ライフサイエンスコーパス: upstream sequence

1 ivator or the repressor complex binds to its upstream sequence.

2 tifs within a 50-base pair region of the GDH upstream sequence.

3 II) within approximately 12 kb of the CYP3A4 upstream sequence.

4 d by a negative regulatory element in its 5' upstream sequence.

5 one linear plasmid, which was defined by the upstream sequence.

6 al activity that lies between the -490/-72bp upstream sequence.

7 associated with a number of A-tracts in the upstream sequence.

8 r control elements detected in 3.6 kb of the upstream sequence.

9 zation efficiency is negatively regulated by upstream sequence.

10 induction was controlled by 335 bp of CTLA-4 upstream sequence.

11 and activity increased 5-fold with 300 bp of upstream sequence.

12 h was proportional to the copy number of the upstream sequence.

13 increased or decreased with mutations in the upstream sequence.

14 e locus of 10 kb containing 5.6 kb of the 5' upstream sequence.

15 by varying amounts (0.4, 1.5, and 8.5 kb) of upstream sequence.

16 ls for the discovery of regulatory motifs in upstream sequences.

17 activity was due to fusion of the domain to upstream sequences.

18 virus often retained the PPT and additional upstream sequences.

19 scription, insect systems require additional upstream sequences.

20 ein-DNA interaction were identified in CyIIa upstream sequences.

21 ix dependence of the position of cre2 and/or upstream sequences.

22 54 bp, and full activity requires additional upstream sequences.

23 ut acts as an attenuator in combination with upstream sequences.

24 egregate in the population with two distinct upstream sequences.

25 egregate in the population with two distinct upstream sequences.

26 higher than that of the ribozyme without the upstream sequences.

27 iption factors through the analysis of their upstream sequences.

28 an directly bind to specific PMEPA1 promoter upstream sequences.

29 RNA promoters, which often contain A+T-rich upstream sequences.

30 only in expressing cells by the addition of upstream sequences (-1085/-852 bp).

31 A hybrid gene that contains 51B upstream sequences (-475 to +1) attached to the ATG star

32 us contained six DHS within 7.0 kb of the 5' upstream sequence (-7.0 kb) and two DHS in intron 2.

33 The functionality of the upstream sequences (-709 to +135) as a promoter in cultu

34 In the absence of additional upstream sequences, a dependence upon the NS1 binding si

35 ences reveals highly conserved omp3 and omp2 upstream sequences across species, suggesting a unified

36 The far upstream sequence alone exhibits no enhancer activity.

37 Z construct, which has 1.5 kilobase pairs of upstream sequences along with the promoter and first int

38 less promoter flanked by 1.5 kilobases of 5'-upstream sequence and a 1.8-kilobase intron.

39 DCTN1 along with characterization of the 5' upstream sequence and alternative splice variants previo

40 ure, possibly reflecting misfolding with the upstream sequence and dynamics intrinsic to the ribozyme

41 Analysis of the bfpA upstream sequence and identification of the transcriptio

42 be recapitulated with as little as 568 bp of upstream sequence and intragenic sequence containing the

43 six-base complementarity between an adjacent upstream sequence and Methanococcus 16S rRNA.

44 All constructs containing at least 192 bp of upstream sequence and the 5'UTR conferred tissue-specifi

45 ays indicated that the combination of the 5' upstream sequence and the first intron supported the hig

46 frameshifting is influenced by the flanking upstream sequence and the nucleotides in the spacer elem

47 ntify a number of pseudogenes with conserved upstream sequences and activity, hinting at potential re

48 receptor (TCR) responsiveness requires both upstream sequences and an intronic region, PRRIV, previo

49 The upstream sequences and conservation of overlapping ortho

50 demonstrated that the U-tail interacts with upstream sequences and may play roles in both stabilizat

51 noncanonical poly(A) signals contain A-rich upstream sequences and tend to have a higher frequency o

52 , with identical distances between conserved upstream sequences and the downstream -10 elements and t

53 have demonstrated previously that the 9.0 kb upstream sequences and the first intron residing in the

54 rocess, cis-acting ribozymes cleave adjacent upstream sequences and thereby resolve replication inter

55 steps), automatically constructs orthologous upstream sequences, and provides automated benchmarks fo

56 About 300 base pairs of upstream sequence are required for high level promoter a

57 The upstream sequences are also required for maximal binding

58 s between factors recognizing downstream and upstream sequences are involved.

