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1 such as solitary kidneys, hypodysplasia, or ureteric abnormalities (in a total of 29 affected indivi
4 ian kidney, an epithelial progenitor pool at ureteric branch tips (UBTs) creates the urine-transporti
5 we demonstrated a requirement for Ilk during ureteric branching and cell cycle regulation in collecti
7 whereas Fgfr2(UB-/-) kidneys had more severe ureteric branching defects than Frs2alpha(UB-/-), Fgfr2(
8 Hoxb7cre line (Fgfr2(UB-/-)) develop severe ureteric branching defects; however, ureteric deletion o
9 racterize the processes of nephrogenesis and ureteric branching during kidney development have many l
10 opmental disorder characterized by defective ureteric branching morphogenesis and nephrogenesis, rank
11 gfr2(UB-/-) mice have more severe defects in ureteric branching morphogenesis than previously reporte
15 g fibroblast growth factor receptor 2 in the ureteric bud (Fgfr2(UB-/-)) and in littermate controls.
17 n of both the Hdac1 and Hdac2 genes from the ureteric bud (UB) cell lineage of mice causes bilateral
18 at isolated metanephric mesenchymal (MM) and ureteric bud (UB) cells grown in three-dimensional (3D)
20 s study, we showed that Adam10 deficiency in ureteric bud (UB) derivatives leads to a decrease in uri
21 s of the kidney and urinary tract, including ureteric bud (UB) ectopia, double ureters/collecting sys
23 Mdm2 mRNA and protein are expressed in the ureteric bud (UB) epithelium and metanephric mesenchyme
24 eloping kidney, we analyzed branching of the ureteric bud (UB) in whole kidney culture as well as in
25 d epithelial differentiation of the isolated ureteric bud (UB) independent of glial cell line-derived
26 in renal and urinary tract mesenchyme led to ureteric bud (UB) induction defects and vesicoureteral r
27 ct morphogenesis requires subdivision of the ureteric bud (UB) into the intra-renal collecting system
28 rphogenesis requires the sub-division of the ureteric bud (UB) into the intra-renal collecting system
33 ate that Fras1 is expressed in the branching ureteric bud (UB), and that renal agenesis occurs in hom
34 ed cap mesenchyme surrounding the tip of the ureteric bud (UB), is downregulated after differentiatio
35 ephric mesenchyme (MM), which along with the ureteric bud (UB), is responsible for the mutually induc
36 ulture in which the MM is separated from the ureteric bud (UB), the natural inducer, can be used as a
37 cting system of the kidney, derived from the ureteric bud (UB), undergoes repetitive bifid branching
38 Defects in the growth and branching of the ureteric bud (UB), which gives rise to the collecting sy
39 cting system of the kidney develops from the ureteric bud (UB), which undergoes branching morphogenes
42 ation of Dchs1 also reduces branching of the ureteric bud and impairs differentiation of ureteric bud
44 equired for normal morphogenesis of both the ureteric bud and metanephric mesenchyme-derived structur
46 derived through the mutual induction of the ureteric bud and metanephric mesoderm, whereas the malpi
48 inductive interactions between the embryonic ureteric bud and the metanephric mesenchyme are the basi
53 nvasion of the metanephric mesenchyme by the ureteric bud at an early stage of kidney development.
54 nt in mutant mesenchyme dorsal to the mutant ureteric bud at embryonic day (E) 10.5, while mutant ure
56 t reductions were measured in the numbers of ureteric bud branch points and tips, as well as in the t
59 ddition, DPP and annexin 2 colocalize in the ureteric bud branches of embryonic metanephric kidney.
62 13.5 to 15.5 mice grow in size and continue ureteric bud branching and tubule formation over a 4- to
63 Ret receptor tyrosine kinase is crucial for ureteric bud branching morphogenesis during kidney devel
64 of embryonic kidneys with HDACi impairs the ureteric bud branching morphogenesis program and provoke
66 re) resulted in no apparent abnormalities in ureteric bud branching or in distal ureter maturation, a
67 ized by urinary tract abnormalities, reduced ureteric bud branching, and delayed disconnection of the
69 ntrast, fgfr2(UB-/-) mice have very aberrant ureteric bud branching, thin ureteric bud stalks, and fe
73 e, transgenic overexpression of Wnt9b in the ureteric bud causes reduced branching in multiple founde
74 several genetic labeling methods to observe ureteric bud cell behaviors in developing mouse kidneys.
76 of a dominant-negative RA receptor in mouse ureteric bud cells abolishes Ret expression and Ret-depe
77 rsely, we find that RA-receptor signaling in ureteric bud cells depends mainly on RA generated in nea
78 se around populations of cap mesenchymal and ureteric bud cells in a cyclical, predictable manner.
79 is, indicating that RA-receptor signaling in ureteric bud cells is crucial for renal development.
