ライフサイエンスコーパス: unwanted

1 r treating autoimmune diseases or to inhibit unwanted Ab responses.

2 at their respective effective doses without unwanted accumulative side effects is the key to success

3 able to focus on a complex task and inhibit unwanted actions or interfering information (i.e., inhib

4 cts fail to recruit this pathway and inhibit unwanted actions.

5 or RIG-I recognizes viral RNA while avoiding unwanted activation by self RNA.

6 posing patients to side effects linked to an unwanted activation of one of the two receptors.

7 uard against tissue damage that results from unwanted activation.

8 to understand what mechanisms exist to curb unwanted activation.

9 therapy in young infants is associated with unwanted adverse effects such as respiratory depression.

10 ifferent protein systems, thereby preventing unwanted aggregation and enabling the biological use of

11 didate with maximum Fc sialylation devoid of unwanted alterations to the IVIg mixture.

12 Unwanted and antibody-tethered cells are selectively dep

13 In this study, we aimed to bypass the unwanted and default MHC class II Ag presentation and tr

14 ent of treatment strategies aimed to prevent unwanted and detrimental heterotopic bone formation.

15 -cell genome during CSR and SHM, AID induces unwanted (and sometimes oncogenic) mutations at numerous

16 man PR, but older generation progestins have unwanted androgenic side effects in humans.

17 hat are considered moderate in many studies, unwanted artifacts are introduced that result in nonphys

18 the crystal structure; in other cases it is unwanted, as it changes the physical and chemical proper

19 e excitation and photothermal disassembly of unwanted assemblies in solution.

20 apse, a psychiatric condition perpetuated by unwanted associative memories.

21 Targeting of such Ags can result in unwanted autoimmune attack of normal tissues or inductio

22 thology/pedagogy, and best practices against unwanted autonomous machine behavior.

23 of these repair steps is established and how unwanted back-reactions that jeopardize the repair effic

24 ric tagging strategy to substantially reduce unwanted background and achieve nanometer spatial resolu

25 n is often required to spectrally un-mix the unwanted background signals.

26 elopment of strategies to reduce the load of unwanted bacteria is a fundamental challenge in industri

27 oke action tendencies that sometimes lead to unwanted behavior (e.g., eating chocolate when trying to

28 Unwanted beta2-blockade risks causing life-threatening b

29 l 50% faster per cell and generated half the unwanted biomass when supplied N2 instead of ammonium.

30 cells may offer a new target to prevent this unwanted bone.

31 long list of hits with many citations being unwanted by the user.

32 Nitrous oxide (N2O) is an unwanted byproduct during biological nitrogen removal pr

33 on method, in-source fragmentation generates unwanted byproducts of identical mass to common metaboli

34 nt diabetes in the NOD mouse but also elicit unwanted calcemic side effects.

35 ve surgery may contribute to this problem of unwanted care.

36 -concordant treatment decisions and minimize unwanted care.

37 ellular pathway by which pathogens and other unwanted cargoes are degraded.

38 antities of offal, as well as undersized and unwanted catch in the form of discards.

39 nnabinoid CB1 and/or CB2 receptors; however, unwanted CB1-mediated cannabimimetic effects limit clini

40 produce tolerance, physical withdrawal, and unwanted CB1-mediated central nervous system side effect

41 on (UTR), thereby ensuring a dual control of unwanted cell death: at the level of p53/CEP-1 and at th

42 reatly reduced technical noise and minimizes unwanted cell doublet events in mass cytometry data, and

43 n neurodegenerative diseases without causing unwanted cell growth and migration, genes regulating gro

44 e cells could serve as a new defense against unwanted cell proliferation or tumor growth.

45 ating developmental paths that often lead to unwanted cell types.

46 ection, and the risk of differentiating into unwanted cell types.

47 IL-10 plays an important role in eliminating unwanted cells and cellular debris in a silent way.

48 The elimination of unwanted cells by apoptosis is necessary for tissue morp

49 of control can be used to selectively remove unwanted cells from a Split GAL4 expression pattern or t

50 sis factor receptor family in getting rid of unwanted cells.

