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1 CKR2 down-regulation and concurrent miR-146b up-regulation.
2 Rac1 geranylgeranylation reduced 11beta-HSD2 up-regulation.
3 however, 30,000 muatm stimulated widespread up-regulation.
4 antly, BOX5 attenuated NRTI-induced cytokine up-regulation.
5 on impairs glucose deprivation-induced GLUT1 up-regulation.
6 siRNA abolished the aldosterone-induced CTGF up-regulation.
7 lpha2delta1 Delta1059-1063) impaired current up-regulation.
8 ecipitation) to characterize Pb-induced gene up-regulation.
9 nterfering RNA suppressed ET-1-induced TRPC6 up-regulation.
10 ighlights the deleterious effects of Mirta22 up-regulation.
11 lose-induced inhibition corresponds with the up-regulation and biogenesis of a cyclical AgrD-type, pe
13 roph function opposite to those of LTs, with up-regulation and down-regulation of gonadotrophin gene
15 ing abrogates activin-A-driven IL10 and ICOS up-regulation and impairs the suppressive functions of h
16 scillospira decrease coupled to a 2-butanone up-regulation and increases in Ruminococcus and Dorea we
17 n-regulation in osteosarcomas leads to CCNE1 up-regulation and more aggressive growth phenotypes.
20 owever, the causal relationship between Plk1 up-regulation and tumorigenesis is incompletely investig
23 nse in neural stem cells and identified SPP1 up-regulation as a potential novel mechanism linking Pb
24 fering RNA knockdown or MCU plasmid-mediated up-regulation, as well as through modulation of the upst
25 iption factor 4 and C/EBP homologous protein up-regulation, associated with caspase-independent apopt
26 the hypothesis that for an efficient oxygen up-regulation at least two regulation mechanisms must be
29 tochondrial biogenesis was dependent on TFAM up-regulation but was independent of the activation of t
30 oarray-based genome-wide profiling indicated up-regulation by mycorrhization of genes involved in fla
31 eceptors (RIG-I/MDA-5) and that NKG2D ligand up-regulation can be blocked by the expression of viral
32 To probe for mechanistic insight into how AC up-regulation can impact intestinal inflammation, we inv
33 MP2A expression is independent of TFEB, TFEB up-regulation corrected lysosome distribution and lysoso
34 ivity was not increased, indicating that PDH up-regulation did not compensate for defects in the PDH
35 vation/deactivation of C3 cycle enzymes, and up-regulation/down-regulation of photoprotective process
36 PSS activity, exhibiting a growth-dependent up-regulation from the exponential to the stationary pha
38 riants, we test a recently proposed affinity up-regulation hypothesis which states that collagen bind
39 mediated by pyruvate dehydrogenase kinase 1 up-regulation in activated MPs, resulting in regional py
44 topathological observations and the MYH mRNA up-regulation in Longissimus dorsi muscle confirm the an
45 co-evolution with host plants and in-planta up-regulation in particular, aided identification of eff
46 FATc4 signaling pathway and consequent TRPC6 up-regulation in PASMCs, while these inhibitory effects
47 1/2), which phosphorylate S10 in H3, inhibit up-regulation in phosphorylated S10 in H3 (p-S10H3) as w
48 athway: basket, c-jun) that are countered by up-regulation in some negative elements (the insulin-sig
51 iate early gene expression revealed parallel up-regulation in the hippocampus and cortex, sustained i
53 mad3 did not prevent the TGFbeta-induced TAZ up-regulation, indicating that this canonical pathway is
57 by cystinosin, Rab11, and RILP and that CMA up-regulation is a potential clinically relevant mechani
58 e also show that Hop GLKD-induced transposon up-regulation is due to inefficient piRNA biogenesis.
60 both cohorts and that STAT1-dependent PD-L1 up-regulation-known to inhibit Th17 differentiation in m
64 e demonstrate here that IL-4-dependent Cox-1 up-regulation occurs at the post-transcriptional level v
66 t to demonstrate a clear role for SP1 in the up regulation of PKCbetaII expression in CLL cells, and
67 and 4 moisture gradients regimes showed the up-regulation of 124, 130, 126 and 162 and down-regulati
69 ed gene expression characterized by a strong up-regulation of a core activation program, coupled with
70 ntial triacylglycerol (TAG) accumulation and up-regulation of a gene, GPD2, encoding a multidomain en
72 terestingly, deletion of AMD1 results in the up-regulation of a number of genes related to transporte
73 (TPA), respectively) is associated with the up-regulation of a previously uncharacterized long nonco
74 used to dissect the role of alpha7 nAChR in up-regulation of Abeta induced by gp120, METH and NT.
