ライフサイエンスコーパス: unwind

1 hile hydrolyzing approximately 5 ATPs per bp unwound.

2 telomeric duplexes that are otherwise poorly unwound.

3 to the substrates that were the most readily unwound.

4 and nucleic acid that forms as duplexes are unwound.

5 as the double helix melts, and before it is unwound.

6 5'-flap structures; however, it is unable to unwind 3'-flaps.

7 ing, whereby the AdnA nuclease processes the unwound 5' strand to liberate a short oligonucleotide pr

8 of the panhandle structure by N protein, the unwound 5' terminus likely remains transiently bound to

9 wild-type T antigen was able to specifically unwind a 31-bp DNA containing only site II in an ATPase-

10 mer to locate the lesion, orient the DNA and unwind a 5' flap for subsequent incision.

11 d sequence bias allows NPH-II to efficiently unwind a DNA x RNA hybrid containing a purine-rich DNA t

12 inding affinity of DrRecQ and its ability to unwind a partial duplex DNA substrate.

13 ed DNA tail of 15 nucleotides to efficiently unwind a simple duplex DNA substrate.

14 f anti-CS20 antibodies the force required to unwind a single fimbria was increased several-fold and t

15 ver, replication defective mutants failed to unwind a small origin containing circular DNA whereas re

16 UvrD has been shown to unwind a variety of substrates including partial duplex

17 All four proteins unwound a 10 bp helix in vitro in the presence of ATP; h

18 y base pairs it has unwound, and once it has unwound a critical length, it reverses the unwinding rea

19 FANCJ and BLM synergistically unwound a DNA duplex substrate with sugar phosphate back

20 However, Pif1 working with pol delta readily unwound a full-length Okazaki fragment initiated by a fo

21 blocking Rac1 interactions until irradiation unwound a helix linking LOV to Rac1.

22 her superfamily 2 helicase, RECQ1, failed to unwind all G4 substrates tested under conditions in whic

23 sodium-coupled transporter, LeuT, define an unwound alpha-helix as the central element of the ion-bi

24 isoforms and similar cleavage efficiency of unwound alpha1(I) and alpha2(I) chains suggested increas

25 icases, such as BLM and WRN, can efficiently unwind alternate/secondary structures during telomere re

26 its native homolog, P68 RNA helicase did not unwind an analogous small interfering RNA duplex.

27 along DNA at up to 250 bp per second and can unwind an average of 14,000 bp, with some complexes capa

28 Interestingly, 8 of the 10 mutants failed to unwind an origin-containing DNA fragment and nine of the

29 Moreover, hnRNP A1 can effectively unwind an RNA hairpin upon binding, displacing a bound p

30 which increases the propensity of origins to unwind and adopt non-B DNA structure, rather than the ab

31 case and nuclease domains of Cas3 proceed to unwind and degrade the entire DNA target in a unidirecti

32 These enzyme complexes unwind and digest the DNA duplex from the broken end unt

33 on of a single ATP molecule is sufficient to unwind and displace an 8 base pair rRNA strand annealed

34 ic forces are applied via electrospinning to unwind and orient the molecular chains of a non-graphiti

35 amines the ability of WRN, BLM, and RecQ5 to unwind and POT1 to bind telomeric D-loops containing 8-o

36 nits, with a unique biomechanical ability to unwind and rewind.

37 city by inhibiting their natural capacity to unwind and rewind.

38 richia coli RNAP uses binding free energy to unwind and separate 13 base pairs of lambdaP(R) promoter

39 to-ISVP* conversion, neighboring mu1 trimers unwind and separate.

40 hyrin bound, the pi helix is not extended or unwound and is in the "substrate-bound" conformation.

41 ent stalling, G-quadruplexes are efficiently unwound and replicated.

42 ery to access the DNA, the chromatin must be unwound and the DNA cleared of histone proteins.

43 rnover conditions, although the substrate is unwound and the repressor displaced when the single-stra

44 e further showed that blunt dsRNA is locally unwound and threaded through the helicase domain in an a

45 After splicing, U2/U6 is unwound and U6 annealed to U4 to reassemble the tri-snRN

46 BLM can 'measure' how many base pairs it has unwound, and once it has unwound a critical length, it r

47 stalled forks are actively dechromatinized, unwound, and repressed by an ATR-dependent checkpoint pa

48 and can be pre-programmed to either wind or unwind, as encoded in their geometry.

49 rce spectroscopy, we found that CS2 fimbriae unwind at a constant force of 10 pN and have a corner ve

50 even though the helicase on its own does not unwind at its optimal rate.

