ライフサイエンスコーパス: upstream regulator

1 TGF-beta1 was identified as the primary upstream regulator.

2 le evidence on the potential relevance of an upstream regulator.

3 epair pathways and altered activities of key upstream regulators.

4 n analysis of transcription factors to infer upstream regulators.

5 s a Bayesian approach to infer corresponding upstream regulators.

6 titumor activity but circumvented control by upstream regulators.

7 e ERK1/2 activation by BCAR1/BCAR3 and other upstream regulators.

8 volves loss of duplicate copies of genes and upstream regulators.

9 ps into account to arrive at the best set of upstream regulators.

10 trogene expression can be induced by various upstream regulators.

11 et there is little information regarding its upstream regulators.

12 bout how expression of Eya1 is controlled by upstream regulators.

13 and Rictor were identified as potential key upstream regulators.

14 binding sites, or inactivation of the three upstream regulators, abolishes both reporter and endogen

15 n or stability nor by the involvement of its upstream regulators Akt and MAPK.

16 proinflammatory functional gene sets, while upstream regulator analysis coupled with Western blottin

17 Pathways, functional and upstream regulator analysis of the intersections between

18 Upstream regulator analysis predicted the TLR4 ligands,

19 The causal analytics tools 'Upstream Regulator Analysis', 'Mechanistic Networks', 'C

20 The causal analytics tools 'Upstream Regulator Analysis', 'Mechanistic Networks', 'C

21 r-associated protein with death domain as an upstream regulator and transforming growth factor beta-a

22 t significant numbers of canonical pathways, upstream regulators and cellular functions.

23 these lineages and have begun to dissect the upstream regulators and downstream effectors of Etv2 fun

24 By including both upstream regulators and downstream effectors, we can sys

25 a melanogaster, we first screened for FoxO's upstream regulators and downstream effectors.

26 Combined, these results identify upstream regulators and downstream functions of chodl du

27 MAPKs bind to many of their upstream regulators and downstream substrates via a shor

28 number of molecules have been identified as upstream regulators and downstream targets of Akt, the m

29 However, the identities of the upstream regulators and downstream targets that mediate

30 with less clear temporal separation between upstream regulators and downstream targets.

31 is predicted that LPS and MPLA share similar upstream regulators and have comparable effects on canon

32 two key links; that of a plant MAPKKK to its upstream regulators and of brassinosteroid to a specific

33 d that PO differentially regulates predicted upstream regulators and pathways, including LPS, members

34 f differentially affected cellular pathways, upstream regulators and predicted miRNA-target interacti

35 biphasic regulation is due to repression of upstream regulators and promotion of AMS protein degrada

36 ebrates, we report deep conservation of both upstream regulators and segmental activity of enhancer e

37 However, the upstream regulators and signaling pathways that control

38 We report the predicted upstream regulators and signalling pathways characterizi

39 a physical and functional interface between upstream regulators and the Pol II transcriptional machi

40 n the Hippo field has focused on identifying upstream regulators, and a complex Hippo interactome has

41 nally co-regulated mRNA subsets share common upstream regulators, and sequence elements generated by

42 entification of mRNA targets of FMRP and its upstream regulators, and the use of small molecules to s

43 , this is true even when fluctuations in the upstream regulator are far below the dissociation consta

44 involved in myogenesis have been identified, upstream regulators are less well understood.

45 s several components of the network, but its upstream regulators are still poorly characterized.

46 Thyroid- and TH-associated upstream regulators as well as thyroid-related diseases

47 d an evolutionary shift in many of the known upstream regulators at the base of the arthropod lineage

48 ew statistical method that will infer likely upstream regulators based on observed patterns of up- an

49 reciprocally controls the activation of its upstream regulator c-Abl.

50 nse is triggered when noisy expression of an upstream regulator crosses a critical threshold.