75 cold tolerance was reflected by the gradual up-regulation of abscisic acid-dependent and C-REPEAT-BI
76 n conditions activated fibroblasts, shown by up-regulation of alpha-smooth muscle actin, pro-collagen
77 providing a causal mechanism underlying the up-regulation of alpha-synuclein SUMOylation in the dise
78 offer a perspective regarding the consistent up-regulation of alpha5beta1 integrin and FN in many tum
79 n, resulting from down-regulation of MCU and up-regulation of an inhibitory subunit, mitochondrial ca
80 We reported that in the pancreas remarkable up-regulation of angiogenesis as downstream of the HIF s
81 However, PGC1beta overexpression triggers up-regulation of apoptosis and autophagy genes, resultin
83 erface residues abrogates starvation-induced up-regulation of autophagy but does not affect basal aut
85 and have severe adipocyte defects caused by up-regulation of beta-catenin transcriptional activities
86 l atmospheric CO2 concentration will trigger up-regulation of Bt toxin expression in transgenic rice,
87 antitative PCR and Western blotting revealed up-regulation of C3 and CFB expression in cSCC cells.
91 we postulate instead arises through blunted up-regulation of CD147 expression and subsequent activat
92 is finding, in combination with the striking up-regulation of CD3, CD8 and CD94, suggests that CD8+ T
96 Moreover, loss of cell-cell adhesion caused up-regulation of cell-ECM adhesion, leading to reduced c
100 tif chemokine ligand (CXCL) 1 chemokines and up-regulation of chemokine (Ccl2, Ccl7, Cxcl1, Cxcl2, an
101 ion by stimulating leukocyte recruitment via up-regulation of circulating platelet surface P-selectin
103 BBP ZNF384-rearranged ALL showed significant up-regulation of CLCF1 and BTLA expression, and ZNF384 f
104 s smooth muscle alpha-actin fiber formation, up-regulation of collagen I, and down-regulation of coll
105 y immune response following IOP elevation is up-regulation of complement C3 in astrocytes of DBA/2J a
106 ry control for down-regulation of growth and up-regulation of conidia production between 18 and 24 ho
107 suggest a new paradigm where IL-4-dependent up-regulation of Cox-1 expression may play a key role in
109 The STIA model was characterized by early up-regulation of CXCR2/CXCR2 ligand gene expression in a
111 hibition of XBP1 expression caused a reduced up-regulation of DDR messenger RNAs in regenerating hepa
112 s in persistence of let-7 microRNAs, and the up-regulation of de novo methyltransferases Dnmt3a/b is
115 ge-specific selection revealed the polygenic up-regulation of dozens of biofilm suppressor genes in s
117 /BMP10 synergize with TNFalpha to induce the up-regulation of endothelial selectins and adhesion mole
118 ed PCa cells further indicated a significant up-regulation of enzymes in the major reactive oxygen sp
119 s, identifying a potential mechanism of late up-regulation of EP4 and impaired gliding function in EP
120 n only transient deletion of EP4, suggesting up-regulation of EP4 in an alternative cell population i
121 UTR shortening in S. pombe coordinates with up-regulation of expression for genes involved in transl
122 cally regulated Ras isoform with significant up-regulation of expression observed pre-term in stomach
123 oplasmic-interacting protein, BOD1, leads to up-regulation of expression of numerous genes modulating
124 from the preferential use of glucose to the up-regulation of fatty acid oxidation (FAO) in myeloid c
126 and adults with r-bursicon homodimers led to up-regulation of five anti-microbial peptide (AMP) genes
127 lation of MYC2, but only JA also induced the up-regulation of flavonoid and terpenoid biosynthetic ge
128 the developing kidney, including a fivefold up-regulation of Foxd1, a known regulator of nephron pro
129 This interaction induces STAT3-dependent up-regulation of FOXp3, CD39, IL-10, and granzyme B, res
130 dian-controlled factors are required for the up-regulation of FT1 expression and the acceleration of
131 e show that SR20 triggers tumor apoptosis by up-regulation of gene expression of tumor necrosis facto
132 tion of IL-1beta, which in turn drove strong up-regulation of genes associated with cartilage degrada
133 s involved in xylan and lignin synthesis and up-regulation of genes for the specific set of transcrip
135 of Erdr1-overexpressing cells identified the up-regulation of genes involved in Fas-mediated cell dea
136 mbryonic development and vasculogenesis, and up-regulation of genes involved in hematopoietic organ d
137 ponsive to toxin challenge nor was there any up-regulation of genes involved in multi-xenobiotic resi
138 lopment and function of normal B cells, show up-regulation of genes involved in T-cell signaling, and
142 her augmented the antioxidant system through up-regulation of glucose influx, the pentose phosphate p
143 campal cultures, synaptic activity caused an up-regulation of glycolytic genes and a concomitant down
144 lia and splenomegaly in adulthood due to the up-regulation of granulocyte-colony stimulating factor (
