ライフサイエンスコーパス: unusually high

1 Median age was unusually high (11.5 years) compared with that in histor

2 In fact, 566 rice genomic regions had unusually high (328 contigs/48.6 Mb/13.6% of genome) or

3 n approximately 35-kb circular DNA genome of unusually high A/T content (>86%) that is replicated by

4 We hypothesized that the mobilities of unusually high absolute values are caused by the cross-l

5 We anticipate that these unusually high activities, despite still being too low f

6 engths (0-500mMNaCl), but it also reveals an unusually high activity and stability under alkaline con

7 2 (BIN1) Src homology-3 (SH3) domain with an unusually high affinity (Kd 24 nm).

8 -binding motif PxxxPR, which is required for unusually high affinity binding.

9 The alphaX ligand binding domain has an unusually high affinity for carboxyl groups, with KD at

10 ndicated that A. fulgidus RbcL2 possesses an unusually high affinity for oxygen (Ki=5 microM); O2 is

11 In addition, AS8 exhibits an unusually high affinity for the 16S ribosomal RNA, chara

12 of the Acm1 degron sequences results from an unusually high affinity interaction with the substrate r

13 In particular, the unusually high affinity of marine and terrestrial AOA fo

14 We propose that the unusually high affinity of O1 and O4 to their targets in

15 trast, the second LIP5 MIT module binds with unusually high affinity to a novel MIM element within th

16 ed NMDA receptors and that bind glycine with unusually high affinity.

17 ith water ice particles, it accounts for the unusually high albedos of the other satellites orbiting

18 s Shale-type deposits, and resulted from the unusually high alkalinity of Cambrian oceans.

19 r on gels ( approximately 60 kDa) due to the unusually high amount of bound negatively charged dye, w

20 elin membrane, which ensheaths axons, has an unusually high amount of cholesterol.

21 We detected unusually high amount of shared identical-by-descent (IB

22 Diversity was unusually high and the time to the most recent common an

23 ng 5 cases of debilitating neuropathy and an unusually high angioedema rate.

24 the transition state, is responsible for the unusually high ( approximately 5 years) reaction half-li

25 Finally, we observed unusually high association rate constants for the intera

26 Activity with dihydropterin-6-aldehyde was unusually high at 0 degrees C.

27 l model for OR promoter recognition in which unusually high AT content, a unique epigenetic signature

28 r contrast to homologous AAA domains, has an unusually high ATPase activity and forms a hexamer in so

29 promoter fragments 0.9-6.2 kb long exhibited unusually high basal promoter activity when transfected

30 ecting extra-large zeolites because of their unusually high basicity combined with their large size a

31 not only binds in the groove but also has an unusually high binding constant in SPR experiments (2.9

32 and stereochemical diversity, exhibiting an unusually high bond-forming efficiency as well as high s

33 However, there are unusually high bone marrow transplant (BMT) rejection ra

34 Finally, we localize an unusually high 'burst-phase' of HDX in the large tetrame

35 (e.g., Rh/ReOx, Rh/MoOx, Ir/VOx) demonstrate unusually high C-O scission activity at moderate tempera

36 m mechanical calculations indicate that this unusually high capacitance may be attributed to a negati

37 bricated from the prepared carbons exhibited unusually high capacitance per unit surface area (>30 mu

38 , such as exhibiting novel protein folds and unusually high carbohydrate affinity, and ability to pot

39 atriciarum xylanase NpXyn11A, which displays unusually high catalytic activity and is one of the few

40 plain why the Neocallimastix enzyme displays unusually high catalytic activity.

41 Synaptic vesicles contain unusually high cholesterol, but the exact role of choles

42 on between carbon fiber and CO2 molecule for unusually high CO2 uptake and resistive sensing.

43 gest that if Nosema spp. are contributing to unusually high colony losses in recent years, the mechan

44 lower than that of the other arrestins, the unusually high concentration of ARR1 in rods would favor

45 RI shedding defect, there was nonetheless an unusually high concentration of functional TNFRI at the

46 H5N1 avian influenza viruses (HPAIV) present unusually high concentrations in serum of proinflammator

47 The petal wax was found to contain unusually high concentrations of C(22) and C(24) fatty a

48 .4 microseconds at 5 kelvin) are obtained at unusually high concentrations.