51 tors Egr1, Atf3, Jun, Fos, and Mafb, and the upstream regulators Csf1r, Tgfb1, and Tgfbr1, which are

52 Modules of miRegulome (upstream regulators, downstream targets, miRNA regulated

53 response gene PHOTOPERIOD1 (Ppd-H1) and its upstream regulator EARLY FLOWERING3 (HvELF3).

54 - and gain-of-function studies indicate that upstream regulators, Expanded, Merlin and Kibra, play a

55 d that they do this in parallel to the known upstream regulator Fat cadherin.

56 ive RNA-binding protein RCF3 is an important upstream regulator for heat stress-responsive gene expre

57 ings suggest that SIRT1 functions as a novel upstream regulator for LKB1/AMPK signaling and plays an

58 hese observations strongly support FER as an upstream regulator for the RAC/ROP-signaled pathway that

59 tool called 'TRES' that predicts the likely upstream regulators for a given gene list.

60 ceptor-like kinase (RLK) family as potential upstream regulators for RAC/ROP signaling.

61 CN5L1 liver specific knockout mice and their upstream regulator, FoxO1 protein levels are decreased v

62 involving the MYC locus or mutations of its upstream regulators, how c-MYC expression is induced and

63 Novel, potential upstream regulators identified offer potential therapeut

64 okine G-CSF (r(2)=0.0683, p < 0.05), and its upstream regulator IL-17 (r(2)=0.0891, p < 0.05) both co

65 of the top diseases, functions, pathways and upstream regulators implied that a common underlying mec

66 d that can efficiently estimate p-values for upstream regulators in current biological settings.

67 on, and demonstrate differential activity of upstream regulators in different subcellular domains.

68 different components have been identified as upstream regulators in Drosophila and vertebrates.

69 s eyeless (ey) and twin of eyeless (toy) are upstream regulators in the retinal determination gene ne

70 Upstream regulators including the bZIP transcription fac

71 There are still few data about potential upstream regulators initiating aberrant CDX2 expression

72 ssary for IFN-gamma-mediated quiescence, its upstream regulator IRF-1 was required.

73 ulation of the Hippo pathway and discovering upstream regulators is thus a major quest.

74 RNA interference of MLC-4, as well as of its upstream regulators, LET-502 (Rho-associated coiled-coil

75 ng of a dicitrate transporter fecBCDE and an upstream regulator likely for iron uptake, whereas the o

76 called Expression2Kinases (X2K) to identify upstream regulators likely responsible for observed patt

77 omotes dephosphorylation of cofilin1 and its upstream regulators, LIM kinase (LIMK) and Slingshot-1 p

78 This study identifies cofilin1 and its upstream regulators, LIMK and SSH1, as end targets of a

79 he membrane lipid transporter ABCA1, and its upstream regulator Liver X receptor (LXR) in the macroph

80 and identification of the binding sites for upstream regulators, mean its workings can finally start

81 raised important considerations as to which upstream regulators mediate cAMP inhibition of PI3K/AKT,

82 or by inhibiting the activity of JNK or its upstream regulator, MKK-7.

83 he ribosome protein S6 kinase (S6K1) and its upstream regulator mTOR in the control of platelet activ

84 sion and recruitment of its newly identified upstream regulator MYC.

85 Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway

86 cytosolic form of Gpx4 was identified as an upstream regulator of a novel form of non-apoptotic cell

87 tify Wnt-beta-catenin signaling as a crucial upstream regulator of a Tbx1-Fgf8 signaling pathway and

88 Our study indicates MIF is a central and upstream regulator of ADPKD pathogenesis and provides a

89 tion, we have identified a tension-sensitive upstream regulator of alpha-actinin-4 as synaptopodin.

90 with inducible hepatic deletion of LKB1, an upstream regulator of AMPK.

91 to inhibition of protein phosphatase 2A, an upstream regulator of ATM.

