ライフサイエンスコーパス: unusual

1 s low and the geometry of the dinuclear site unusual.

2 ated guenon species, such an epidemiology is unusual.

3 ndent of the chemical composition, is highly unusual.

4 marks of tunneling, including large KIEs and unusual activation parameters, with linear Arrhenius and

5 The unusual activity of this catalyst is attributed to the s

6 ysis define the features that facilitate the unusual acyl conjugation with S-adenosylmethionine (SAM)

7 Through these studies, an unusual additive effect with DMAP has been uncovered tha

8 eceptor on human MoDC that routes cargo into unusual Ag processing pathways, which reduces surface ex

9 N- and C-terminal extensions create a highly unusual all alpha-helical split-dimerization region, ter

10 as a result of the presence of the guanidino-unusual amino acid L-allo-End, while the other is at the

11 The enzyme is unusual among mammalian P450s in that the predominant ox

12 have attracted much attention because of the unusual and key catalytic role of an N-terminal proline.

13 ctivity of these enzymes, and introducing an unusual and powerful way of analyzing their catalytic el

14 ika virus (ZIKV) epidemic has been linked to unusual and severe clinical manifestations including mic

15 stic involvement of the sternum is extremely unusual and should be considered malignant unless proven

16 This points to an unusual and subtle structural organization effect of the

17 maps of natural evolving systems are highly unusual, and it may help create evolvable artificial sys

18 Case reports regularly document unique or unusual aspects of glucose transporter type 1 deficiency

19 clinically unexploited mode of action and an unusual assembly.

20 d use of DMSO as a cosolvent, along with its unusual attributes, have inspired numerous studies.

21 base that activates cholesterol during this unusual autoprocessing event; mutation of the catalyzing

22 Here, we report an unusual autosomal recessive neurodegenerative condition,

23 The unusual auxetic behaviour in combination with other rema

24 The unusual aza-cylic product is distinct from the more comm

25 tering (RBS) was employed to understand this unusual behavior as to whether it is a mixture of two ph

26 ture of the mechanisms responsible for their unusual behavior is not well understood.

27 e underlying mechanisms responsible for this unusual behavior.

28 n nanostructures suggests that the predicted unusual behaviors of 1D boron may find powerful applicat

29 ates a new way to design soft materials with unusual behaviors.

30 ed systems are critical to understanding the unusual behaviours of heterochromatin, and how chromatin

31 Here, we demonstrate an unusual Berry phase-induced spectroscopic feature: a sud

32 sometimes leading to depauperate clades with unusual bill morphologies.

33 are macrocyclic polyketides known to have an unusual bioactivity profile influenced by compound glyco

34 of this family, shedding new light on their unusual biology.

35 They stem from unusual biosynthetic sequences that lead to the incorpor

36 Plants possess unusual blunt-ended telomeres that are unable to form t-

37 that include: marked positive mood, pleasant/unusual bodily sensations and pro-social, empathic feeli

38 st potent compound (10bm), which contains an unusual bromodifluoroacetamide at the thiophene 2-positi

39 For snR48 and U18, the unusual C/D alone is enough for the modification of two

40 However, for the snR13 snoRNA the unusual C/D motif and extra base-pairing, which stimulat

41 me steric crowding that previously has given unusual (C5Me5)(-) reactivity to (C5Me5)3M complexes in

42 We present an unusual case of a patient who unexpectedly developed a r

43 d the way they work in concert to yield this unusual case of multiple hypervalence, has potential for

44 detailed imaging of the clinical picture of unusual cases of XLRS.

45 ion has been suggested to be catalyzed by an unusual catalyst, a MAD1:C-MAD2 tetramer, but how the ca

46 e provides insights that help to explain the unusual CC dimer structure and potential sources of stab

47 An essential and unusual challenge was to make the auction simple enough

48 lationship between superconductivity and the unusual change in carrier density that points to possibl

49 Ca(2+) concentrations than alphaVbeta6 These unusual characteristics are likely to be important in th

50 Herein, a novel glycan with an unusual chemical composition and structure in the oral s

51 eaction mechanism and the rationale for this unusual chemoselectivity.