51 ell death that may be activated to eliminate unwanted cells.

52 Upon nutrient starvation, autophagy digests unwanted cellular components to generate catabolites tha

53 argeting cannabinoid CB2 receptors to bypass unwanted central effects associated with CB1 receptor ac

54 ppresses pathological pain but also produces unwanted central side effects.

55 e of reference electrodes, and show that the unwanted changes in the reference potential are not uniq

56 ility in motor output, a ubiquitous if often unwanted characteristic of motor performance, predicts m

57 We avoid unwanted charge current shunting by the low resistive NM

58 several tissue types to identify potentially unwanted chemical effects that could limit the therapeut

59 he solution that prevent the metal ions from unwanted chemical reactions and keep the solution stable

60 erly measured or omitted from studies due to unwanted chemical transformations that occur during samp

61 tes, in addition to essential nutrients, and unwanted chemicals.

62 therapeutic enzymes was effective to remove unwanted circulating small biochemical(s)/substrates, an

63 Unwanted clots lead to heart attack and stroke that resu

64 control invading pathogens, while minimizing unwanted collateral tissue damage.

65 eed to reduce emissions from both wanted and unwanted combustion, discovery of this state points to p

66 s ubiquitous and widely considered to be the unwanted consequence of a noisy nervous system.

67 formation on biotic or abiotic surfaces has unwanted consequences in medical, clinical, and industri

68 To minimize unwanted consequences, environmentally friendly approach

69 e associated lack of specificity can lead to unwanted consequences, most notably an enhanced suscepti

70 Although this can lead to unwanted consequences, such as causing decoherence in qu

71 tegration method for the region and removing unwanted contributions.

72 To avoid unwanted cross-talk, signaling cascades are very specifi

73 us, how do cells insulate themselves against unwanted crosstalk?

74 ated turnover removes damaged organelles and unwanted cytoplasmic constituents and thus plays critica

75 anelles that function to degrade and recycle unwanted, damaged and toxic biological components.

76 However, an unwanted degradation known as "peeling" often compromise

77 tems and highlight the ability to dissociate unwanted delta, kappa1, and alpha2 actions from analgesi

78 Formation of unwanted deposits on steels during their interaction wit

79 attention to bioethical implications such as unwanted detection of carriers and inconclusive diagnose

80 ude that a selection process exists by which unwanted differentiating cells are eliminated from the e

81 using of light as well as holography without unwanted diffraction artefacts.

82 nd a C29D substitution was included to avoid unwanted disulfide bond formation between unpaired cyste

83 However, the possibility of unwanted ecological effects and near-certainty of spread

84 e relevant for water quality and may trigger unwanted ecological effects.

85 the renal proximal tubule could enhance this unwanted effect.

86 l utility of an anti-IL-8 therapy to prevent unwanted effects of IL-8 up-regulation on survival, angi

87 duction of cardiovascular risk without known unwanted effects on individual health.

88 ity; however, these drugs are complicated by unwanted effects on motor, central nervous system and ca

89 ated in disease pathogenesis and may produce unwanted effects when given in high doses.

90 low separating desired antihyperalgesia from unwanted effects, but the lack of selective agents has h

91 Unwanted sound may have unwanted effects, especially on those who are most vulne

92 However, its applications are hampered by unwanted effects, particularly off-targeting through miR

93 ns, as each protein domain may contribute to unwanted effects, such as degradation, tumorigenesis, an

94 lgesia is independent of adenosine A1 or A2A unwanted effects.

95 introduce stoichiometry artifacts and other unwanted effects.

96 ared to conductive probes and greatly limits unwanted electrical pickup between probe and recording s

97 The ability to suppress unwanted emotional memories is crucial for human mental

98 Unwanted enzyme side reactions and spontaneous decomposi

99 16beta-(m-carbamoylbenzyl)-E2 to remove its unwanted estrogenic activity.

