1 New, curative medicines are needed
urgently.
2 ective vaccines against gonorrhea are needed
urgently.
3 nst infectious diseases needs to be improved
urgently.
4 rms and reporting criteria of IRE are needed
urgently.
5 eptides and carbapenems need to be addressed
urgently.
6 Thus, novel therapeutic targets are needed
urgently.
7 A Phase 3 trial is needed
urgently.
8 r diagnostic challenges need to be addressed
urgently.
9 prevent malaria during pregnancy are needed
urgently.
10 priate therapeutic regimens should be tested
urgently and implemented comprehensively if spread of ar
11 and approved new drugs and treatments, which
urgently are needed.
12 sponsible for disease relapse, and should be
urgently assessed when considering aborting therapy on t
13 These studies
urgently call for more reliable and accurate segmentatio
14 These dangers
urgently compel the development of agents for ameliorati
15 ge burden of malaria in developing countries
urgently demands the development of novel approaches to
16 Treatment guidelines need to be
urgently developed and implemented.
17 one of the top 10 vaccines that needs to be
urgently developed.
18 The possibility of MoCD type A needs to be
urgently explored in every encephalopathic neonate to av
19 Surgical procedures performed
urgently had a 12.3% rate of morbidity (n = 2560) and a
20 asis of urgency because operations performed
urgently have distinct rates of morbidity and mortality
21 extracorporeal treatment should be initiated
urgently in the context of severe poisoning.
22 Women
urgently need a self-initiated, multipurpose prevention
23 uding subnational health system performance,
urgently need assessment.
24 nd increasing drug use in MSM in Bangkok, we
urgently need innovative and acceptable HIV prevention i
25 We
urgently need to adopt strategies that limit further cli
26 s (n = 703) suggests that, as scientists, we
urgently need to change our practices for presenting con
27 ence, but on a number of assumptions, and we
urgently need to develop better proxy measures (or indic
28 An effective vaccine is
urgently needed against the H7N9 avian influenza virus.
29 of autophagy-related proteins may provide an
urgently needed alternative strategy for the elimination
30 g up effective interventions in this area is
urgently needed and likely to yield long run benefits of
31 To combat this problem, new antibiotics are
urgently needed and some plant-associated bacteria are a
32 ies to define the appropriate SF cutoffs are
urgently needed and would also provide an opportunity to
33 strategies to manage this invasive pest are
urgently needed as its range continues to expand.
34 dying disease and drug treatment effects are
urgently needed as more relevant tools to identify new d
35 eatment choices for paediatric psychosis are
urgently needed because extrapolations from adult studie
36 r data from randomized controlled trials are
urgently needed because lepirudin was recalled from the
37 The study of marijuana use disorders is
urgently needed because of increasing marijuana legalisa
38 Early and convenient diagnosis is
urgently needed for acute Stanford type A aortic dissect
39 rring any significant skin reactogenicity is
urgently needed for cutaneous vaccination.
40 Hence, new tools are
urgently needed for efficient, inexpensive manipulation
41 petitors of protein-protein interactions are
urgently needed for functional analysis of large-scale g
42 c vaccine with high efficacy and low cost is
urgently needed for global control of HCV infection.
43 Effective treatments are
urgently needed for hepatocellular carcinoma (HCC), whic
44 rrent TBMs and research areas where data are
urgently needed for model parameterization or evaluation
45 Safe and effective treatments are
urgently needed for patients with relapsed or refractory
46 have been developed for cryptococcosis) are
urgently needed for pneumocystosis, talaromycosis, and h
47 this infectious virus in the environment are
urgently needed for public health protection.
48 New drugs are
urgently needed for resistant strains, shortening durati
49 otential as a prognostic biomarker, which is
urgently needed for stratification into pathophysiologic
50 point of care molecular diagnostic tests are
urgently needed for the analysis of multidrug resistant
51 e problem, and a more efficacious vaccine is
urgently needed for the control and prevention of diseas
52 Better treatments are
urgently needed for the control of chronic asthma and re
53 ventions preventing neonatal GBS disease are
urgently needed for the increasing group of HIV-exposed
54 kers and non-invasive diagnostic methods are
urgently needed for the screening of gastric cancer to r
55 A vaccine is
urgently needed in areas where HTLV-1 is endemic.