52 The rise of Zika virus (ZIKV) and its unusual clinical manifestations provided ground for spec

53 derstand the structural basis of HLA-DQ2.5's unusual CLIP association characteristics, better insight

54 ernally Expressed Gene 3) domain contains an unusual cluster of YY1 binding sites.

55 of sensory cell-specific expression of this unusual co-receptor and reveal its additional role in th

56 luride (GeTe) is both polar and metallic, an unusual combination of properties in any material system

57 rmeability assays provided evidence that the unusual combination of structural features in gichigamin

58 4 ZFs, we observed that ZFs 3 and 4 form an unusual compact and stable structure that restricts thei

59 y and escape from crossing over - make it an unusual component of the genome, and have led to its gen

60 ReSe2 and ReS2 are unusual compounds amongst the layered transition metal d

61 y tagged proteins within the NE exhibited an unusual concentration dependence.

62 Strikingly, the AAUAAA PAS assumes an unusual conformation that allows this short motif to be

63 "epoxide" mechanism that proceeds through an unusual conformational itinerary.

64 d that the members of the miR166 family have unusual conservation patterns and demonstrated that the

65 We demonstrate that this unusual cyclic behaviour is governed by a type of correl

66 ulations suggest that these STSs catalyze an unusual cyclization path involving reprotonation, intram

67 of remarkable enzyme catalysis including an unusual cytidilation reaction and the use of iron-sulfur

68 tes and conditions such as exercise place an unusual demand on liver energy metabolism, and this dema

69 10 women; mean age, 44 years) who contracted unusual dermatitis after an occupational exposure in Jul

70 An unusual diastereodivergent NCAL process was discovered t

71 onditions, raising the possibility that this unusual dimer might have a biologically relevant role in

72 sensory processing, in that they provide an unusual direct link between sensory (auditory/somatosens

73 The Patescibacteria LexA-binding motif has unusual direct-repeat structure, and comparative analyse

74 athways through bridging ligands but also an unusual, direct Mn(III)-Ce(IV)-Mn(III) metal-to-metal ch

75 Wickerol A (1) is an unusual diterpene with remarkable activity against the H

76 This unusual dual catalytic activity of vinorine hydroxylase

77 We recently reported unusual early dynamics in an experimental system using a

78 Interestingly, the unusual effect of downsizing the ZIF-67 crystals and the

79 ZrMe-BTC displays unusual electronic and steric properties compared to hom

80 l two-dimensional materials because of their unusual electronic properties.

81 study of cholesterol oxidase has revealed an unusual elongated main chain nitrogen to hydrogen bond d

82 The unusual envelope found in AFV1 also has many implication

83 perties of human AID and found that it is an unusual enzyme in that it exhibits binding affinities fo

84 environments that lack this nutrient; thus, unusual enzyme reactions have also evolved to cleave the

85 ived global attention because of some of its unusual epidemiological and clinical features, including

86 kylosing spondylitis (AS) is associated with unusual ERAP1 genotypes.

87 This unusual example of a four-electron reaction involves car

88 These are the unusual examples of Zr-MOFs (or MOFs in general) based o

89 Here we report an unusual exception, identifying a strain of HIV-1 group O

90 In the Unusual Experiences Enquiry (UNIQUE) study, we investiga

91 alts showed excellent moisture stability, an unusual feature in compounds of this type.

92 How widespread these unusual features are across diplonemids is unclear.

93 ies for studying magnetism by harnessing the unusual features of atomically thin materials, such as e

94 als of LAF-1 and its IDR display a number of unusual features, including 'high concentration' binodal

95 Overexpression of UNUSUAL FLORAL ORGANS also alters C. hirsuta leaf shape

96 low affinity observed for GCRho monomers is unusual for this enzyme class and suggests that dimer fo

97 One jet had an unusual form observed for the first time, which emerged

98 This unusual form of AOB plasticity may act to filter sustain

99 The unusual form of synaptic plasticity expressed by the LPP

100 ta in support of hypotheses about the use of unusual formal features and the interplay between sound

101 teractions and magnetic fields gives rise to unusual forms of superconductivity and magnetism in quan

102 The unusual fracture morphology suggests that bisphosphonate

103 ain of BAZ1A, but not that of BAZ1B, has the unusual function of binding DNA.