51 nctional forms of RecQ can be assembled that unwind at rates tailored to the diverse biological funct

52 te in heterotrimeric collagen I is partially unwound at equilibrium.

53 covalently modify the 5' or 3' end of RNA or unwind base-paired regions.

54 e triple helical structure has to be locally unwound before hydrolysis, but this process is not well

55 We have found that the helicase does not unwind blunt-ended DNAs or substrates with 3'-ss tails.

56 Its ability to unwind both DNA and RNA, as well as aberrant, noncanonic

57 charomyces pombe showed that it can bind and unwind both DNA and RNA, but the S. pombe protein is not

58 rminated with 3'-ssDNA; however, such DNA is unwound by RecQ to create ssDNA for RecJ exonuclease.

59 s were functional RNAs (ribozymes) that were unwound by the helicase, and the first synthesised prote

60 g by trapping the non-template strand in the unwound conformation.

61 it is typically assembled, and an extended, unwound conformation.

62 e site of VKOR that alters between wound and unwound conformations.

63 The ability of the enzyme to unwind D-loops formed on superhelical plasmid DNA by the

64 ing mechanism is critical for its ability to unwind damaged DNA molecules.

65 Helicases are ubiquitous proteins that unwind DNA and participate in DNA metabolism including r

66 Replicative DNA helicases generally unwind DNA as a single hexamer that encircles and transl

67 evolves into two hexamers that encircle and unwind DNA bi-directionally.

68 hromosome maintenance helicase was unable to unwind DNA bound by this archaeal RNA polymerase in a st

69 s in all cell types are hexameric rings that unwind DNA by steric exclusion in which the helicase enc

70 The ability of UvsW to unwind DNA duplexes is likely to be mechanistically link

71 tion as efficient RNA helicase, and does not unwind DNA duplexes.

72 There is much debate about how helicases unwind DNA during DNA replication and how their activity

73 singly, we find that RecBCD can processively unwind DNA for at least 80bp beyond the reverse polarity

74 y a specific subset of Mcm subunits (Mcm467) unwind DNA in vitro.

75 rk, we have examined the ability of FANCJ to unwind DNA molecules with specific base damage that can

76 ine abolishes the ability of the helicase to unwind DNA or allow T7 polymerase to mediate strand-disp

77 hydrolysis to produce the force required to unwind DNA or destabilize protein bound to DNA is requir

78 ded DNA (ssDNA) translocase but is unable to unwind DNA processively in vitro.

79 the role of the helicase to more efficiently unwind DNA repair intermediates to maintain genomic stab

80 ed DNA, whereas two monomers are required to unwind DNA to a detectable degree.

81 UvrD303 mutation may enable the helicase to unwind DNA via a "strand displacement" mechanism, which

82 ntenance (SsoMCM) helicase has been shown to unwind DNA via a SEW mode to enhance unwinding efficienc

83 nt (kcat), consequently the combined enzymes unwind DNA with kinetic parameters resembling enzymes tr

84 enzymes are from different superfamilies and unwind DNA with opposite polarities.

85 d of the eukaryotic replication machinery to unwind DNA, in a process that requires ATP hydrolysis.

86 igins, load the replicative helicase on DNA, unwind DNA, synthesize new DNA strands, and reassemble c

87 haped, hexameric helicases that encircle and unwind DNA.

88 hexameric motor domains are loaded onto and unwind DNA.

89 helicases are ATP-driven motor proteins that unwind DNA.

90 equences at the hairpin loop and stem and to unwind DNA.

91 lates with the ability of these complexes to unwind DNA.

92 compassing a broad distribution of rates, to unwind DNA.

93 sDNA overhangs; helicases such as BLM, which unwind DNA; and other proteins such as BRCA1 and CtIP wh

94 Local zones of easily unwound DNA are characteristic of prokaryotic and eukary

95 Although any individual RecBCD molecule unwound DNA at a constant rate for an average of approxi

96 g H. pylori addA(NUC)B or addAB(NUC) mutants unwound DNA but had approximately half of the exonucleas

97 s(-1) and a dissociation step from partially unwound DNA of k(off) = 1.9 s(-1).

98 , MTERF1 binds a significantly distorted and unwound DNA structure, exhibiting a protein conformation

99 pin, slipped strand, triplex, quadruplex, or unwound DNA structures.