56 o humans and areas in which more research is
urgently needed in order to lessen the burden of macrova
57 and affordable CD4 cell counting methods are
urgently needed in resource-limited settings.
58 ma survivors and could inform development of
urgently needed intervention strategies.
59 e, it may be of use to explore the effect of
urgently needed more specific anti-inflammatory mediator
60 Investigation is
urgently needed on the full diversity of Cannabis chemot
61 Additional research is
urgently needed on the risk, pathogenesis, and effective
62 st that studies of NTEs in other tissues are
urgently needed prior to long-term space missions outsid
63 More information is
urgently needed regarding how human practices influence
64 ic tests for tuberculosis case detection are
urgently needed that are affordable, robust, and easy to
65 roteostasis capacity, which may help develop
urgently needed therapies for neurodegeneration and othe
66 An international consensus is
urgently needed to achieve comparability with respect to
67 New diagnostics are
urgently needed to address emerging antimicrobial resist
68 iatric, and adolescent medicine settings are
urgently needed to address mental health and substance d
69 Novel antibacterials are
urgently needed to address the growing problem of bacter
70 d hence informative immunological assays are
urgently needed to address these knowledge gaps and guid
71 th LTBI at risk of progressing to disease is
urgently needed to address this latent reservoir if the
72 need for more efficient data collection, are
urgently needed to advance ABDD and to improve HABP/VABP
73 rack large numbers of cells in real time are
urgently needed to advance our understanding of importan
74 Large prospective trials are
urgently needed to answer this question.
75 cted and unprotected tropical ecosystems are
urgently needed to avoid further defaunation.
76 eliable tools for patient stratification are
urgently needed to avoid overtreatment of low-risk patie
77 nfectious and tropical diseases in Africa is
urgently needed to better describe the distribution of p
78 EM can cause injury or death, strategies are
urgently needed to better understand its causes so that
79 y shifting legal landscape, more research is
urgently needed to better understand the impact of legal
80 More data are
urgently needed to better understand this variability an
81 nkey model of Zika virus (ZIKV) infection is
urgently needed to better understand transmission and pa
82 Potent immunotherapies are
urgently needed to boost antitumor immunity and control
83 Detailed datasets are
urgently needed to characterize temporal changes in popu
84 ith new targets and mechanisms of action are
urgently needed to combat potential pandemics, emerging
85 New antibiotics and strategies are
urgently needed to combat S. aureus associated infection
86 Collaborative efforts are
urgently needed to combat the emerging hypertension burd
87 Novel antibiotics are
urgently needed to combat the rise of infections due to
88 o cross-resistance to CQ or CNS toxicity are
urgently needed to combat this deadly human disease.
89 es for novel antiviral strategies, which are
urgently needed to control dengue virus infections.
90 e risk of AF development and progression are
urgently needed to curtail the AF epidemic and improve o
91 Additional research in broad populations is
urgently needed to develop a precise definition for ACOS
92 nding of how aging promotes CVD is therefore
urgently needed to develop new strategies to reduce dise
93 A better knowledge of connectivity is
urgently needed to develop sound environmental managemen
94 stic value; however, improved approaches are
urgently needed to enable rapid detection of nucleic aci
95 tion of the adequacy of ecological models is
urgently needed to enhance their utility in developing t
96 and care of this population, and efforts are
urgently needed to enhance tuberculosis screening in thi
97 n of multiple bacterial pathogens in food is
urgently needed to ensure food safety.
98 ed by urinary thiocyanate, interventions are
urgently needed to ensure improved processing of cassava
99 Further studies are
urgently needed to explore the contribution of eosinophi
100 chniques for intracellular pH monitoring are
urgently needed to gain new insights into single-cell re
101 flammation promotes lymphatic dysfunction is
urgently needed to guide the development of novel therap
102 ognition and protection of roadless areas is
urgently needed to halt their continued loss.