92 ass III phosphoinositide 3-kinase that is an upstream regulator of autophagy, resulted in hepatocyte

93 This study identifies PKCzeta as a novel key upstream regulator of BA-regulated SHP function, reveali

94 As an upstream regulator of BCAT1 expression, we identified Mu

95 results show that ROCK1 acts as a prominent upstream regulator of Beclin1-mediated autophagy and mai

96 TOR may therefore function as a common upstream regulator of both autophagy and lipl-4 expressi

97 sive cytoplasmic adapter molecule that is an upstream regulator of both IkappaB kinase (IKK) and c-Ju

98 ether, our results indicate that BRCA1 is an upstream regulator of BRCA2 in the DNA-damage response,

99 o persistent pain in EAE and functions as an upstream regulator of CaMKIIalpha signaling.

100 by inhibiting mTOR, placing mTOR as a novel upstream regulator of caspase-2 and supporting the possi

101 tified cyclin-dependent kinase (CDK) 6 as an upstream regulator of CDK2 controlling SAMHD1 phosphoryl

102 ctor AP-2gamma (TFAP2C) functions as a novel upstream regulator of Cdx2 expression and position-depen

103 Oxygen (O2) acts as a potent upstream regulator of cell function.

104 ations demonstrate that GflB is an essential upstream regulator of chemoattractant-mediated cell pola

105 nscription factor E2F3 (E2F3) as a prominent upstream regulator of cocaine-induced changes in gene ex

106 molog of the mammalian MAGI scaffolds, is an upstream regulator of E-Cad-based AJs during cell rearra

107 es show for the first time that DPAGT1 is an upstream regulator of E-cadherin N-glycosylation status

108 , these findings define DEPTOR as a critical upstream regulator of EC activation responses and sugges

109 protein kinase C (PKC) betaII is a critical upstream regulator of Egr-1 in response to vascular stre

110 poietic transcription factor PU.1 is a major upstream regulator of Elf-1.

111 Thus, we identify Aurora-B as a key upstream regulator of end-on conversion in human cells a

112 Thus, paxillin serves as a specific upstream regulator of Erk in response to receptor-tyrosi

113 d a novel regulatory mechanism of MSI2 as an upstream regulator of ESR1 and revealed the clinical rel

114 findings reveal mitochondrial dynamics as an upstream regulator of essential mechanisms governing ste

115 ngs identify mesodermal foxc1a/b as a direct upstream regulator of etsrp in angioblasts.

116 Scube3 may be a critical upstream regulator of fast fiber myogenesis by modulatin

117 threonine-specific kinase p38 as a druggable upstream regulator of FOXC2 stability and function that

118 Hence, Fra-2 is a key upstream regulator of Foxo1 and Irf4 expression and infl

119 protein kinase, is a previously unidentified upstream regulator of Foxo1.

120 essential function for Six1 in the MM as an upstream regulator of Grem1 in initiating branching morp

121 , via its tubulin-association, is a critical upstream regulator of HDAC6 activity and that FTase expr

122 1alpha induction, suggesting that KLF5 is an upstream regulator of HIF-1alpha.

123 Ajuba, an upstream regulator of Hippo signaling that functions as

124 Retinoic acid is a known upstream regulator of HOXA5 expression.

125 re, we identify HNF4alpha as a potential key upstream regulator of IBD candidate genes.

126 uman peripheral blood cells and to define an upstream regulator of its activation through the release

127 In the present study, we identified the upstream regulator of Jab1/Csn5 expression and demonstra

128 hese data demonstrate that DLK is a critical upstream regulator of JNK-mediated neurodegeneration dow

129 itor of DNA binding protein 2 (ID2) as a key upstream regulator of KDR activation during myeloid diff

130 tegies, we also showed that PKCepsilon is an upstream regulator of Lck, and Fyn is a downstream targe

131 B-Raf, an upstream regulator of MEK, constitutively interacts with

132 A2 transcription factor was identified as an upstream regulator of miR-194, consistent with a strong

133 hioredoxin-interacting protein (TXNIP) as an upstream regulator of miR-204, we also assessed whether

