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1 ffect more mature structures or cells in the ureteric bud.
2 ric mesenchyme to inductive signals from the ureteric bud.
3 ing the inductive signals emanating from the ureteric bud.
4 d as simply the non-branching portion of the ureteric bud.
5 GDNF supplied only by the Wolffian duct and ureteric bud.
6 in turn elicits an inductive signal from the ureteric bud.
7 including the proximal tubular cells and the ureteric bud.
8 y organ cultures stimulates branching of the ureteric bud.
9 reduction of the growth and branching of the ureteric bud.
10 istinct analages, metanephric mesenchyme and ureteric bud.
11 rentiate in response to WNT signals from the ureteric bud.
12 stromal cells control Ret expression in the ureteric bud.
13 esenchyme is independent of induction by the ureteric bud.
14 It is not found in the ureteric bud.
15 iple branching morphogenesis of the isolated ureteric bud.
16 bud growth and downregulation of Ret in the ureteric bud.
17 utant kidneys apparently fail to fuse to the ureteric bud.
18 elopment from metanephric mesenchyme but not ureteric bud.
19 pression of a stabilized beta-catenin in the ureteric bud.
20 pends on precise control of branching of the ureteric bud.
21 embryonic circulation form a ring around the ureteric bud.
22 that later emerges as the tip of the primary ureteric bud.
23 one from mouse E12.5 and one from rat E13.5 ureteric buds.
24 pic mesonephric tubules and ectopic anterior ureteric buds.
26 timized method for making a branch-competent ureteric bud, a tissue fundamental to kidney development
27 ed in its pathogenesis: A primary failure of ureteric bud activity and a disruption produced by fetal
28 MM leads to kidneys with cranially displaced ureteric buds along the Wolffian duct or duplex ureters.
29 ops from interactions between the epithelial ureteric bud and adjacent metanephric mesenchyme, which
31 ng kidney showed expression in the branching ureteric bud and collecting ducts, expression that persi
32 w that they are targeted by factors from the ureteric bud and from the renal stroma, and that epithel
34 ation of Dchs1 also reduces branching of the ureteric bud and impairs differentiation of ureteric bud
38 but it mediates its effects on the adjacent ureteric bud and metanephric mesenchyme, which fail to g
39 equired for normal morphogenesis of both the ureteric bud and metanephric mesenchyme-derived structur
41 derived through the mutual induction of the ureteric bud and metanephric mesoderm, whereas the malpi
42 or regulating branching morphogenesis of the ureteric bud and perhaps other embryonic epithelial stru
45 inductive interactions between the embryonic ureteric bud and the metanephric mesenchyme are the basi
49 s, sidekick expression was observed first in ureteric bud and ureteric bud-derived tissues in a patte
52 demonstrated that ErbB4 is expressed in the ureteric buds and developing tubules of embryonic rat ki
53 Inductive interactions between the branching ureteric buds and the metanephric mesenchyme lead to mes
54 tanephros for both proper development of the ureteric buds and the patterning of renal vesicles for n
57 itors (NP), early epithelial NP derivatives, ureteric bud, and cortical stroma; p-Creb was present in
58 al for normal branching morphogenesis of the ureteric bud, and lies downstream of significant extrace
59 express GFP in the mesonephros, metanephros, ureteric bud, and sex ducts may be useful for cell linea
60 nd that Erk MAP kinase is normally active in ureteric bud, and that inhibiting Erk activation with th
61 e the target of inductive signaling from the ureteric bud, and that renal stroma is not absolutely re
62 mesenchyme, and adjacent to the stalk of the ureteric bud, and that Vegfa was able to stimulate growt
65 niche, and Fgf9, secreted from the adjacent ureteric bud, are necessary and sufficient to maintain p
66 mes demonstrate the dichotomous branching of ureteric bud as it progresses from a simple, symmetrical
67 nvasion of the metanephric mesenchyme by the ureteric bud at an early stage of kidney development.
69 nt in mutant mesenchyme dorsal to the mutant ureteric bud at embryonic day (E) 10.5, while mutant ure
71 t reductions were measured in the numbers of ureteric bud branch points and tips, as well as in the t
72 becomes progressively more elaborate as the ureteric bud branches into undifferentiated mesenchyme.
75 ddition, DPP and annexin 2 colocalize in the ureteric bud branches of embryonic metanephric kidney.
