ライフサイエンスコーパス: urea transporter

1 inity, small molecule inhibitors of the UT-B urea transporter.

2 an antibody to the rat vasopressin-regulated urea transporter.

3 concentration by stimulating aquaporin-2 and urea transporters.

4 t there are at least four different rat UT-A urea transporters.

5 ithout the inverted repeat of mammalian-type urea transporters.

6 cted with a reporter construct driven by the urea transporter-A promoter, in which the nitric oxide d

7 onor S-nitroso-N-acetylpenicillamine reduces urea transporter-A reporter activity under isotonic and

8 g the inner medullary collecting duct (IMCD) urea transporter A1 (UT-A1) and urea transporter A3 (UT-

9 Urea transport, mediated by the urea transporter A1 (UT-A1) and/or UT-A3, is important f

10 ease in inner medulla aquaporin-2 (AQP2) and urea transporter A1 (UT-A1) in GD rats as compared with

11 f TonEBP/NFAT5 target genes ClC-K1, Barttin, urea transporter-A1, and aquaporin 2 that are required f

12 ncomitantly, expressions of ClC-K1, Barttin, urea transporter-A1, and aquaporin 2 were significantly

13 oride channel 1 and its subunit Barttin, the urea transporter-A1, and the water channel aquaporin 2,

14 duct (IMCD) urea transporter A1 (UT-A1) and urea transporter A3 (UT-A3) have very low levels of urea

15 ys also had decreased expression of the UT-A urea transporter and collectrin, which is involved in ap

16 tein expression of renal sodium chloride and urea transporters and aquaporins in hypothyroid rats (HT

17 ions by analyzing experimental structures of urea transporters and proteins crystallized in the prese

18 TonEBP target genes, including aquaporin-2, urea transporter, and aldose reductase.

19 olecular evidence for facilitated and active urea transporters, and integrative studies of their acut

20 ne-concentrating ability is reduced; and (c) urea transporters are expressed in non-renal tissues, an

21 the effect of adrenal steroids on the UT-A1 urea transporter because it is involved in the urine-con

22 rea transporters, UT-A and UT-B, and several urea transporter cDNA isoforms have been cloned from hum

23 ransporters, UT-A and UT-B, encoding several urea transporter cDNA isoforms in humans, rodents, and s

24 We report here the cloning of a novel urea transporter, designated UT1, from the rat inner med

25 echanism of dietary salt excretion relies on urea transporter-driven urea recycling by the kidneys an

26 Four isoforms of the UT-A urea transporter family have been cloned to date.

27 ut whether it is mediated by the kidney UT-A urea transporter family is unknown.

28 present the 2.3 A structure of a functional urea transporter from the bacterium Desulfovibrio vulgar

29 In addition to the facilitated urea transporters, functional evidence exists for active

30 The UT3 class of urea transporters functioned as efficient water channels

31 ating mechanism, we deleted 3 kb of the UT-A urea transporter gene containing a single 140-bp exon (e

32 rs, the molecular biology of the facilitated urea transporter gene families and cDNAs, and integrativ

33 the H. pylori urease cluster, including the urea transporter gene ureI.

34 Urea transporters have been cloned from kidney medulla (

35 Recently, three types of urea transporters have been cloned, UT1 and UT2 from rat

36 owing to its high polarity, and specialized urea transporters have evolved to achieve rapid and sele

37 otide variation in the kidney-specific human urea transporter, HUT2, is associated with variation in

38 orter UT-B has been proposed to be the major urea transporter in erythrocytes and kidney-descending v

39 and expression of the vasopressin-regulated urea transporter in rat terminal IMCD.

40 eviously characterized vasopressin-regulated urea transporter in the apical membrane of the terminal

41 le of inner medullary collecting duct (IMCD) urea transporters in the renal concentrating mechanism,

42 creased urea and a corresponding increase in urea transporters in the renal medulla as the result of

43 The UT-A1 urea transporter is a glycoprotein with two different gl

44 lusions can be made: (1) The collecting duct urea transporter is present in at least two forms (97 an

45 s among aquaporin-2 (AQP2), aquaporin-4, and urea transporter isoforms A1 and A3.