134 receptor protein tyrosine kinase TYRO3 as an upstream regulator of MITF expression by a genome-wide g

135 The loss of RASSF1A (an upstream regulator of MOAP-1) is one of the earliest det

136 ough Raptor-associated mTORC1 is a known key upstream regulator of mRNA translation, initiation and e

137 PA-generating enzyme that is an established upstream regulator of mTORC1, is found to negatively aff

138 A critical upstream regulator of NF-kappaB activation is protein ki

139 Collectively, our results uncover MLK4 as an upstream regulator of NF-kappaB signaling and a potentia

140 The TGFbeta-associated kinase 1 (TAK1) is an upstream regulator of NF-kappaB signaling.

141 ticular, c-MYC was identified as a candidate upstream regulator of OGT target genes and OGT inhibitio

142 s Dlx3 downstream of Wnt signaling and as an upstream regulator of other transcription factors that r

143 ggesting a novel role for this protein as an upstream regulator of p100.

144 strate that Sox2 plays a novel role as a key upstream regulator of p27(Kip1) to maintain the quiescen

145 ough CDC42 has previously been considered an upstream regulator of Pak2, we found a paradoxical decre

146 cription factor as a critical dose-dependent upstream regulator of Pax6 expression during lens format

147 cers, indicative of DNA methylation being an upstream regulator of phylotypic enhancer function.

148 As RAS can be a positive upstream regulator of PI3-K, it has been proposed that t

149 vious findings that cell surface GRP78 is an upstream regulator of PI3K/AKT signaling, we show here t

150 The results identify MARK2 as an upstream regulator of PINK1 and DeltaN-PINK1 and provide

151 plicated by numerous studies as the critical upstream regulator of primordial follicle activation via

152 kappaB pathway, implying that Fyn is a major upstream regulator of proinflammatory signaling.

153 ort that one kinase, PIPKI-alpha, is a novel upstream regulator of Rac1 that links activated integrin

154 Thus, Trex1 is an upstream regulator of radiation-driven anti-tumour immun

155 Targeting CDK9 or c-MYC, an upstream regulator of RBPJ, with small molecules also de

156 identifies CHD7 as a previously unrecognized upstream regulator of Reln, and provides direct in vivo

157 sphate tensin homolog on chromosome 10 is an upstream regulator of renal PPM1A deregulation.

158 Loss of Moesin (Moe), an upstream regulator of Rho1 activity, results in increase

159 F breakpoint cluster region (Bcr) as a major upstream regulator of RhoA activity, stress fibers, and

160 variants, we provide evidence that Nck is an upstream regulator of RhoA-dependent, MMP14-mediated bre

161 gether, our findings indicate that Osx is an upstream regulator of Satb2 during bone formation.

162 aliana activating factor1 (ATAF1) as a novel upstream regulator of senescence.

163 We present evidence that the upstream regulator of sigma(F), the phosphatase SpoIIE,

164 ur results suggest that TAK1 is an important upstream regulator of skeletal muscle cell differentiati

165 our data suggest that Mesp-b is an intrinsic upstream regulator of skeletal muscle progenitors and th

166 d to coprecipitate with forkhead box O3, the upstream regulator of SOD2.

167 , our data indicate that OsMADS26 acts as an upstream regulator of stress-associated genes and thereb

168 gether, these findings implicate Isc1p as an upstream regulator of Swe1p levels and stability and Cdc

169 e ubiquitin-modifying enzyme TNFAIP3/A20, an upstream regulator of T cell receptor (TCR) signaling in

170 We also identify Stat3 as an upstream regulator of Tcf3.

171 rved an attenuation of NF-kappaB pathway, an upstream regulator of the aforementioned genes, concomit

172 as well as the activation of PI3K, the main upstream regulator of the Akt.