76 o beta(6) integrin resulted in inhibition of ureteric bud branching and complete lack of mesenchyme c
77 vity with serine protease inhibitors reduced ureteric bud branching and inhibited glomerulogenesis an
80 13.5 to 15.5 mice grow in size and continue ureteric bud branching and tubule formation over a 4- to
82 n, FGFR2, but not FGFR1, appears crucial for ureteric bud branching morphogenesis and stromal mesench
83 Ret receptor tyrosine kinase is crucial for ureteric bud branching morphogenesis during kidney devel
84 c mesenchyme cell line that induces isolated ureteric bud branching morphogenesis in the presence of
85 of embryonic kidneys with HDACi impairs the ureteric bud branching morphogenesis program and provoke
88 re) resulted in no apparent abnormalities in ureteric bud branching or in distal ureter maturation, a
89 ized by urinary tract abnormalities, reduced ureteric bud branching, and delayed disconnection of the
91 ntrast, fgfr2(UB-/-) mice have very aberrant ureteric bud branching, thin ureteric bud stalks, and fe
96 ependent on at least two known regulators of ureteric bud branching; the GDNF-Ret signalling system a
97 of the Wt1 gene eliminates outgrowth of the ureteric bud, but Gdnf has been identified as a target o
100 e, transgenic overexpression of Wnt9b in the ureteric bud causes reduced branching in multiple founde
101 several genetic labeling methods to observe ureteric bud cell behaviors in developing mouse kidneys.
103 tion of branching tubules in an immortalized ureteric bud cell line cultured three-dimensionally in a
104 of a dominant-negative RA receptor in mouse ureteric bud cells abolishes Ret expression and Ret-depe
105 rsely, we find that RA-receptor signaling in ureteric bud cells depends mainly on RA generated in nea
106 se around populations of cap mesenchymal and ureteric bud cells in a cyclical, predictable manner.
107 is, indicating that RA-receptor signaling in ureteric bud cells is crucial for renal development.
108 RA signaling between stromal mesenchyme and ureteric bud cells that regulates Ret expression both du
109 nesis and Vangl2 is known to be expressed in ureteric bud/collecting duct and metanephric mesenchymal
110 ecting ducts: galectin-3 is expressed in the ureteric bud/collecting duct lineage during nephrogenesi
111 s of the Wolffian ducts and the duct derived ureteric bud/collecting duct system in an undifferentiat
112 ferent transcripts that were enriched in the ureteric bud compared with metanephric mesenchyme and pr
114 tified several genes whose expression in the ureteric bud depends on Etv4 and Etv5, including Cxcr4,
117 ssion was observed first in ureteric bud and ureteric bud-derived tissues in a pattern similar to oth
118 trast, mice lacking talins in the developing ureteric bud developed kidney agenesis and collecting du
119 s expressed Cre recombinase in the branching ureteric bud, developing renal tubules, and sex ducts.
120 ively in renal tubules, mesonephric tubules, ureteric bud, developing ureter, and Wolffian duct.
126 s highly expressed in the basal membranes of ureteric bud epithelia during early development of the m
129 in associated with the Wolffian duct and the ureteric bud, epithelial structures with well-defined ro
130 a new reciprocal signaling loop between the ureteric bud epithelium and the stromal mesenchyme, depe
131 cate a novel role of Wnt7b signaling and the ureteric bud epithelium in renal medullary capillary dev
133 elopmentally regulated and restricted to the ureteric bud epithelium of the fetal metanephric kidney.
134 utively active, cAMP-independent PRKX in the ureteric bud epithelium stimulates branching morphogenes
135 nt involves reciprocal signaling between the ureteric bud epithelium, inducing metanephric mesenchyme
141 e isolated progenitors were treated with the ureteric bud factor LIF, they expressed epithelial prote
143 g fibroblast growth factor receptor 2 in the ureteric bud (Fgfr2(UB-/-)) and in littermate controls.
145 ession and Ret-dependent functions including ureteric bud formation and branching morphogenesis, indi
147 nchyme and are required for the induction of ureteric bud formation and its subsequent branching morp
148 derived neurotrophic factor (GDNF) initiates ureteric bud formation and promotes subsequent branching
149 ls that regulates Ret expression both during ureteric bud formation and within the developing collect
150 Histological analysis revealed a failure in ureteric bud formation at the initial stage of metanephr
151 ng the metanephric blastema and inducing the ureteric bud formation but not for its normal branching.