100 ntaining two methods to clean FCM files from unwanted events: (i) an automatic method that adopts alg

101 Unwanted evolution can underlie the emergence of drug an

102 essive role in transcription and counteracts unwanted expression in noninductive conditions.

103 of the first part of this study (Eliminating unwanted far-field excitation in objective-type TIRF. Pt

104 Graphene suppresses unwanted faradaic reaction effects on the cells and the

105 us to logically block differentiation toward unwanted fates and rapidly steer pluripotent stem cells

106 trophilic inflammation that is a potentially unwanted feature of the acute response to viral infectio

107 in fishing practices to limit the capture of unwanted fish results in trophic cascades that can benef

108 and their potential to serve as pathways for unwanted fluid migration.

109 To identify the sources of this unwanted fluorescence excitation in deeper sample layers

110 Some of them are potentially unwanted for the flavour of the product.

111 used for basic signal processing by ablating unwanted frequency components on the nanostructure there

112 practice, allowing the selective removal of unwanted fruitlets.

113 without generating excessive amounts of this unwanted gas product.

114 gest that LDL plays a particular role in the unwanted gel formation of egg yolk after conventional fr

115 ecular confinement that minimize the risk of unwanted genome editing.

116 Unwanted greening can be inhibited by simply changing th

117 sembly directly discourages recombination at unwanted half-site combinations, enhancing the specifici

118 nd C-related inflammation, autoimmunity, and unwanted harmful immune responses to viral gene transfer

119 ed for a broadly applicable method to remove unwanted high-abundance species prior to sequencing.

120 le misfolding can impact safety by eliciting unwanted immune or other off-target responses.

121 Many factors contribute to this unwanted immune response, from the product itself, to it

122 te that innate immune blockade can eliminate unwanted immune responses in gene therapy.

123 Low-dose interleukin-2 (IL-2) inhibited unwanted immune responses in several clinical settings a

124 urrent treatments to control pathological or unwanted immune responses often use broadly immunosuppre

125 Although drugs are available to suppress unwanted immune responses, they have limited efficacy wi

126 ry T cells (Tregs) are essential to suppress unwanted immunity or inflammation.

127 zymatic stability, rapid body clearance, and unwanted immunostimulation.

128 lled peptide chains allows one to filter out unwanted information and observe the labelled moieties o

129 coherence caused by the cavity decay and the unwanted inter-cavity crosstalk are greatly suppressed.

130 Unwanted interaction between a quantum system and its fl

131 ce such as insulating a gene circuit against unwanted interactions with its context, and we describe

132 ss of autophagy, through which cells capture unwanted intracellular material for lysosomal degradatio

133 the mechanisms used by host cells to remove unwanted intracellular organisms, and often found to be

134 stem (UPS) plays a critical role in removing unwanted intracellular proteins and is involved in prote

135 om brine; (2) intermediate washing to remove unwanted ions; (3) final washing for unloading the lithi

136 ker (Brk), the DPP branch of the FFL filters unwanted JNK activity.

137 e the underside of the cantilever to prevent unwanted ligand adsorption, and this process requires te

138 d locomotion and indirect pathway to inhibit unwanted locomotion.

139 phed from spheres to complex shapes--without unwanted loss of liquid.

140 Momentum separators can reduce unwanted low-density gases and introduce the analyte int

141 nic molecule in solution is measured free of unwanted lower-order contamination.

142 TDA promotes algal health by killing unwanted marine pathogens; however, its mode of action (

143 nonfatty food matrices showed the absence of unwanted matrix compounds in the cleaned-up PAH fraction

144 utic approach for the selective treatment of unwanted memories associated with psychiatric disorders

145 This negative coupling was greater when unwanted memories intruded into awareness and needed to

146 ion of new information by removing unused or unwanted memories or by suppressing their expression.

147 Suppressing retrieval of unwanted memories reduces their later conscious recall.

148 ions that involve the automatic intrusion of unwanted memories.