59 olar macrophages, confirming that additional upstream sequences are required for expression in macrop

60 that 126 base pairs (bp) of the VIP receptor upstream sequences are sufficient to mediate transcripti

61 s that the first 164 amino acids of hPR-B (B-upstream sequence) are absent in hPR-A.

62 as not significantly changed by inclusion of upstream sequences as far as -1461 bp.

63 ive transcription within BCL6 as well as far upstream sequences at nucleosomal resolution in B-cell l

64 iated protein, H-NS, preferentially binds to upstream sequences at the nir promoter and represses pro

65 e activity of this promoter was repressed by upstream sequences between -0.9 and -2.5 kb in cells tha

66 The 49-residue upstream sequence blocked incorporation of both endogeno

67 ntaining the sarA transcript plus additional upstream sequence but not the sarA transcript alone.

68 Protection of upstream sequences by RNAP in footprinting experiments o

69 tionality of intron 1 sequence in context of upstream sequences by using transient transfection assay

70 ilies that are flanked by a highly conserved upstream sequence called the upstream homology box, or U

71 d the results argue that transcription of an upstream sequence can alter the termination response of

72 4a-like stem-loop, which can have additional upstream sequence composing a portion of the stem.

73 the B-Peru gene with the first 710 bases of upstream sequence conferred the same levels of aleurone

74 also reveal that the 3' strand of ISTL1 and upstream sequences constitute an inhibitory region that

75 The upstream sequence contained a TATA box and several other

76 Upstream sequences containing this transcription start s

77 ection assays, we show that 4.0 kb of the 5' upstream sequences contains sufficient genetic informati

78 The effects of the upstream sequences correlated generally with their degre

79 ng domain of the F protein together with its upstream sequence could significantly destabilize the gr

80 Conserved upstream sequences (CUS) in their compact promoters bind

81 her proteins that bind to flanking conserved upstream sequences (CUS: S, X, X2, and Y boxes) to these

82 VIZARD also includes annotation and upstream sequence databases for the majority of genes re

83 In in vitro assays, upstream sequence-dependent transcription from the human

84 for IFN-inducibility, as well as an adjacent upstream sequence, designated kinase conserved sequence-

85 These data indicate that the CyIIa upstream sequences differ extensively from those of CyI.

86 dentical dual overlapping promoters, but the upstream sequences differ.

87 The 0.4-kb u-PAR upstream sequence directed weak and strong LacZ expressi

88 ecify serotonergic phenotype, whereas its 5'-upstream sequence directs lim-4 function in AWB.

89 Thus, while 0.4 kb of upstream sequence directs u-PAR expression in the epidid

90 Upstream sequence driving GUS expression in transgenic p

91 Moreover, upstream sequence driving GUS expression in transgenic p

92 d two binding sites for PrrA within the hemA upstream sequences, each of which contains an identical

93 major promoters P1 and P2 as well as the far upstream sequence element (FUSE) and CT elements, which

94 NA polymerase II and consists of a bipartite upstream sequence element (USE) and an element close to

95 ment gene is unusual in that it possesses an upstream sequence element (USE) required for full activi

96 genes requires a TATA box in addition to an upstream sequence element (USE), and polymerase specific

97 nds specifically to the SL RNA gene promoter upstream sequence element and is absolutely essential fo

98 are flanked at their 5' ends by a conserved upstream sequence element called the upstream homology b

99 This process depends on an upstream sequence element denoted termination upstream r

100 inator is governed primarily by a tripartite upstream sequence element designated rut.

101 L1A2, and COL2A1, and demonstrate that these upstream sequence elements (USEs) influence polyadenylat

102 the marked TNF-alpha genes demonstrated that upstream sequence elements such as NF-kappaB are not req

103 oes not cater for the incorporation of large upstream sequences essential for regulated tissue-specif

104 The upstream sequence extends 25 bases in length, is initiat

105 genome-wide set of expression ratios and the upstream sequence for each gene, and outputs statistical

106 endogenous u-PAR protein required 1.5 kb of upstream sequence for optimal expression.