49 ucture reveals features that can explain the unusually high conductance of Slo channels and how contr

50 In surface-supported bilayers, MelP5 forms unusually high conductance, equilibrium pores at peptide

51 of Cl- from the nucleus may result from its unusually high content of "excess" DNA that imposes an i

52 erived from HS oligosaccharides, we found an unusually high content of GlcN residue in a recently pur

53 l-trans-retinol provides a rationale for the unusually high content of PE and its long-chain unsatura

54 ll alpha-helical hydrophobic protein with an unusually high content of valine residues.

55 Unusually high copy numbers of approximately 10,000 in O

56 including at least one parent and child, had unusually high copy numbers of HHV-6 DNA per milliliter

57 nd, fus3Delta cells were found to exhibit an unusually high correlation between mother and daughter c

58 entification of sets of adjacent probes with unusually high correlation between the individual interg

59 he data provide additional insights into the unusually high cross-link density found in mature beaks.

60 This difference is a major contributor to unusually high CRP-mediated activation of cddP.

61 bimorph thermal actuators that bend with an unusually high curvature, ~900 m(-1).K(-1) over a wide t

62 atellites because its slow rotation produces unusually high daytime temperatures and water ice sublim

63 nt the coleophomone B (2)/C (3) synthesis an unusually high degree of efficiency.

64 tertiary propargylic C-H substrates with an unusually high degree of functional-group tolerance, thu

65 positive for viral infection and exhibits an unusually high degree of genomic methylation compared to

66 nome architectures are mosaic, reflecting an unusually high degree of horizontal genetic exchange in

67 ticular, with real data there tends to be an unusually high degree of maximum clique overlap.

68 S in combination with cryo-TEM confirms this unusually high degree of order (chi(SAXS) = 82%) and sho

69 selections have been observed to possess an unusually high degree of secondary structure.

70 The antibody genes had an unusually high degree of somatic mutation.

71 for interconversion of 1-Li aggregates were unusually high (DeltaG(double dagger) ca. 9 kcal/mol for

72 The cerebral vasculature meets the brain's unusually high demand for oxygen and glucose by providin

73 asmic reticulum (ER) and are likely to place unusually high demands on the resident chaperones and fo

74 mounts are denatured even in the presence of unusually high denaturant concentrations involving a com

75 tes demonstrates that motif co-occurrence in unusually high densities is essential for optimal DCC re

76 This includes unusually high densities of butchered tortoise and wild

77 equencing was performed for a family with an unusually high density of lung adenocarcinoma with avail

78 equences revealed 16 genomic regions with an unusually high density of rapidly evolving genes.

79 he sperm flagellum, where it is expressed at unusually high density.

80 The unusually high deuterium kinetic isotope effect of 81 is

81 hydes gives tetrasubstituted dioxolanes with unusually high diastereoselectivity.

82 methyl carbonate anions together induce the unusually high diastereoselectivity.

83 t from layer 10 neurons, respond with tonic, unusually high discharge rates (>150 spikes/s).

84 750 to approximately 635 Myr ago, indicating unusually high dissolved phosphate concentrations in the

85 p and that Hepatocystis parasites display an unusually high diversity and prevalence in epauletted fr

86 structural features, all orthologs share the unusually high DNA binding affinities and low catalytic

87 olar molecule with no H-bonding ability, the unusually high efficiencies of dPMP insertion are ascrib

88 Pol IV incorporates rNTPs into DNA with an unusually high efficiency relative to dNTPs, a property

89 hly reduced redox states that correlate with unusually high Enemark-Feltham numbers.

90 Decreased need for sleep, unusually high energy, and increased goal-directed activ

91 ms: elevated mood, decreased need for sleep, unusually high energy, increased goal-directed activity,

92 Finally, vis-UV MCD spectra show an unusually high-energy Fe(II) --> alphaKG pi* metal-to-li

93 that the hydrogen atom transfer reaction has unusually high entropic demand, which results in substan

94 The takeoff sites UUU and AGG yielded unusually high enzyme activities, sufficient for protein

95 ly, the compound binds in the groove with an unusually high equilibrium constant.

96 heir chemical stability, predictability, and unusually high excitation-emission differential.

