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1                                  There is an urgent need to accurately model how environmental change
2                      The second concerns the urgent need to address ethical issues when evaluating th
3                                  There is an urgent need to address manpower and infrastructural defi
4 study in the scientific community due to the urgent need to address many of the most important questi
5 bate, on both sides, continues to hamper the urgent need to address the diverse and pressing challeng
6                       The results support an urgent need to address vaccine hesitancy in policy dialo
7                       Therefore, there is an urgent need to assess the MRI characteristics of PML in
8                           Hence, there is an urgent need to be prepared with vaccines and therapeutic
9                                  There is an urgent need to better define the natural history of FPIE
10 ronment to the leukemic cells, indicating an urgent need to better understand the factors that promot
11         A broader theme that emerged was the urgent need to bring the glycosciences back into the mai
12                                  There is an urgent need to build mitigation capacity where amphibian
13                                  There is an urgent need to build the research capacity of this field
14                          Therefore, there is urgent need to characterize dysregulated TK signaling ax
15 e, sequencing of tumor samples is driving an urgent need to classify whether or not mutations seen in
16 eries, and dental implantations, there is an urgent need to combat implant-associated infection.
17                                  There is an urgent need to come up with a vaccine that will curtail
18                                    Given our urgent need to conserve both wildlife and the food secur
19                       Therefore, there is an urgent need to continue researching in order to discover
20 Available data in athletes have indicated an urgent need to control for testing conditions such as hy
21                         Clearly, there is an urgent need to define common standards for data analysis
22                     This challenge shows the urgent need to define novel strategies to provide long-t
23 tical role in the catalysis, and there is an urgent need to define the actual metal used by MetAP in
24 xt of little clinical evidence, indicates an urgent need to define the appropriate use of these medic
25                    Findings also indicate an urgent need to destigmatize DUD and educate the public,
26                   Nonetheless, there remains urgent need to determine the basis for sepsis-related co
27  serious at higher temperatures, there is an urgent need to determine the mortality projection of spe
28                                  There is an urgent need to determine whether oversulfated chondroiti
29                       Therefore, there is an urgent need to develop a high-throughput and efficient s
30                             There is thus an urgent need to develop a representative animal model to
31                       Therefore, there is an urgent need to develop alternative technologies.
32                            Thus, there is an urgent need to develop alternative, egg-independent vacc
33                                  There is an urgent need to develop an efficacious and affordable vac
34                                  There is an urgent need to develop and validate noninvasive tests th
35                                  There is an urgent need to develop antifibrotic therapies for chroni
36                        Currently there is an urgent need to develop antitrypanosomal therapy due to t
37                         Clearly, there is an urgent need to develop better tolerated and more effecti
38                                  There is an urgent need to develop bioinformatics tools as to gain i
39                                  There is an urgent need to develop biomarkers that predict patient p
40                                  There is an urgent need to develop both novel non-chemical approache
41                    Our results emphasize the urgent need to develop cheap protein alternatives to bus
42                   Therefore, there exists an urgent need to develop effective treatment strategies sp
43 humans is clearly warranted, and there is an urgent need to develop effective vaccines against them.
44                                  There is an urgent need to develop fertility-related information ada
45                                  There is an urgent need to develop guidelines for the expansion of o
46                                  There is an urgent need to develop long-lasting alternative insectic
47                       Therefore, there is an urgent need to develop mechanism-based novel approaches
48                                  There is an urgent need to develop methods to accurately and rapidly
49                       Therefore, there is an urgent need to develop methods to identify the populatio
50                                  There is an urgent need to develop nanocarriers for the treatment of
51                                     There is urgent need to develop new acceleration techniques capab
52 l drugs such as chloroquine, demonstrates an urgent need to develop new and alternative approaches to
53                            While there is an urgent need to develop new and effective drugs for treat
54                              There is now an urgent need to develop new and effective treatments.
55                    Consequently, there is an urgent need to develop new antimicrobials to treat A. ba
56                                  There is an urgent need to develop new classes of antibiotics to tac
57 r this deadly disease; therefore there is an urgent need to develop new diagnostics to accurately det
58                                     It is an urgent need to develop new drugs for Mycobacterium tuber
59 stance to available antibiotics, there is an urgent need to develop new drugs.
60                                  There is an urgent need to develop new pathogenic R5 simian/human im
61                                  There is an urgent need to develop new pathophysiology-oriented ther
62                       Therefore, there is an urgent need to develop new sources of insulin-producing
63 ival with current therapies, emphasizing the urgent need to develop new therapeutic approaches.
