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1 ilarity, it demonstrates selectivity for the upstream activator.
2 in, possibly through the interaction with an upstream activator.
3 losteric relief of autoinhibition by diverse upstream activators.
4 een questioned and little is known about its upstream activators.
5 rion forms are inducible by their respective upstream activators.
6 ved to connect the IKK signalsome complex to upstream activators.
7 the latter for activation via enhancer-bound upstream activators.
8 ein synthesis and reduced activity of mTORC1 upstream activators.
9 its metabolites would stimulate eNOS and its upstream activators Akt and phosphatidylinositol 3-kinas
10 e, consisting of Ypt1 and autophagy-specific upstream activator and downstream effector, regulates th
11         Because c-Src is known to be both an upstream activator and downstream mediator of epidermal
12 orms this function by functioning as both an upstream activator and downstream target for Cdc42.
13 hermore, the activation of HPK1, a known JNK upstream activator and HIP-55-interacting protein, was a
14 al mechanism of repressing both the opposing upstream activator and its downstream targets provides a
15                     Here we investigated the upstream activators and downstream effectors of signalin
16                             Here we identify upstream activators and downstream effectors of TET1 in
17 enzymes are positioned in proximity to their upstream activators and downstream substrates.
18 s achieved through complexes containing both upstream activators and downstream targets of Rho.
19 scription and acts as a mediator between the upstream activators and general transcription machinery.
20 ue to the ability of the mutant to sequester upstream activators and its inability to activate downst
21  structurally and functionally and that both upstream activators and the basal transcription apparatu
22  Ypt/Rab GTPases, are stimulated by specific upstream activators and, when activated, recruit specifi
23 orms selective interactions with substrates, upstream activators, and phosphatases.
24 paBbeta complexes are regulated by different upstream activators, and that NF-kappaB plays a key role
25 o cytoplasm where it associates with the JNK upstream activator, apoptosis signal-regulating kinase 1
26 moter complex as well as a contact point for upstream activators, appears similar to the dual roles t
27 ntimately linked to cancer as several of its upstream activators are frequently mutated in human dise
28 n silencing induction by depolarization, but upstream activators are unknown.
29 lasts since deletion of p53 or its requisite upstream activator ARF abrogates the growth-promoting ef
30 ctive activation of phospholipase D1 and its upstream activator Arf1.
31 at Ser259 regulates the coupling of Raf-1 to upstream activators as well as to its downstream substra
32 letion reduced the activity of CDC25 and its upstream activators, Aurora A and Plk1.
33 ts of Ras, PI3K, or Akt, or treated with the upstream activator BDNF.
34 n of a dominant negative form of MKK4, a JNK upstream activator, blocked Netrin-1-induced JNK1 activa
35 egulates expression of CaMKIV and one of its upstream activators, CaMKK1 (calmodulin-dependent protei
36                               Although their upstream activator, CASP1, and its amplifier, CASP11, ar
37 a cytosolic location that prevents access by upstream activators (caspase-8, -9, and -10).
38  inhibiting the binding between MLK3 and its upstream activator, Cdc42.
39 on, beta-arrestins scaffold cofilin with its upstream activator CIN, to facilitate the localized gene
40                                          The upstream activator Concertina, in its GTP but not GDP bo
41 oth an Etk downstream target gene and an Etk upstream activator, constituting a reciprocal Etk-VEGF a
42 nd DAF-8 that is independent of their normal upstream activator, DAF-7.
43  Rho-family GTPases (Rac, Rho, Cdc42), their upstream activators (Dbl-family guanine nucleotide excha
44 omplex, whereas enforced induction of p38 by upstream activators (e.g. MKK3 and MKK6) enhanced both C
45 hymal cells via inducing expression of their upstream activator, Endothelin1 (Edn1), within ectoderma
46 on of activated mutant MAPK kinase 6b(E), an upstream activator for p38(MAPK), increased cell migrati
47                           Rho GTPase and its upstream activator, guanine nucleotide exchange factor 2
48 o/Rac/Cdc42 superfamily of GTPases and their upstream activators, guanine nucleotide exchange factors
49 ce of the interaction of Rac with its direct upstream activators, guanine nucleotide exchange factors
50  up-regulated whereas those of miR-7 and its upstream activator HoxD10 are progressively down-regulat
51 PIKfyve-catalyzed synthesis and requires the upstream activator hVac14 (called herein ArPIKfyve) that
52 kappaB, or by dominant-negative forms of the upstream activator IkappaB kinase (IKK).