173 ATR kinase is a critical upstream regulator of the checkpoint response to various

174 e recapitulated by mutations in Expanded, an upstream regulator of the conserved Hippo pathway, and m

175 led that Pals1 functions as a dose-dependent upstream regulator of the crosstalk between Hippo- and T

176 ed ataxia telangiectasia mutated protein, an upstream regulator of the DDR pathway, and we found a si

177 rferon gamma was identified as a significant upstream regulator of the expression changes for RR and

178 We further identify that Brd4 is an upstream regulator of the expression of c-Myc which has

179 rexpression increased expression of PAR1, an upstream regulator of the Hippo pathway; PAR1 promotes i

180 KIBRA (kidney brain protein), an upstream regulator of the Hippo signaling pathway encode

181 e E-cadherin/catenin complex functions as an upstream regulator of the Hippo signaling pathway in mam

182 t the cytoskeleton-membrane interface, as an upstream regulator of the Hippo signaling pathway.

183 ontaining cell adhesion molecule, acts as an upstream regulator of the Hpo pathway.

184 onclude that alpha6 integrin is an essential upstream regulator of the IGF-1R survival pathway that r

185 LEAFY-like genes in Welwitschia, could be an upstream regulator of the MADS-box genes APETALA3/PISTIL

186 testicular development, thereby acting as an upstream regulator of the male pathway in P. sinensis.

187 rter of EMT, we discovered that S100A4 is an upstream regulator of the master EMT regulators SNAIL2 a

188 Expression of c-myc, a crucial upstream regulator of the miR-17 polycistron, correlated

189 sults demonstrate that Foxd3 is an essential upstream regulator of the Nodal pathway in zebrafish dor

190 y shown to require IkappaB kinase (IKK), the upstream regulator of the nuclear factor (NF)-kappaB pat

191 The CaMKK2/CaMKIV relay is an upstream regulator of the oncogenic mammalian target of

192 monstrates that alpha2M*/CS-GRP78 acts as an upstream regulator of the PDK1/PLK1 signaling axis to mo

193 Fam20C is potentially an upstream regulator of the phosphate-regulating hormone f

194 esponsive element-binding protein target and upstream regulator of the PI3K/Akt pathway, as a novel c

195 findings support the notion that BAG2 is an upstream regulator of the PINK1/PARKIN signaling pathway

196 nstrate that in SSc fibroblasts, c-Abl is an upstream regulator of the profibrotic PKCdelta/phospho-F

197 studies have demonstrated that cyclin D1, an upstream regulator of the Rb/E2F pathway, is an essentia

198 SCL1 and RET implicated ASCL1 as a potential upstream regulator of the RET oncogene.

199 nflammatory cytokine that acts as a critical upstream regulator of the SA secretory phenotype (SASP).

200 at cardiomyocyte PDGFR-beta was an essential upstream regulator of the stress-induced paracrine angio

201 The phosphorylation of TSC2, an upstream regulator of the TORC1 pathway, at the AMPK sit

202 Thus, Pitx2 has long been considered as an upstream regulator of the transcriptional hierarchy in e

203 urther discovered that FoxO1 is an essential upstream regulator of the VCAM1 gene.

204 and identifies Hedgehog signaling as a novel upstream regulator of their prosensory function in the m

205 ed formation of ceramide, and PKCdelta is an upstream regulator of this pathway.

206 Transforming growth factor-beta (TGF-beta), upstream regulator of TIMP-1, increased with age but was

207 ranscriptional repressor ZBTB1 is a critical upstream regulator of TLS.

208 These results demonstrate that RasC is an upstream regulator of TORC2 and that the TORC2-PKB signa

209 RC1, suggesting that PTEN may not be a major upstream regulator of TSC/mTORC1 during early postnatal

210 Interestingly, disruption of Pten, an upstream regulator of TSC1/TSC2, in the same cells, does

211 Our results define Rspo1 as a key upstream regulator of two crucial pathways necessary for

212 ation factor 6 (ARF6), a small G protein and upstream regulator of type I phosphatidylinositol phosph

213 Our study identifies PKA as an upstream regulator of UBE3A activity and shows that an a

214 initiated by lysophosphatidic acid (LPA), an upstream regulator of Yap that can cause fetal haemorrha

215 y sequestering actin assembly activities and upstream regulators of actin assembly at the leading edg

216 -1, similarly promotes regeneration, but the upstream regulators of apoptosis CED-9/Bcl2 and BH3-doma

217 binding proteins cofilin and VASP, which are upstream regulators of conformational integrin changes.

