ライフサイエンスコーパス: uptake inhibitor

1 desipramine (DMI, a selective noradrenaline uptake inhibitor).

2 ecadienamides as a selective endocannabinoid uptake inhibitor.

3 robably by way of its effect as an adenosine uptake inhibitor.

4 sporter and is thus a nonselective monoamine uptake inhibitor.

5 tively) and is thus a nonselective monoamine uptake inhibitor.

6 ts of GBR 12909, a highly selective dopamine uptake inhibitor.

7 dulate striatal dopamine neurons, that of an uptake inhibitor.

8 has been prepared that function as dopamine uptake inhibitors.

9 r releasing agents as well as several potent uptake inhibitors.

10 have been precluded by the lack of specific uptake inhibitors.

11 predeplete the SR or by mitochondrial Ca(2+) uptake inhibitors.

12 of novel drugs within this class of dopamine uptake inhibitors.

13 lecular probes within this class of dopamine uptake inhibitors.

14 ide a CoMFA model for this class of dopamine uptake inhibitors.

15 ylalanine (L-dopa) or the selective dopamine uptake inhibitor 1-2(bis[4-fluorophenyl] methoxy]ethyl)-

16 on of compounds related to the dopamine (DA) uptake inhibitors: 1-[2-(diphenylmethoxy)ethyl]-4-(3-phe

17 The glutamate uptake inhibitor (3S)-3-[[3-[[4-(trifluoromethyl)benzoyl

18 Conversely, the administration of a dopamine uptake inhibitor (4',4"-difluoro-3-alpha-[diphenylmethox

19 butylmethylxanthine (IBMX) or with adenosine uptake inhibitor adenosine deaminase.

20 Intriguingly, structurally unrelated AEA uptake inhibitors also blocked the cellular release of A

21 of TBZ were attenuated by the catecholamine uptake inhibitor and antidepressant bupropion, and this

22 at functions as both a low-potency monoamine-uptake inhibitor and as a prodrug for the monoamine-rele

23 Both dopamine uptake inhibitors and sigma(1) receptor antagonists have

24 antidepressants, 7 of selective serotonin re-uptake inhibitors, and 2 from other classes

25 demonstrated by the use of GABA antagonists, uptake inhibitors, and double-labeling experiments showi

26 Although the serotonin uptake inhibitors are the only FDA-approved medications

27 In search of an alpha2-antagonist/5-HT uptake inhibitor as a potential new class of antidepress

28 e binding domains for tropane-based dopamine uptake inhibitors at the DAT.

29 estigated the effects of the selective NE re-uptake inhibitor atomoxetine (ATO) and the mixed DA/NE r

30 fluid concentrations of selective serotonin uptake inhibitors averaged 11.6% (SD=9.9%) of maternal s

31 clinically relevant compounds: the monoamine uptake inhibitor bupropion and the dopamine antagonist r

32 (benztropine) analogues are potent dopamine uptake inhibitors but exhibit behavioral profiles that d

33 a-(diphenylmethoxy)tropane class of dopamine uptake inhibitors can result in ligands with high affini

34 d in cells treated with a mitochondrial Ca2+ uptake inhibitor, carbonyl cyanide m-chlorophenylhydrazo

35 ys administration of the selective serotonin-uptake inhibitor citalopram vs placebo in volunteers (n=

36 stration for 4 weeks of the noradrenaline re-uptake inhibitor desipramine (5 mg/kg).

37 inhibitor fluoxetine and the norepinephrine uptake inhibitor desipramine failed to reverse the effec

38 ined after treatment with the neuronal amine-uptake inhibitors desipramine and cocaine, the alpha 1-a

39 r fluvoxamine), a norepinephrine-specific re-uptake inhibitor (desipramine), or saline and killed aft

40 inhibitor, paroxetine, to the norepinephrine uptake inhibitor, desipramine.

41 induction by the specific serotonin releaser-uptake inhibitor dexfenfluramine and alterations in the

42 methoxy)tropane (benztropine)-based dopamine uptake inhibitors do not demonstrate cocaine-like pharma

43 inding by 5-HT-receptor antagonists and 5-HT-uptake inhibitors does not affect the synaptic efflux el

44 mate levels by reverse dialysis of glutamate uptake inhibitors facilitates mating.

