranslated regions, providing an important resource fo
288 roximal APA sites, resulting in shortened 3' untranslated regions, while nonmethylated transcript iso
299 regions including promoters, terminators and untranslated sequences could drive stable luciferase tra
300 n many species, CsrA activity is governed by untranslated sRNAs, CsrB and CsrC in Escherichia coli, w
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