64                                  There is an urgent need to develop new therapeutics for this disease
65  usually die within one year, emphasizing an urgent need to develop new treatment strategies for this
66                    However, there remains an urgent need to develop new vaccines for HIV/AIDS, malari
67 of cruzain inhibitors has been driven by the urgent need to develop novel and more effective drugs fo
68 istant strains of P. aeruginosa, there is an urgent need to develop novel antibiotic and anti-virulen
69                                  There is an urgent need to develop novel antimicrobial therapies to
70 ehydration and supporting care suggesting an urgent need to develop novel approaches to improve stand
71                            Thus, there is an urgent need to develop novel therapeutic interventions t
72 ss the blood-brain barrier, underscoring the urgent need to develop novel therapeutic strategies.
73                                  There is an urgent need to develop novel therapeutics for suppressin
74                            Thus, there is an urgent need to develop novel therapeutics for this disea
75 new antibiotics virtually empty, there is an urgent need to develop novel therapeutics.
76                                  There is an urgent need to develop novel therapies for controlling c
77                                  There is an urgent need to develop novel therapies for controlling r
78                                    Given the urgent need to develop novel, potent antibiotics, the re
79                       Therefore, there is an urgent need to develop novel, specific amyloidophilic ra
80   Our study provides an early warning of the urgent need to develop policies that manage nitrogen emi
81                             These include an urgent need to develop pretest education for all pregnan
82 ral therapy approved for humans, there is an urgent need to develop prophylactic and therapeutic opti
83                                  There is an urgent need to develop regimens that incorporate chemoth
84 eum and other fossil fuels, has motivated an urgent need to develop renewable, carbon-neutral, econom
85                            Thus, there is an urgent need to develop second-generation M2 inhibitors t
86                      There is, therefore, an urgent need to develop single-dose and long-lasting rabi
87                         However, there is an urgent need to develop substitutes for pure Pt catalysts
88                    Consequently, there is an urgent need to develop targeted therapies capable of eli
89                                  There is an urgent need to develop technologies that use renewable e
90                                  There is an urgent need to develop therapies that modify both the un
91                                  There is an urgent need to develop therapies that slow down the prog
92                            The first was the urgent need to differentiate between tumor cell and tumo
93 e of Mycobacterium tuberculosis, there is an urgent need to discover antituberculosis agent with nove
94                       Therefore, there is an urgent need to discover effective therapeutic agents for
95                        There is therefore an urgent need to discover more effective targets for PEL m
96                                  There is an urgent need to discover new anti-tubercular agents with
97                    Our results highlight the urgent need to document and understand Neotropical salam
98              The NESARC-III data indicate an urgent need to educate the public and policy makers abou
99                                  There is an urgent need to either significantly expand the R55/R56 m
100                                  There is an urgent need to elicit and validate highly efficacious ta
101 the widespread plight of coral reefs and the urgent need to enact conservation measures.
102             To meet this demand, there is an urgent need to enhance the accessibility and reach of su
103                                  There is an urgent need to ensure the robustness of fractional-dose
104                                  There is an urgent need to establish national risk assessment system
105                            Thus, there is an urgent need to establish standard panels of HIV-1 refere
106                                  There is an urgent need to establish sustainable technologies for in
107                    This change indicates the urgent need to evaluate and document ophthalmic manifest
108  Raquel Gonzalez and colleagues highlight an urgent need to evaluate antimalarials that can be safely
109 ctor for VL treatment success, suggesting an urgent need to evaluate the recently proposed optimal al
110 individuals with mental illness indicates an urgent need to examine HIV risk behavior in this populat
111 ise in antimicrobial resistance, there is an urgent need to examine market mechanisms that are approp
112                                  There is an urgent need to expand basic science approaches for negle
113                                  There is an urgent need to expand the surgical care delivery system
114                       Therefore, there is an urgent need to explore genetic factors involved in this
115                            Thus, there is an urgent need to explore new approaches for modulating the
116                             There is thus an urgent need to explore new control solutions, one of whi
117 of emerging infectious diseases, there is an urgent need to facilitate multidisciplinary research in
118 tructure-structure alignment algorithm is in urgent need to facilitate the comparative study.
119 gainst disseminated disease, and there is an urgent need to fill this gap.