97 T lymphocytes with unusually high expression of the voltage-gated Kv1.3 cha

98 (-) reacts with O(2) to form a quasi-stable, unusually high-extinction flavin hydroperoxide species t

99 egans and human genomes, suggesting that the unusually high factor association at HOT regions may be

100 ingers palpation technique was noted to have unusually high failure rates.

101 ng that CoVs with intact ExoN replicate with unusually high fidelity.

102 ries, as well as studies of populations with unusually high fish consumption (e.g., the Seychelles),

103 ified a set of up-regulated transcripts with unusually high fold changes in the CLL samples, several

104 ype II RTS patient-derived cells demonstrate unusually high frequencies of chromosomal aberrations, s

105 account for the presence of an allele at an unusually high frequency in an isolated population if th

106 oup A KIR haplotype and the HLA-C1 ligand to unusually high frequency in the Japanese, who provide a

107 ducator of C1-specific NK cells, has reached unusually high frequency in the Yucpa.

108 Anti-PL-7 was found at an unusually high frequency in this group of Japanese patie

109 to end-stage renal disease (6 of 14) and an unusually high frequency of cardiac (8 of 14) and/or neu

110 e protein data bank, our analysis reveals an unusually high frequency of cysteine pairings relative t

111 or speed in the racehorse has resulted in an unusually high frequency of the C-variant (g.66493737C/T

112 The unusually high frequency of the Raman band for the C(4)=

113 er of SNP sites in these categories revealed unusually high genetic distances between the two most di

114 The unusually high glycan density on the gp120 subunit limit

115 nals; both approaches indicated that P(r) is unusually high (>/=0.8).

116 Dopant 1 exhibited an unusually high helical twisting power, which is signific

117 humans than in other vertebrates but appears unusually high in flies and especially low in nematodes.

118 arotenoid levels in these outliers were also unusually high in the lens and in the peripheral retina.

119 Remarkably, an unusually high in-plane Fermi velocity up to 1.5x10(6) m

120 The authors detected an unusually high incidence of cases of medically attended

121 Our previous observations of unusually high incorporations of acrylates in copolymeri

122 re dependence of loop residue reactivity was unusually high, indicating that conformational changes i

123 CO geometry is nonlinear as indicated by the unusually high intensity of the Fe-C-O bending vibration

124 This study reveals that the unusually high intra-specific variation of volatile terp

125 of 1.5-1.7) for a structural Mg2+ ion and an unusually high intrinsic affinity of the structural ion

126 PBP 3 had an unusually high k(2)/K' value relative to other PBPs for

127 1) and 0.23 s(-1), respectively, yielding an unusually high K(D) of 1.6 mM.

128 PanK-III enzymes have an unusually high Km for ATP, are resistant to feedback inh

129 known MYOD1 enhancers, and one displayed an unusually high level of 5-hydroxymethylcytosine in a qua

130 One explanation may be an unusually high level of convergent and parallel evolutio

131 g of the Fab part of rhuMAb suggest that the unusually high level of glycation of lysine residue 49,

132 : during 2009 in the Northern Hemisphere, an unusually high level of influenza virus activity over th

133 lysis showed that the proximate cause was an unusually high level of intracellular unincorporated iro

134 These antibodies all exhibit an unusually high level of somatic mutation, presumably owi

135 ide further support for a model in which the unusually high level of variability in NKT cell number a

136 he ribosomal E-, P- and A-sites, there is an unusually high level, 15%, of +1 ribosomal frameshifting

137 ent of eyes from donors age 48 and older had unusually high levels (66.3 +/- 15.1 ng) of macular caro

138 systems, orange carrots are characterized by unusually high levels of alpha-carotene in addition to b

139 cells expressing these variants accumulated unusually high levels of alpha1 as rings in N(alpha)-ace

140 Furthermore, the prevalence and unusually high levels of antimitochondrial antibodies (A

141 We suggest that despite the unusually high levels of ANXA5 in bundles, it does not p

142 Human and mouse HSCs had unusually high levels of ascorbate, which decreased with

143 Human lens membranes contain unusually high levels of cholesterol and sphingolipids,

144 neocortical neurons may be characterized by unusually high levels of energy metabolism.

145 The H. pylori species exhibits unusually high levels of genetic variation between strai

146 fer a tool for studying genomes that sustain unusually high levels of heterochromatinization.