107 f they were, they require the cooperation of upstream sequences for gamma gene induction.

108 the coding region of 51B do not require 51B upstream sequences for their effect.

109 The additional 306 bp of upstream sequence from 330 to 636 bp also appears to pla

110 e show that the proximal 5.2 kilobases of 5'-upstream sequence from the K6a gene fails to direct sust

111 oter revealed protection of the TATA box and upstream sequences from -38 to -20 (top strand) and -40

112 Here, we analyzed the effects of upstream sequences from several additional E. coli promo

113 Upstream sequences from the 7SL RNA gene, U6 RNA gene, v

114 We show that as few as 154 base pairs of 5'-upstream sequences from the cap site can direct the kera

115 rts long-term expression by fusing 6.3 kb of upstream sequences from the rat tyrosine hydroxylase (TH

116 We previously showed that addition of upstream sequences from the rat tyrosine hydroxylase (TH

117 For example, by grouping upstream sequences from three archaebacterial species, w

118 Inclusion of an additional upstream sequence, from 280 to 636 bp 5' to cbbFI, resul

119 For the JDV LTR, upstream sequences, from nucleotide -196 and beyond, as

120 ATM-mediated phosphorylation of the upstream sequence further inhibits RING dimerization.

121 The current study reports the upstream sequences, genomic organization and localizatio

122 rol genes without p53 binding sites in their upstream sequences (group 3) were also examined.

123 abolished transcriptional activity, but the upstream sequence had no effect on TXAS promoter activit

124 Different upstream sequences had different effects, increasing tra

125 is unusually G+C rich (75% G+C in 1200 bp of upstream sequence), has 17 putative SP1 transcription fa

126 Several candidate binding partners for this upstream sequence have been identified in vitro.

127 In humans, distant upstream sequences have been implicated in regulation of

128 When the upstream sequence (hSK1(-)(25b)) or both sequences (hSK1

129 expression assays demonstrate that 2.2 kb of upstream sequence in either species is sufficient to dri

130 onstructs containing nested deletions of the upstream sequence in the human RPE cell lines ARPE19 and

131 ation of the Bax promoter involves a complex upstream sequence in which two Brn-3a response elements

132 Finally, despite the potency of the upstream sequences in conferring high-level, development

133 To explore the roles of these upstream sequences in hpyIM regulation, promoter analysi

134 r necessarily consists of a TATA element and upstream sequences in order to specify the direction of

135 nteract with proteins that bind to conserved upstream sequences in promoters of class II major histoc

136 box) is the 5'-most element of the conserved upstream sequences in promoters of major histocompatibil

137 On various sets of upstream sequences in S. cerevisiae, our program identif

138 by HSF-1 overexpression, and HSF-1 binds to upstream sequences in the regions -1080/-845, -533/-196,

139 ked by inclusion of another PNA, targeted to upstream sequences in the U5 region of the viral RNA.

140 PT-1 substrate, raising the possibility that upstream sequences in this protein may play a role in it

141 SIVmac239delta 3 (deficient in nef, vpr, and upstream sequences in U3).

142 with SIVmac239 delta3 (lacking nef, vpr, and upstream sequences in U3).

143 elta42, exhibits increased dependence on the upstream sequences in vivo.

144 To address this, a 5.15 kb ABI3 upstream sequence including a 4.6 kb full-length promote

145 e response of one isolate with a distinctive upstream sequence including a variant regulatory-motif p

146 The most active segment contained a 177-bp upstream sequence including apparent Crx and Nrl transcr

147 Insertion in pGL3 of a 1635 bp segment of upstream sequence including the most upstream exon (B1c)

148 its transcriptional regulation, we replaced upstream sequences including a DNase I hypersensitive (H

149 binding, and truncation studies suggest that upstream sequences including FRB are required for kinase

150 Upstream sequences (including the first seven codons) of

151 ntained with several further deletions of 5'-upstream sequence, including a short 59-base pair fragme

152 d, measured haplotype analyses that excluded upstream sequences, including the ACE promoter, from har

153 A set of 31 of these upstream sequences increased transcription from 136- to

154 e that repression is due to gp33 blocking an upstream sequence-independent DNA-binding site on RNAP (

155 MP-4 promoters and report substantially more upstream sequence information than that which has been p

156 n constructs containing -14.5 and -0.6 kb of upstream sequence into beta3-AR gene knockout mice.

