ライフサイエンスコーパス: upfront

1 chnically could undergo a surgical resection upfront.

2 e considered in younger patients if not used upfront.

3 ore with patients whose tumors were resected upfront.

4 ert consensus to warrant a 2-stent technique upfront.

5 and neck squamous cell carcinoma (HNSCC) by upfront (18)F-FDG PET/CT (i.e., on the day of biopsy and

6 d 693 (84.9%) had postoperative radiotherapy upfront; 36.8% of 3-year-olds and 4.1% of 8-year-olds ha

7 have tested one of three approaches: (1) an upfront AI, (2) a sequential approach after 2-3 years of

8 ients for optimal doses and/or modalities of upfront AML therapy.

9 d), or loss incentive ($42 allocated monthly upfront and $1.40 removed each day the goal was not achi

10 free survival was 66.5% for patients treated upfront and 41.4% for relapsed patients.

11 The upfront and delayed groups each included 301 patients.

12 y to platinum-based chemotherapy in both the upfront and recurrent setting, and have an overall impro

13 onable treatment for WM patients in both the upfront and salvage settings, though randomized studies

14 brought proximal, this must be screened for upfront, and (b) cooperative or synergistic interactions

15 With a more upfront approach to DKT by offering this option to patie

16 Larger CD34 quantities should be collected upfront as the risk of MDS could be reduced by applying

17 se-positive anaplastic large cell lymphoma), upfront auto-SCT was associated with a superior OS (HR,

18 significant event-free survival advantage to upfront autologous transplantation compared with interfe

19 etermine whether these patients benefit from upfront biventricular pacing.

20 on ongoing maintenance subsidies rather than upfront capital cost subsidies.

21 findings highlight the necessity for careful upfront cellular enrichment in biospecimens that form th

22 elevant to the inclusion of anthracycline in upfront chemoimmunotherapy for these elderly patients an

23 ABC DLBCL has a worse survival after upfront chemotherapy and is characterized by constitutiv

24 Patients must have received upfront chemotherapy and up to two prior chemotherapy re

25 myelogenous leukemia achieve remission with upfront chemotherapy, many patients still suffer relapse

26 GCB DLBCL have equally poor survivals after upfront chemotherapy.

27 from postmastectomy radiation therapy after upfront chemotherapy.

28 medulloblastoma into the next generation of upfront clinical trials, with the goal of both improving

29 These data suggest that upfront combination strategies targeting EGFR amplificat

30 iated RAS-mTOR signaling and is prevented by upfront combination therapy with PLX8394 and either an E

31 of bleeding, implantation is associated with upfront complications.

32 cycline-based chemotherapies with or without upfront concurrent chemoradiotherapy or radiotherapy wit

33 h-risk areas are excluded) but also increase upfront conservation costs.

34 icin, vincristine, and prednisone (CHOP) and upfront consolidation with autologous stem cell transpla

35 elective neck dissection comes with greater upfront cost and patient morbidity.

36 teral vs 224 bilateral) because of the large upfront cost of the implant.

37 the advantages of gasoline automobiles: low upfront cost, long driving range and fast refuelling.

38 Object oriented designs, though has upfront costs, are practical now and can provide such an

39 ositive indications for malignant disease in upfront diagnosis.

40 Upfront doxycycline is a rational and active treatment f

41 only in ocular adnexal MALT lymphomas where upfront doxycycline may be a reasonable and effective in

42 and exclusively involves the use of cytoxics upfront (e.g., radiation and chemotherapy).

43 tional analysis demonstrated that the use of upfront EGFR-TKI, and deferral of radiotherapy, is assoc

44 Overall, this technology is a multiplexable upfront enrichment applicable with multiple downstream m

45 nsitivity, specificity and typically require upfront enrichment, ligation and/or amplification steps.

46 The results show that upfront environmental and economic investments are neede

47 as few as one million reads, allowing for an upfront evaluation of the sample integrity before whole

48 Larger scale, upfront funding for evaluation of health financing initi

49 One way to do this that would not require upfront funding is to change the policies that regulate

50 On a population level, upfront genotyping seemed cost saving.

51 At month 12, LS BMD was 4.4% higher in the upfront group than in the delayed group (95% CI, 3.7% to

52 In the upfront group, mean serum N-telopeptide and bone-specifi

53 or to glucose exhaustion experience a larger upfront growth cost but also a shorter diauxic lag.

54 Patients treated upfront had higher rates of CR (65.0%) and VGPR-dFLC (66

55 gnated as having "postoperative radiotherapy upfront" if they received radiotherapy within 90 days of

56 ombination with androgen-deprivation therapy upfront in advanced or high-risk prostate cancer.Tumours

57 Therefore, PEGasparaginase should be used upfront in induction, and we suggest that the dose could

58 nd neck MRI (CHCT/MRI) with (18)F-FDG PET/CT upfront in the diagnostic workup of patients with oral,

59 ge, 65 years; range, 32 to 87 years) treated upfront in the trials MCL Younger or MCL Elderly were po

60 ating surgically correctable PA outweigh the upfront increased costs in patients at the time patients

61 enocarcinoma and provide a rationale for the upfront inhibition of both ALK and MEK to forestall resi

62 Upfront inhibition of both ALK and the kinase MEK enhanc

63 The indications for upfront laryngectomy in the management of laryngeal canc

64 h early hepatocellular carcinoma (HCC-cirr), upfront liver resection (LR) and salvage liver transplan

65 carcinoma (HCC) patients, to try to obviate upfront liver transplantation, with the "safety net" of

66 Of 130 HCC-cirr patients who underwent upfront LR (group LR), 90 (69%) recurred, 31 could under

67 tterns reflect the differing payment models: upfront lump-sum payments (cooperative group) versus mil

68 digm and is currently being expanded with an upfront multicategorical approach following recent advan

69 was used to identify patients who underwent upfront nodal dissection for mucosal head and neck squam

70 ays for a matched cohort of patients with an upfront open procedure.