147 es from different parts of Africa and in the unusually high levels of linkage disequilibrium over a c

148 The presence of unusually high levels of macular carotenoids in older do

149 ve enhancers in close genomic proximity with unusually high levels of Mediator binding, as measured b

150 We observed unusually high levels of nonsynonymous polymorphism in t

151 Tannat berries have unusually high levels of polyphenolic compounds, produci

152 being possibly advantageous, as indicated by unusually high levels of population differentiation, lon

153 Unusually high levels of recombinant A1AT were expressed

154 polymerases as one potential explanation for unusually high levels of replication fidelity.

155 These genes also exhibit unusually high levels of segregating nonsynonymous polym

156 TGF)-beta (but not myostatin), which induces unusually high levels of TGF-beta pSmad3 in resident sat

157 nt and its high rate of turnover necessitate unusually high levels of transport into the cilium.

158 rinsic property of CAP-Gly likely due to its unusually high loop content and may be required for its

159 ccumulate an intracellular polysaccharide of unusually high M(r).

160 pollutants to the risk of the occurrence of unusually high mean summer temperatures throughout a lar

161 The unusually high measured hydraulic diffusivity of 2.4 x 1

162 cture of six out of seven chromosomes and an unusually high metal accumulation in leaves, which remai

163 used a mutation accumulation study to see if unusually high microsatellite mutation rates contribute

164 nning nano- through milliseconds reveals its unusually high mobility, both free and assembled on poly

165 Furthermore, the unusually high-molecular-weight polymers used allow gels

166 The causes of the unusually high mortality in the 1918 pandemic were not e

167 We demonstrated that S. pyogenes has an unusually high mRNA turnover rate, with median and mean

168 However, the protein has an unusually high native-state heat capacity, and consequen

169 The dimer of dengue C protein has an unusually high net charge, and the structure reveals an

170 TPR designed from straight consensus has an unusually high net charge.

171 variants in a rhesus macaque that developed unusually high neutralizing antibody titers to SIVmac239

172 mmonia levels, is always acidic even for the unusually high NH3 levels found in Beijing (pH = 4.5) an

173 s from regression-identified gene pairs with unusually high nonsynonymous divergence from a reference

174 III) peroxide intermediate 2, which exhibits unusually high nucleophilic reactivity.

175 ng overlap significance if a gene set has an unusually high number of annotations.

176 This issue also includes an unusually high number of cancer-related databases and ot

177 the agent of Q fever in humans, contains an unusually high number of conserved, selfish genetic elem

178 ponents of the T3S apparatus that contain an unusually high number of cysteine residues compared to o

179 winter of 2003-2004 in the UK and caused an unusually high number of deaths in children.

180 /411/2002-like(H3N2), was associated with an unusually high number of fatalities in children.

181 0 repeats of a seven amino acid motif and an unusually high number of histidine residues.

182 unique binding configuration, PBP-1 forms an unusually high number of hydrogen bonds (14) with the ph

183 This hypothesis seems to be supported by the unusually high number of M >or= 8 earthquakes occurring

184 roto-Calepineae Karyotype (n = 7) through an unusually high number of pericentric inversions.

185 interesting changes in three regions: (i) an unusually high number of predicted amino acid changes (1

186 Eleven is an unusually high number of pseudogenes for a homeobox gene

187 eria responsible for tuberculosis produce an unusually high number of secreted proteins, many of whic

188 e substitution within helix 4 resulted in an unusually high number of severely transport-defective mu

189 ith a common root structure that contains an unusually high number of terminal alphaGal-Gal moieties.

190 ycobacterium tuberculosis genome contains an unusually high number of toxin-antitoxin modules, some o

191 by disulfide bonds but nevertheless keeps an unusually high number of unpaired cysteines in its secre

192 .78-kb) 5' untranslated region (UTR) with an unusually high number of upstream AUGs (uAUGs), i.e., 64

193 ndifferentiated spermatogonia accumulated in unusually high numbers as early as 10 d after birth, whe

194 These abnormalities resulted in an unusually high OC number, which is consistent with a rec

195 Unusually high occipital Abeta deposition is associated

196 in occipital lobe (lvPPA-high), representing unusually high occipital uptake compared to other region

197 to collagen sequences highlights regions of unusually high or low stability, and these regions often

198 oroughly search for subsets of the data with unusually high or unusually low estimated values of the

199 Rod regions show unusually high oxidation levels.

200 he heme-bound ligand, which accounts for its unusually high oxygen affinity (222 microm(-1)).

