コーパス検索結果 (1語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 ilarity, it demonstrates selectivity for the upstream activator.
2 in, possibly through the interaction with an upstream activator.
3 losteric relief of autoinhibition by diverse upstream activators.
4 een questioned and little is known about its upstream activators.
5 rion forms are inducible by their respective upstream activators.
6 ved to connect the IKK signalsome complex to upstream activators.
7 the latter for activation via enhancer-bound upstream activators.
8 ein synthesis and reduced activity of mTORC1 upstream activators.
9 its metabolites would stimulate eNOS and its upstream activators Akt and phosphatidylinositol 3-kinas
10 e, consisting of Ypt1 and autophagy-specific upstream activator and downstream effector, regulates th
13 hermore, the activation of HPK1, a known JNK upstream activator and HIP-55-interacting protein, was a
14 al mechanism of repressing both the opposing upstream activator and its downstream targets provides a
19 scription and acts as a mediator between the upstream activators and general transcription machinery.
20 ue to the ability of the mutant to sequester upstream activators and its inability to activate downst
21 structurally and functionally and that both upstream activators and the basal transcription apparatu
22 Ypt/Rab GTPases, are stimulated by specific upstream activators and, when activated, recruit specifi
24 paBbeta complexes are regulated by different upstream activators, and that NF-kappaB plays a key role
25 o cytoplasm where it associates with the JNK upstream activator, apoptosis signal-regulating kinase 1
26 moter complex as well as a contact point for upstream activators, appears similar to the dual roles t
27 ntimately linked to cancer as several of its upstream activators are frequently mutated in human dise
29 lasts since deletion of p53 or its requisite upstream activator ARF abrogates the growth-promoting ef
31 at Ser259 regulates the coupling of Raf-1 to upstream activators as well as to its downstream substra
34 n of a dominant negative form of MKK4, a JNK upstream activator, blocked Netrin-1-induced JNK1 activa
35 egulates expression of CaMKIV and one of its upstream activators, CaMKK1 (calmodulin-dependent protei
39 on, beta-arrestins scaffold cofilin with its upstream activator CIN, to facilitate the localized gene
41 oth an Etk downstream target gene and an Etk upstream activator, constituting a reciprocal Etk-VEGF a
43 Rho-family GTPases (Rac, Rho, Cdc42), their upstream activators (Dbl-family guanine nucleotide excha
44 omplex, whereas enforced induction of p38 by upstream activators (e.g. MKK3 and MKK6) enhanced both C
45 hymal cells via inducing expression of their upstream activator, Endothelin1 (Edn1), within ectoderma
46 on of activated mutant MAPK kinase 6b(E), an upstream activator for p38(MAPK), increased cell migrati
48 o/Rac/Cdc42 superfamily of GTPases and their upstream activators, guanine nucleotide exchange factors
49 ce of the interaction of Rac with its direct upstream activators, guanine nucleotide exchange factors
50 up-regulated whereas those of miR-7 and its upstream activator HoxD10 are progressively down-regulat
51 PIKfyve-catalyzed synthesis and requires the upstream activator hVac14 (called herein ArPIKfyve) that
54 in nuclear factor kappaB (NF-kappaB) and its upstream activator IkappaB kinase-beta (IKK-beta, encode
55 ve colon cancer behavior and functions as an upstream activator in the Jagged1/Notch signaling pathwa
57 machinery, this motif does not mimic natural upstream activators: instead of mimicking an activated s
58 o caused constitutive hyperactivation of its upstream activator, IRE1alpha, which could degrade a sub
59 hich recognises RFXV/I motifs present in its upstream activator [isoforms of the With-No-lysine (K) k
61 lly, the identification of the p38-dependent upstream activator MAP kinase kinase 6 as a member of th
63 n-activated protein kinases (MAPKs) by their upstream activators, MAPK/ERK kinases (MEKs), is crucial
64 e dialyzed with recombinant p38alpha and its upstream activator, MEK-6, which substantially inhibited
65 member of the MAPK family, and its specific upstream activator MEK5 were activated in response to in