71 phamide, bortezomib, and dexamethasone (CVD) upfront or at relapse.

72 ole were randomly assigned to receive either upfront or delayed-start zoledronic acid (4 mg intraveno

73 hort, but was relevant in certain subgroups (upfront pancreatectomy (n = 117; P = 0.049); without VR

74 mm for the SMA-margin in specific subgroups (upfront pancreatectomy, N0 patients without NAT, N+ pati

75 ase groups studied here, thus questioning an upfront pathological role of these serum AB.

76 Conclusions and Relevance: Nephrectomy after upfront pazopanib therapy could be performed safely and

77 ive: To establish the safety and efficacy of upfront pazopanib therapy prior to cytoreductive nephrec

78 Upfront phase II window trials can efficiently provide r

79 Routine use of EN is preferable to upfront PN in these patients.

80 t for active surveillance exceeded that from upfront radical prostatectomy after 3-5 years of follow-

81 common standard arm combined with a general upfront randomization and performed prospective analyses

82 ontinuation design is more powerful than the upfront randomization design when the treatment effect i

83 ntinuation design is more efficient than the upfront randomization design when treatment benefit is r

84 power of the randomized discontinuation and upfront randomization designs under two models for the t

85 power of the randomized discontinuation and upfront randomization designs under two previously propo

86 iscontinuation design is not as efficient as upfront randomization if treatment has a fixed effect on

87 oximately 1 hour, he elected to proceed with upfront RC and extended lymph node dissection in conjunc

88 serve as financial intermediaries to pay the upfront recovery expenses for deceased donor kidneys bef

89 stablish consensus classification and assess upfront resectability.

90 followed by resection and those who received upfront resection (UR)-as well as a subgroup of UR patie

91 Upfront resection and microvascular tumor invasion were

92 Upfront resistance to chemotherapy and relapse following

93 essel disease, EES was associated with lower upfront risk of death and stroke when compared with coro

94 Upfront screening for these variants, in addition to the

95 ility of ASCT and use of novel agents in the upfront setting of multiple myeloma and pPCL began after

96 th increasing use of the novel agents in the upfront setting, several reports have emerged raising co

97 ly negative nodes has an accuracy similar to upfront SLNB and reduces the need for axillary lymph nod

98 s a classical randomized clinical trial with upfront stratification for the marker.

99 44 patients, among whom 460 (44.1%) received upfront surgery and 584 (55.9%) received CRT.

100 local-regional control with BCT with either upfront surgery or surgery after neoadjuvant chemotherap

101 Lack of OS benefit with upfront surgery persisted in a subset analysis of patien

102 On multivariable Cox regression, upfront surgery was not associated with increased OS whe

103 from postmastectomy radiation therapy after upfront surgery, no such data exist for guiding decision

104 imary surgery, whereas 13 patients underwent upfront surgery.

105 al cavity squamous cell carcinoma undergoing upfront surgical resection for curative intent were iden

106 In the present analysis, we examine whether upfront surgical resection improves overall survival in

107 eukemia, upfront therapy, upfront therapies, upfront therapeutic, upfront therapeutics, upfront treat

108 apy, upfront therapies, upfront therapeutic, upfront therapeutics, upfront treatment, front-line trea

109 ronic lymphocytic leukemia, upfront therapy, upfront therapies, upfront therapeutic, upfront therapeu

110 n in more than 2 decades despite advances in upfront therapy and improved survival for de novo ALL.

111 in a low-dose, 5-day regimen has activity as upfront therapy in older patients with AML, and it has a

112 e an urgent need not only for more effective upfront therapy to prevent relapse, but also for the dev

113 g the keywords chronic lymphocytic leukemia, upfront therapy, upfront therapies, upfront therapeutic,

114 he TT approach uses all myeloma-active drugs upfront to target drug-resistant subclones during initia

115 may allow directing more aggressive therapy upfront to the patients most likely to benefit while spa

116 eriences, which involve intensive amounts of upfront training, human error with limited quality contr

117 Upfront treatment of acute TTP includes plasma exchange

118 , upfront therapeutic, upfront therapeutics, upfront treatment, front-line treatment, first-line trea

119 The US community-based, phase IIIB UPFRONT trial was designed to compare three frontline bo

120 Even so, upfront tumor eradication is frequently not achieved wit

121 course of treatment appear to be superior to upfront tumor resection.

122 h non-anthracycline-based chemotherapies and upfront use of concurrent chemoradiotherapy or radiother

123 r those receiving postoperative radiotherapy upfront vs postoperative radiotherapy deferred (5-year O

124 ufficient data to resolve the controversy of upfront WBRT versus SRS in the management of patients wi

125 Children's Oncology Group has conducted five upfront window trials in patients with newly diagnosed m

126 al Registry should have its aims established upfront, with appropriate governance and oversight, and

127 djuvant Synergy Trial (Z-FAST) indicate that upfront zoledronic acid therapy prevents bone loss in th