155 Branching morphogenesis of the epithelial ureteric bud forms the renal collecting duct system and
157 nt in directing the initial outgrowth of the ureteric bud from the Wolffian duct by controlling the e
159 tors frizzled (Fz) 4 and Fz8 lead to reduced ureteric bud growth and a reduction in kidney size, a ph
160 rm a signaling complex that is essential for ureteric bud growth and branching morphogenesis of the u
163 to altered stromal cell patterning, impaired ureteric bud growth and downregulation of Ret in the ure
164 strate that elevated levels of FGF-7 augment ureteric bud growth and increase the number of nephrons
166 rucial for controlling Ret expression in the ureteric bud; however, the mechanism by which retinoid-s
168 HGFA was localized around the tips of the ureteric bud in developing kidneys, while HGF was expres
169 ructures except those that were derived from ureteric bud in embryonic kidney through adult kidney.
172 ford Grobstein made the observation that the ureteric bud induced the nephrogenic mesenchyme to under
174 ng axis in MM development and regulating the ureteric bud induction site are incompletely understood.
175 -2 was also involved in morphogenesis of the ureteric bud, inhibiting its branching and changing the
176 nce of alpha8beta1 integrin, invasion by the ureteric bud into the metanephric mesenchyme is inhibite
177 In the developing kidney, the epithelial ureteric bud invades the metanephric mesenchyme, which d
182 g morphogenesis of the Wolffian duct derived ureteric bud is integral in the generation of ureteric t
183 phic factor (Gdnf), a primary inducer of the ureteric bud, is expanded more anteriorly in Foxc1 homoz
184 ix molecule FRAS1, normally expressed by the ureteric bud, leads to bilateral renal agenesis in human
186 nch points and tips, as well as in the total ureteric bud length, volume and area, while significant
187 delivery system and microinjection into the ureteric bud lumen of embryonic day 11 mouse metanephric
188 region are expressed in developing nephrons, ureteric bud, mesonephric tubules, Wolffian duct, and Mu
190 lopment of a normal kidney depends on proper ureteric bud morphogenesis, the cellular events underlyi
192 or (HGFA), is expressed and activated by the ureteric bud of the developing kidney in vivo and in vit
196 entiated MM (unlike the upper portion of the ureteric bud) or more differentiated metanephric kidney.
197 , Eya1 homozygosity results in an absence of ureteric bud outgrowth and a subsequent failure of metan
198 nesis of the kidneys secondary to failure of ureteric bud outgrowth and branching tubule formation su
200 Lim 1 influences nephric duct extension and ureteric bud outgrowth by regulating and or maintaining
201 organ culture is not sufficient to stimulate ureteric bud outgrowth from Pax2 mutant nephric ducts, i
202 evelopment of metanephric kidney begins with ureteric bud outgrowth from the Wolffian duct (WD).
203 Gdnf expression, which is required to direct ureteric bud outgrowth via activation of the c-ret Rtk,
206 metanephric development predominantly to the ureteric bud, precursor of the collecting duct, and indu
207 mesoderm, nephric duct, mesonephric tubules, ureteric bud, pretubular aggregates and their derivative
208 efects but had cranially displaced or duplex ureteric buds, probably as a result of decreased Bmp4 ex
210 sexpression of GDNF in the Wolffian duct and ureteric buds resulted in formation of multiple, ectopic
212 into Fras1(bl/bl) mice, thereby reducing the ureteric bud's expression of this anti-branching molecul
213 ation, regions of mutant mesenchyme near the ureteric bud(s) express Eya1 and Six1, but not Six2, Sal
216 distribution in the caudal Wolffian duct and ureteric bud, similar to Ret(-/-) cells, revealing a cel
218 es Gdnf, which stimulates branching, and the ureteric bud stimulates continued growth of the mesenchy
219 oordinates the position and outgrowth of the ureteric bud such that kidney development can begin.
220 ture disrupts branching morphogenesis of the ureteric bud, suggesting that gelB plays a role in kidne
222 ic kidneys that were caused by supernumerary ureteric buds that fail to separate from the wolffian du
223 ce and cell migration, develop supernumerary ureteric buds that remain inappropriately connected to t
224 wever, once Gdnf stimulates branching of the ureteric bud, the Flk1-dependent angioblast signal is no
225 sential for outgrowth and positioning of the ureteric bud, the inducer of metanephric mesenchyme.
230 of the genes that was highly specific to the ureteric bud tip was cytokine-like factor 1 (CLF-1).
