ライフサイエンスコーパス: untreatable

1 e of disability in patients and is currently untreatable.

2 of human cancers that are largely presently untreatable.

3 ses that were formerly considered relatively untreatable.

4 ccept their debility as either inevitable or untreatable.

5 e pathophysiology is not well understood, is untreatable.

6 itating dysfunction is currently unknown and untreatable.

7 line that is poorly understood and currently untreatable.

8 ons, including those previously deemed to be untreatable.

9 ectious diseases were rife because they were untreatable.

10 ns occurring posttransplantation are usually untreatable.

11 a on the cell cytoskeletal system and may be untreatable.

12 er that is progressive, fatal, and currently untreatable.

13 " in which many bacterial infections will be untreatable.

14 th advanced disease and renders them largely untreatable.

15 mitochondrial diseases, which remain largely untreatable.

16 lateral sclerosis (ALS), which is currently untreatable.

17 of phenotypes that remains for the most part untreatable.

18 )-producing Escherichia coli (STEC), remains untreatable.

19 ns caused by these pathogens being virtually untreatable.

20 rited retinal dystrophy previously medically untreatable.

21 degenerative retinal diseases, which remain untreatable.

22 mostly considered difficult to treat or even untreatable.

23 hereditary blindness worldwide, are largely untreatable.

24 n perception that many of these symptoms are untreatable.

25 atients who were previously considered to be untreatable.

26 Geographic atrophy (GA), an untreatable advanced form of age-related macular degener

27 This condition is currently untreatable and carries a significant risk of melanoma w

28 ears ago, this disorder is still regarded as untreatable and its pathogenesis is poorly understood de

29 ms of retinitis pigmentosa (RP) is currently untreatable and leads to partial or complete vision loss

30 Idiopathic pulmonary fibrosis (IPF) is an untreatable and often fatal lung disease that is increas

31 Several teeth were deemed untreatable and removed at the time of consultation and

32 g insult, i.e. treatable/self-limited versus untreatable and sustained.

33 omal storage disorders (LSDs) are severe and untreatable, and mechanisms underlying cellular dysfunct

34 The tooth was deemed untreatable, and was extracted.

35 Untreatable bacterial infections constitute a dark but v

36 The growing threat of untreatable bacterial infections has refocused efforts t

37 sence of creatine in the brain, is currently untreatable because CRT is required for creatine entry i

38 ng off future treatment of cases that may be untreatable because of high resistance levels.

39 Many untreatable blinding diseases involve degeneration of re

40 e retinal pigmented epithelium (RPE), causes untreatable blindness in millions worldwide.

41 photoreceptor cells is the leading cause of untreatable blindness in the developed world, with inher

42 congenital amaurosis, are a leading cause of untreatable blindness with substantive impact on the qua

43 al degenerative diseases are major causes of untreatable blindness, and novel approaches to treatment

44 nal neovascularization is the major cause of untreatable blindness.

45 e eye diseases are the most common causes of untreatable blindness.

46 iffuse coronary artery disease is frequently untreatable by coronary artery bypass or angioplasty.

47 ible emergence of a bacterial strain that is untreatable by US Food and Drug Administration (FDA)-app

48 ry of novel drug therapies for the otherwise untreatable C. parvum.

49 ear survival rates of less than 10%, into an untreatable cancer class.

50 By contrast, untreatable cancer mortality was not significantly linke

51 y prove to be a breakthrough in an otherwise untreatable cancer.

52 ld vaccine will change the way we approached untreatable cancers, but more importantly, will allow a

53 eatments for cerebral amyloid angiopathy, an untreatable cause of haemorrhagic stroke and vascular co

54 l-defined small vessel disease and a largely untreatable cause of intracerebral haemorrhage and contr

55 erception of light (NPL) in individuals with untreatable causes of visual loss.

56 netic screening has reduced the incidence of untreatable childhood genetic diseases and improved the

57 ing nephrogenic systemic fibrosis (NSF), the untreatable condition recently linked to gadolinium (Gd)

58 diseases is reactive Muller cell gliosis, an untreatable condition that leads to tissue scarring and

59 successful, improving outcome in a hitherto untreatable condition.

60 Ischemic acute kidney injury is a serious untreatable condition.

61 the diagnosis and prediction of rare, often untreatable conditions, to the prediction of common, oft

62 ising therapeutic target for these currently untreatable conditions.

63 on may be an effective therapy for diffuse, "untreatable" coronary disease by supplying a robust infl

64 ntial new therapeutics against the virtually untreatable cryptosporidial infection in immunocompromis

65 How the inflammasome is activated in this untreatable disease is largely unknown.

66 preventing the development of this otherwise untreatable disease process.

67 anide with nephrogenic systemic fibrosis, an untreatable disease, has spawned renewed interest in alt

68 ment plan, may be the answer to a heretofore untreatable disease.

69 ools to test potential therapeutics for this untreatable disease.

70 novel therapeutic targets for this currently untreatable disease.

71 y effective form of therapy for a previously untreatable disease.

72 lly be used to treat patients with currently untreatable disease.

73 aps identify a novel target for an otherwise untreatable disease.

74 RTANCE Prion disorders are invariably fatal, untreatable diseases typically associated with long incu

75 the iPSC technology into novel therapies for untreatable diseases.

76 ing the course of these invariably fatal and untreatable diseases.

77 has been transformed from a rare and largely untreatable disorder to a common genetic disease with ma

78 d be effective treatments for this currently untreatable disorder.