100 this region of T antigen provides the proper unwound DNA substrate for initiation to occur, we demons

101 The DnaB-DnaC complex binds to the unwound DNA within the Escherichia coli replication orig

102 ular Cell, heterodimerizes with FANCM, binds unwound DNA, and reveals how the Fanconi anemia core com

103 transiently in mRNA and in single-stranded, unwound DNA.

104 How do helicases unwind double helices?

105 s been observed to use dTTP, but not ATP, to unwind double-stranded (ds)DNA as it translocates from 5

106 Helicases are ubiquitous enzymes that unwind double-stranded DNA (dsDNA) to reveal single-stra

107 DNA helicases are motor proteins that unwind double-stranded DNA (dsDNA) to reveal single-stra

108 Hepatitis C virus NS3 helicase can unwind double-stranded DNA and RNA and has been proposed

109 UvrD couples ATP binding and hydrolysis to unwind double-stranded DNA and translocate along ssDNA w

110 wer concentrations of Aq793 were required to unwind double-stranded DNA that had a 3'-poly(dT) overha

111 ases utilize the energy of ATP hydrolysis to unwind double-stranded DNA while translocating on the DN

112 along single-stranded (ss) nucleic acid, and unwind double-stranded nucleic acids.

113 Helicases are proteins that unwind double-stranded nucleic acids.

114 ession of RhlE or RNase R, both of which can unwind double-stranded RNA.

115 al ring-shaped T7 helicase molecules as they unwound double-stranded DNA (dsDNA) or translocated on s

116 monomer of Saccharomyces cerevisiae Pif1 can unwind dsDNA (double-stranded DNA).

117 We found that T7 helicase does in fact unwind dsDNA in the presence of ATP and that the unwindi

118 limits and controls the enzyme's capacity to unwind dsDNA.

119 he helicase to bind DNA, hydrolyze dTTP, and unwind dsDNA.

120 track along the sugar phosphate backbone and unwind dsDNA.

121 DHX36 unwound dsDNA poorly compared with G4s of comparable int

122 EAD-box protein that utilizes ATP to locally unwind dsRNA, to investigate helicase specificity and me

123 Helicases unwind duplex DNA ahead of the polymerases at the replic

124 plicative hexameric helicases are thought to unwind duplex DNA by steric exclusion (SE) where one DNA

125 uses the energy of nucleotide hydrolysis to unwind duplex DNA during mitochondrial DNA replication.

126 ns the Rep helicase activity can function to unwind duplex DNA during strand displacement synthesis.

127 DNA helicase preferentially utilizes dTTP to unwind duplex DNA in vitro but also hydrolyzes other nuc

128 To unwind duplex DNA in vitro, UvrD needs to be activated e

129 picomolar concentrations and can efficiently unwind duplex DNA molecules as long as 23,000 base pairs

130 These results indicate that RecBCD can unwind duplex DNA processively in the absence of ssDNA t

131 a 3' single-stranded DNA region to load and unwind duplex DNA structures.

132 istic DNA-dependent NTPase activity, and can unwind duplex DNA substrates independently of the N-term

133 tion RPA stimulates FANCJ helicase to better unwind duplex DNA substrates.

134 ong a DNA strand in a 3' to 5' direction and unwind duplex DNA utilizing a DNA-dependent ATPase activ

135 g, allowing it to refold, or going beyond to unwind duplex DNA, Pif1 repeatedly unwinds G4 DNA, keepi

136 operate on the complementary DNA strands to unwind duplex DNA.

137 m2-7/GINS (CMG) complex that is competent to unwind duplex DNA.

138 ns of the DExH/D family are ATPases that can unwind duplex RNA in vitro.

139 eins are ATPase enzymes that destabilize and unwind duplex RNA.

140 vities that can operate on each strand of an unwound duplex DNA.

141 ested under conditions in which the helicase unwound duplex DNA.

142 Extension of the 5'-tail of the unwound duplex induces a large conformational change in

143 ited to accommodate one or two strands of an unwound duplex.

144 ee-step mechanism in which DEAD-box proteins unwind duplexes as "local strand separators." This unwin

145 translocation along single strand DNA and to unwind duplexes en route.

146 hydrolysis activity or reduce its ability to unwind duplexes show that the efficiency of ATP hydrolys

147 plication requires helicases to processively unwind duplexes.

148 DNA turn, consistent with the length of DNA unwound during transcription initiation.

149 m loop (U6 ISL), a stable helix that must be unwound during U4/U6 assembly.

150 tructured loop or a Watson-Crick duplex were unwound equally well by both enzymes.