80 RA signaling between stromal mesenchyme and ureteric bud cells that regulates Ret expression both du
81 ferent transcripts that were enriched in the ureteric bud compared with metanephric mesenchyme and pr
82 tified several genes whose expression in the ureteric bud depends on Etv4 and Etv5, including Cxcr4,
83 trast, mice lacking talins in the developing ureteric bud developed kidney agenesis and collecting du
88 cate a novel role of Wnt7b signaling and the ureteric bud epithelium in renal medullary capillary dev
89 utively active, cAMP-independent PRKX in the ureteric bud epithelium stimulates branching morphogenes
92 ession and Ret-dependent functions including ureteric bud formation and branching morphogenesis, indi
93 nchyme and are required for the induction of ureteric bud formation and its subsequent branching morp
94 derived neurotrophic factor (GDNF) initiates ureteric bud formation and promotes subsequent branching
95 ls that regulates Ret expression both during ureteric bud formation and within the developing collect
96 ng the metanephric blastema and inducing the ureteric bud formation but not for its normal branching.
99 Branching morphogenesis of the epithelial ureteric bud forms the renal collecting duct system and
101 tors frizzled (Fz) 4 and Fz8 lead to reduced ureteric bud growth and a reduction in kidney size, a ph
104 ructures except those that were derived from ureteric bud in embryonic kidney through adult kidney.
107 ng axis in MM development and regulating the ureteric bud induction site are incompletely understood.
108 nce of alpha8beta1 integrin, invasion by the ureteric bud into the metanephric mesenchyme is inhibite
113 nch points and tips, as well as in the total ureteric bud length, volume and area, while significant
114 delivery system and microinjection into the ureteric bud lumen of embryonic day 11 mouse metanephric
115 lopment of a normal kidney depends on proper ureteric bud morphogenesis, the cellular events underlyi
117 Lim 1 influences nephric duct extension and ureteric bud outgrowth by regulating and or maintaining
118 evelopment of metanephric kidney begins with ureteric bud outgrowth from the Wolffian duct (WD).
122 es Gdnf, which stimulates branching, and the ureteric bud stimulates continued growth of the mesenchy
127 of the genes that was highly specific to the ureteric bud tip was cytokine-like factor 1 (CLF-1).
128 anephric mesenchyme are required to modulate ureteric bud tip Wnt patterning in order to initiate bra
131 al. identify a peculiar mitotic behavior in ureteric bud tips whereby dividing cells leave the epith
132 ls, which are abnormally arranged around the ureteric bud tips, and impairment of nephron morphogenes
133 ling promotes directed cell movements in the ureteric bud tips, and suggest a model in which these ce
134 xin2 are ectopically expressed in the mutant ureteric bud tips, suggesting that upregulated canonical
135 m the surrounding mesenchyme to cells at the ureteric bud tips, via the Ret receptor tyrosine kinase
143 bud at embryonic day (E) 10.5, while mutant ureteric bud tissues undergo high rates of apoptosis by
144 action of the metanephric mesenchyme and the ureteric bud to be the major inductive event that mainta
145 ch represses Ret levels and signaling in the ureteric bud to ensure normal ureteric morphogenesis.
147 last growth factor receptor 2 (Fgfr2) in the ureteric bud using a Hoxb7cre line (Fgfr2(UB-/-)) develo
148 inus at embryonic day 10.5, formation of the ureteric bud was delayed, the ureteric bud was smaller a
149 rmation of the ureteric bud was delayed, the ureteric bud was smaller and branching of the ureteric b
150 tractive factor to pattern the growth of the ureteric bud within the developing kidney, and that any
151 into Fras1(bl/bl) mice, thereby reducing the ureteric bud's expression of this anti-branching molecul
152 ation, regions of mutant mesenchyme near the ureteric bud(s) express Eya1 and Six1, but not Six2, Sal
154 entiated MM (unlike the upper portion of the ureteric bud) or more differentiated metanephric kidney.
156 timized method for making a branch-competent ureteric bud, a tissue fundamental to kidney development
158 itors (NP), early epithelial NP derivatives, ureteric bud, and cortical stroma; p-Creb was present in
159 mesenchyme, and adjacent to the stalk of the ureteric bud, and that Vegfa was able to stimulate growt
161 niche, and Fgf9, secreted from the adjacent ureteric bud, are necessary and sufficient to maintain p
162 of the Wt1 gene eliminates outgrowth of the ureteric bud, but Gdnf has been identified as a target o
163 nsistently, TfR1 provided transferrin to the ureteric bud, but not to the capsule or the stroma.