218 A molecular screen to find upstream regulators of cVg1 in normal embryos and in emb

219 all regulatory RNAs (microRNAs) that control upstream regulators of cytoskeletal proteins are also in

220 Nck-interacting kinase (TNIK or MAP4K7), as upstream regulators of DLK/JNK signaling in neurons.

221 ferentiation, regulatory elements as well as upstream regulators of Elf-1 need to be identified.

222 hese results position PKA, Ras, and B-Raf as upstream regulators of ERK activation and identify B-Raf

223 However, upstream regulators of Etv2 in hemangiogenesis, generati

224 nd we have been looking to define the direct upstream regulators of Fgf10 in this sensory organ, as p

225 ng further evidence that these Zic genes are upstream regulators of Hedgehog-mediated Myf5 activation

226 is caused by mutations in the genes encoding upstream regulators of hepcidin or more rarely in the he

227 ent for cilia in transducing the activity of upstream regulators of Hh signaling but distinct phenoty

228 homeobox genes (Cdx) genes, known to act as upstream regulators of Hox genes.

229 Very little is known about the upstream regulators of HSFs.

230 IL-1beta and upstream regulators of IFN-gamma, IL-12, and IL-18 were

231 known, relatively little is known about the upstream regulators of insulin transcription.

232 ) dual-specificity phosphatases as potential upstream regulators of ischemic neuronal death and Cdk4

233 ing a bioinformatics approach, we identified upstream regulators of KIM-1 after AKI.

234 vations highlight Chk1 and STAT3 as critical upstream regulators of KIM-1 expression after AKI and ma

235 GTPases, RhoA, Rac1, and Cdc42, as potential upstream regulators of membrane fusion.

236 However, the upstream regulators of miRNA biogenesis machineries rema

237 mponents of the gamma-secretase complex, are upstream regulators of multiple cellular pathways via re

238 We discuss the upstream regulators of myogenesis that lead to the activ

239 l border specifiers Pax3 and Zic1 are direct upstream regulators of neural crest specifiers Snail1/2,

240 rial function directly by phosphorylation of upstream regulators of PGC-1alpha and subsequently decre

241 Frs2alpha and tyrosine phosphatase Shp2, two upstream regulators of Ras signaling.

242 critical threshold, we know little about the upstream regulators of SHH expression in the forebrain.

243 Nothing is known about the upstream regulators of SND1.

244 use of integrative analyses for identifying upstream regulators of the affected downstream molecular

245 We identified potential upstream regulators of the core network, including inter

246 (Yki) (YAP in mammals) has been established, upstream regulators of the Hippo kinase cascade are less

247 Other upstream regulators of the Hippo pathway mediate this ef

248 lated or its relationship to the other known upstream regulators of the Hippo pathway remains poorly

249 st- and DNA damage-inducible) interacts with upstream regulators of the JNK and p38 stress response k

250 Recently, oncogenic mutations in NRAS/KRAS, upstream regulators of the RAF/MEK/ERK pathway, have bee

251 g growth factor-beta, and IL-13 as potential upstream regulators of the serum protein patterns in the

252 y, to create membrane domains that partition upstream regulators of the TORC1 and TORC2 signaling pat

253 Although many mysteries remain about the upstream regulators of these changes, we review the core

254 ream gene signatures can be used to identify upstream regulators of transcription factor activity, an

255 nuity Pathway Analysis demonstrated that the upstream regulators of type I and type III interferons,

256 n factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to saf

257 ockout of Lats1 and Lats2 kinase, the direct upstream regulators of YAP and TAZ.

