ライフサイエンスコーパス: unusually

1 Here we show that Cerox1, an unusually abundant cytoplasmic long noncoding RNA (lncRN

2 nder a wide variety of conditions results in unusually abundant gaseous octamer clusters that exhibit

3 eral cases in which particular homologs were unusually amenable to structure recovery in folding simu

4 Phosphonates are rare and unusually bioactive natural products.

5 Mountain regions are unusually biodiverse, with rich aggregations of small-ra

6 aches, we find evidence for a functional and unusually blue-shifted rhodopsin that is expressed in sm

7 eutralizers, i.e., individuals who developed unusually broad and potent neutralizing antibody respons

8 and spectral shape of the continuum band, an unusually broad band extending from 2,300 to well below

9 t the quasicrystalline phase forms across an unusually broad composition range in the Al-Cu-Fe-Cr sys

10 High sensitivity and an unusually broad dynamic range should enable mGluR2/7 to

11 acterized by high DNAse hypersensitivity and unusually broad H3K4me3 signal.

12 l lineages, which may in part underlie their unusually broad phylogenetic distribution.

13 The unusually broad physical and chemical property window of

14 in Micromonospora griseorubida possesses an unusually broad substrate scope, whereas the homologous

15 nged life span relative to its body size, is unusually cancer resistant, and manifests few physiologi

16 tains a multicopper oxidase (MCO) MnxG that, unusually, catalyzes the two-electron oxidation of Mn(II

17 Sequence analysis of the EBV genome is unusually challenging because of the large number and le

18 l-colony variants (SCVs) are associated with unusually chronic and persistent infections despite acti

19 that it is a dimeric flavocytochrome with an unusually close interaction between the heme and the FAD

20 ected remote places with few people that are unusually cold or dry or both.

21 g-wave radiative cooling efficiency, causing unusually cold temperatures 2-6 years post-equinox.

22 of the central regulatory region reveals an unusually compact tetratricopeptide repeat (TPR) region

23 atigraphic section in Colorado that contains unusually complete fossils of mammals, reptiles, and pla

24 iron porphyrin-catalyzed ORR and provides an unusually complete mechanistic study of an ORR reaction.

25 y, LeBlanc and co-workers have discovered an unusually complex dentition in a fossil relative of the

26 Compared with other mammals, humans have an unusually complex social life.

27 o be especially impactful when perception is unusually confounding.

28 This structural motif is unusually consistent across all species from all geologi

29 e 2013-14 summer at Lizard Island, which was unusually cool and 0.5 degrees C less than the long-term

30 Unusually, dehydrogenation occurs by water loss.

31 ped in the nanosecond spectra, indicating an unusually delayed formation.

32 The yeast genome displays unusually dense transcript spacing, with interleaved and

33 nt that cell killing by PAF26 is complex and unusually dependent on extracellular Ca(2+) and componen

34 itors to bind to a previously unreported and unusually disordered conformation of the IRE1alpha kinas

35 ny and structural and functional roles of an unusually diverse group of GH1-containing proteins in pl

36 Mechanistic studies revealed that unusually double beta-F eliminations and fluorine effect

37 This creates a unique and unusually dynamic symmetry-mismatched vertex that is cen

38 ogen and plant symbiont), that renders it an unusually effective model for studying genetic mechanism

39 The unusually efficient hole transfer coupling of a molecula

40 ncillary ligands that render the uranium ion unusually electron rich.

41 Southern Africa is characterised by unusually elevated topography and abnormal heat flow.

42 Of interest are unusually emissive pai-conjugated enamines containing a

43 vents are highly dynamic ecosystems and are unusually energy rich in the deep-sea.

44 ulted in a reduction in metabolic stability; unusually, enzyme-mediated oxidation was found to take p

45 binds in the substrate-binding pocket, with unusually extensive interactions with the cofactor S-ade

46 Unusually fast His37 protonation was observed (2.0 x 10(

47 so a high iodine (I(2)) uptake capacity with unusually fast kinetics, the fastest among reported poro

48 lective butenolide coupling that exhibits an unusually fast rate of C-C bond formation driven by exqu

49 We show that a large and unusually flexible interface enables this interaction to

50 As shown previously and unusually for actin-like filaments, the MamK subunits fr

51 e characteristic of head-tailed viruses and, unusually for archaeal and bacterial viruses, a nearly c