231 anephric mesenchyme are required to modulate ureteric bud tip Wnt patterning in order to initiate bra
234 , N-myc loss causes a decrease in numbers of ureteric bud tips and developing glomeruli in explants a
237 al. identify a peculiar mitotic behavior in ureteric bud tips whereby dividing cells leave the epith
238 ls, which are abnormally arranged around the ureteric bud tips, and impairment of nephron morphogenes
239 ling promotes directed cell movements in the ureteric bud tips, and suggest a model in which these ce
240 nchyme does not aggregate tightly around the ureteric bud tips, but remains loosely associated, embed
241 xin2 are ectopically expressed in the mutant ureteric bud tips, suggesting that upregulated canonical
242 m the surrounding mesenchyme to cells at the ureteric bud tips, via the Ret receptor tyrosine kinase
250 bud at embryonic day (E) 10.5, while mutant ureteric bud tissues undergo high rates of apoptosis by
251 action of the metanephric mesenchyme and the ureteric bud to be the major inductive event that mainta
252 ch represses Ret levels and signaling in the ureteric bud to ensure normal ureteric morphogenesis.
253 al structure which eventually fuses with the ureteric bud to generate a continuous nascent nephron.
256 resumably enables the nephronectin-deficient ureteric buds to invade the metanephric mesenchyme and b
259 3 -/mice have been shown to display enhanced ureteric bud (UB) branching early in development, and cu
260 The specific roles of HSPGs and CSPGs on ureteric bud (UB) branching morphogenesis are unclear, a
261 n of both the Hdac1 and Hdac2 genes from the ureteric bud (UB) cell lineage of mice causes bilateral
262 at isolated metanephric mesenchymal (MM) and ureteric bud (UB) cells grown in three-dimensional (3D)
263 a very simple system consisting of isolated ureteric bud (UB) cells, which undergo branching morphog
265 s study, we showed that Adam10 deficiency in ureteric bud (UB) derivatives leads to a decrease in uri
266 s of the kidney and urinary tract, including ureteric bud (UB) ectopia, double ureters/collecting sys
268 Mdm2 mRNA and protein are expressed in the ureteric bud (UB) epithelium and metanephric mesenchyme
269 otein-rich fractions inhibitory for isolated ureteric bud (UB) growth were separated from a condition
270 ween the metanephric mesenchyme (MM) and the ureteric bud (UB) in the developing kidney leads to bran
271 eloping kidney, we analyzed branching of the ureteric bud (UB) in whole kidney culture as well as in
272 d epithelial differentiation of the isolated ureteric bud (UB) independent of glial cell line-derived
273 in renal and urinary tract mesenchyme led to ureteric bud (UB) induction defects and vesicoureteral r
274 rphogenesis requires the sub-division of the ureteric bud (UB) into the intra-renal collecting system
275 ct morphogenesis requires subdivision of the ureteric bud (UB) into the intra-renal collecting system
276 at the normal branching morphogenesis of the ureteric bud (UB) is critical for development of the met
281 ate that Fras1 is expressed in the branching ureteric bud (UB), and that renal agenesis occurs in hom
282 ed cap mesenchyme surrounding the tip of the ureteric bud (UB), is downregulated after differentiatio
283 ephric mesenchyme (MM), which along with the ureteric bud (UB), is responsible for the mutually induc
284 ulture in which the MM is separated from the ureteric bud (UB), the natural inducer, can be used as a
285 cting system of the kidney, derived from the ureteric bud (UB), undergoes repetitive bifid branching
286 Defects in the growth and branching of the ureteric bud (UB), which gives rise to the collecting sy
287 cting system of the kidney develops from the ureteric bud (UB), which undergoes branching morphogenes
292 last growth factor receptor 2 (Fgfr2) in the ureteric bud using a Hoxb7cre line (Fgfr2(UB-/-)) develo
293 inus at embryonic day 10.5, formation of the ureteric bud was delayed, the ureteric bud was smaller a
294 phric mesenchyme of mutant embryos lacking a ureteric bud was found to be defective in the expression
295 rmation of the ureteric bud was delayed, the ureteric bud was smaller and branching of the ureteric b
296 To determine roles of FGFR1 and FGFR2 in the ureteric bud, we used a conditional targeting approach.
297 d cell behavior in the branching tips of the ureteric bud, which we term "mitosis-associated cell dis
298 he newly formed epithelial bud, known as the ureteric bud, will continue to branch ultimately differe
299 tractive factor to pattern the growth of the ureteric bud within the developing kidney, and that any
300 genously express Ksp-cadherin, including the ureteric bud, Wolffian duct, Mullerian duct, and develop
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