157 serine or threonine, were examined, and the upstream sequences involved in the developmental regulat

158 ntaining approximately 1.7 kilobase pairs of upstream sequence is required for induction of promoter

159 omoter indicates that as little as 212 bp of upstream sequence is sufficient for this expression, alt

160 We show that the 504-bp 5' upstream sequence is the shortest promoter directing rep

161 everal distinct and repeated motifs in their upstream sequences is examined here using publicly avail

162 A construct in which 2.5 kb of AtZFP1 upstream sequences is linked to the beta-glucuronidase g

163 w that a clone containing Myf5 and 140 kb of upstream sequences is sufficient to recapitulate the kno

164 The upstream sequence lacked TATA and CCAAT boxes at the exp

165 Analysis of the 5' upstream sequence led to the identification of an osmoti

166 The removal of upstream sequences led to decreased overall expression w

167 construct containing 2473 base pairs of hINV upstream sequence linked to luciferase, with POU homeodo

168 e its expression in vivo and that additional upstream sequences located between -0.7 and -2.7 kb are

169 Promoter constructs with only 143 bp of upstream sequence maintained high activity.

170 ufficient for this expression, although more upstream sequence may be involved in quantitative regula

171 This defect was most severe when the upstream sequence motif was altered.

172 Although 21U-RNA loci share a conserved upstream sequence motif, the mature 21U-RNAs are not con

173 orter construct containing 285 base pairs of upstream sequence nearly abolished promoter activity, an

174 g studies focusing on the coding regions and upstream sequence of 152 candidate genes in a total of 1

175 The authors examined the 5' upstream sequence of CTRP5 for the presence of a promote

176 We first showed that the upstream sequence of CXCR1 (-800 to +86 base pairs (bp))

177 a lacZ reporter construct, containing 3.8 kb upstream sequence of Dlx2, led to the mapping of regulat

178 These results indicate that the 49-residue upstream sequence of F1 binds in an inhibitory mode to N

179 e located between -960 and -550 bp in the 5'-upstream sequence of K6a and that their activity is infl

180 this study, promoter analyses show that the upstream sequence of POTH1 drives beta-glucuronidase act

181 enesis in tandem TTGAC motifs located in the upstream sequence of StSP6A suppressed the short day-ind

182 types to bind to a double TTGAC motif in the upstream sequence of target genes.

183 A promoter containing 2133 base pairs of upstream sequence of the 5'-flanking region of mVGLUT2 c

184 We show that the 571-base pair (bp) 5'-upstream sequence of the baboon chymase gene, which enco

185 We also show that a 434-bp 5' upstream sequence of the D. virilis Crz gene, when intro

186 wed that these nuclear factors bind the same upstream sequence of the endogenous Col24a1 gene.

187 lucuronidase (GUS) gene fused to a 3.2 kb 5' upstream sequence of the gene encoding the pea FTase bet

188 ultiple GATC binding sites for Dam within an upstream sequence of the gidA gene and one such target s

189 Mutational analysis of the upstream sequence of the human BRCA2 gene revealed an E2

190 y from the coding region to the LCR with the upstream sequence of the human LW gene, a distance of >3

191 myces cerevisiae) one-hybrid screen with the upstream sequence of the KNOX gene Oskn2 from rice (Oryz

192 Five kilobases of 5' upstream sequence of the mouse red-green (M) opsin gene

193 oter activity of the 2.4-kilobase or shorter upstream sequence of the TH gene.

194 Analysis of the 5' upstream sequence of WdCHS3 provided evidence for a nega

195 n profiling identify hypo-methylation within upstream sequences of 6 genes and hyper-methylation of 1

196 y protein (PpsR, FNR, IHF) binding motifs in upstream sequences of a number of photosynthesis genes h

197 Interestingly, upstream sequences of all known hypha-specific genes are

198 nd that the instability does not require the upstream sequences of am.

199 The Sp-1 binding site is conserved in 5' upstream sequences of both the mouse and the human genes

200 Unique to 2HAPI is the ability to retrieve upstream sequences of co-regulated genes for promoter an

201 y for predicting novel regulatory modules in upstream sequences of coregulated genes.