79 be a promising therapeutic strategy for this untreatable disorder.

80 rosopagnosia has largely been regarded as an untreatable disorder.

81 ce therapeutic approaches for this currently untreatable disorder.

82 treatments for this debilitating, currently untreatable disorder.

83 amilial variants are progressive and largely untreatable disorders with poorly understood molecular m

84 ars that many infectious diseases may become untreatable, disruptive innovations are in the process o

85 ycobacterium tuberculosis strains that cause untreatable drug-resistant disease are a threat worldwid

86 e cancer usually metastasizes to bone and is untreatable due to poor biodistribution of intravenously

87 Once regarded as largely untreatable, evidence-based decision making now guides c

88 lize visual acuity in a number of previously untreatable eye diseases, of which the main are age-rela

89 duration of complications due to previously untreatable flavivirus meningoencephalitis.

90 itional measures to respond to the threat of untreatable gonorrhea.

91 ectrum cephalosporins raises the prospect of untreatable gonorrhoea.

92 te concentrations in patients with otherwise untreatable gout is progressing.

93 ultimately lead to novel therapies for this untreatable group of disorders.

94 ate nodules smaller than 2 cm did not become untreatable HCC with delayed HCC diagnosis of 6-12 month

95 cm at HCC diagnosis, and none progressed to untreatable HCC.

96 athway mediating neuronal death in currently untreatable human neurodegenerative disorders, including

97 eep anterior chamber (3 eyes in each group), untreatable hypotony in 1 eye in the PPV group (that led

98 tic melanoma, and the disease is essentially untreatable if not cured surgically.

99 children, but is generally considered to be untreatable in adults.

100 ses, many of which were viewed as relatively untreatable in the 1950s.

101 ation (AMD), a progressive condition that is untreatable in up to 90% of patients, is a leading cause

102 brosis and muscular dystrophies in currently untreatable individuals.

103 ccal antibiotic resistance and the threat of untreatable infection are focusing attention on strategi

104 ultifocal leukoencephalopathy is a currently untreatable infection of the brain.

105 re community as the cause of a wide range of untreatable infections.

106 cterial drug discovery brings the spectre of untreatable infections.

107 ing pattern of causes of death from formerly untreatable infectious diseases to chronic degenerative

108 egulator (RPGR) cause X-linked RP (XLRP), an untreatable, inherited retinal dystrophy that leads to p

109 s potentially could lead to the emergence of untreatable invasive K. pneumoniae infections; our data

110 splants, offers the potential for correcting untreatable large tissue defects.

111 course and prognosis in the degenerative and untreatable later phase of multiple sclerosis.

112 chronic disease (111/117; 94.9%) than for an untreatable life-threatening illness (95/117; 81.2%) (p

113 -2-regulated apoptotic pathway in previously untreatable lymphoid malignancies.

114 effective targeted therapy for this commonly untreatable malignancy.

115 lass of immunotherapy for use in settings of untreatable metastatic disease.

116 se', where mankind faces its biggest threat, untreatable microbes.

117 ng drug resistance threatens to make malaria untreatable, necessitating both the discovery of new ant

118 in cases of deteriorating renal function or untreatable nephrotic syndrome.

119 interrupt mitochondrial fusion and cause the untreatable neurodegenerative condition Charcot-Marie-To

120 ion of RdCVF is a promising therapy for this untreatable neurodegenerative disease.

121 pongiform encephalopathies (TSEs) are fatal, untreatable neurodegenerative diseases associated with t

122 Prion diseases are fatal, untreatable neurodegenerative diseases caused by the acc

123 ritical insights into the mechanism of these untreatable neurodegenerative diseases.

124 pathway; inactivation of ATP7A results in an untreatable neurodegenerative disorder, Menkes disease.

125 from pathogenic repeat sequences in multiple untreatable neurodegenerative disorders.

126 ne of the most common recessively inherited, untreatable, neurodegenerative diseases of humans, is ch

127 A1) and Huntington disease, are progressive, untreatable, neurodegenerative disorders.

128 Currently untreatable neurological diseases are especially attract

129 Huntington's disease (HD) is an untreatable neurological disorder caused by selective an

130 untington disease is a dominantly inherited, untreatable neurological disorder featuring a progressiv

131 rom being a psychoanalytic colloquialism for untreatable neurotics to becoming a valid diagnosis with

132 Spinal muscular atrophy is an untreatable potentially fatal hereditary disorder caused

133 amilial frontotemporal dementia, a currently untreatable progressive neurodegenerative disease.

134 ry for quickly distinguishing treatable from untreatable rapidly progressive dementias and for future

135 inically significant therapies for currently untreatable retinal disease.

136 ation in X-linked retinoschisis, a currently untreatable retinopathy.

137 e in mental abilities, increased severity of untreatable seizures, blindness, loss of motor skills an

138 There exists a family of currently untreatable, serious human diseases that arise from the

139 ay hypersecretion is a serious and presently untreatable symptom of chronic inflammatory airway disea

140 of drug-resistant M.tb. strains to initiate untreatable TB epidemics, as it is possible that loss or

141 discuss the emerging problem of functionally untreatable tuberculosis, and the issues and challenges

142 ries, heralding the possibility of virtually untreatable tuberculosis.

143 c levels in East Asia, is a leading cause of untreatable visual impairment.

144 erial pathogens has rendered some infections untreatable with available antibiotics.

145 ervous system and renal cell carcinoma, both untreatable with conventional chemotherapies.