149 le suppress retrieval given a reminder of an unwanted memory, they are considerably more likely to fo

150 evelopment represent a potential pathway for unwanted migration of fluids (brine, drilling and stimul

151 However, this workflow may produce unwanted mispaired IgG species in addition to the desire

152 hondrial DNA polymerase (Pol gamma), causing unwanted mitochondrial toxicity.

153 ous over the Gly-Asp-Lys motif by preventing unwanted MMP hydrolysis.

154 g a novel scheme for resonantly coupling out unwanted modes, whereas birefringence is engineered by f

155 to re-edit previously modified loci, causing unwanted mutations (indels) alongside intended changes.

156 A damage in cells, but it can also introduce unwanted mutations and is sometimes hijacked by other pa

157 imit their utility in clinical therapies, as unwanted mutations caused by DSBs can have deleterious e

158 single gRNA generally induce lower levels of unwanted mutations than matched monomeric Cas9 nickases.

159 Excess unwanted noise can clearly be detrimental to health and

160 as traditionally been considered a source of unwanted noise, recent work demonstrates that variabilit

161 We show this nanostructure strongly absorbs unwanted off-axis light rays, whilst transmitting the de

162 d for targeted genome editing but can induce unwanted off-target mutations with high frequencies.

163 idely used for genome editing but can induce unwanted off-target mutations.

164 macodynamics properties coupled with limited unwanted off-target reactivity.

165 selectivity and likely critical for reducing unwanted off-target toxicities.

166 r) and systemic (host) processes that elicit unwanted, often opposing, influences on cancer growth.

167 The removal of unwanted or damaged mitochondria by autophagy, a process

168 teins into sources of energy or clearance of unwanted or damaged proteins from the cytosol.

169 enetrations into the sampled environment are unwanted or infeasible because of health, safety, or env

170 ells, conventional chemotherapies cause many unwanted or intolerable side effects.

171 abolic cellular self-eating process by which unwanted organelles or proteins are delivered to lysosom

172 Undaria pinnatifida is known as unwanted organism in New Zealand.

173 scission is the process by which plants shed unwanted organs, either as part of a natural development

174 fluorescence improves resolution and reduces unwanted out-of-focus excitation, and is compatible with

175 ficantly with propagation length, generating unwanted out-of-focus fluorescence that enforces practic

176 ity of Zika and dengue viruses, an analogous unwanted outcome might occur with some Zika virus vaccin

177 n, and an insoluble inorganic oxidant limits unwanted oxidation of substrates.

178 Chemotoxicity due to unwanted p53 activation in the bone marrow remains an un

179 d activation correlated with the presence of unwanted paraesthesias.

180 This suggests that unwanted peptide truncation may occur during synthesis o

181 However, their unwanted persistence elsewhere or in particular situatio

182 imitations and is due to the formation of an unwanted photoisomer.

183 with vitamin B12 (cobalamin) is hampered by unwanted physiologic tissue uptake mediated by transcoba

184 Unfortunately, the use of CO2 has potential unwanted physiological effects, including altered respir

185 ng that the vacuole may be key to removal of unwanted plant cells, and may carry out functions that a

186 Such materials can therefore remediate unwanted pollutants from the environment including: immo

187 This sensing protocol avoids unwanted possible side reactions observed in alkyne-base

188 ion in murine experimental asthma is free of unwanted pro-remodeling effects and ameliorates airway h

189 This review focuses on the unwanted production of oxygen gas, which decreases the c

190 Superparamagnetism is an unwanted property of small magnetic particles where the

191 strategy used in protein evolution to limit unwanted protein aggregation.

192 tabolic process that enables cells to remove unwanted proteins and damaged organelles, had not been e

193 esis beyond its established role in removing unwanted proteins from the immature vesicle.

194 Thus, enhanced removal of unwanted proteins is a potential therapeutic strategy fo

195 ely coordinated systems that rapidly correct unwanted proteomic changes.

196 : Instead of deterministically reversing the unwanted qubit evolution, we use control pulses to shape

197 ry in vivo to reduce kidney uptake and avoid unwanted radiation toxicity.

198 kynes with surface metal atoms often induces unwanted reaction pathways when thermal energy is provid

199 to function as activation barrier to prevent unwanted reactions against minor allergens.