151 for NSF in which approximately 1 residue is unwound for every hydrolyzed ATP molecule.

152 on with PCNA allows the helicase activity to unwind fork-blocking CAG/CTG hairpin structures to preve

153 many genetic observations, the detection of unwound fork structures in vivo and the identification o

154 y, we show that HEL308 appears to target and unwind from the junction between single-stranded to doub

155 equilibria, in which filaments progressively unwind from their native twist with increasing surface i

156 This strand is then unwound from its complement and transferred in the 5'-to

157 the budding yeast Pif1 known to efficiently unwind G-quadruplex rescues all the telomeric defects of

158 ChlR1 unwound G-quadruplex (G4) DNA with a strong preference f

159 CJ helicase is among those helicases able to unwind G4 DNA in vitro, and FANCJ mutations are associat

160 amily members have been shown to bind to and unwind G4 structures.

161 36 uses a local, non-processive mechanism to unwind G4 substrates, reminiscent of that of eukaryotic

162 FANCJ unwound G4 DNA substrates in an ATPase-dependent manner.

163 lizes exclusively adenosine triphosphates to unwind helices, oligomerizes to function as efficient RN

164 viously shown to bind to hormone as a partly unwound helix, forms a complete alpha-helix that displac

165 s, MutS and MutL, may utilize its ability to unwind Holliday junctions directly in the prevention of

166 and reinforced when the protein was shown to unwind Holliday junctions.

167 is reactions until about four base pairs are unwound in a burst.

168 FANCJ efficiently unwound in a kinetic and ATPase-dependent manner entropi

169 The number of base pairs unwound in a single binding event for Dda is increased f

170 r experiments, which show that SNAREs can be unwound in a single encounter with NSF.

171 blished an RNA substrate for NS3 that can be unwound in a single sub-step.

172 U4 and U6 are then unwound in order for U6 to pair with U2 to form the spli

173 amp opening allows DNA to be loaded into and unwound in the RNAP active-center cleft, that DNA loadin

174 mulated with a mechanism in which the DNA is unwound in two kinetic steps with rate constant of k(unw

175 positions a nucleosome, evidently partially unwound, in a structure that facilitates Gal4 binding to

176 Strikingly, BLM unwound individual DNA molecules in a repetitive manner,

177 nitiation factor eIF4B, which is critical to unwind its structured 5' untranslated region (5'UTR).

178 s manner while the second copies the already unwound lagging-strand template in a discontinuous manne

179 Consistently, WRN efficiently unwound large (CTG)(n) hairpins and promoted DNA polymer

180 to the central channel of the N-tier and the unwound leading single-strand DNA traverses the channel

181 cessivity; yet, it is unable to processively unwind linear dsDNA, even 60 base-pairs long.

182 structures, and forked duplexes but fails to unwind linear duplex DNA.

183 by Prp8, wild type Delta247-Brr2 is able to unwind long stable duplexes in vitro, and even the RP mu

184 ding protein POT1 stimulates WRN helicase to unwind longer telomeric duplexes that are otherwise poor

185 eins bind to structured RNAs and efficiently unwind loosely associated duplexes, which biases the pro

186 While xDNA2 acts on ssDNA unwound mainly by the Xenopus Werner syndrome protein (x

187 orce studied, nucleosomes containing H4-R45H unwind more rapidly and rewind more slowly than nucleoso

188 substrate containing a Holliday junction is unwound most efficiently.

189 hydrolysis-coupled conformational changes to unwind mRNA secondary structures during translation init

190 ases, uses two distinct active mechanisms to unwind mRNA structure: it destabilizes the helical junct

191 helicases are dependent on their ability to unwind nucleic acid duplexes in an ATP-dependent fashion

192 m ATP hydrolysis to translocate along and/or unwind nucleic acids.

193 Although the existence of different unwound nucleosome states has been hypothesized, there h

194 the existence of two distinct states of the unwound nucleosome, which are accessible at physiologica

195 e an unblocked 5' single-stranded DNA end to unwind or cleave DNA.

196 x small interfering RNAs, but were unable to unwind or eject the passenger strand and form functional

197 imulated ATPases that translocate on RNA and unwind or remodel structured RNA in an ATP-dependent fas

198 The beta-hairpin is not required to unwind or to overcome the bottleneck but is essential fo

199 transmembrane segment 5 (TM5i) in either an unwound or a helical conformation.

200 ng that the oxidation process is favored for unwound or single-strand regions of DNA.