52 reover, we show that this transformation is, unusually for RiPP biogenesis, largely insensitive to pe

53 Unusually, HA was retained on the surface of high-eIF4E

54 Unusually, herpesviruses have evolved a complex mechanis

55 the transition state, is responsible for the unusually high ( approximately 5 years) reaction half-li

56 We anticipate that these unusually high activities, despite still being too low f

57 engths (0-500mMNaCl), but it also reveals an unusually high activity and stability under alkaline con

58 structural adaptation of NamPT, providing an unusually high affinity toward Nam, necessary to maintai

59 ed NMDA receptors and that bind glycine with unusually high affinity.

60 We detected unusually high amount of shared identical-by-descent (IB

61 Importantly, some compounds exhibited unusually high antisickling activity despite moderate ef

62 We found that Ubc6 has an unusually high basal activity that does not require stro

63 ve blue-green bones and other tissues due to unusually high biliverdin concentrations-a phenomenon ca

64 of the APOE3 Christchurch (R136S) mutation, unusually high brain amyloid levels and limited tau and

65 (e.g., Rh/ReOx, Rh/MoOx, Ir/VOx) demonstrate unusually high C-O scission activity at moderate tempera

66 on between carbon fiber and CO2 molecule for unusually high CO2 uptake and resistive sensing.

67 sterone and androstenedione were measured in unusually high concentrations (1.6-12 and 7.8-40 ng/g we

68 In the tumor microenvironment, unusually high concentrations of extracellular adenosine

69 ison exons are likely to contribute to their unusually high conservation and contrast with the dispen

70 However, unusually high contact resistance has been observed acro

71 erived from HS oligosaccharides, we found an unusually high content of GlcN residue in a recently pur

72 alyze sequences of spidroin NTDs and find an unusually high content of the amino acid methionine.

73 aying surprising water and air-tolerance and unusually high coupling rates in dilute conditions.

74 and theoretical studies suggested that this unusually high degree of catenation stems from the secon

75 t generates the toxin mycolactone display an unusually high degree of sequence similarity, implying t

76 tal hearts are unexpectedly asymmetric, with unusually high dGTP and GTP levels compared with those i

77 Our results reveal an unusually high diversity of floral volatiles among popul

78 structural features, all orthologs share the unusually high DNA binding affinities and low catalytic

79 arge microcrystals up to 200 mum across show unusually high emission that is not observed for limited

80 heir chemical stability, predictability, and unusually high excitation-emission differential.

81 nuclear speckles, with chromosome regions of unusually high expression located at the apex of chromos

82 T conv cells had unusually high expression of PD-1 and the IL-33 receptor

83 ingers palpation technique was noted to have unusually high failure rates.

84 birthdates called for induction appear with unusually high frequency among employees who were draft

85 record in Europe and was associated with an unusually high frequency of reassortments between H5 HPA

86 ates by synthesizing novel polyhydrides with unusually high hydrogen-to-metal ratios.

87 One explanation may be an unusually high level of convergent and parallel evolutio

88 We suggest that despite the unusually high levels of ANXA5 in bundles, it does not p

89 Human and mouse HSCs had unusually high levels of ascorbate, which decreased with

90 Since 2015 both lineages have shown unusually high levels of epidemic activity, the reasons

91 the appearance of outliers; rare cells with unusually high levels of sasA expression, having increas

92 rmations, which allows for the generation of unusually high levels of the cis-isomer by irradiation w

93 Also identified in two samples displaying unusually high lytic gene expression was a novel rLCV ci

94 mmonia levels, is always acidic even for the unusually high NH3 levels found in Beijing (pH = 4.5) an

95 It possesses both unusually high nucleotide incorporation rates and high-e

96 peculiar core oligosaccharide composed of an unusually high number of hexuronic acids containing beta

97 Mycobacterium tuberculosis genome harbors an unusually high number of toxin-antitoxin (TA) systems.

98 tasis in evolution has resulted in taxa with unusually high numbers of primitive characters.

99 This unusually high occupancy was verified experimentally, th

100 The atomic-scale origin of the unusually high performance and long-term stability of wu

101 from other leptosporangiate ferns, achieving unusually high photosynthetic capacities through amphibi

102 d, intrinsically disordered polypeptide with unusually high polyproline type II helix propensity.