201 cifically interact with host genes that have unusually high p300 association within the gene body.

202 of synphilin-1 occurs appreciably only at an unusually high parkin to synphilin-1 expression ratio or

203 viruses, which cause disease in humans, have unusually high pathogenicity.

204 nza virus appeared, but it has not exhibited unusually high pathogenicity.

205 The MPER has an unusually high percentage of tryptophan residues that li

206 The atomic-scale origin of the unusually high performance and long-term stability of wu

207 artment to the plasma membrane, resulting in unusually high permease activity at the cell surface.

208 nalogs and rhodopsin mutants, to improve the unusually high photosensitivity of rhodopsin are propose

209 erimental studies with CO2 have revealed its unusually high physical solubility in these media.

210 Glu468 in the active site contribute to the unusually high pK(a) value, 10.5, of Cys461.

211 eads to excellent electrocatalytic activity, unusually high poison tolerance, and reliable stability

212 d, intrinsically disordered polypeptide with unusually high polyproline type II helix propensity.

213 E1 of the small ubiquitin-like modifier has unusually high populations in both ordered and disordere

214 /bulk oxidation state, which may explain the unusually high potential stability of the resulting ISE.

215 he method provides oxidation potentials with unusually high precision and accuracy.

216 This unusually high precursor frequency of clonal CD4 T cells

217 We have observed an unusually high prevalence of dementia of the Alzheimer t

218 ently, the overexpression of VCC leads to an unusually high proportion of cotyledons with high-comple

219 sesses specific interneuronal equipment with unusually high proportion of CR+ interneurons, what migh

220 The comparison revealed an unusually high proportion of indels in non-coding DNA.

221 f allergen-specific patches consisting of an unusually high proportion of surface-exposed hydrophobic

222 s noted that the autoantibodies possessed an unusually high proportion of the IgG3 isotype in contras

223 rs of nine well-recognized phyla but also an unusually high proportion of three candidate divisions (

224 inal aspect is manifest by the appearance of unusually high pyrophosphorolysis activity by the T4 DNA

225 ics provides a plausible explanation for the unusually high quantum yield of 40% for the primary isom

226 mal insulation, removing the requirement for unusually high radiogenic heat production to achieve cru

227 Cryptosporidium hominis TS-DHFR exhibits an unusually high rate of catalysis at the TS domain, at le

228 GNN and NCC-GNN codon doublets, for which an unusually high rate of G to C and C to G transversions w

229 ional rate across diverse tumor types and an unusually high rate of loss of heterozygosity, has the s

230 ion, this backpropagation also results in an unusually high rate of rise of membrane potential at the

231 ination, though they are characterized by an unusually high rate of switching and by atypical substra

232 Replication forks also appear to stall at an unusually high rate throughout schizogony.

233 iption of the specific mechanisms that allow unusually high rates of recombination without deleteriou

234 ing further evidence that the chicken has an unusually high recombination rate.

235 s ferrooxidans is a blue copper protein with unusually high redox potential and acid stability.

236 and adjacent amino acid sites, although the unusually high reduction potentials of the adjacent Fe-S

237 Baseline MPOD in enrolled subjects was unusually high relative to an age-matched control group

238 bility of postsynaptic receptors, without an unusually high release probability.

239 her mammalian ocular microbiomes but with an unusually high representation of bacteria from the famil

240 Bartonellae have unusually high requirements for heme, which is their onl

241 s demonstrate that light-weight materials of unusually high resistance to structural damage from shoc

242 control of constitutive signaling, and their unusually high resolution enabled a structure-based camp

243 The unusually high resolution of these structures that makes

244 n air in a differential mobility analyzer of unusually high resolution.

245 heir genes pass through a temporary phase of unusually high responsiveness to oocyte reprogramming fa

246 This is supported by the unusually high rigidity of the Arg(10) side chain and it

247 a showed that soccer players in Italy had an unusually high risk of amyotrophic lateral sclerosis (AL

248 is judged by the endocrinologist as being at unusually high risk.