120 s and drug resistant mutants, highlights the urgent need to find antivirals with novel mechanisms of
121                    Consequently, there is an urgent need to find better mechanisms of inhibiting myel
122                        Therefore there is an urgent need to find new therapeutic strategies to treat
123 ion transitions are dramatic and point to an urgent need to focus on preventive approaches in health
124                   In particular, there is an urgent need to focus our efforts on effective therapeuti
125 nce factors that we discover underscores the urgent need to halt the advance of pathogenic chytrids a
126                                  There is an urgent need to help people with serious mental illness t
127                            Thus, there is an urgent need to identify and characterize aberrantly expr
128                       Therefore, there is an urgent need to identify and target signaling molecules w
129 barriers and infected humans underscores the urgent need to identify anti-TSE drugs.
130    To overcome this shortcoming, there is an urgent need to identify appropriate surrogate endpoints.
131                                  There is an urgent need to identify biomarkers for hepatocellular ca
132 ce with this therapeutic class highlights an urgent need to identify biomarkers of HAP sensitivity, i
133                                  There is an urgent need to identify electrocardiographic characteris
134                                  There is an urgent need to identify environmental risk and protectiv
135 arily to metastatic spread, highlighting the urgent need to identify factors involved in this progres
136 nd flagella play in human disease creates an urgent need to identify genes involved in ciliary assemb
137 adjunctive treatments for CM, so there is an urgent need to identify new targets for therapy.
138                                  There is an urgent need to identify new therapeutic opportunities fo
139                                  There is an urgent need to identify new treatments for tuberculosis
140                       Therefore, there is an urgent need to identify new, safe, and targeted therapeu
141                         As such, there is an urgent need to identify novel drugs to treat TB infectio
142                                  There is an urgent need to identify novel risk factors and primary p
143  approved in the past 2 decades, there is an urgent need to identify novel targets and therapeutic st
144 KIT/PDGFRA kinase inhibitors and there is an urgent need to identify novel therapeutic strategies.
145                            Thus, there is an urgent need to identify potential underlying mechanisms
146                                  There is an urgent need to identify relevant tumor markers showing h
147                                  There is an urgent need to identify reliable biomarkers of amyotroph
148 ed with many human diseases, and there is an urgent need to identify specific DUBs associated with th
149                       Therefore, there is an urgent need to identify specific targets and effective p
150 ariants in the clinical setting, there is an urgent need to identify the best variant caller(s) from
151                                  There is an urgent need to identify therapeutic targets for BLBC, be
152 aving but limited resource, there remains an urgent need to identify those patients at greatest risk
153 ing SCID patients early in life, there is an urgent need to identify validated approaches through pro
154                   Our analyses underline the urgent need to implement global strategies to measure se
155 heria diagnostics EQA alarmingly reflect the urgent need to improve laboratory performance in diphthe
156 national quality-control study underline the urgent need to improve methods used to monitor HDV virem
157 timal anticoagulation control, suggesting an urgent need to improve oral anticoagulation care for mos
158                     Consequently there is an urgent need to improve our understanding of the mechanis
159                                  There is an urgent need to improve outcomes and reduce costs for pat
160  rates of antibiotic resistance, there is an urgent need to improve prevention of pneumococcal diseas
161                                  There is an urgent need to improve the current inconsistent--sometim
162 y and chronic airway diseases, which face an urgent need to improve the level of disease control, enh
163  of pancreatic cancer increases, there is an urgent need to improve the training of surgeons and deve
164 ith low-access to HCV services emphasises an urgent need to include resource-limited settings in the
165                     The study emphasizes the urgent need to incorporate climate change into the IUCN
166                        There is therefore an urgent need to increase multisectoral coverage of qualit
167                                  There is an urgent need to increase the number of coinfected patient
168                             We highlight the urgent need to integrate a broader perspective into loca
169 ediatric antiretroviral therapy, there is an urgent need to introduce a simple, low-cost infant human
170                        There is therefore an urgent need to investigate novel vaccination approaches.
171                              This prompts an urgent need to investigate the molecular mechanisms unde
172 ely for drug and vaccine design, there is an urgent need to make the link between these DNA sequences
173                  These findings highlight an urgent need to manage the sustainability of game hunting
174     To optimize their use, there has been an urgent need to minimize both warm and cold ischemia, whi
175                                          The urgent need to minimize the potential harm deriving from
176                                          The urgent need to mitigate climate change invokes both oppo
177 ems resembling kidney characteristics are in urgent need to model disease as well as to establish rel
178                   This work demonstrates the urgent need to monitor Lm strains at the global level an
179  primary productivity (NPP), emphasizing the urgent need to monitor the impacts of climate change.