45 ministration for 4 weeks of the serotonin re-uptake inhibitor fluoxetine (1 mg/kg); and (3) daily adm

46 an acute dose of the selective serotonin re-uptake inhibitor fluoxetine (10 mg/kg) decreased the tim

47 The 5-HT uptake inhibitor fluoxetine and the norepinephrine uptak

48 -controlled trial of the selective serotonin-uptake inhibitor fluoxetine hydrochloride was conducted

49 At low concentration (1.0 nM), the 5-HT uptake inhibitor fluoxetine potentiated the reflex, but

50 single injection of a serotonin specific re-uptake inhibitor (fluoxetine or fluvoxamine), a norepine

51 Treatment with the serotonin re-uptake inhibitor, fluoxetine, for 6 days (20 mg/kg daily

52 trial of the potent and selective serotonin uptake inhibitor fluvoxamine maleate.

53 r, safer class of serotonin/noradrenaline re-uptake inhibitors, for example duloxetine and milnacipra

54 e given injections of selective serotonin re-uptake inhibitors (gain-of-function models).

55 , hydrocortisone, and selective serotonin re-uptake inhibitors) given within the first month after a

56 Fenfluramine, a serotonin releaser and uptake inhibitor, has been widely prescribed as an appet

57 these two classes of tropane-based dopamine uptake inhibitors have distinct pharmacological profiles

58 holinesterase is inhibited, when the choline uptake inhibitor, hemicholinium-3, is present or when ex

59 the presence of a competitive, high-affinity uptake inhibitor, hemicholinium-3.

60 re extensively (>80%) prevented by the amine uptake inhibitor imipramine, the MAO inhibitor pargyline

61 inhibitor, can act as a 5-HT/norepinephrine uptake inhibitor in vivo.

62 stimulant in extrastriatal regions and other uptake inhibitors in the striatum.

63 nerally more potent than cocaine as dopamine uptake inhibitors in vitro, although their actions in vi

64 imultaneous analysis of environmental iodide uptake inhibitors, including thiocyanate and nitrate.

65 tion of l-deprenyl combined with DAT and NET uptake inhibitors increased dopamine above control level

66 peak was confirmed by showing that dopamine uptake inhibitors increased the peak and dopamine synthe

67 Infusion of fluoxetine, a serotonin uptake inhibitor, increased dialysate serotonin concentr

68 tration changes evoked by infusing glutamate uptake inhibitor into the striatum of anesthetized rats.

69 , we reverse-dialyzed a mixture of glutamate uptake inhibitors into the MPOA before and during mating

70 The efficacy of Midodrine and Serotonin Uptake Inhibitors is currently under review.

71 re compared with cocaine and the atypical DA uptake inhibitor, JHW 007.

72 azep, an antiplatelet agent, is an adenosine uptake inhibitor known to block induction of monocyte TF

73 antagonists and potentiated by the glutamate uptake inhibitor L-(-)-threo-3-hydroxyaspartic acid.

74 hetized rat during infusion of the glutamate uptake inhibitor l-trans-pyrrolidine-2,4-dicarboxylic ac

75 strocyte-T cell cocultivation by a glutamate uptake inhibitor, l-aspartic acid beta-hydroxamate, abol

76 sing glutamate in the cleft with a glutamate-uptake inhibitor (M-trans-pyrrolidine-2,4-dicarboxylic a

77 ertraline hydrochloride (50 mg/d), or the NE uptake inhibitor maprotiline hydrochloride (150 mg/d) (n

78 e current study suggests that norepinephrine uptake inhibitors may present clinical advantages when t

79 While the dopamine uptake inhibitors may share with cocaine neurochemical m

80 hort synthesis of the nanomolar serotonin re-uptake inhibitor (-)-mesembrine.

81 tor atomoxetine (ATO) and the mixed DA/NE re-uptake inhibitor methylphenidate (MPH), both with proven

82 a significant but lesser amount by the GABA uptake inhibitor nipecotic acid (300 microM).

83 /-)baclofen (10 mum), GABA (2 mm) or by GABA uptake inhibitor nipecotic acid (5 mm).