200 free PLP concentrations low enough to avoid unwanted reactions with other important cellular nucleop

201 which shield the reactive carbon chain from unwanted reactions.

202 n of the olefin produced, leading to further unwanted reactions.

203 A Pt-catalyzed hydrosilylation helped stymie unwanted rearrangements facilitated by vinyl group parti

204 GD for mercury capture is the possibility of unwanted reduction of dissolved Hg(2+), leading to the r

205 ators may be useful in management to prevent unwanted regime shifts, at least in some situations.

206 the corresponding read-coverage, eliminating unwanted regions.

207 t and environmental conditions, to avoid the unwanted release of plastic degradation products in rece

208 undesirable or toxic side effects and evade unwanted removal by endogenous clearing mechanisms.

209 posure to sunlight has played a role in this unwanted result.

210 is a nucleic acid repair enzyme that removes unwanted ribonucleotides from DNA.

211 Most unwanted RNA transcripts in the nucleus of eukaryotic ce

212 In budding yeast, a number of these unwanted RNA transcripts, including spliced-out introns,

213 raction of trace elements and the removal of unwanted salt matrices, enabling accurate and rapid anal

214 transgene, while simultaneously removing the unwanted selectable marker gene.

215 ation for Cas9 in vitro, using it to deplete unwanted sequence from DNA libraries.

216 No major unwanted short-term effects on AC structure, proteoglyca

217 ver, tactile allodynia did not develop as an unwanted side effect in any of the groups, even though t

218 after a course of antibiotics, which has the unwanted side effect of depleting commensal bacteria.

219 ver, they imply that analgesics may have the unwanted side effect of reducing empathic resonance and

220 Reductions in unwanted side effects (e.g., hemorrhage or immunogenicit

221 ment methods for KS and PEL are fraught with unwanted side effects and low efficiency, the search for

222 herapeutics exhibit limitations in efficacy, unwanted side effects and the potential for drug abuse a

223 ully balanced within cells in order to avoid unwanted side effects associated with excessive activity

224 ch is common to both isoforms, might lead to unwanted side effects caused by neutralization of the ho

225 Moreover, the absence of unwanted side effects in our cytological studies, and th

226 fective, lack of selectivity for GR leads to unwanted side effects in some patients.

227 PPIs may have unwanted side effects in vulnerable populations.

228 ERPIN-ICU program, weighed against potential unwanted side effects is favourable.

229 lance between putative benefit and potential unwanted side effects needs to be considered.

230 lance between putative benefit and potential unwanted side effects needs to be considered.

231 ed, allowing new approaches for reducing the unwanted side effects of systemic delivery, increasing t

232 ernative to conventional therapies that have unwanted side effects such as drug resistance and toxici

233 d strategies of drought tolerance that avoid unwanted side effects that limit growth and yield, and m

234 t dosing intervals, peripheral vasodilation, unwanted side effects, and restricted use in pediatric p

235 argeted to specific channel states to reduce unwanted side effects, as well as in the design of bette

236 get binding of hydrophobic drugs can lead to unwanted side effects, either through specific or non-sp

237 ch of today's pharmacopeia can cause serious unwanted side effects, such as immune suppression.

238 eased isoform selectivity in order to reduce unwanted side effects, while retaining procognitive effe

239 rmacological treatments without evidence for unwanted side effects.

240 ischemia-reperfusion injury and could avoid unwanted side effects.

241 cs of the drug, enhance efficacy, and reduce unwanted side effects.

242 icant collateral damage to normal tissue and unwanted side effects.

243 treatment and its possible implications for unwanted side effects.

244 ed to a quest for therapeutics without these unwanted side effects.

245 subtypes, thus increasing the likelihood of unwanted side effects.

246 s have also shown beneficial effect, without unwanted side effects.

247 erefore of greatest importance in preventing unwanted side effects.

248 properties, and poor selectivity along with unwanted side effects.

249 role in drug development to eliminate their unwanted side effects.