147 cclimation (48 mmHg) resulted in significant up-regulation of Hbalpha-2, Hbalpha-3.2, and Hbbeta-3.1,
151 by type I interferon (IFN) and the resulting up-regulation of hundreds of interferon-stimulated genes
152 ay; shifts in cellular metabolism, including up-regulation of hypoxia inducible factor-1alpha's downs
153 ) caused (i) stabilization of HIF-2alpha and up-regulation of hypoxia-regulated genes including BNIP3
154 tigen transport to the LN, but inhibited the up-regulation of IFN-I-induced markers on DCs and effect
155 masome in a protracted manner, leading to an up-regulation of IL-1beta and IL-18 production in human
156 matosus lesions showed significant epidermal up-regulation of IL-6 compared with control via real-tim
157 blotting analysis of PELP1-cyto HMECs showed up-regulation of inhibitor of kappaB kinase (IKK) and in
158 to trigger activation of IRF3 and subsequent up-regulation of interferon (IFN)-stimulated genes (ISGs
160 of beta-catenin was further indicated by the up-regulation of its downstream targets cyclin D1, c-Myc
162 the reduction of vascular remodeling and the up-regulation of Kallikrein-kinin system contribute, at
164 y gammaH2AX foci and comet assays and to the up-regulation of Ku70 and DNA-dependent protein kinase,
168 liferation through down-regulation of GR and up-regulation of manganese superoxide dismutase and redu
171 oluble than bulk particles, resulting in the up-regulation of metallochaperone-like genes or the down
174 ate, for the first time, the transcriptional up-regulation of miR-34c-5p in response to TCR stimulati
178 T1-MMP-dependent activation of pro-MMP-2 and up-regulation of MT1-MMP at the gene and protein levels.
179 ed enhanced Pi starvation responses, such as up-regulation of multiple genes involved in Pi uptake an
180 asal levels and TRAF3IP2 silencing-dependent up-regulation of multiple late differentiation genes.
181 zed plants with either ABA or JA induced the up-regulation of MYC2, but only JA also induced the up-r
182 repression of histone marks and did not show up-regulation of myosin heavy chain and myotube formatio
183 ts preferential trafficking likely drive the up-regulation of nAChRs on the cell surface upon nicotin
185 ssels during EAE progression correlates with up-regulation of neuronal Wnt3 expression, as well as br
186 productive development and observed striking up-regulation of neuropeptide genes during dauer entry.
187 Through meta-analysis, we discovered similar up-regulation of neuropeptides in the dauer-like infecti
188 This was accompanied by cardiac fibrosis and up-regulation of NFAT-c2, reflecting increased calcineur
189 al stretch were shown to induce the profound up-regulation of NGF in osteoblasts within 1 h of loadin
190 is coincides with TCP20 and NLP6&7-dependent up-regulation of nitrate assimilation and signaling gene
192 wide reduction of DNA methylation, and (iii) up-regulation of noncoding RNAs, including microRNAs, wi
193 in retinas of the treated rats, as shown by up-regulation of NRF-2-dependent gene expression and dow
194 he transcription factor STAT5 results in the up-regulation of numerous genes implicated in breast can
195 ticular markers Amh and Sox9, and remarkable up-regulation of ovarian regulators, Cyp19a1 and Foxl2.
196 alyses of evolved B. bassiana implicated the up-regulation of oxidative stress resistance genes in th
205 e mechanism is linked to the transcriptional up-regulation of PHYTOALEXIN-DEFICIENT4, which is an imp
206 , we demonstrate that IL-4 and IL-33 promote up-regulation of PPARgamma in lung-resident CD11b(+) DCs
207 ceding the NB Cycloheximide abolished the NB up-regulation of PPD1, suggesting that this process is d
209 metabolic inflexibility is driven by robust up-regulation of pyruvate dehydrogenase kinase 4 (PDK4)
211 onsistently, the IVVY motif mutant triggered up-regulation of recombinant recognition sequence-bindin
212 expression studies revealed a smoke-induced up-regulation of Rho-GTPase-dependent actin cytoskeletal
214 eptor expression increased markedly, and the up-regulation of SDF-1, and its receptor C-X-C chemokine
216 roadly, the transcriptomic analysis revealed up-regulation of several defense and SA-responsive and/o
218 reas the other group was characterized by an up-regulation of several transcripts, including XDH1, gl
224 ced suppression of FOXa2 gene expression and up-regulation of SPDEF, alterations in gene and protein
227 significance appear to involve constitutive up-regulation of sulfate/selenate uptake and assimilatio
228 ters, PbceA or PpsdA , resulting in a strong up-regulation of target gene expression and ultimately a
229 Immortalization by TPMs requires a gradual up-regulation of telomerase, coinciding with telomere fu
230 istent with skin expression, AD serum showed up-regulation of Th2 (IL-13, CCL17, eotaxin-1/CCL11, CCL
231 tion of microglia are accompanied by a rapid up-regulation of the 18-kDa translocator protein (TSPO).