53 ssion of a constitutively active form of the upstream activator IkappaB kinase beta (IKKbeta).
54 in nuclear factor kappaB (NF-kappaB) and its upstream activator IkappaB kinase-beta (IKK-beta, encode
55 ve colon cancer behavior and functions as an upstream activator in the Jagged1/Notch signaling pathwa
56                     In addition, several JNK upstream activators, including the phorbol ester TPA, an
57 machinery, this motif does not mimic natural upstream activators: instead of mimicking an activated s
58 o caused constitutive hyperactivation of its upstream activator, IRE1alpha, which could degrade a sub
59 hich recognises RFXV/I motifs present in its upstream activator [isoforms of the With-No-lysine (K) k
60       Mitochondrially localized JNKs but not upstream activators, like mixed-lineage kinases (MLKs) o
61 lly, the identification of the p38-dependent upstream activator MAP kinase kinase 6 as a member of th
62 nases transduce signals emanating from their upstream activators MAP kinase kinases (MEKs).
63 n-activated protein kinases (MAPKs) by their upstream activators, MAPK/ERK kinases (MEKs), is crucial
64 e dialyzed with recombinant p38alpha and its upstream activator, MEK-6, which substantially inhibited
65  member of the MAPK family, and its specific upstream activator MEK5 were activated in response to in
66 rpin or a dominant-negative form of the ERK5 upstream activator, MEK5, in T cells led to downregulati
67 -Jun N-terminal kinase (JNK), along with its upstream activator MEKK-1, is typically thought of as a
68 pproach to achieve targeted expression of an upstream activator, mitogen-activated protein kinase kin
69 using inhibitors targeting the shared ERK1/2 upstream activator, mitogen-activated protein kinase kin
70 by mediating interaction between Akt and its upstream activator MK2.
71 ression of dominant negative p38alpha or its upstream activator, MKK3, inhibited EGF receptor phospho
72 inase c-Jun N-terminal kinase (JNK)2 and its upstream activator MKK4 were phosphorylated in platelets
73 reover, we demonstrate that p38alpha and its upstream activator, MKK6, phosphorylate STAT4 on serine
74 n of the constitutively active mutant of the upstream activator, MKK6b (GST-MKK6b S207E T211E), in th
75 ed mitogen-activated protein kinase, p38, by upstream activator MKK6bE led to significant induction o
76  p38 MAPK was constitutively turned on by an upstream activator (MKK6bE).
77 s the affinity of the Arp2/3 complex for its upstream activators N-WASP and ActA.
78 nally truncated isoforms associated with the upstream activator NIK (NF-kappaB-inducing kinase).
79 ide 3-kinase/PI3K functioned as an essential upstream activator of Akt and ERK1/2 in glutamate-treate
80 tivity of phosphatidylinositol 3-kinase (the upstream activator of Akt) in insulin signaling.
81 Phosphoinositide 3 kinase (PI3K) is a direct upstream activator of AKT, and plays a critical role in
82  the activity of mTOR complex 2 (mTORC2), an upstream activator of Akt, and this occurs independent o
83 ositol 3-kinase (LY294002), thought to be an upstream activator of Akt, exacerbated cortical apoptosi
84                            Oncogenic Ras, an upstream activator of Akt, requires NF-kappaB to initiat
85  and LY294002, inhibitors of PI3-kinase, the upstream activator of Akt.
86 ciated with an enhanced activity of PDK1, an upstream activator of Akt1.