104 ed, alpha-enaminone synthones and reveal the unusual functionalities of these building blocks.

105 t it is still unclear why cells utilize this unusual gene structure.

106 Here, we report the unusual genetic behavior of a quantitative gain-of-funct

107 Here we track unusual genetic patterns in one hybrid population over t

108 An unusual genome architecture characterizes the two relate

109 of known X-ray structures reveals that this unusual geometry results from a phylum-specific cleavage

110 e close tunneling distance occurs through an unusual ground state active site arrangement or by therm

111 Obligate intracellular bacteria are an unusual group of organisms that have evolved to replicat

112 This view is supported by the observation of unusual growth of nucleated domains, which we term "tree

113 by the recent discovery of a Pt8L4 cage with unusual gyrobifastigium-like geometry.

114 d crystallizes as a C3-symmetric dimer in an unusual head-to-head fashion.

115 The final step involved a highly unusual Heck cyclization whereby ligand control enabled

116 ctive-site sterics, partially mediated by an unusual heme-polypeptide ester bond.

117 species under mild catalytic conditions with unusual heteroatom preference and high efficiency.

118 As a consequence, unusual heterobimetallic Au(I)/Pt(II) complexes containi

119 These highly unusual heterobimetallic complexes represent a missing l

120 In these contexts, the XIST RNA adopts an unusual, highly dispersed organization, which may explai

121 entification of three BOT samples presenting unusual histologic features that could be associated wit

122 at near-atomic resolution, which reveals an unusual "hole" on the surface, surrounded by five enceph

123 Then, three decades ago, an unusual human leukocyte antigen (HLA) molecule was ident

124 n-Tie2 signaling, medullary AVR exhibited an unusual hybrid endothelial phenotype, expressing lymphat

125 al surrogate for the OH group, can act as an unusual hydrogen bond donor, as confirmed by crystallogr

126 ally the most flexible learners, adopting an unusual hypothesis more easily than either 6-y-olds or a

127 l conformation in methanol, stabilized by an unusual (i,i+3) staple which cross-links two d-amino aci

128 xperiments have suggested that lacosamide is unusual in binding selectively to the slow-inactivated s

129 )-binding histidines with binding geometries unusual in proteins.

130 EcChiP is unusual in that it is homologous to porins and monomeric

131 ed disease in their natural hosts, CAdV A is unusual in that it may cause high morbidity and sometime

132 Ascoviruses are also unusual in that most encode a caspase or caspase-like pr

133 Four yeast snoRNAs are unusual in that they are predicted to methylate two nucl

134 The pseudomonads are unusual in that they often contain multiple full and par

135 dynamic range linear field responses and an unusual in-plane EB effect.

136 the examples highlighted represent not only unusual instances of productive deep-seated natural prod

137 rovides a simple chemical perspective on the unusual insulating behavior of such materials, complemen

138 Here we report the unusual interlayer quantum transport behavior resulting

139 An unusual intramolecular aldol addition was developed for

140 The unusual intrinsic electronic structure of the [B12X12](2

141 The SUR1-ABC core is found in an unusual inward-facing conformation whereby the two nucle

142 P-glucose pyrophosphorylase, SVEN_3972 is an unusual ITP-mannose pyrophosphorylase, and SVEN_2781 is

143 n also contribute to receptor binding due to unusual kinetic characteristics of the sialidase site wh

144 city via both the secondary binding site and unusual kinetic properties of the sialidase site which p

145 The origin of these unusual kinetics is found to be a feedback cycle involvi

146 c mutational bias and ultimately leads to an unusual level of microstructural plasticity, raising the

147 t ADAMTS17 has unique characteristics and an unusual life cycle.

148 troduces deep sea hydrothermal vents and the unusual life forms they host.

149 ed to their environmental niches and produce unusual lipids and energy storage compounds.