232 n together our findings demonstrate that the up-regulation of the ALOX5 gene pathway is responsible f
236 in Hcy levels, memory and learning deficits, up-regulation of the ALOX5 pathway, increased Abeta leve
239 erens junctional integrity was caused by the up-regulation of the closely related family member plako
240 matin, and gain of 5-hmC was correlated with up-regulation of the cognate transcripts, including many
241 through quantitative adaptations, namely an up-regulation of the content of several groups of protei
242 RAGE acting as a decoy were associated with up-regulation of the DAMP-related signaling pathway via
243 brucei cells overexpressing TbHrg displayed up-regulation of the early procyclin GPEET and down-regu
244 ivation of the ERK1/2 and STAT3 pathways and up-regulation of the inhibitor of DNA binding transcript
246 ls via ROS-induced activation of Src kinase, up-regulation of the K(+) channel Kir4.1, and stimulatio
247 , which is homologous to mouse mIgE, and the up-regulation of the long form of mIgE (mIgEL ), which i
249 thermore, PM blebbing triggered SRF-mediated up-regulation of the metastasis-associated ERM protein E
250 mediated phosphorylation and subsequent gene up-regulation of the mineralization inhibitors matrix Gl
251 RR or Tir8) or activation of IL-1R, leads to up-regulation of the mTOR pathway and increased levels o
252 and CD8(+) T cell-injected mice, leading to up-regulation of the Na-Cl co-transporter NCC, p-NCC and
253 uronal transdifferentiation, and concomitant up-regulation of the neuronal markers calretinin and cal
254 ligand during development in vivo results in up-regulation of the Nod-like receptor member Nod1, whic
256 Slt2p was defective in crd1Delta cells, and up-regulation of the PKC pathway by expression of the PK
257 BD colon biopsies, quantifying a significant up-regulation of the resolvin and protectin pathway comp
258 proteins and their oxidation resulted in an up-regulation of the SigH, SigE, Zur and NrdR regulons i
259 ibrogenesis, driven at least in part through up-regulation of the SK1 pathway and cell migration in H
263 HE9 in hBMVECs without external cues induced up-regulation of the transferrin receptor (TfR) and down
265 of Actbeta or Actgamma leads to compensatory up-regulation of the two other isoforms, which allows ma
268 lity that bursicon heterodimers also lead to up-regulation of these genes can not been excluded.
270 nic activity of PRKCI relates in part to the up-regulation of TNFalpha to promote an immune-suppressi
272 a modest but potentially relevant pervasive up-regulation of translational machinery observed in syn
273 ver, the molecular mechanisms underlying the up-regulation of TRPC6 expression and PDE5 modulation of
274 sion of capsaicin, which was associated with up-regulation of TRPV1 expression in laryngeal C neurons
275 vs. XgDeltaavrHah1 revealed the differential up-regulation of two basic helix-loop-helix (bHLH) trans
276 322)/503 promotes chemoresistance due to the up-regulation of two of its targets: BCL-2 and insulin-l
277 reacts with exactly two others, can exhibit up-regulation of two products even when only a single ch
278 transcription factor for ICCs-and consequent up-regulation of v-kit Hardy-Zuckerman 4 feline sarcoma
282 perate grasses, vernalization results in the up-regulation of VERNALIZATION1 (VRN1) to establish comp
283 esulted in down-regulation of E-cadherin and up-regulation of vimentin, which were reversed by FPR2 k
286 ly CCR7-dependent manner; and induces ICAM-1 up-regulation on lymphatic vessels, allowing neutrophils
287 of one of the constituents, the input-guided up-regulation or down-regulation of the CDN's constituen
290 4 beats per minute) superimposed on exercise up-regulation (stroke frequency >25 strokes per minute a
291 inhibited phosphorylation of STAT1 and PD-L1 up-regulation, suggesting that diminished SOCS3 expressi
293 translated sORFs, including five with low-Pi up-regulation that correlated with enhanced translation
295 In addition, we found the transcriptional up-regulation to co-occur with the chromatin structural
296 d that hypomethylation leading to CNTFRalpha up-regulation, together with autocrine expression of CNT
297 els inversely correlates with SAMHD1 protein up-regulation upon type I and II interferon stimulation
300 y specimens suggested that SNAI1 cytoplasmic up-regulation was preceded by a transient increase of ph
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