87 lin-dependent protein kinase kinase beta, an upstream activator of AMPK, and by the mTORC1 inhibitor
88       Inhibition of Ras, which represents an upstream activator of AP-1, also significantly inhibited
89  phosphatidylinositol-3-phosphate kinase, an upstream activator of Arf6, also had no effect on the in
90 a signaling pathway whereby Abeta acts as an upstream activator of astroglial nuclear factor kappa B
91  Nbs1 contributes to the DDR by acting as an upstream activator of ATM in response to double-strand D
92             We propose here that CARD9 is an upstream activator of BCL10 and NF-kappaB signaling.
93 ermal growth factor receptor (EGFR), a known upstream activator of both the prosurvival phosphoinosit
94 rget gene, MKK7D, a constitutively activated upstream activator of c-Jun N-terminal kinases (JNK).
95 d protein kinase kinase kinase 1 (Mekk1), an upstream activator of c-Jun, enhances the interaction of
96 n-1, rather than toll-like receptors, is the upstream activator of calcineurin.
97               Furthermore, inhibition of the upstream activator of CaM-KI, CaM-KK, using siRNA also r
98 Rs; APV) or CaM-kinase kinase (STO-609), the upstream activator of CaM-kinase I (CaMKI), as well as b
99 of neurons expressing dnCaMI or dnCaMKK, the upstream activator of CaMKI, exhibit collapsed morpholog
100 inhibition of CaM-kinase kinase (CaMKK), the upstream activator of CaMKI.
101 hibition (STO-609) of CaM kinase kinase, the upstream activator of CaMKI.
102 y 10-fold, and the amount of CaMK kinase (an upstream activator of CaMKIV) protein and mRNA was signi
103 ghly expressed CAM-kinase-kinase (CAMKK), an upstream activator of CaMKIV, suggesting a role for CaMK
104 rine caspase family, has been shown to be an upstream activator of caspase-1 in regulating cytokine m
105 or of host immunity and functions as a high, upstream activator of cells within the innate and the ad
106 ition, this study implicates ATR as a direct upstream activator of Chk1 in human cells.
107 f Rac1, suggesting that Rac1 functions as an upstream activator of cyclin D(1) in this system.
108                 In addition to serving as an upstream activator of Dpp and Wg, Ci acts combinatoriall
109                                          The upstream activator of EGF receptor transactivation, c-Sr
110      Moreover, we identify IGF-1R as a novel upstream activator of endogenous Abl kinases, and demons
111                           Using p16ink4a, an upstream activator of endogenous RB, or a constitutively
112 the phosphorylation state of Raf1 kinase, an upstream activator of ERK signaling.
113 togen-activated protein/ERK kinase (MEK, the upstream activator of ERK), and ERK.
114 te that two different inhibitors of MEK, the upstream activator of ERK, block catecholamine- and beta
115 tors or a dominant-negative form of MEK, the upstream activator of ERK, reduced the survival of patie
116 and primary neurons, inhibition of MEK-1, an upstream activator of ERK-1/2 protects against MG132-ind
117 ctivation was blocked by inhibiting MEK, the upstream activator of ERK.
118                 PD98059, an inhibitor of the upstream activator of ERK1/2, the MAP/ERK kinase MEK1/2,
119 post-ischemic phosphorylation of MEK1/2, the upstream activator of ERK1/2, was unaffected by precondi
120 nhibitors were also shown to affect MEK5, an upstream activator of ERK5, another class of MAPK with h
121 that encodes constitutively active MEK1, the upstream activator of ERKs, also protected cells against
122  of a constitutively active Mek1, a specific upstream activator of ERKs, maintained myoblast viabilit
123 -regulated kinase (ERK) kinase-1 (MEK1), the upstream activator of ERKs.
124 t upon the kinesin-1 light chain KLC2 and an upstream activator of HDAC6, aurora A kinase.
125                                          The upstream activator of Hh signaling, the Hh ligand, origi
126 tutively active Smoothened protein (Smo), an upstream activator of Hh signaling.
127            These studies position mTOR as an upstream activator of HIF-1 function in cancer cells and
128 osis signal-regulating kinase 1 (ASK1) is an upstream activator of JNK and p38 MAPK signaling cascade
129 ptosis signal-regulating kinase-1 (ASK1), an upstream activator of JNK and p38.
130 bited in cells deficient in MEK kinase 1, an upstream activator of JNK in reovirus-infected cells.