66 rpin or a dominant-negative form of the ERK5 upstream activator, MEK5, in T cells led to downregulati
67 -Jun N-terminal kinase (JNK), along with its upstream activator MEKK-1, is typically thought of as a
68 pproach to achieve targeted expression of an upstream activator, mitogen-activated protein kinase kin
69 using inhibitors targeting the shared ERK1/2 upstream activator, mitogen-activated protein kinase kin
71 ression of dominant negative p38alpha or its upstream activator, MKK3, inhibited EGF receptor phospho
72 inase c-Jun N-terminal kinase (JNK)2 and its upstream activator MKK4 were phosphorylated in platelets
73 reover, we demonstrate that p38alpha and its upstream activator, MKK6, phosphorylate STAT4 on serine
74 n of the constitutively active mutant of the upstream activator, MKK6b (GST-MKK6b S207E T211E), in th
75 ed mitogen-activated protein kinase, p38, by upstream activator MKK6bE led to significant induction o
79 ide 3-kinase/PI3K functioned as an essential upstream activator of Akt and ERK1/2 in glutamate-treate
81 Phosphoinositide 3 kinase (PI3K) is a direct upstream activator of AKT, and plays a critical role in
82 the activity of mTOR complex 2 (mTORC2), an upstream activator of Akt, and this occurs independent o
83 ositol 3-kinase (LY294002), thought to be an upstream activator of Akt, exacerbated cortical apoptosi
87 lin-dependent protein kinase kinase beta, an upstream activator of AMPK, and by the mTORC1 inhibitor
89 phosphatidylinositol-3-phosphate kinase, an upstream activator of Arf6, also had no effect on the in
90 a signaling pathway whereby Abeta acts as an upstream activator of astroglial nuclear factor kappa B
91 Nbs1 contributes to the DDR by acting as an upstream activator of ATM in response to double-strand D
93 ermal growth factor receptor (EGFR), a known upstream activator of both the prosurvival phosphoinosit
94 rget gene, MKK7D, a constitutively activated upstream activator of c-Jun N-terminal kinases (JNK).
95 d protein kinase kinase kinase 1 (Mekk1), an upstream activator of c-Jun, enhances the interaction of
98 Rs; APV) or CaM-kinase kinase (STO-609), the upstream activator of CaM-kinase I (CaMKI), as well as b
99 of neurons expressing dnCaMI or dnCaMKK, the upstream activator of CaMKI, exhibit collapsed morpholog
102 y 10-fold, and the amount of CaMK kinase (an upstream activator of CaMKIV) protein and mRNA was signi
103 ghly expressed CAM-kinase-kinase (CAMKK), an upstream activator of CaMKIV, suggesting a role for CaMK
104 rine caspase family, has been shown to be an upstream activator of caspase-1 in regulating cytokine m
105 or of host immunity and functions as a high, upstream activator of cells within the innate and the ad
110 Moreover, we identify IGF-1R as a novel upstream activator of endogenous Abl kinases, and demons
114 te that two different inhibitors of MEK, the upstream activator of ERK, block catecholamine- and beta
115 tors or a dominant-negative form of MEK, the upstream activator of ERK, reduced the survival of patie
116 and primary neurons, inhibition of MEK-1, an upstream activator of ERK-1/2 protects against MG132-ind
119 post-ischemic phosphorylation of MEK1/2, the upstream activator of ERK1/2, was unaffected by precondi
120 nhibitors were also shown to affect MEK5, an upstream activator of ERK5, another class of MAPK with h
121 that encodes constitutively active MEK1, the upstream activator of ERKs, also protected cells against
122 of a constitutively active Mek1, a specific upstream activator of ERKs, maintained myoblast viabilit
128 osis signal-regulating kinase 1 (ASK1) is an upstream activator of JNK and p38 MAPK signaling cascade
130 bited in cells deficient in MEK kinase 1, an upstream activator of JNK in reovirus-infected cells.
131 nstitutively active mutant Rac-1 (Val12), an upstream activator of JNK, abrogated Deltap85-induced lu
132 a dominant negative mutant form of SEK1, an upstream activator of JNK, likewise suppressed JNK activ
133 dominant-negative forms of JNK1 and MKK4, an upstream activator of JNK, results in loss of TGF-beta-s
134 y, versus control, 40.5%), whereas MEKK1, an upstream activator of JNK, sharply reduced apoptosis in
138 of Myc, whereas inhibition of Rho kinase, an upstream activator of LIMK1, stimulates Myc expression.