165 ix molecule FRAS1, normally expressed by the ureteric bud, leads to bilateral renal agenesis in human
166 mesoderm, nephric duct, mesonephric tubules, ureteric bud, pretubular aggregates and their derivative
167 distribution in the caudal Wolffian duct and ureteric bud, similar to Ret(-/-) cells, revealing a cel
168 wever, once Gdnf stimulates branching of the ureteric bud, the Flk1-dependent angioblast signal is no
169 To determine roles of FGFR1 and FGFR2 in the ureteric bud, we used a conditional targeting approach.
170 d cell behavior in the branching tips of the ureteric bud, which we term "mitosis-associated cell dis
171 he newly formed epithelial bud, known as the ureteric bud, will continue to branch ultimately differe
187 nesis and Vangl2 is known to be expressed in ureteric bud/collecting duct and metanephric mesenchymal
188 ecting ducts: galectin-3 is expressed in the ureteric bud/collecting duct lineage during nephrogenesi
189 s of the Wolffian ducts and the duct derived ureteric bud/collecting duct system in an undifferentiat
190 rucial for controlling Ret expression in the ureteric bud; however, the mechanism by which retinoid-s
192 MM leads to kidneys with cranially displaced ureteric buds along the Wolffian duct or duplex ureters.
193 demonstrated that ErbB4 is expressed in the ureteric buds and developing tubules of embryonic rat ki
194 Inductive interactions between the branching ureteric buds and the metanephric mesenchyme lead to mes
195 tanephros for both proper development of the ureteric buds and the patterning of renal vesicles for n
196 sexpression of GDNF in the Wolffian duct and ureteric buds resulted in formation of multiple, ectopic
198 ic kidneys that were caused by supernumerary ureteric buds that fail to separate from the wolffian du
199 ce and cell migration, develop supernumerary ureteric buds that remain inappropriately connected to t
200 resumably enables the nephronectin-deficient ureteric buds to invade the metanephric mesenchyme and b
202 efects but had cranially displaced or duplex ureteric buds, probably as a result of decreased Bmp4 ex
207 dentified genes that are regulated by Ilk in ureteric cells using a whole-genome expression analysis
208 ailable to the urologist in the treatment of ureteric colic as well as the advantages and disadvantag
210 e passage for people managed expectantly for ureteric colic, but emphasised the need for high-quality
216 ha, compound mutant mice were generated with ureteric deletion of Fgfr1 and with Fgfr2(LR/LR) point m
217 severe ureteric branching defects; however, ureteric deletion of fibroblast growth factor receptor s
218 s required for early branching events of the ureteric duct that occur prior to the onset of nephrogen
220 e Esrrg protein is detected throughout early ureteric ducts as cytoplasmic/sub-membranous staining; w
221 een three lineages (stromal, mesenchymal and ureteric) ensures correct nephron progenitor self-renewa
223 amina propria cells directly adjacent to the ureteric epithelium and differentiated smooth muscle cel
227 ly, the linked BAC confers expression in the ureteric epithelium, whereas sequences within any of the
236 gfr2 and Frs2alpha have crucial roles in the ureteric lineage, they appear to act separately and addi
238 ntial for developmental specification of the ureteric mesenchyme and ureteric smooth muscle cells.
239 2(LR/LR) mice also had subsequent defects in ureteric morphogenesis, including dilated, hyperprolifer
243 Sdc4-null mice were subjected to unilateral ureteric obstruction and aristolochic acid nephropathy (
245 ild-type C57BL/6 mice (n=14), and unilateral ureteric obstruction was performed later to induce renal
248 el of progressive renal fibrosis (unilateral ureteric obstruction, UUO), and absence of galectin-3 pr
254 Surgeon-controlled robotic management of ureteric pathology involving all parts of the ureter wit
258 and urinary tract (CAKUT), including vesico-ureteric reflux (VUR), are major causes of ESRD in child
262 nascent ureteric urothelium and ending with ureteric smooth muscle cell differentiation, with Tshz3
264 gulates differentiation and proliferation of ureteric smooth muscle progenitor cells during murine ki
269 ologic complications (MUCs: urinary leak and ureteric stenosis [US]) in kidney transplants procured f
270 survival after percutaneous ureteroplasty of ureteric stenosis after renal transplantation and to com
271 ith percutaneous ureteroplasty of transplant ureteric stenosis were not significantly worse than thos
277 n ureteroneocystostomy over a double pigtail ureteric stent was performed in all transplants, and ure
281 stent was performed in all transplants, and ureteric stents were removed after approximately 6 weeks
282 undergoing expectant management for a single ureteric stone identified by CT at 24 UK hospitals.
285 ovel EAS system in a patient with transplant ureteric stricture when antegrade stent placement or sur
286 d beta-catenin are elevated in the nuclei of ureteric, stromal, and mesenchymal cells within dysplast
287 tosis-associated cell dispersal." Premitotic ureteric tip cells delaminate from the epithelium and di
289 Given the high rate of cell division in ureteric tips, this cellular behavior causes extensive e
291 ltured embryonic kidneys, without increasing ureteric tree branching, and promoted mesenchymal-to-epi
292 identifying novel mediators, the tips of the ureteric tree were isolated and microarray analyses were
293 which, in turn, causes mispatterning of the ureteric tree, while delaying and disorganizing nephroge
294 s work showed that Wnt7b is expressed in the ureteric trunk epithelium and activates canonical Wnt si
295 ression of Ret and its downstream targets in ureteric trunks, and exhibited upregulation of Ret/Etv4/
297 dney requires reciprocal signaling among the ureteric tubules, cap mesenchyme and surrounding stromal
298 with sonic hedgehog secreted by the nascent ureteric urothelium and ending with ureteric smooth musc
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