131 nstitutively active mutant Rac-1 (Val12), an upstream activator of JNK, abrogated Deltap85-induced lu
132  a dominant negative mutant form of SEK1, an upstream activator of JNK, likewise suppressed JNK activ
133 dominant-negative forms of JNK1 and MKK4, an upstream activator of JNK, results in loss of TGF-beta-s
134 y, versus control, 40.5%), whereas MEKK1, an upstream activator of JNK, sharply reduced apoptosis in
135                            MAPK kinase-4, an upstream activator of JNK, was also significantly activa
136 -negative form of Src, implicating Src as an upstream activator of JNK.
137                                   A specific upstream activator of JNKs is the mitogen-activated prot
138 of Myc, whereas inhibition of Rho kinase, an upstream activator of LIMK1, stimulates Myc expression.
139 activated kinase kinase (MEK1), an immediate upstream activator of MAPK in estrogen receptor positive
140 owth factor-beta-associated kinase-1 (TAK1), upstream activator of MAPK, but not p38 MAPK restored ce
141                   Inhibition of the specific upstream activator of MAPK, MAPK kinase (MEK), blocked f
142 t or constitutively active MAPK kinase-1, an upstream activator of MAPK, partially blocked IGFBP-3-in
143 studies demonstrate that p38alpha is a major upstream activator of MAPKAP kinase 2 and a key componen
144 diate these effects by deactivating Raf, the upstream activator of MEK.
145 was even greater upon cotransfection with an upstream activator of mitogen-activated protein kinases
146                                    MIF is an upstream activator of monocytes/macrophages, and it is c
147 at mechanical stimuli utilize PA as a direct upstream activator of mTOR signaling.
148 8) in AKT, a known substrate of CaMKK and an upstream activator of mTOR-dependent translation, was pr
149   Rheb, a Ras-related small GTPase, is a key upstream activator of mTOR.
150 ely active form of the small GTPase Rheb, an upstream activator of mTor.
151 tor (M-CSF) was implicated as a contributing upstream activator of mTORC2 in a pathway that involved
152        Thus, Pitx2 is the first demonstrated upstream activator of myogenesis in the extraocular musc
153 tic weakness and that oxidative stress is an upstream activator of nuclear factor-kappaB.
154 yzing 3T3-L1 cell lines harboring a specific upstream activator of p38 (a constitutively active mitog
155 tively active MAP kinase kinase 6 (MKK6), an upstream activator of p38 MAP kinases.
156 ely active mutant of MAPK kinase 6 (MKK6, an upstream activator of p38 MAPK) but not constitutive act
157     Constitutively active MKK6, an immediate upstream activator of p38 MAPK, induced selectin ligand
158 duced MyD88-dependent activation of MKK4, an upstream activator of p38 MAPK.
159                  Mice deficient for MKK3, an upstream activator of p38 mitogen-activated protein (MAP
160 n of an activated form of MKK6 (an immediate upstream activator of p38) rescues the ability of Cdo(-/
161 h MKK6b(E), a constitutively active specific upstream activator of p38, led to a potent inhibition of
162 ctive form of MAPK kinase 3 (Ad-CA-MKK3), an upstream activator of p38.
163 n, suggesting a possible role for Pyk2 as an upstream activator of p38.
164 noprecipitated with the MAPK kinase MKK3, an upstream activator of p38.
165  a constitutively active mutant of MKK6, the upstream activator of p38.
166 ate apoptosis signal-regulating kinase 1, an upstream activator of p38/JNK in the MAPK signaling casc
167     A constitutively active form of MEK6, an upstream activator of p38delta, can also produce cell de
168                            Inhibition of the upstream activator of p44/42 MAPK, mitogen-activated pro
169  either was indirect, perhaps mediated by an upstream activator of p53, or was due to oxidation of on
170 RF tumor suppressor is widely regarded as an upstream activator of p53-dependent growth arrest and ap
171  As mammalian target of rapamycin (mTOR), an upstream activator of p70 S6Kinase is, in part, regulate
172 n receptor substrate-2 (IRS2) expression, an upstream activator of PI3K, we therefore anticipated tha
173 mosome segments containing PIK3CA, ERBB2 (an upstream activator of PIK3CA), and CCNE1 (a target of FB
174 s, providing genetic evidence that PDK1 (the upstream activator of PKB) is required for the phosphory
175 onstrated that LY294002, an inhibitor of the upstream activator of PKB, phosphatidylinositol 3-kinase