139 activated kinase kinase (MEK1), an immediate upstream activator of MAPK in estrogen receptor positive
140 owth factor-beta-associated kinase-1 (TAK1), upstream activator of MAPK, but not p38 MAPK restored ce
142 t or constitutively active MAPK kinase-1, an upstream activator of MAPK, partially blocked IGFBP-3-in
143 studies demonstrate that p38alpha is a major upstream activator of MAPKAP kinase 2 and a key componen
145 was even greater upon cotransfection with an upstream activator of mitogen-activated protein kinases
148 8) in AKT, a known substrate of CaMKK and an upstream activator of mTOR-dependent translation, was pr
151 tor (M-CSF) was implicated as a contributing upstream activator of mTORC2 in a pathway that involved
154 yzing 3T3-L1 cell lines harboring a specific upstream activator of p38 (a constitutively active mitog
156 ely active mutant of MAPK kinase 6 (MKK6, an upstream activator of p38 MAPK) but not constitutive act
157 Constitutively active MKK6, an immediate upstream activator of p38 MAPK, induced selectin ligand
160 n of an activated form of MKK6 (an immediate upstream activator of p38) rescues the ability of Cdo(-/
161 h MKK6b(E), a constitutively active specific upstream activator of p38, led to a potent inhibition of
166 ate apoptosis signal-regulating kinase 1, an upstream activator of p38/JNK in the MAPK signaling casc
167 A constitutively active form of MEK6, an upstream activator of p38delta, can also produce cell de
169 either was indirect, perhaps mediated by an upstream activator of p53, or was due to oxidation of on
170 RF tumor suppressor is widely regarded as an upstream activator of p53-dependent growth arrest and ap
171 As mammalian target of rapamycin (mTOR), an upstream activator of p70 S6Kinase is, in part, regulate
172 n receptor substrate-2 (IRS2) expression, an upstream activator of PI3K, we therefore anticipated tha
173 mosome segments containing PIK3CA, ERBB2 (an upstream activator of PIK3CA), and CCNE1 (a target of FB
174 s, providing genetic evidence that PDK1 (the upstream activator of PKB) is required for the phosphory
175 onstrated that LY294002, an inhibitor of the upstream activator of PKB, phosphatidylinositol 3-kinase
177 C was previously identified as the immediate upstream activator of PKD, PKD vs PKC selectivity was es
179 el in which PHS, rather than simply being an upstream activator of Pkh1, also activates kinases that
181 h a linear pathway, in which RhoG acts as an upstream activator of Rac1, indicating that increased su
182 tein directly activated by cAMP) is a likely upstream activator of Rap1, since Epac is present in the
183 ) mice, suggesting that Flt3 is an important upstream activator of Ras in early B cell progenitors.
186 ogether, these findings identify dHAND as an upstream activator of Shh expression and important trans
187 that RPTPalpha functions as a physiological upstream activator of Src-family kinases in fibroblasts
188 und that alphavbeta6 integrin acted as a key upstream activator of TGF-beta in evolving pancreatic ca
189 e kinase kinase kinase (MAP4K) family and an upstream activator of the c-Jun N-terminal kinase (JNK)
191 eonine kinase that has been identified as an upstream activator of the c-Jun NH(2)-terminal kinase (J
194 ATF3 promoter can be activated by MEKK1, an upstream activator of the ERK and JNK kinase pathway, bu
195 NGF treatment and cotransfection with an upstream activator of the extracellular signal-regulated
196 ciated with a down-regulation of c-Raf-1, an upstream activator of the extracellular signal-regulated
197 hage migration inhibitory factor (MIF) is an upstream activator of the innate response that mediates
201 on of mice that are deficient for a specific upstream activator of the kinase, MAP kinase kinase 3, r
203 ssion of a dominant negative form of Ras, an upstream activator of the MAPK pathway, also inhibited s
205 sfection of constitutively active MEKK-1, an upstream activator of the mitogen-activated protein (MAP
208 titutively active form of RalA (RalA23V), an upstream activator of the RalBP1 signaling pathway, incr
209 dominant inhibitory mutant of the immediate upstream activator of the stress-activated protein kinas
210 protein kinase kinase kinase-1 (MEKK-1), an upstream activator of the stress-activated protein kinas
212 ain (Rheb) small GTPase is known to be a key upstream activator of TORC1, although the mechanism of R
214 ctivation of inositol-requiring enzyme 1, an upstream activator of XBP1, leading to phosphorylation o
216 infection, Src and p110beta PI 3-kinase are upstream activators of Akt and the IL-8 promoter and tha
219 novel MAGUK family members that function as upstream activators of BCL10 and NF-kappaB signaling.
220 Importantly, loss of flbC or flbD encoding upstream activators of brlA in the absence of nsdD resul
221 s of calcium injury in neurons, calpains are upstream activators of Erk1,2 signaling and are likely t
224 e phosphorylation of MKK7, MKK4, and MKK3/6, upstream activators of JNK and p38, was markedly reduced
227 horing mixed lineage kinase (MLK) 2 or MLK3, upstream activators of JNKs, to the receptor complex.