258 hat this approach can correctly identify the upstream regulator on expression data sets for which the

259 overexpression bypasses the requirement for upstream regulators or DNA damage to promote a G2 cell c

260 The 64 genes targeted encode known upstream regulators or downstream effectors of type IA P

261 encing miR-34a expression independent of its upstream regulator, p53.

262 LSC function through a pathway involving an upstream regulator, Pax5, and a downstream effector, p27

263 etal muscle, and with the suppression of the upstream regulators PGC1alpha and AMPKalpha2.

264 s and expression of NFkappaB1, c-Rel and its upstream regulators phosphatidylinositol 3-kinase/RAC-al

265 its inhibitors or with the inhibitor of its upstream regulator PI3K significantly inhibited HCV infe

266 bited constitutive activation of Akt and its upstream regulators PI3K, phosphoinositide-dependent kin

267 We compared several upstream regulator profiles, including constant expressi

268 sub-networks and the connections with their upstream regulator receptors to obtain a systems view of

269 However, its regulation by upstream regulators remains poorly characterized.

270 viously unrecognized roles for GPR10 and its upstream regulator REST in the pathogenesis of uterine f

271 abling convergent advection of MyoII and its upstream regulators Rho1 GTP, Rok and MyoII phosphatase.

272 (DNMT3a) in human cancer, the nature of its upstream regulator(s) and relationship with the master c

273 response occurs because of adaptation of its upstream regulator Stat5, both requiring the EpoR distal

274 We show that, in contrast to canonical upstream regulators such as Crumbs, Kibra, Expanded, and

275 This is all the more important since it is upstream regulators such as this that need to be directl

276 s was undisturbed, depletion of G3BP1 or its upstream regulator TDP-43 disturbed normal interactions

277 ne-triggered activation of NF-kappaB and its upstream regulator TGF-beta-activated kinase-1 in murine

278 s response networks frequently have a single upstream regulator that controls many downstream genes.

279 K shuttles between cellular compartments, an upstream regulator that is fixed in one compartment coul

280 e Bayesian network can be queried to suggest upstream regulators that can be causally linked to the a

281 genes (DEGs), over-represented pathways, and upstream regulators that contribute to kidney disease pr

282 complex with transcription factors and their upstream regulators that control Ccl5 expression.

283 n VSMCs and connects these roles to specific upstream regulators that control their expression.

284 identification of a repertoire of intrinsic upstream regulators that drive the dopaminergic stress r

285 sma glucose levels and altered expression of upstream regulators that include RXRalpha, PPARalpha, an

286 Upstream regulators that orchestrate this remarkable cha

287 geting endothelin and angiotensin, which are upstream regulators that promote VSM contraction, was no

288 in the core autophagy machinery and describe upstream regulators that respond to extracellular and in

289 vated protein) kinases or mutations in their upstream regulators that result in neuro-cardio-facial-c

290 icrodeletions encompassing p190RhoGAP or its upstream regulator, the Abl2/Arg tyrosine kinase, have b

291 Loss of Abl or its upstream regulator, the adaptor protein Disabled, lead t

292 ied, little is known about the role of their upstream regulators, the Rho guanine nucleotide exchange

293 se results indicate that Ddk functions as an upstream regulator to monitor S-phase checkpoint signali

294 rrelations associated with expression of the upstream regulators TSC1, TSC2, AKT, p-AKT, PDPK1, PTEN,

295 WNK1 increases the expression of the PI3KC3 upstream regulator unc-51-like kinase 1 (ULK1), its phos

296 While Notch signaling, including its upstream regulator Vegf, is known to regulate this proce

297 Our results suggest that Arp2/3 and the upstream regulator, WAVE2, are essential co-factors hija

298 In the screen for upstream regulators we identified a LONG PALE HYPOCOTYL

299 indicating that this process shares the same upstream regulators with beta-catenin stabilization.

300 triiodothyronine (reverse) were inferred as upstream regulators with differences in incidence and st