84 In contrast, the selective GABA uptake inhibitor NNC 05-0711 (10 microM) increased the a

85 GABA-B receptors and the effects of the GABA-uptake inhibitor NO-711 (10 microM) were increased in wi

86 Experiments with the uptake inhibitor nomifensine indicated that this was cau

87 stemic injection (intraperitoneal) of the DA uptake inhibitor, nomifensine, was significantly less ef

88 nhibitors of tyrosine kinases decreased GABA uptake; inhibitors of tyrosine phosphatases increased GA

89 Local injection of glutamate uptake inhibitors or barium had no effect on the peak ch

90 MI or zimelidine (ZMI, a selective serotonin uptake inhibitor) or desipramine (DMI, a selective norad

91 The current study compared the serotonin uptake inhibitor, paroxetine, to the norepinephrine upta

92 Two other serotonin re-uptake inhibitors, paroxetine and imipramine, in doses e

93 NE uptake inhibitors partially antagonized the effect of SN

94 The GABA uptake inhibitor (R)-N-[4,4-bis(3-methyl-2-thienyl)but-3

95 The GABA uptake inhibitor (R)-N[4,4-bis(3-methyl-2-thienyl)but-3-

96 exposure to clomipramine (CMI), a monoamine uptake inhibitor, results in persistent alterations in a

97 ions of Fluoxetine (8 mg/kg), a serotonin re-uptake inhibitor, reversed the effects of bulbectomy on

98 is secretory response, whereas the adenosine uptake inhibitors S-(4-nitrobenzyl)-6-thioguanosine and

99 ine and other potent and selective serotonin uptake inhibitors seem warranted in children and adolesc

100 venlafaxine hydrochloride per day, the 5-HT uptake inhibitor sertraline hydrochloride (50 mg/d), or

101 ansmission, using the selective serotonin re-uptake inhibitor (SSRI) fluoxetine.

102 avenous challenge with the selective 5-HT re-uptake inhibitor (SSRI), citalopram, in healthy human pa

103 was rescued by inclusion of Guvacine, a GABA uptake inhibitor, suggesting that the reported lower lev

104 ice and in mice given selective serotonin re-uptake inhibitors than in wild-type mice, but were dimin

105 de (modafinil, (+/-)-1) is a unique dopamine uptake inhibitor that binds the dopamine transporter (DA

106 alogues are tropane ring-containing dopamine uptake inhibitors that display binding and behavioral pr

107 analogs are tropane ring-containing dopamine uptake inhibitors that produce behavioral effects marked

108 Administration of a glutamate uptake inhibitor, threo-beta-hydroxy-aspartate (50 mM),

109 The effect of the gamma-aminobutyric acid uptake inhibitor tiagabine hydrochloride was studied on

110 mg atomoxetine, a selective noradrenaline re-uptake inhibitor to 25 patients with Parkinson's disease

111 used high-throughput screening for nutrient uptake inhibitors to identify a compound highly specific

112 of acute administration of various monoamine uptake inhibitors to reverse the effects of TBZ.

113 either a low level (30 muM) of the glutamate uptake inhibitor, trans-pyrrolidine-2,4-dicarboxylic aci

114 sideration of concomitant serotonin-specific uptake inhibitors treatment during breast cancer chemoth

115 om FAAH(-/-) mice and in the presence of the uptake inhibitor UCM707.

116 simultaneously function as both a monoamine-uptake inhibitor (via the parent drug PDM) and as a mono

117 ion in mice treated for 4 weeks with glycine uptake inhibitor was approximately twice as dense as in

118 riments with GABA antagonists, agonists, and uptake inhibitors, we found that these fast IPSPs are li

119 nfluence the reinforcing effects of dopamine uptake inhibitors, we investigated the local anesthetic

120 nd in vivo biological activities as dopamine uptake inhibitors were determined.

121 boxylic acid methyl ester class of monoamine uptake inhibitors, where the 2beta-carbomethoxy group ha

122 ne (ZMI) and desipramine (DMI) are monoamine uptake inhibitors which increase synaptic concentrations

123 ke traditional antidepressants (serotonin re-uptake inhibitors), which take weeks to reach efficacy.

124 pport the hypothesis that the interaction of uptake inhibitors with DAT induces a protease-resistant

125 his series and ultimately to design dopamine uptake inhibitors with favorable lipophilicities for dru

126 Combined effects of uptake inhibitors with l-deprenyl on dopamine clearance