228 owever, no significant activation of several upstream activators of MEK, including Ras, Rap1, and Raf
229 ular signal-regulated kinase (ERK) 1/2 MAPK (upstream activators of MSK1) reduced MOR expression leve
231 ding the participation of these molecules as upstream activators of N-WASP in the initiation of actin
234 ed tumorigenesis in vivo Genes encoding some upstream activators of NOTCH were highly enriched for H3
235 MAPK kinase-3 (MKK3), MKK6 (the immediately upstream activators of p38 kinase) and a MAP3K, i.e., TG
238 m mass spectrometry approach that identifies upstream activators of PI3K both in vitro and in vivo.
241 e show that light-gated translocation of the upstream activators of Rho-family GTPases, which control
242 signaling pathway, whereas SEK1 and MEK1 are upstream activators of SAPK/JNK and ERK pathways, respec
247 4 signalling in brain endothelial cells, but upstream activators of this disease pathway have yet to
248 Our analysis uncovered KLHL9 deletions as upstream activators of two previously established master
249 mour suppressor protein kinase is the major "upstream" activator of the energy sensor AMP-activated p
251 ssors that must bind within 100 bp of either upstream activators or the core transcription complex to
252 ls, p50(Cool-1) suppresses Pak activation by upstream activators; p85(Cool-1) has a permissive effect
255 etal muscle FNDC5 (irisin precursor) and its upstream activator peroxisome proliferator-activated rec
256 itions of the mTOR signaling, as well as its upstream activators, phosphatidylinositol 3-kinase and A
257 R-associated factor 2 as well as PKB and its upstream activator phosphoinositide 3-kinase (PI3K).
258 ks the translocation of Akt/PKB, but not its upstream activator phosphoinositide-dependent kinase-1,
259 -gamma mutant neurons by inhibiting PKC, its upstream activator phospholipase C, or the gamma-Pcdh bi
260 phosphatidylinositol 3-kinase (PI3K) and its upstream activator PI3K enhancer PIKE, predicted targets
261 uction of the substrate required by both its upstream activator, PI3K, and its downstream target, PLC
263 equently, LEOPARD syndrome SHP2 mutants bind upstream activators preferentially and are hypersensitiv
264 n silenced chromatin inhibits the binding of upstream activator proteins or polymerase or (2) silenci
266 tial for growth or secretion when either the upstream activator rab, Sec4p, or the downstream SNARE-b
268 ma invasion and metastasis 1 (Tiam1) and its upstream activator Ras in a phosphoinositide-3-kinase-in
269 minus may assist in its association with the upstream activators (Ras1 and Rap1) through a CRN-mediat
272 ssion of TOR and RAPTOR, together with their upstream activator Rheb, was sufficient to provide TORC1
273 of the -35 element (GTGGGA; the rRNA operon upstream activator [RUA]) that is conserved in monocot a
274 ctivated protein kinase (MAPk); however, the upstream activator(s) of p38 MAPk is unknown, and conseq
275 e that inhibition of IKKalpha/IKKbeta or its upstream activators sensitizes cells to death by inducin
276 the control of multiple tandem copies of the upstream activator sequence (UAS) often show evidence of
277 of transcription, defined the 3' end of the upstream activator sequence (UAS) regulatory element, an
278 me sequence showed that the regulatory site, upstream activator sequence (UAS), the putative binding
280 rap screen using GAL4 to drive expression of upstream activator sequence (UAS)-linked transgenes in e
285 Single insertions containing four distinct upstream activator sequences were far less susceptible t
288 MAPK docking sites show specificity for the upstream activator similar to that reported for the full
292 dependent recruitment of the MAPK cascade to upstream activators that are unique to one or the other
293 n disrupted the interaction of SHP2 with its upstream activator, the Grb2-associated binder 2 adaptor
294 the function in beta-selection of its known upstream activator, the serine/threonine kinase Pim1: ME
296 not processed by hepsin, we investigated the upstream activators, urokinase-type plasminogen activato
297 GTPase Rac was constitutively active and its upstream activator Vav was constitutively phosphorylated
298 vation of temperature-sensitive Vps34 or its upstream activator, Vps15, blocks the Cvt and macroautop
299 n kinase kinase 7 (mutant D), a JNK-specific upstream activator, was expressed in myocytes by adenovi
WebLSDに未収録の専門用語(用法)は "新規対訳" から投稿できます。