202 Computational analysis of upstream sequences of genes modulated by Ral depletion i

203 Analysis of the upstream sequences of genes specifically expressed durin

204 Promoter upstream sequences of highly androgen-inducible genes we

205 consisting of miRNA-target pair information, upstream sequences of miRNAs, transcriptional regulatory

206 ish flk1 endothelial enhancer, as well as in upstream sequences of mouse flk1 and human kdr genes, su

207 ve transcription factor binding sites in the upstream sequences of similarly expressed genes has rece

208 The PNR element required upstream sequences of the alpha-MHC gene for negative ge

209 riptional GFP reporters corresponding to 5 '-upstream sequences of the ftn-1 and ftn-2 genes.

210 rogen receptor binding to predicted promoter upstream sequences of the PMEPA1 gene was confirmed by c

211 romoter activity of the 5.6- or 9.0-kilobase upstream sequences of the rat TH gene, which had been sh

212 ed by genomic fusion events between promoter upstream sequences of the TMPRSS2 and coding sequences o

213 We found that upstream sequences of the transcription factor gene tcf2

214 o the separate genes in humans, however, the upstream sequences of the two howler genes show homology

215 nic plants containing the 1.1- and 1.0-kb 5' upstream sequences of the two MCCase subunit genes, resp

216 Statistical analysis of 5' upstream sequences of the VP1/ABA-regulated genes identi

217 Inferred by the upstream sequences of their putative rice (Oryza sativa)

218 Fur also bound the upstream sequences of three Borrelia genes: BB0646 (gene

219 Upstream sequences of U1A-1 and U1A-2 were cloned and th

220 egion and upstream regulatory region or over upstream sequences only.

221 Hybridization analyses revealed that the upstream sequence originally identified 5' of the full-l

222 croarray expression data, and examination of upstream sequence patterns.

223 pression of GA1 cDNA driven by the 2.4 kb 5'-upstream sequence plus the GA1 genomic coding region int

224 Using this enhancer and upstream sequence, polymorphic variants of APPb can now

225 Upstream sequences preceding the lonS coding region rese

226 Finally, an upstream sequence, previously predicted to be a proximal

227 Deletion of 64 bp (-192/-128) from this upstream sequence reduced expression levels by 80.

228 Analysis of the upstream sequences required for transcription of the cyc

229 The action of the upstream sequences required that they be present in cis,

230 Fusion of 396 and 1825 bp of LEACO1 upstream sequence resulted in strong and specific induct

231 ht ventricular expression to the human dHAND upstream sequence revealed two conserved consensus sites

232 basal P1-rr promoter fragment but different upstream sequences revealed no detectable silencing effe

233 Deletion analysis of the upstream sequence reveals that a 247-bp proximal promote

234 ter constructs driven by either 9 or 1 kb of upstream sequence selectively transcribe the transgene i

235 The first 251-bp fragment at the GS upstream sequence showed basal promoter activity, but fa

236 urther extensive mutagenesis of the beta-PDE upstream sequences showed no additional regulatory eleme

237 omparisons with other vertebrate rhodopsin 5 upstream sequences showed significant nucleotide homolog

238 Comparative genomic analysis of upstream sequences shows a discrete region that is highl

239 The AT-rich upstream sequences spanning bases -48 to -85 and bases -

240 to ORF K12 itself, more frequently encompass upstream sequences spanning two sets of 23-nucleotide GC

241 hat mediates functional interactions between upstream sequence-specific activators and the general tr

242 SP-D promoter construct containing 698 bp of upstream sequence (SS698).

243 contrast, the proximal 960 base pairs of 5'-upstream sequence suffice to mediate an induction of bet

244 We showed earlier that a 2300 bp upstream sequence suffices to faithfully recreate this p

245 ately -6 kilobase pairs to -59 base pairs of upstream sequences, terminating at nucleotide +47), iden

246 The gI promoter contains an activating upstream sequence that binds the cellular transactivator

247 d region of the first exon and the immediate upstream sequence that confers transcriptional activatio

248 f the C/EBPbeta promoter containing a 541-bp upstream sequence that could account for this effect.