201 regulated during formation of complexes that unwind origin DNA and load replicative helicase.

202 ATPase and helicase activities but failed to unwind origin DNA and support SV40 DNA replication.

203 ities but with a severely reduced ability to unwind origin DNA and to support SV40 DNA replication in

204 The class D mutants unwound origin DNA normally but were compromised in thei

205 R to be highly processive: one molecule can unwind over 500 bp of a structured substrate.

206 ppears to be dictated by the geometry of the unwound part of the transmembrane (TM) helix 3, mostly a

207 The NMDGT motif on the partially unwound part of the transmembrane helix TM7 and the resi

208 s release to the cytoplasm provided that the unwound part of TM3 switches from a shielding to a yield

209 how that PcrA, in combination with RepD, can unwind plasmid lengths of DNA in a single run, and that

210 ase the processivity of PcrA, allowing it to unwind plasmid lengths of DNA.

211 ites attention to the functional role of the unwound portion of TM helices (TM6 Trp-202-Glu-208 in Ad

212 athway between the sodium-binding sites, the unwound portion of transmembrane helix 1 and the substra

213 f residues in the opposing hairpin loops and unwound portions of adjacent helices.

214 branch migration by RecA, where a completely unwound product consisting of the paired nascent leading

215 d SSB; however, RuvAB generates a completely unwound product consisting of the paired nascent leading

216 rved pi helix was in the extended, partially unwound "product release" state.

217 ated helicases in cancer cells are unable to unwind quadruplexes, which are impediments to transcript

218 he ability of BC200 to act as an acceptor of unwound quadruplexes via a cytosine-rich region near the

219 hybrids in human cells, and can efficiently unwind R-loops in vitro.

220 A shorter 12-bp substrate is unwound rapidly under single turnover conditions.

221 o acids 128-142 and 147-154) separated by an unwound region (amino acids 143-146).

222 RecQ helicases unwind remarkably diverse DNA structures as key componen

223 in a substantial reduction in the ability to unwind replication fork and Holliday junction structures

224 imulate group I and group II intron splicing unwind RNA duplexes by local strand separation and have

225 Viral RNA helicases of the NS3/NPH-II group unwind RNA duplexes by processive, directional transloca

226 nt DEAD-box proteins, Ded1p and Mss116p, can unwind RNA duplexes from internal as well as terminal he

227 oteins are mainly known for their ability to unwind RNA duplexes in an ATP-dependent fashion.

228 Both mutants completely lost ability to unwind RNA duplexes with 5' overhangs.

229 odel for how DEAD-box proteins recognize and unwind RNA duplexes.

230 NS3 has been shown to unwind RNA in a discontinuous manner, pausing after long

231 s a DEAD-box RNA-dependent ATPase thought to unwind RNA secondary structure in the 5'-untranslated re

232 H-box helicases, which use ATP hydrolysis to unwind RNA secondary structures.

233 of a very short 5' UTR, eIF4A is required to unwind RNA structure in the sapovirus genome to facilita

234 onetheless, polyadenylation enables TRAMP to unwind RNA substrates that it otherwise cannot separate.

235 domains, bacteria, archaea, and eukarya, to unwind RNA-containing substrate was determined.

236 ure on every encounter, and is sufficient to unwind RNA-DNA heteroduplex but not duplex DNA.

237 ites on RNase E, with which it cooperates to unwind RNA.

238 two mechanisms by which RNA helicase enzymes unwind RNA: The nonprocessive DEAD group catalyzes local

239 RNA, thereby facilitating the release of the unwound rRNA mother strand and the recycling of DbpA for

240 ch syndrome, activities must also exist that unwind secondary structures to facilitate replication fi

241 omain (TM6a) that is separated by a central, unwound section from a cytoplasmically localized domain

242 D-box proteins have been shown to use ATP to unwind short RNA helices, it is not known how they disru

243 AdnAB helicase under conditions in which the unwound single strands are coated by SSB and thereby pre

244 ing a synthetic sequence that mimics freshly unwound single-stranded DNA at replication fork showed t

245 lecular G4 DNA likely to form in transiently unwound single-stranded genomic regions.

246 nwinding and/or by POT1 loading on partially unwound ssDNA strands to prevent strand re-annealing.

247 vironment in the absence of the receptor, is unwound starting at T(32) to provide optimal contacts in

248 o capture its DNA substrate when it is in an unwound state.

249 r results demonstrate not only that multiple unwound states exist but that their accessibility can be

250 We anticipate that the two unwound states reported here will be the basis for futur

251 nealing of a complementary RNA by making the unwound strand more accessible.