103 HA-IV subgroups appeared in 2015 and 2017 in unusually high proportions (13.1% and 14.4%, respectivel

104 sidue at the protein surface that imparts an unusually high quantum yield of photoreduction.

105 Replication forks also appear to stall at an unusually high rate throughout schizogony.

106 at pluripotent stem cells are not subject to unusually high rates of genetic or epigenetic alteration

107 Unusually high rates of Plasmodium sporozoite infections

108 ain the gigantism of the double coconut than unusually high rates of seed size increase.

109 transcription factor overexpression induces unusually high rates of transcription and that sustainin

110 s demonstrate that light-weight materials of unusually high resistance to structural damage from shoc

111 control of constitutive signaling, and their unusually high resolution enabled a structure-based camp

112 th a differential mobility analyzer (DMA) of unusually high resolution.

113 ensity in all RLFS-positive genomes revealed unusually high RLFS densities in herpesvirus genomes, wi

114 ttributed to wind changes associated with an unusually high sea level pressure (SLP) pattern over the

115 these bimetallic electrocatalysts exhibit an unusually high selectivity for the formation of multi-ca

116 DFT calculations suggest an explanation for unusually high stereoselectivity.

117 The recent observation of unusually high thermal conductivity exceeding 1000 W m(-

118 congenital Zika syndrome retrospectively by unusually high ZIKV-specific antibody titers.

119 Here, we leverage the unusually high Zn(II) concentration in beta-cells to dev

120 tion entropy for ion transport, but manifest unusually high, liquidlike ionic conductivities (e.g., 1

121 The structure further revealed an unusually hinged 2-subdomain arrangement.

122 al dichalcogenide (2D TMD) layers present an unusually ideal combination of excellent opto-electrical

123 at this struggle occurred during a period of unusually inclement weather, famine, and disease in the

124 ha/beta receptor 1 (IFNAR1) and IFNAR2, but, unusually, it had a preference for IFNAR1.

125 Here we describe an unusually large amber specimen attached to a Prosaurolop

126 is that they produce and continually degrade unusually large amounts of abnormal immunoglobulins.

127 ents, hypothyroidism has been ameliorated by unusually large amounts of dietary I(-).

128 The nucleus of oocytes (germinal vesicle) is unusually large and its nuclear envelope (NE) is densely

129 g phenomena such as chiral magnetic effects, unusually large anomalous Hall effect and quantum anomal

130 On the other hand, an unusually large bathochromic shift is observed in CT ban

131 enhanced pi-pi stacking in the solid state, unusually large blue-shifts in the absorbance and emissi

132 The forest was an unusually large carbon source during the same period.

133 rn humans live in an "exploded" network with unusually large circles of trust that form due to prosoc

134 Ca(2+)-activated K(+) channel, Slo1, has an unusually large conductance and contains a voltage senso

135 y analyzing time series data contained in an unusually large dataset of rivalry state durations assoc

136 f the QBS is found to be 0.2206 eV, which is unusually large due to strong correlation and polarizati

137 stand out among RNA viruses because of their unusually large genomes ( approximately 30 kb) associate

138 There is growing evidence that phages with unusually large genomes are common across various microb

139 ing (three to 24 individuals, 4.1%) and nine unusually large mass stranding events (>25 individuals,

140 observation of hexagonal Moire patterns with unusually large micrometer-sized lateral areas (up to ~1

141 und that the WNV frameshift signal formed an unusually large number of different metastable structure

142 H. pylori has an unusually large number of DNA methyltransferases (MTases

143 /Starmerella (W/S) clade, known to harbor an unusually large number of genes of alien origin.

144 as established in response to a report of an unusually large number of paediatric HIV diagnoses in La

145 Unusually large outbreaks of mumps across the United Sta

146 We found that HLA-DQ2.5 has an unusually large P4 pocket and a positively charged pepti

147 the SO species are partly explained by their unusually large photosynthetic antennae, which are among

148 The presence of unusually large proteins predicted to function in attach

149 The unusually large rain event, combined with the extensive

150 spatial frequency patterns presented over an unusually large receptive field: could this cell be a (d

151 Mycobacterium tuberculosis possesses an unusually large representation of type II toxin-antitoxi

152 up to 2.45 m at the channel margin), causing unusually large retreat rates of several sections of the

153 The results reveal that the crystals have an unusually large semigap of ~16 eV and a specific band na

154 The unusually large semigap rationalizes extremely long life

155 The results agree with the unusually large set of equilibrium and nonequilibrium ex

156 Phonon interference patterns with unusually large signal amplitudes have been revealed by

157 Here we exploit the unusually large size of Arabidopsis peroxisomes to demon

158 l desiccation tolerance-promoting sugars and unusually large stores of palmitate.