249 yces cerevisiae U6 RNA gene, SNR6, possesses upstream sequences that allow productive binding in vitr

250 We uncovered upstream sequences that include start codons of zebrafis

251 Here we have investigated the proximal upstream sequences that participate in transcriptional a

252 We show that 63 bp of upstream sequence, that includes a consensus site for PO

253 tive to ribozyme precursor without the extra upstream sequences, the kinetic profile for self-cleavag

254 ingle base substitutions in the nir promoter upstream sequences: these deletions and substitutions pr

255 screen for tandem TTGAC cis-elements in the upstream sequence to catalog StBEL5 target genes.

256 (A) site requires only the DSE and an A-rich upstream sequence to direct efficient cleavage and polya

257 iardia with DNA constructs that used the GDH upstream sequence to drive the expression of a luciferas

258 3 or C2C12 cells required only 165 bp of the upstream sequence to warrant detailed examination of its

259 suggests that several genes may incorporate upstream sequences to influence targeting capacity.

260 n of genomic RNA, which can also anneal with upstream sequences to stabilize alternative conformation

261 ist of a TATA box and a purine-rich adjacent upstream sequence (transcription factor B (TFB)-responsi

262 length bacterial promoter, encompassing both upstream sequences (UP-elements) and core promoter modul

263 An upstream sequence (US) of the gp63 gene was cloned in fr

264 were derived that are missing nef, vpr, and upstream sequences (US) in the U3 region of the LTR (SIV

265 A conserved T-stretch within the upstream sequence was examined in detail and found to be

266 The 135 bp upstream sequence was found to harbor a 3-fold excess of

267 aining as little as 17 base pairs (bp) of 5'-upstream sequence was functional in mouse brain.

268 le IA-2 coding sequence and 4 kb proximal 5'-upstream sequence was isolated and mapped.

269 additional approximately 200 nucleotides of upstream sequence was required for induced levels of act

270 ssion from a construct containing additional upstream sequences was cell type-restricted.

271 ary to the HBV polyadenylation signal and 5'-upstream sequences was complexed to a targetable DNA car

272 d a genomic clone containing 4876-nucleotide upstream sequences was found to have promoter activity i

273 similarity between CyIIa and CyI (and CyIIb) upstream sequences was limited and included a consensus

274 ncludes the transcribed region and 4.7 kb of upstream sequence, was isolated and characterized.

275 hich has an additional 7.7 kilobase pairs of upstream sequences, was expressed in the ventricle and o

276 To understand the function of the upstream sequences, we have asked whether the Bombyx mor

277 at -59 to -50 and its adjacent 20-base pair upstream sequence were demonstrated to play a critical r

278 Similar effects of the upstream sequence were observed with primer-templates te

279 54 base pairs (bp) of upstream sequence were sufficient to direct IGF-I gene t

280 The relative effects of different upstream sequences were compared in the context of their

281 Its immediate upstream sequences were fused to luciferase reporters an

282 ites of protein-DNA interaction in the CyIIa upstream sequences were identified by DNase I footprinti

283 nse occurred even when the btuB promoter and upstream sequences were replaced by the heterologous bla

284 tion in transfection assays, but intron 1 or upstream sequences were required for expression in the v

285 Other upstream sequences were shown to work with the sensory v

286 virus 35S promoter containing the -92 to +6 upstream sequence, whereas oligomers of Gap boxes or AE

287 n binding site previously located in the CyI upstream sequences, whereas the others appear to be uniq

288 functionally relevant proteins to conserved upstream sequences which regulate class II transcription

289 nal in vivo data indicated that further nepA upstream sequences, which are likely to bind a potential

290 The availability of the human beta-PDE 5' upstream sequence will allow patients with retinal degen

291 promoter elements and genetic markers in the upstream sequence will enable the screening of patients

292 Nase footprinting analysis of 1.6 kbp of the upstream sequence with nuclear extracts from human lung

293 Constructs containing -1287/+113 of 5' upstream sequence with or without intron 1 directed high

294 L5, 92% contained tandem TTGAC motifs in the upstream sequence within 3 kb of the transcription start

295 of the mu S poly(A) site, we have found that upstream sequences within the Cmu gene, specifically the

296 transcription of an RP gene it must bind to upstream sequences; yet for Rap1p to repress the transcr