252 randed (ss) DNA that is complementary to the unwound strand.

253 ity of WRN helicase by maintaining partially unwound strands in a melted state, rather than preventin

254 e, a serine and a main-chain carbonyl in the unwound stretch of trans-membrane helix 5 at the deepest

255 Helicases that unwind structured DNA molecules are emerging as an impor

256 eIF4A has been thought to unwind structures formed in the untranslated 5' region v

257 56 is an ATP-dependent RNA helicase that can unwind substrates with 5' or 3' overhangs or blunt ends

258 on, we tested the ability of the helicase to unwind substrates with site-specific oxidative DNA lesio

259 demonstrate that WRN and BLM preferentially unwind telomeric D-loops containing 8-oxodG and that POT

260 er eIFs, 4F, 4A, and 4B, which cooperatively unwind the cap-proximal region of mRNA and later also as

261 at T antigen has a mechanism to specifically unwind the central palindrome.

262 a "skip residue," which is likely to locally unwind the coiled-coil and perhaps contributes to the bi

263 anslocate along one strand of the duplex and unwind the complementary strand.

264 translocate along one strand of the DNA and unwind the complementary strand.

265 aryotes, these factors include a helicase to unwind the DNA ahead of the replication fork, a single-s

266 beta at the origins of latent replication to unwind the DNA for replication.

267 t least one of the helicases will completely unwind the DNA prior to dissociation.

268 a hypothesis owing to its ability to locally unwind the double helix.

269 t Mtr4p can, in the presence of ATP or dATP, unwind the duplex region of a partial duplex RNA substra

270 t the predominant role of UvrD in vivo is to unwind the excised 13-mer from dsDNA and that mutation o

271 Fewer kinetic steps were required to unwind the fork compared to the ss/ds junction, suggesti

272 Both FMRP and FXR1P RGG box are able to unwind the G quartet structure of S3F RNA, however, the

273 rtiary contacts, and then CYT-19 uses ATP to unwind the helix, liberating the product strands.

274 combinant P68 RNA helicase was sufficient to unwind the let-7 duplex.

275 ovel activity in HeLa cell extracts that can unwind the let-7 microRNA duplex.

276 imately 13 pN of force, barely sufficient to unwind the most stable structures in mRNAs, thus providi

277 ting was not the major reason they failed to unwind the origin because supplying an EP region as a mi

278 he N. gonorrhoeae RecQ helicase can bind and unwind the pilE G4 structure.

279 e enzyme's inability to efficiently bind and unwind the pilE G4 structure.

280 ere used to dissect pDC function in vivo and unwind the potential mechanisms involved.

281 chromosome replication requires DnaA-ATP to unwind the replication origin, oriC, and load DNA helica

282 ptor strand uses its long RNA-binding arm to unwind the RNA secondary structure.

283 d strand displacement [TMSD] ability, helped unwind the secondary structures of the RNA molecule and

284 Replicative helicases that unwind the template DNA for polymerases at the fork can

285 Brr2 is an RNA-dependent ATPase required to unwind the U4/U6 snRNA duplex during spliceosome assembl

286 anded DNA-binding protein, FANCJ efficiently unwound the DNA substrate harboring the thymine glycol d

287 ated that if the terminator DNA is partially unwound, the resulting melted DNA could bind tightly to

288 HrP helix is gently curved and C-terminally "unwound." The receptor accommodates the altered binding

289 a Warsaw breakage syndrome patient failed to unwind these triplexes.

290 Unable to smoothly unwind, this conflict bends the helices until the helix

291 -tail and the length of the duplex DNA to be unwound, this activity is sufficiently strong to mask th

292 ty converts it into a superhelicase that can unwind thousands of base pairs processively, even agains

293 substrate binding by stabilizing the partly unwound TM1' helix.

294 to prevent spurious recombination events and unwind trinucleotide sequences that are prone to hairpin

295 sed to destabilize protein-DNA complexes and unwind triple helix alternate DNA structures.

296 differ when sequences are presented from an unwound triple helix versus an independent single strand

297 we test the ability of G4R1/RHAU to bind and unwind unimolecular G4-DNA.

298 We find that U4/U6 is efficiently unwound using DNA oligonucleotides by coupling unwinding

299 gical substrate that a monomer of FacXPD can unwind with a processivity sufficient for expansion of t

300 Particularly, the GC-rich dsDNAs are unwound with lower amplitudes under single-turnover cond