159 tions indicate that effect sizes need not be unusually large to produce the observed burden.

160 Unusually large von Willebrand factor (VWF), the first r

161 y can reproduce the recent observation of an unusually large zero-energy peak in a superconductor int

162 studies have shown that these fields can be unusually large, but it has been unclear to what extent

163 vered in a patient with Pierson syndrome and unusually late onset of proteinuria.

164 Here, we investigated the role of an unusually located and highly conserved glutamic acid (Gl

165 G's dominant fluorescence lifetime in DNA is unusually long (9-29 ns), facilitating its selective mea

166 stingly, we also identified and validated an unusually long 16-mer epitope peptide restricted by A*02

167 We demonstrate that ATXN1's unusually long 5' untranslated region (5' UTR) negativel

168 ther eukaryotes, P. vivax genes tend to have unusually long 5' untranslated regions and also present

169 'conditionally hyperdependent' mRNAs contain unusually long 5'-UTRs with heightened propensity for se

170 They also contain unusually long and highly hydrophobic segments which pos

171 Several microscopic mechanisms behind the unusually long carrier lifetime have been proposed, such

172 bout a quarter of large clonal lineages with unusually long CDR3s are generated through tandem fusion

173 odomain in complex with AR3X, a bNAb with an unusually long CDRH2 that was isolated from the chronica

174 periods of anomalous poleward flow, and the unusually long duration of heatwave events.

175 Most bacterial CRISPR array transcripts are unusually long for untranslated RNA, suggesting the exis

176 the Bill & Melinda Gates Foundation made an unusually long funding commitment toward a surveillance

177 long noncoding RNA MALAT1 is dependent on an unusually long intramolecular triple helix.

178 Responding with an unusually long latency to light stimulation, OND RGCs re

179 Their unusually long lifespan predisposes neurons to neurodege

180 ter display light-green phosphorescence with unusually long lifetimes and circular polarization that

181 rseshoe-like hydrophobic pocket formed by an unusually long loop.

182 h Methylorubrum extorquens and identified an unusually long polyglutamate side chain of up to 24 glut

183 x of the HIV-1 envelope (Env) trimer feature unusually long protruding loops, which enable them to pe

184 EL-irradiated ferredoxin microcrystals using unusually long pulses of 80 fs.

185 d how this influences T(1) and T(m) and show unusually long relaxation times given that the ligand sh

186 um half-life in vivo by taking advantages of unusually long serum half-life of human serum albumin (H

187 can be linked to charge distribution in the unusually long targeting sequence of YME1L.

188 nutrients from the plant apoplast during an unusually long-lasting biotrophic stage.

189 itant with photoconversion of the flavin, an unusually long-lived tyrosyl radical with a red-shifted

190 Patient lymphocyte telomeres were unusually long.

191 antioselectivity levels (up to 97% ee) at an unusually low 0.2 mol % catalyst loading.

192 n of methyl allenyl ether is associated with unusually low activation barriers.

193 n, there is a decline in cellular [ATP]; the unusually low affinity of IP6Ks for ATP compels 5-InsP7

194 We found sequence-encoded regions of unusually low bendability within nucleosome-depleted reg

195 Viral genome analysis indicates unusually low CpG dinucleotide depletion in KYAV compare

196 vealed orthosteric fragment 5a to express an unusually low D(3)R affinity ( K(i) = 2.7 muM).

197 from previously established mechanisms, the unusually low electronic thermal conductivity is a signa

198 ommon compounds where the metal atoms are in unusually low formal oxidation states.

199 ial spinel NiZnAl-ferrite thin films with an unusually low Gilbert damping parameter (<3 x 10(-3) ),

200 ity = 97.5%); the warfarin arm maintained an unusually low ischemic stroke rate (0.73%).