150 Other interesting observations include unusual localization of ceramides on the endosperm/scute

151 r affinity; its crystal structure reveals an unusual locked rod-shaped array.

152 lation of these events requires formation of unusual, long-range mammalian-specific RNA duplexes.

153 However, unusual low energy transitions originate from Baird 4npi

154 Focus has naturally been drawn to the unusual magnetic orders that hint at the underlying spin

155 peratures below this resistivity minimum, an unusual magnetoresistance which is negative at low field

156 major part of the stability arises from the unusual match between residue-level PP2 dihedral angle b

157 at have been invoked in the context of these unusual materials.

158 are of great research interest due to their unusual mechanical responses and a wide range of potenti

159 wth-differentiation factor 11 (GDF11) and an unusual mechanism of its inactivation in TNBC.

160 ve neoplasms.Deep penetrating nevi (DPN) are unusual melanocytic neoplasms with unknown genetic drive

161 In this paper, nanoparticle-induced unusual melting and solidification behaviours of metals

162 The discovery of the unusual melting and solidification of materials that con

163 Unusual meningococcal strains with low level of virulenc

164 cently labeled mensacarcin together with its unusual metabolic effects in melanoma cells provide evid

165 Unusual metallic states involving breakdown of the stand

166 lution over eastern China is associated with unusual meteorological conditions, including weaker wind

167 lves, besides the triazole ring opening, the unusual migration of the cyano group.

168 The unusual mix of morphological traits displayed by extinct

169 ), provided important insights into Braque's unusual mixed paint media that are also helpful to infor

170 The reaction provided an unusual mode for cyclization as sodium sulfide, a soft n

171 he master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.

172 thetic strategies that may capitalize on the unusual molecular environment provided by liquid crystal

173 aces absent from the other SMC complexes; an unusual 'molecular latch' and a functional 'hub'.

174 These structures reveal that an unusual monodentate Zn(2+) coordination mode is exploite

175 urassic eleutherodontid mammaliaform with an unusual mosaic of highly specialized characteristics, an

176 This case is interesting due to an unusual MRI appearance of AH, presenting as a solid-cyst

177 The unusual nature of this protein-RNA interaction provides

178 These unusual negative velocity events correspond to vortices

179 We describe an unusual net [2+2] cycloaddition reaction between boron a

180 The unusual Ni(IV) oxido species is stabilized within a dinu

181 e (FeSe) is of intense interest owing to its unusual nonmagnetic nematic state and potential for high

182 pear to converge to a state that contains an unusual number of chromosomes when they are grown in cul

183 ondrial DNA loci allowed us to recognize the unusual NumtS evolution that acted differently on primat

184 d tricistronic messages along the genome, an unusual occurrence for large dsDNA viruses.IMPORTANCE Un

185 tructural features which could cause such an unusual occurrence revealed a positively charged lysine

186 Herein we delineate an unusual one-dimensional coordination polymer (CP), 3, pr

187 eco-Triterpenoids are characterized by their unusual open C-ring.

188 atic loop for substrate guidance and have an unusual open-access copper site, yet they can still reac

189 The crescents are highly unusual, open-ended membranes, and their origin and biog

190 omic next generation sequencing can identify unusual or novel microbes and is therefore well suited f

191 n to be a versatile approach to achieve such unusual outcomes relying on materials with highly anisot

192 oporphyrins are known to stabilize metals in unusual oxidation states such as Cu and Ni in +1 oxidati

193 ncreased maternal behavior and also promoted unusual paternal care in rats, as measured by pup-retrie

194 teeth, including cementocyte-like cells and unusual patterns of cementum resorption and repair.

195 atients; atypical lesions were more commonly unusual PC metastases (1.0%) or benign (3.1%).

196 fungus Hymenochaete rubiginosa, produced an unusual peptide, tryptorubin A, which contains heteroaro

197 sly studied selective KOP-r antagonists have unusual pharmacodynamic and pharmacokinetic properties (

198 in-targeted oligonucleotides has highlighted unusual pharmacokinetic and pharmacodynamic properties o

199 CRF01_AE HIV-1 strains have an unusual Phe 43 cavity-filling His 375 residue, which inc

200 Here we show an unusual phenomenon that tin (Sn) microparticles with bot

201 ive agent of human malaria, induces a highly unusual phenotype by which DCs up-regulate costimulatory

202 d and quantitative description of a range of unusual physical responses in the normal state.