180 r by adaptation or by migration, there is an urgent need to obtain estimates of dispersal distance.
181                                  There is an urgent need to offer targeted, age-appropriate routine H
182                  These results reinforce the urgent need to overcome barriers to scaling up pediatric
183 e of these two recent papers in light of the urgent need to produce an efficacious HIV vaccine and di
184                           These data show an urgent need to provide direct experimental validation of
185 ite of the simplicity of the concept and the urgent need to provide such a treatment to patients, the
186                                  There is an urgent need to push back against the environmental force
187                                  There is an urgent need to quantify anthropogenic influence on fores
188                     Analogously, there is an urgent need to quantify the mechanics of emerging electr
189 ated for coronavirus infections, there is an urgent need to rapidly identify potential therapeutics t
190                     These results support an urgent need to re-evaluate current global guidelines for
191 urrent pedagogic models, and underscores the urgent need to realign and synergize these models to ref
192                                  There is an urgent need to reassess how to approach anemia control i
193                    Climate change imposes an urgent need to recognise and conserve the species likely
194 -resistant Enterobacteriaceae highlights the urgent need to reduce carbapenem dependence.
195                       Our results suggest an urgent need to reform African governments' and foreign a
196 s and other soft tissue defects, there is an urgent need to regenerate skin.
197                                     There is urgent need to regularly monitor and improve the availab
198                                  There is an urgent need to report the successes and failures of thes
199                                  There is an urgent need to rethink policies and strategies to combat
200                                  There is an urgent need to rethink the immunology of Mycobacterium t
201                   Conclusions pointed out an urgent need to review legislative limits in food matrice
202                         However, there is an urgent need to rigorously estimate actual mortality rate
203                        These data suggest an urgent need to scale up access to quality HIV prevention
204                        There is therefore an urgent need to scale up vector control and access to hea
205 f equilibrium, and so there is a growing and urgent need to sensitize students and citizens to the im
206                                  There is an urgent need to standardize processes used to develop cli
207                                  There is an urgent need to standardize reporting of methods and defi
208 implications of optical imaging, there is an urgent need to standardize surgical navigation tools and
209                              This implies an urgent need to systematically evaluate many aspects of t
210                            Thus, there is an urgent need to test novel therapeutic agents to countera
211               Hence our study emphasizes the urgent need to test the inflammatory properties of trans
212                    Consequently, there is an urgent need to translate diagnostic strategies to establ
213                                  There is an urgent need to translate these assays to the study of ce
214      This strongly suggests that there is an urgent need to treat breast cancer with a personalized a
215 f the EGFR-PI3K/Akt pathway, underscores the urgent need to understand alternative downstream pathway
216                                  There is an urgent need to understand and establish the pharmacokine
217 ansplantation from older donors, there is an urgent need to understand how brain death leads to kidne
218                                  There is an urgent need to understand how the paradigm that has guid
219                                    Given the urgent need to understand how the thousands of loci that
220  containing this water annually, creating an urgent need to understand its effects on bird health.
221                                  There is an urgent need to understand signaling cascades that promot
222                                  There is an urgent need to understand the basis of resistance to opt
223  to urbanization and development there is an urgent need to understand the dynamics of vector-borne d
224                                  There is an urgent need to understand the effect of such disturbance
225                                  There is an urgent need to understand the factors that contribute to
226 ratures and decreasing rainfall, there is an urgent need to understand the influence of climate chang
227                        Therefore there is an urgent need to understand the mechanisms by which glucoc
228  treat RVFV infection, and thus, there is an urgent need to understand the mechanisms by which the vi
229                          Indeed, there is an urgent need to understand the mechanisms linking unhealt
230                                  There is an urgent need to understand the mechanisms of A. baumannii
231 stant (MDR) tuberculosis (TB) highlights the urgent need to understand the mechanisms of resistance t
232 cobacterium tuberculosis has underscored the urgent need to understand the molecular mechanisms of im
233   To mitigate or eliminate PWMI, there is an urgent need to understand the pathological mechanism(s)
234 hways, medicinal chemistry efforts remain an urgent need to yield selective and efficacious AP-1 inhi

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