249 Incarcerated youth are an unusually high-risk cohort with numerous unmet medical a

250 in the Persian/Arabian Gulf (PAG) withstand unusually high salinity levels and regular summer temper

251 these bimetallic electrocatalysts exhibit an unusually high selectivity for the formation of multi-ca

252 mechanistic investigation suggests that the unusually high selectivity may be due to the catalyst's

253 ons were evaluated as a means to explain the unusually high selectivity observed at room temperature.

254 ylinositol (PtdIns) 3,4,5-trisphosphate with unusually high selectivity.

255 r experiments show that these nanopores have unusually high sensitivity (0.65 nA/A) to extremely smal

256 in the tubercle bacillus contributes to the unusually high sensitivity of M. tuberculosis to isoniaz

257 rogenitor cells from a patient that exhibits unusually high sensitivity to erythropoietin with concom

258 at silicone block polyimide polymers have an unusually high sensitivity to nonpolar organic vapors, i

259 are localized by tRNAs and short regions of unusually high sequence similarity.

260 We infer that the unusually high set point of virus carriage in P. falcipa

261 ackgrounds after treatment with 2-ME created unusually high signal-to-noise ratios.

262 F obelin mutant is noteworthy because of the unusually high speed with which it responds to sudden ch

263 tern USA, which causes Lyme borreliosis with unusually high spirochaetaemia.

264 Cytogenetic studies revealed an unusually high spontaneous chromosome aberration rate, c

265 cted bicyclic peptide antagonist exhibits an unusually high stability in vivo and subsequently deciph

266 rise the domain-domain interface crucial for unusually high stability of gammaD-crystallin.

267 role in establishing the high Eox/sq and the unusually high stability of the anionic semiquinone stat

268 h infectivity rate, low infectious dose, and unusually high stability outside the host.

269 e identification of a set of frameworks with unusually high stability toward water vapor.

270 edly gave rise to fulleroid derivatives with unusually high stability.

271 biochemistry and whole-body physiology with unusually high statistical power.

272 DFT calculations suggest an explanation for unusually high stereoselectivity.

273 s, suggest essential elements underlying its unusually high substrate specificity.

274 nsynonymous/synonymous base substitutions is unusually high, suggesting a rapid adaptive evolution of

275 This frequency is unusually high, suggesting an imidazolate character of t

276 superior colliculus, we detected areas with unusually high T(2) values that likely represented accum

277 nce fluctuations play a critical role in the unusually high Tc of PuCoGa5.

278 l spectra an N5-type spectrum is observed at unusually high temperature (indicating a significant cha

279 The prepared LBL films also revealed unusually high temperature resilience up to 500 degrees

280 SrRu2 O6 exhibits unusually high-temperature magnetic order, with antiferr

281 corresponding cyclononadienyl anion requires unusually high temperatures (120 degrees C), and computa

282 ve out of seven species that were exposed to unusually high temperatures exhibited significant decrea

283 In addition, TDP-43 demonstrated an unusually high tendency to aggregate, a property intrins

284 e folds into a monomolecular quadruplex with unusually high thermal stability and unique optical prop

285 on of intramolecular i-motif structures with unusually high thermal stability.

286 the Q(D) site are discussed, in light of the unusually high thermodynamic stability of MSQ(D).

287 Si nanowires were recently shown to have an unusually high thermoelectric figure of merit.

288 yos, the DSSA reagent permitted detection of unusually high thiol levels in the zebrafish chorion.

289 s of bilaterian Shakers and channels with an unusually high threshold for voltage activation.

290 s lacking telomerase activity revealed their unusually high tolerance for genome instability.

291 r a bisphenol A (BPA) exposure study who had unusually high total BPA concentrations.

292 uding 1T-TaSe2, 1T-TaS2 and 1T-TiSe2 exhibit unusually high transition temperatures to different CDW

293 strategy has been established for achieving unusually high triplet levels for bipolar molecules (E(T

294 ped in a specific conformation because of an unusually high-unfolding barrier that results in very sl

295 on the Escherichia coli chromosome, display unusually high variability among 11 otherwise very simil

296 O2 due to their reactivity with CO2, as well unusually high viscosities in both the neat and complexe

297 Unusually high viscosities observed for suspensions of n

298 ese substrates at 10(6)-10(7) M(-1) s(-1) is unusually high, which qualifies the enzyme as an extreme

299 congenital Zika syndrome retrospectively by unusually high ZIKV-specific antibody titers.

300 We conclude that the unusually high Zp activity level in AGS cells is due to