103 neurological, and substance use disorders is
urgently needed to help reduce the large and increasing
104 Further work is
urgently needed to identify other sources of, and pathwa
105 Phylogenomic studies are
urgently needed to identify the global population struct
106 ize models of care for PHIVY as they age are
urgently needed to improve long-term outcomes among PHIV
107 uing clinical and translational research are
urgently needed to improve, and, crucially, to personali
108 Novel health policies and programmes are
urgently needed to increase awareness of diabetes and to
109 ty of new entities toward the AOX enzyme are
urgently needed to increase effectiveness, reduce costs,
110 monitoring of wild pollinator populations is
urgently needed to inform management strategies into the
111 Biomarkers that reflect disease activity are
urgently needed to inform patient management and for use
112 detecting ricin in a variety of matrixes are
urgently needed to limit exposure to individuals as well
113 Novel intervention strategies are therefore
urgently needed to maintain the current momentum for con
114 ilure of artemisinin combination therapy are
urgently needed to monitor the spread of partner drug re
115 es in their use, and the progress that is so
urgently needed to overcome the devastating effect of fu
116 Accurate biomarkers are
urgently needed to predict response in these settings an
117 patient adherence across health sectors are
urgently needed to prevent this.
118 Ongoing research into this pathogen is
urgently needed to produce viable vaccine and therapeuti
119 New vaccines are
urgently needed to protect the vulnerable from bacterial
120 Adequate trials with low risk of bias are
urgently needed to provide better evidence.
121 combined with well-validated biomarkers are
urgently needed to provide early indicators of effective
122 the soil and hence comprehensive studies are
urgently needed to quantify the environmental impacts of
123 Rapid large-scale mapping activities are
urgently needed to quantify tropical wetland extent and
124 y, and suicide among young female adults are
urgently needed to reduce injury deaths and morbidity in
125 New techniques are
urgently needed to replace conventional long and costly
126 New antituberculosis regimens are
urgently needed to shorten tuberculosis treatment.
127 Interventions are
urgently needed to significantly reduce both mortality a
128 HIV, hepatitis C virus, and tuberculosis are
urgently needed to stem the multiple overlapping epidemi
129 Innovative interventions are
urgently needed to strengthen community buy-in, to incre
130 revents hepatitis C virus (HCV) infection is
urgently needed to support an emerging global eliminatio
131 Further research is
urgently needed to test the effectiveness of different m
132 Health and American College of Surgeons for "
urgently needed" research, the objectives of the present
133 Further research is
urgently needed, given the burden of congestion and data
134 o document longer-term clinical outcomes are
urgently needed, in order to address the question whethe
135 l chemical properties and fluxes of OPEs are
urgently needed, in order to estimate their environmenta
136 eration and the post-incarceration period is
urgently needed, particularly studies using rigorous exp
137 nt, drug resistance, new drug candidates are
urgently needed, which should preferably act via novel m
138 roducts in a real-life exposure scenario are
urgently needed, yet very rare.
139 tology; thus, identifying novel therapies is
urgently needed.
140 alid mechanism-based prognostic biomarker is
urgently needed.
141 detection and therapeutic stabilization are
urgently needed.
142 he development of a robust sensing system is
urgently needed.
143 ns targeting the most vulnerable children is
urgently needed.
144 derately iodine-deficient pregnant women are
urgently needed.
145 new treatment and diagnostic approaches are
urgently needed.
146 ic and functional heterogeneity of DLBCL are
urgently needed.
147 e reactivated latent HIV reservoir cells are
urgently needed.
148 olesterolemia for which novel treatments are
urgently needed.
149 Animal models of infection are thus
urgently needed.
150 rent practices, and more level 1 evidence is
urgently needed.
151 rnate approaches for vaccine development are
urgently needed.
152 functional sites among correlated markers is
urgently needed.
153 c, and cost-effective diagnostic methods are
urgently needed.
154 haracterize protein-protein interactions are
urgently needed.
155 ation of new human-specific therapeutics are
urgently needed.
156 th data, and describe areas in which data is
urgently needed.
157 and computationally predicted structures are
urgently needed.
158 effective vaccine against ExPEC infection is
urgently needed.
159 educe the burden of bacterial infections are
urgently needed.
160 andemic, and global public health action was
urgently needed.
161 vior, especially highly lethal behavior, are
urgently needed.
162 eventive vaccine to protect against HIV-1 is
urgently needed.
163 study these processes in living T cells are
urgently needed.
164 ce invariably emerges, and new therapies are
urgently needed.
165 ies to promote lung allograft acceptance are
urgently needed.