203 These results show that this unusual physiological phenomenon, in which D2Rs enhance

204 We report a new, highly unusual pliosaurid from the Early Cretaceous of Russia t

205 This unusual poise enables gradual post-translational regulat

206 xtended by the preparation of six additional unusual polyheterocyclic frameworks.

207 A necessary condition for the unusual positive temperature dependence is identified, n

208 alpha subunit of MCR (McrA) contains several unusual post-translational modifications, including a ra

209 ly spliced OsPCS2b transcript that bears the unusual premature termination codon besides the canonica

210 The most commonly held view of this unusual process posits that under prolonged ATP exposure

211 This unusual process significantly increased the complexity o

212 not only leads to new understandings of the unusual properties discovered in this family of compound

213 We explore the stability and unusual properties of both phases, demonstrating mechani

214 The fascinating and unusual properties of this 2D material were indeed recen

215 The proposed cellular metamaterial exhibits unusual properties some of which stemming from the inher

216 f novel mechanical metamaterials with unique/unusual properties such as strongly directional behaviou

217 first known magnetic mineral, magnetite, has unusual properties, which have fascinated mankind for ce

218 s have given reasons for their stability and unusual properties.

219 Interestingly, the products show unusual pseudomigration of the substituent on the arene

220 Searching for new states of matter and unusual quasi-particles in emerging materials and especi

221 The scope of this unusual reaction has been investigated.

222 acyl carrier protein, are classified so that unusual reactions can be compared and underlying assembl

223 two unstable intermediates and a sequence of unusual reactions.

224 Unexpected and unusual reactivity of 2-methylimidazolium salts toward a

225 TUBB2B mutation described here represents an unusual recessive mode of inheritance for missense-media

226 of triplet energy transfer and explained the unusual regiocontrol.

227 The alpha-angelica lactone displays unusual regioselectivity in this reaction, acting as a n

228 unusual transcriptional profile but also by unusual regulation of protein levels through the proteas

229 This unusual regulation was mediated by Ca(2+)/CaM binding to

230 tudy, we sought to find the reasons for this unusual replacement event.

231 Two classes of explanation for this unusual requirement are (1) recycling models, in which t

232 expressed in an unbiased manner, due to the unusual retention of a W-linked copy.

233 Our results shed light on the unusual role of zeroth LLl mode in transport.The transpo

234 transmission electron microscopy, we report unusual room-temperature super-elongation without soften

235 , and contains unique features, including an unusual rotating intracellular structure of unknown func

236 cently published the crystal structure of an unusual (S)P species [(MeAN)2Cu(II)2(O2(2-))](2+) ((S)P(

237 The unusual secondary structure of 1 was confirmed by spectr

238 Unusual selective/preferential transport of Li ions is d

239 This highly unusual selectivity relies on a phospholane-phosphite li

240 s display structural asymmetry and that this unusual self-association mechanism is conserved from fli

241 zolidinone in THF-hydrocarbon mixtures shows unusual sensitivity to the choice of hydrocarbon cosolve

242 Synaesthesia is defined by unusual sensory experiences and has also been linked to

243 Hidden orthologs do not show unusual sequence composition biases that might account f

244 An unusual set of Francisella regulators-the heteromeric ma

245 Atg17 complexes to the yeast PAS, and their unusual shape.

246 anochemical reaction in a ball mill exhibits unusual sigmoidal feedback kinetics that differ dramatic

247 We discovered highly unusual signals, including a column of scattering over a

248 eatment on Campylobacter populations in this unusual situation of long-term colonization of an indivi

249 s known about its ecology and behaviour, but unusual specialisations of visual pigments [1], mitochon

250 This unusual spectral feature is associated with photoconvers

251 In this paper, we study the origin of the unusual spin structure of the spinel CoV2O4, which stand

252 lization group analysis, we propose that the unusual spin-valley locking in hole-doped TMDs together

253 dynamic simulations (SMD), we found that the unusual stability of pseudoknotted element H4a/Psi3 requ

254 The unusual stability of these trianions opens the door to a

255 ets, providing a new tool to understand this unusual state.