176                                  Insulin, an upstream activator of PKCzeta, increased both OAT3-media
177 C was previously identified as the immediate upstream activator of PKD, PKD vs PKC selectivity was es
178 C activation, PKC acts more proximally as an upstream activator of PKD.
179 el in which PHS, rather than simply being an upstream activator of Pkh1, also activates kinases that
180                          The GTPase Rho2, an upstream activator of Pmk1, also co-localized with PI(4,
181 h a linear pathway, in which RhoG acts as an upstream activator of Rac1, indicating that increased su
182 tein directly activated by cAMP) is a likely upstream activator of Rap1, since Epac is present in the
183 ) mice, suggesting that Flt3 is an important upstream activator of Ras in early B cell progenitors.
184  breast cancer cells driven by Her-2/neu, an upstream activator of Ras.
185 king site for either mTOR itself or a common upstream activator of S6K1 and 4E-BP1.
186 ogether, these findings identify dHAND as an upstream activator of Shh expression and important trans
187  that RPTPalpha functions as a physiological upstream activator of Src-family kinases in fibroblasts
188 und that alphavbeta6 integrin acted as a key upstream activator of TGF-beta in evolving pancreatic ca
189 e kinase kinase kinase (MAP4K) family and an upstream activator of the c-Jun N-terminal kinase (JNK)
190  protein kinase, is a hematopoietic-specific upstream activator of the c-Jun N-terminal kinase.
191 eonine kinase that has been identified as an upstream activator of the c-Jun NH(2)-terminal kinase (J
192 was attenuated by the inhibition of PKA, the upstream activator of the CREB pathway.
193           We further showed that ATF4 was an upstream activator of the critical transcription factor
194  ATF3 promoter can be activated by MEKK1, an upstream activator of the ERK and JNK kinase pathway, bu
195     NGF treatment and cotransfection with an upstream activator of the extracellular signal-regulated
196 ciated with a down-regulation of c-Raf-1, an upstream activator of the extracellular signal-regulated
197 hage migration inhibitory factor (MIF) is an upstream activator of the innate response that mediates
198                                   hBVR is an upstream activator of the insulin/IGF-1/MAPK/PI3K signal
199 hreonine protein kinase that functions as an upstream activator of the JNK pathway.
200 Rho1 forms a complex with Slipper (Slpr), an upstream activator of the JNK pathway.
201 on of mice that are deficient for a specific upstream activator of the kinase, MAP kinase kinase 3, r
202         The Ras-like small GTPase Rheb is an upstream activator of the mammalian target of rapamycin
203 ssion of a dominant negative form of Ras, an upstream activator of the MAPK pathway, also inhibited s
204 gnals that negatively regulate MKK4/SEK1, an upstream activator of the MAPKs JNK and p38/HOG1.
205 sfection of constitutively active MEKK-1, an upstream activator of the mitogen-activated protein (MAP
206         We report here that Rheb GTPase, the upstream activator of the mTOR complex 1 (mTORC1) is amp
207 her suggest that focal adhesion kinase is an upstream activator of the RACK1/ERK pathway.
208 titutively active form of RalA (RalA23V), an upstream activator of the RalBP1 signaling pathway, incr
209  dominant inhibitory mutant of the immediate upstream activator of the stress-activated protein kinas
210  protein kinase kinase kinase-1 (MEKK-1), an upstream activator of the stress-activated protein kinas
211               The PI4P5-kinase, Mss4p, is an upstream activator of this pool of Slt2p.
212 ain (Rheb) small GTPase is known to be a key upstream activator of TORC1, although the mechanism of R
213 ffector kinase PKA is a conserved and direct upstream activator of Wnd/DLK.