201 studies reveal that the alkylated Fe has an unusually low isomer shift, which reflects the highly co

202 tiles, birds grow extremely fast and possess unusually low levels of intraspecific variation during p

203 ent cortical TBR1 ChIP-seq peaks also showed unusually low levels of LoF mutations in a reference hum

204 ors and identified a subset of NK cells with unusually low levels of these two kinases.

205 he Fe-hydride in Hhyd was demonstrated by an unusually low Mossbauer isomer shift of the distal Fe of

206 ) distances, while the FT-IR spectra show an unusually low N-N stretching frequency (2019 cm(-1)), su

207 t hematopoietic stem cells (HSCs) exhibit an unusually low rate of protein synthesis relative to othe

208 An unusually low rate of vesicular transport (transcytosis)

209 Here, we demonstrate unusually low sensitivity of a 1.14 mum inner-shell cloc

210 emonstrate that the gel (lbeta) domains have unusually low structural integrity in the three-phase re

211 ained genomic regions are those that have an unusually low variant count in the general population.

212 , in nearly solid-body rotation, exhibits an unusually low vertical vorticity close to the local iner

213 ion of 2009-2010, when acoustic presence was unusually low, the mean percent of hours in which up-cal

214 es that we detected in caterpillar guts were unusually low-density and variable among individuals.

215 de HD149026b(3), which is thought to have an unusually massive core, and recent discoveries such as L

216 These reagents promote an unusually mild carboxylate-assisted oxidative addition t

217 Here, we report the unusually mild thermally induced oxidative cyclodehydrog

218 An unusually nonplanar, ruffled structure that had been sus

219 th other ParE/RelE superfamily TAs, but more unusually occurring as a multiplicity of species-specifi

220 convincing explanation for the origin of the unusually old zircons is yet to surface, however, an upd

221 OD counterparts, contains a copper co-factor unusually open to solvent and lacks zinc for stabilizing

222 This unusually persistent silencing enables a detailed molecu

223 BlMINPP has a typical HP2P-fold but, unusually, possesses a large alpha-domain polypeptide in

224 I150V variant was less soluble and exhibited unusually prolonged protein stability, which suggests th

225 All subjects had radiographic evidence of unusually protruding cervical root morphology in primary

226 xtended to viscous liquids, also known to be unusually quick on these materials.

227 bility below 500 parts per million, which is unusually quiet for a red dwarf.

228 e that resident memory T cells (TRM) undergo unusually rapid attrition within the lung.

229 imals, including flies, fish and frogs, have unusually rapid cell cycles and delayed onset of transcr

230 3 with approximately 35% alpha-helix and are unusually resistant to proteolysis.

231 What is special about B. subtilis is the unusually rich repertoire of alternative states exhibite

232 sion spectroscopy measurements have shown an unusually robust linear dispersion (up to [Formula: see

233 athogens, hard to eradicate because of their unusually robust resistance to antibiotics, disinfectant

234 Pneumococcal growth with hemoglobin was unusually robust, exhibiting a prolonged logarithmic gro

235 Here, we characterize the unusually rugged folding energy landscape of human immun

236 y, we identified an HIV-1 CA variant that is unusually sensitive to IFNs.

237 Adaptations in nCa(V) confer unusually sensitive, voltage-dependent inactivation to i

238 ne with the model predictions, the result is unusually severe levels of intergroup violence.

239 equire ad hoc postprocessing, especially for unusually shaped particles.

240 ive rates, is capable of picking challenging unusually shaped proteins (for example, small, non-globu

241 with an equally small catalytic motif and an unusually short binding arm.

242 and V-D systems lack the cas2 gene and have unusually short CRISPR repeats and spacers.

243 nto two photons (gammagamma), leading to its unusually short lifetime.

244 8 has an intact DYW domain, but possesses an unusually short PLS repeat region of only five repeats.

245 s in trials in which their reaction time was unusually short.

246 nticity have been queried, showing some have unusually similar compositions to other VCs.

247 for both NCBDT- and NFBDT-based systems, an unusually slow ( approximately 400 ps) but ultimately ef

248 Our results showed that CXCL12 binding is unusually slow and driven by the interplay between multi

249 activity and provide an explanation for the unusually slow DDR1 activation kinetics.

250 Indeed, unusually slow psychomotor speed, a measure predictive o

251 ay be used when the response to treatment is unusually slow.