256 plex multi-Q magnetic ground states, hosting unusual states such as chiral density waves and quantum

257 This signals a new chapter in the long and unusual story of GO, which was the first antibody-drug c

258 ducting axons of gerbils that also exhibited unusual structural adaptations in axon myelination for i

259 Overall, our results reveal an unusual structural and thermodynamic basis for the P2204

260 G4 conformations in vitro, all of which bear unusual structural features: Form 1 bears a V-shaped loo

261 il to accurately predict tRNASec, due to its unusual structural fold.

262 usly unreported crystal structures featuring unusual structural motifs.

263 ve attracted great interest because of their unusual structural, chemical, electronic, and magnetic p

264 The unusual structure of these complexes provides a rational

265 sight gained to explain the formation of the unusual structure of zeolite IPC-6.

266 and cryotomography reconstructions reveal an unusual structure that has 42 turret-like projections: 1

267 Given its unusual structure, we investigated the biophysical prope

268 rinary exosomes and profiled, revealing some unusual structures.

269 Despite the unusual study design, with all its limitations, our obse

270 The lissoclimides are unusual succinimide-containing labdane diterpenoids that

271 owever, the catalytic mechanism of this very unusual sulfur-sacrificing reaction remains elusive.

272 Michael Gross rounds up some unusual suspects.

273 omplished from (S)-acetoxysuccinimide via an unusual syn-addition of cuprate to the alpha,beta-unsatu

274 ldehyde and reduces the pyrazine ring via an unusual tautomerizing demethylation reaction.

275 rature, is found necessary for occurrence of unusual temperature dependence.

276 m Strychnos mattogrossensis that contains an unusual tetrahydrofuran ring with a concomitant hemiacet

277 ns form helical dimers that assemble into an unusual tetramer.

278 ivari violins, but not his cellos, exhibited unusual thermooxidation patterns distinct from natural w

279 y), P6 (suspiciousness/persecution), and G9 (unusual thought content), and a total PANSS score greate

280 ; ND individuals were more likely to exhibit unusual thoughts, persecutory ideas, and bizarre thinkin

281 for biomedical text mining, where it is not unusual to find entities labeled by a wide range of diff

282 Their density distribution reveals an unusual topographic organization of a temporal (2,000 ce

283 als, CdSe/CdS core/arm tetrapods exhibit the unusual trait of two-colour (red and green) multiexciton

284 tem cell state is established not only by an unusual transcriptional profile but also by unusual regu

285 ontains a non-canonical CTD to accomplish an unusual transcriptional program; all protein-coding gene

286 Moreover, the co-option of these unusual transcripts into newly born genes seems likely.

287 These unusual transformations involving a (kappa(2) -P,N)Pt(et

288 These experiments define a highly unusual transmembrane topology for the astrotactins, rev

289 PtNTT5, with its unusual transport properties, phylogeny and localization

290 ((i)PrNPPh2)3Fe-PMe3 (6), a compound with an unusual trigonal pyramidal geometry at a Nb(III) center,

291 Carcinosarcomas are unusual tumors that are commonly gynecologic in origin,

292 ow ionic current activation kinetics, and an unusual underlying biphasic gating charge movement with

293 CI 1.13-3.60) to 3.85% (2.37-5.33), with no unusual variation from the adjusted national incidence o

294 We hypothesize that this unusual viral envelope structure results from the extrem

295 Abs) have been shown to occasionally display unusual virus neutralization profiles with nonsigmoidal

296 The emergence of unusual visible PL behavior is associated with the serio

297 The channel has an unusual voltage-sensor-like domain, accounting for its d

298 Mosquitoes exhibit unusual wing kinematics; their long, slender wings flap

299 TIPRL also makes unusual wobble contacts with the scaffold subunit, allow

300 fferent helical conformations, including the unusual Z-conformation.