214 ctivation of inositol-requiring enzyme 1, an upstream activator of XBP1, leading to phosphorylation o
215                                The immediate upstream activators of Akt and STAT5 such as PI-3k and J
216  infection, Src and p110beta PI 3-kinase are upstream activators of Akt and the IL-8 promoter and tha
217               Although some of the immediate upstream activators of Akt have been defined, the roles
218                            Fgf3 and Fgf8 are upstream activators of atoh1 genes during both phases, a
219  novel MAGUK family members that function as upstream activators of BCL10 and NF-kappaB signaling.
220   Importantly, loss of flbC or flbD encoding upstream activators of brlA in the absence of nsdD resul
221 s of calcium injury in neurons, calpains are upstream activators of Erk1,2 signaling and are likely t
222                      Vac14 and Vac7 are both upstream activators of Fab1-catalysed PtdIns(3,5)P(2) sy
223 ed levels of phosphorylated MKK4 and MKK3/6, upstream activators of JNK and p38, respectively.
224 e phosphorylation of MKK7, MKK4, and MKK3/6, upstream activators of JNK and p38, was markedly reduced
225 ivation suggesting that G(i/o) proteins were upstream activators of JNK.
226 protein kinase kinase 7 (MKK7) are immediate upstream activators of JNK1.
227 horing mixed lineage kinase (MLK) 2 or MLK3, upstream activators of JNKs, to the receptor complex.
228 owever, no significant activation of several upstream activators of MEK, including Ras, Rap1, and Raf
229 ular signal-regulated kinase (ERK) 1/2 MAPK (upstream activators of MSK1) reduced MOR expression leve
230                                     However, upstream activators of MyD88 function in response to tra
231 ding the participation of these molecules as upstream activators of N-WASP in the initiation of actin
232                                 A screen for upstream activators of NF-kappaB identified a novel seri
233 ings suggest that PYPAF1 and ASC function as upstream activators of NF-kappaB signaling.
234 ed tumorigenesis in vivo Genes encoding some upstream activators of NOTCH were highly enriched for H3
235  MAPK kinase-3 (MKK3), MKK6 (the immediately upstream activators of p38 kinase) and a MAP3K, i.e., TG
236                                              Upstream activators of p38 MAP kinases, MKK3 and MKK6, i
237  (MKK3), MKK4, and MKK6, are known to be the upstream activators of p38alpha.
238 m mass spectrometry approach that identifies upstream activators of PI3K both in vitro and in vivo.
239                            However, possible upstream activators of PKD, and the time course and sign
240 s, likely through constitutive activation of upstream activators of Raf.
241 e show that light-gated translocation of the upstream activators of Rho-family GTPases, which control
242 signaling pathway, whereas SEK1 and MEK1 are upstream activators of SAPK/JNK and ERK pathways, respec
243 ed upon FFA treatment, potentially acting as upstream activators of the EMT program.
244         Fibroblast growth factors (FGFs) are upstream activators of the mitogen-activated protein kin
245 rs that directly target mTORC1 or, possibly, upstream activators of the mTORC1 pathway.
246 bers of the focal adhesion kinase family are upstream activators of the SFKs after wounding.
247 4 signalling in brain endothelial cells, but upstream activators of this disease pathway have yet to
248    Our analysis uncovered KLHL9 deletions as upstream activators of two previously established master
249 mour suppressor protein kinase is the major "upstream" activator of the energy sensor AMP-activated p
250 -dependent kinase 1 (PDK1), a rate-limiting 'upstream' activator of AGC kinases.
251 ssors that must bind within 100 bp of either upstream activators or the core transcription complex to
252 ls, p50(Cool-1) suppresses Pak activation by upstream activators; p85(Cool-1) has a permissive effect
253 r LIMK1 activation by its membrane-localized upstream activator PAK.
254 ions, rare somatic mutations and loss of its upstream activator, PAX5.