252 icrometers is also not detected, implying an unusually small amount of neutral gas.

253 These results, together with the unusually small electric polarization, its strong magnet

254 y two residues in the HCDR3 region, which is unusually small for an antibody-antigen interaction.

255 xhibit a distinctive architecture wherein an unusually small ligand-sensing aptamer is almost entirel

256 The Mossbauer parameters for 1-O include an unusually small quadrupole splitting for a triplet Fe(IV

257 gyria and in which the brain surface appears unusually smooth.

258 C.neoformans Dnmt5 is an unusually specific maintenance-type CpG methyltransferas

259 pithelial cells resulted in the formation of unusually stable and mature focal adhesions that resiste

260 intracellular parasite Toxoplasma gondii has unusually stable cortical microtubules beneath the alveo

261 nsfer, results in a construct that yields an unusually stable Fe(IV)=O porphyrin at the peroxidatic h

262 xygen at high affinity to reversibly form an unusually stable mu-peroxo adduct.

263 FlgE proteins, which in spirochaetes form an unusually stable, high-molecular-weight complex(9,12-17)

264 This causes them to be unusually stiff.

265 s, but only brain enhancers show evidence of unusually stringent purifying selection.

266 ions and XAFS spectroscopy to understand the unusually strong and selective binding of V by polyamido

267 ino (EN) event was stalled as a result of an unusually strong basin-wide easterly wind burst in June,

268 es like [Formula: see text] Consequently the unusually strong but geologically brief duration of mode

269 The D18 polymer shows unusually strong chain extension and excellent backbone

270 putative inhibitory neurons, which displayed unusually strong coupling to local field potential even

271 istal pyramidal neuron dendrites, provide an unusually strong excitatory drive at the soma of CA2 pyr

272 Although previous studies have shown unusually strong linkage disequilibrium for the sex chro

273 uencing data, we identified 1118 genes under unusually strong negative selection, which tend to be ex

274 rrier densities points to the presence of an unusually strong pairing interaction that has eluded und

275 s in bulk translation, and few genes display unusually strong requirements for both factors.

276 positive selection by identifying loci with unusually strong shared ancestry and detect 12 genome-wi

277 r is kinetically dominant as a result of the unusually strong steric barrier to oxygen rebound to the

278 untries reveal that the US CVD stagnation is unusually strong, contributing to a stark mortality dive

279 Unusually, stronger methyl C-H bonds are borylated prefe

280 The acutely bent VA-I features an unusually structured apical loop, a wobble-enriched, coa

281 he hippocampal epileptiform activity appears unusually susceptible to drugs that impact on K(+) condu

282 Unusually, T. brucei uses RNA polymerase I (Pol I) to tr

283 Unusually, the nematic director is not aligned with the

284 Unusually, the top 3 hits all contained stop codons in t

285 In vitro, R406W-desmin formed unusually thick filaments that organized into complex fi

286 ntially no calving, and was buttressed by an unusually thick melange wedge that increased in thicknes

287 um metaborate to lithium carbonate, produces unusually thin walled CNTs uniform (22-42 nm diameter) C

288 o transform the greenhouse gas CO(2) into an unusually thin walled, smaller diameter morphology of Ca

289 Secondary resistance was mediated, unusually, through two different pairs of cooperative mu

290 Interestingly, this interaction was unusually tight ( approximately 260 nm) for an Hsp70-cli

291 he human fungal pathogen Candida albicans is unusually unstable, suggesting that the process of nucle

292 rt a diversified lysozyme, DslA, which acts, unusually, upon (GlcNAc-) deacetylated peptidoglycan.

293 body size and latitude, moderate impacts of unusually warm or cool temperatures on disease.

294 pectrum disorder, as well as 773 genes under unusually weak selection, which tend to be associated wi

295 ever, on Dongsha Atoll, in the northern SCS, unusually weak winds created low-flow conditions that am

296 e, cyclo-(VVGGVG) or P7, was predicted to be unusually well structured.

297 Here, we observe unusually well-defined Kondo resonances in magnetic mole

298 ng the 2 y period following the eruption and unusually wet conditions.

299 ve interaction with D2 is facilitated by the unusually wide D1-D2 interdomain angle in OSCAR.

300 6)Ru ratio indicates that the spent fuel was unusually young with respect to typical reprocessing pro