46 hannel (aquaporin: Colton antigens), and the urea transporter (Kidd antigens).

47 dent pathway and activation of a specialized urea transporter located in the apical membrane.

48 This new urea transporter may be a sodium- urea antiporter.

49 The UT-A1 urea transporter mediates rapid transepithelial urea tra

50 e, and Northern analysis showed no change in urea transporter mRNA abundance in either inner medullar

51 hypothesis that the abundance of the apical urea transporter of the inner medullary collecting duct

52 wever, the influence of genetic variation in urea transporters on BP has not been examined.

53 These results establish that the urea transporter operates by a channel-like mechanism an

54 ng the concept that phloretin-sensitive IMCD urea transporters play a central role in medullary urea

55 The UT-A1 urea transporter plays an important role in the urinary

56 There was no change in vasopressin-regulated urea transporter protein in the inner medullary base, an

57 (2) The expression level of the 117-kD urea transporter protein is regulated and is inversely c

58 s, including studies of uremic rats in which urea transporter protein is upregulated in liver and hea

59 proaches to perform integrative studies into urea transporter protein regulation, both in normal anim

60 lies and cDNAs, and integrative studies into urea transporter protein regulation, both in the kidney

61 Vasopressin-regulated urea transporter protein was significantly increased in

62 ntibodies have been generated to many of the urea transporter proteins, and several novel findings ha

63 antibodies have been generated to the cloned urea transporter proteins, and the use of these antibodi

64 idney and red blood cells occurs by specific urea transporter proteins.

65 idney inner medulla was mediated by specific urea transporter proteins.

66 is transported by facilitated and by active urea transporter proteins.

67 bbit polyclonal antibodies against the renal urea transporter (RUT) gene product.

68 tified significantly increased levels of the urea transporter SLC14A1 in the OVT73 striatum, along wi

69 carrier family 14 member 1 gene, SLC14A1, a urea transporter that regulates cellular osmotic pressur

70 Thus, both new isoforms encode functional urea transporters that may be vasopressin-regulated.

71 for the existence of facilitated and active urea transporters, the molecular biology of the facilita

72 In addition to these facilitated urea transporters, three sodium-dependent, secondary act

73 The rat renal urea transporter UT-A includes four isoforms.

74 The rat renal urea transporter UT-A includes four mRNA isoforms: UT-A1

75 onstrated a decrease in the abundance of the urea transporter UT-A3.

76 on coefficient in Xenopus oocytes expressing urea transporter UT-B (former name UT3), suggesting that

77 Urea transporter UT-B has been proposed to be the major

78 The urea transporters UT-A1 and UT-A3 mediate rapid transepi

79 orter proteins and a marked reduction of the urea transporters UT-A1 and UT-A3.

80 The vasopressin-regulated urea transporter (UT)-A1 is a transmembrane protein with

81 Two isoforms of the renal urea transporter (UT-A) have been cloned so far: UT-A1 a

82 The facilitated urea transporter (UT-A) in the terminal inner medullary

83 We show that the urea transporter (UT-B) can be used as a gene reporter,

84 The facilitated urea transporter (UT-B) in erythrocytes permits these ce

85 Two gene families for facilitated urea transporters, UT-A and UT-B, and several urea trans

86 cloning of two gene families for facilitated urea transporters, UT-A and UT-B, encoding several urea

87 distinct from the previously reported kidney urea transporter UT2.

88 Protein abundance of renal AQP1 and urea transporters UTA(1) and UTA(2) did not differ signi

89 Urea transporters (UTs) facilitate urea permeation acros

90 A family of molecular urea transporters (UTs) has been identified whose member

91 n knockout mice indicate a critical role for urea transporters (UTs) in the urinary concentrating mec

92 m, the kidney epithelia contain facilitative urea transporters (UTs) that allow rapid equilibration b

93 ucidate the physiological role of the latter urea transporter, we have isolated the rat homologue (UT

94 Urea transporters, which include UT-B in kidney microves