255 etal muscle FNDC5 (irisin precursor) and its upstream activator peroxisome proliferator-activated rec
256 itions of the mTOR signaling, as well as its upstream activators, phosphatidylinositol 3-kinase and A
257 R-associated factor 2 as well as PKB and its upstream activator phosphoinositide 3-kinase (PI3K).
258 ks the translocation of Akt/PKB, but not its upstream activator phosphoinositide-dependent kinase-1,
259 -gamma mutant neurons by inhibiting PKC, its upstream activator phospholipase C, or the gamma-Pcdh bi
260 phosphatidylinositol 3-kinase (PI3K) and its upstream activator PI3K enhancer PIKE, predicted targets
261 uction of the substrate required by both its upstream activator, PI3K, and its downstream target, PLC
262                         Nek6, as well as its upstream activators polo-like kinase 1 and Aurora-A, tar
263 equently, LEOPARD syndrome SHP2 mutants bind upstream activators preferentially and are hypersensitiv
264 n silenced chromatin inhibits the binding of upstream activator proteins or polymerase or (2) silenci
265        Whereas GABP operates as an essential upstream activator, PU.1 assists the flanking "TTTAAA" e
266 tial for growth or secretion when either the upstream activator rab, Sec4p, or the downstream SNARE-b
267 k 'fixes up' the interaction of Pak with its upstream activator, Rac.
268 ma invasion and metastasis 1 (Tiam1) and its upstream activator Ras in a phosphoinositide-3-kinase-in
269 minus may assist in its association with the upstream activators (Ras1 and Rap1) through a CRN-mediat
270 ly suppresses glial responses to injury, but upstream activators remain poorly defined.
271 he ROS sensitivity of these events and their upstream activators remain unclear.
272 ssion of TOR and RAPTOR, together with their upstream activator Rheb, was sufficient to provide TORC1
273  of the -35 element (GTGGGA; the rRNA operon upstream activator [RUA]) that is conserved in monocot a
274 ctivated protein kinase (MAPk); however, the upstream activator(s) of p38 MAPk is unknown, and conseq
275 e that inhibition of IKKalpha/IKKbeta or its upstream activators sensitizes cells to death by inducin
276 the control of multiple tandem copies of the upstream activator sequence (UAS) often show evidence of
277  of transcription, defined the 3' end of the upstream activator sequence (UAS) regulatory element, an
278 me sequence showed that the regulatory site, upstream activator sequence (UAS), the putative binding
279           At these operons, NifA binds to an upstream activator sequence (UAS), with the consensus TG
280 rap screen using GAL4 to drive expression of upstream activator sequence (UAS)-linked transgenes in e
281 cent protein (GFP) gene through a multicopy, upstream activator sequence (UAS).
282 nts, including the putative TATA box and the upstream activator sequence (UAS).
283 es in yeast that contained the CRT/DRE as an upstream activator sequence.
284 ssion of other genes under the regulation of upstream activator sequences (UAS).
285   Single insertions containing four distinct upstream activator sequences were far less susceptible t
286 re likely to include previously unrecognized upstream activator sequences.
287 more Xenopus 5 S rRNA genes that function as upstream activator sequences.
288  MAPK docking sites show specificity for the upstream activator similar to that reported for the full
289                Interactions between 4EBE and upstream activator sites are position, distance, and seq
290 influences transcriptional regulation by the upstream activator Sp1.
291              Activation of Vav1, but not its upstream activator, Syk, is suppressed by cell adhesion.
292 dependent recruitment of the MAPK cascade to upstream activators that are unique to one or the other
293 n disrupted the interaction of SHP2 with its upstream activator, the Grb2-associated binder 2 adaptor
294  the function in beta-selection of its known upstream activator, the serine/threonine kinase Pim1: ME
295 ta or the siRNA knockdown of IKKbeta or its "upstream" activator, the protein kinase TAK1.
296 not processed by hepsin, we investigated the upstream activators, urokinase-type plasminogen activato
297 GTPase Rac was constitutively active and its upstream activator Vav was constitutively phosphorylated
298 vation of temperature-sensitive Vps34 or its upstream activator, Vps15, blocks the Cvt and macroautop
299 n kinase kinase 7 (mutant D), a JNK-specific upstream activator, was expressed in myocytes by adenovi
300 ctivated receptor gamma (PPARgamma), and its upstream activator xanthine-oxidoreductase (XOR).

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