250 that resolve infectious inflammation without unwanted side effects.

251 equences for treating disease and minimizing unwanted side effects.

252 however, systemic delivery of H2S may cause unwanted side effects.

253 al ischemia-reperfusion injury and may avoid unwanted side effects.

254 on reactions with metal cations, which avoid unwanted side reactions and positive feedback mechanisms

255 e replacement of lithium metal anode impedes unwanted side reactions between the dissolved intermedia

256 Low-temperature activation may avoid unwanted side reactions in the development of catalytic

257 s before oxidation because this will lead to unwanted side reactions in which ammonia participates in

258 e from regulators to their targets is not an unwanted side-effect of regulation, but rather acts as a

259 many women do not want to take them owing to unwanted side-effects impacting, for example, the uterus

260 maximise the beneficial effect and diminish unwanted side-effects.

261 and demonstrates how the epidermis triggers unwanted skin inflammation under disease conditions.

262 sted process, whilst eliminating the risk of unwanted solvate formation as well as enabling control o

263 Unwanted sound may have unwanted effects, especially on

264 it conveys and rather than merely containing unwanted sound, clinical environments have a 'soundscape

265 pectrometry (MS) necessitates the control of unwanted sources of variability associated with large di

266 lexed with a library of guide RNAs targeting unwanted species for cleavage, thus preventing them from

267 thesized that the repertoire of T cells with unwanted specificities such as alloreactivity or autorea

268 f optical mechanisms that normally result in unwanted spherical aberrations.

269 ed on fluorescence excitation that can cause unwanted stimulation of the optogenetic probe and other

270 Unwanted structures were detected, both anatomic (e.g.,

271 Such unwanted surfactants have now been utilized to stabilize

272 ferents, which results in the elimination of unwanted synapses and the maintenance and strengthening

273 ed advanced clinical trials because of their unwanted systemic side effects.

274 rgy is a key tolerance mechanism to mitigate unwanted T cell activation against self by rendering lym

275 Unwanted T cell responses during organ transplant, graft

276 r library preparation and other more complex unwanted technical effects.

277 ved global changes across samples are due to unwanted technical variability.

278 Subjects viewed reminders of unwanted thoughts and tried to suppress retrieval while

279 How hippocampal GABA contributes to stopping unwanted thoughts is unknown.

280 suggests that hESC-EC may be protected from unwanted TLR4-mediated vascular inflammation, thus offer

281 t cell proteins (HCP), can potentially cause unwanted toxic or immunogenic responses in patients.

282 tandard in treating bipolar disorder but has unwanted toxicity and side effects.

283 ion and rapid blood clearance may reduce the unwanted toxicity when administrating to patients, and w

284 pecific enhanced bioavailability and limited unwanted toxicity, thus leading to a significant potenti

285 Its role is to bind to DNA, locate unwanted uracil, and remove it using a base flipping mec

286 which confounds real biological signals with unwanted variability.

287 oved using pre-processing in order to remove unwanted variance in the spectra.

288 the method by Houseman et al., the Removing unwanted variation (RUV) approach, the methods in FaST-L

289 we show that a global version of removal of unwanted variation (RUV), a data-driven approach, remove

290 pose a normalization strategy, called remove unwanted variation (RUV), that adjusts for nuisance tech

291 Biases, artifacts and other sources of unwanted variation are present in the data, requiring su

292 The effects of unwanted variation have been extensively documented in g

293 In this paper, we discuss the causes of unwanted variation in metabolomics experiments, review c

294 priate methodology to use for accounting for unwanted variation in methylation array studies.

295 Although the removal of this unwanted variation is a vital step in the analysis of me

296 nt a statistical approach for the removal of unwanted variation to obtain normalized metabolomics dat

297 of factors or 'batch effects' can contribute unwanted variation to the data, commonly used RNA-seq no

298 ed metabolomics approaches for handling this unwanted variation, and present a statistical approach f

299 nts are inevitably subject to a component of unwanted variation, due to factors such as batch effects

300 e particularly susceptible to the effects of unwanted variation.