166 most aggressive form of lung cancer, remain
urgently needed.
167 Therefore, novel analgesic treatments are
urgently needed.
168 vel molecular-driven therapeutic options are
urgently needed.
169 genesis, vulnerabilities, and treatments are
urgently needed.
170 cancer deaths, and effective treatments are
urgently needed.
171 mportance, and new approaches to therapy are
urgently needed.
172 cially those measurable in the periphery are
urgently needed.
173 on--individuals for whom real-world data are
urgently needed.
174 ral insight into ligand-binding to HSP70s is
urgently needed.
175 the identification of actionable targets is
urgently needed.
176 diction uncertainty, and detection limit are
urgently needed.
177 ant EGFR-driven tumors and new therapies are
urgently needed.
178 t spans multiple sectors and stakeholders is
urgently needed.
179 novative approaches to tackle infections are
urgently needed.
180 revention, including effective vaccines, are
urgently needed.
181 ication, new drugs to treat hypertension are
urgently needed.
182 ogies in finding new plant-derived drugs are
urgently needed.
183 ar and phenotypic features of the disease is
urgently needed.
184 cit approach to allocating recovery funds is
urgently needed.
185 nes to protect against tuberculosis (TB) are
urgently needed.
186 ible vaccines against dengue are hence still
urgently needed.
187 respectful, evidence-based care for all, is
urgently needed.
188 and rapidly scalable production platform is
urgently needed.
189 Its reduction is
urgently needed.
190 odels with greater relevance to human AKI is
urgently needed.
191 IV testing and linkage to care among men are
urgently needed.
192 fficacy and broader spectrum of activity are
urgently needed.
193 that is clean, renewable and inexpensive is
urgently needed.
194 d rapid diagnostic platform technologies are
urgently needed.
195 slative changes and consumer information are
urgently needed.
196 nce and antimicrobial resistance patterns is
urgently needed.
197 ls and new approaches to developing them are
urgently needed.
198 ays involved in pancreatic tumorigenesis are
urgently needed.
199 llowed by SRS at intracranial progression is
urgently needed.
200 , intracellular accumulation of the drug, is
urgently needed.
201 l strategies of prevention and treatment are
urgently needed.
202 ly pure form through asymmetric synthesis is
urgently needed.
203 nts' behaviours driving these differences is
urgently needed.
204 against acute organophosphorus poisoning is
urgently needed.
205 the development of curative therapeutics is
urgently needed.
206 ting trafficking of CLL cells to LNs is thus
urgently needed.
207 Novel fungicides are
urgently needed.
208 ability; therefore, effective treatments are
urgently needed.
209 any important technological applications are
urgently needed.
210 for triple-negative breast cancer (TNBC) are
urgently needed.
211 or detection of Zaire ebolavirus (ZEBOV) are
urgently needed.
212 ent and spread of miltefosine resistance are
urgently needed.
213 ication of a generic gene-based treatment is
urgently needed.
214 rted actions to address these challenges are
urgently needed.
215 caused by multidrug resistant pathogens are
urgently needed.
216 s in less-developed regions of the world are
urgently needed.
217 therapies to improve treatment outcomes are
urgently needed.
218 atients to individual treatment regimens are
urgently needed.
219 Therefore, new treatment strategies are
urgently needed.
220 or developed tumor resistance mechanisms are
urgently needed.
221 atic assessments of its actual potential are
urgently needed.
222 As a consequence, novel chemotypes are
urgently needed.
223 or bivalent EV71/CVA16 vaccine is therefore
urgently needed.
224 hus, cross-protective immunotherapeutics are
urgently needed.
225 ppropriate plasma transfusion strategies are
urgently needed.
226 re sensitive detection methods are therefore
urgently needed.
227 ilizes starch and includes a colour blank is
urgently needed.
228 ing is limited, and research in this area is
urgently needed.
229 ic strategies for malignant mesothelioma are
urgently needed.
230 practice and new therapeutic approaches are
urgently needed.
231 Therefore, novel, non-toxic therapies are
urgently needed.
232 nt outcomes, alternatives to antibiotics are
urgently needed.
233 ve measures, especially, when surgery is not
urgently needed.
234 and undertreatment of aggressive disease are
urgently needed.
235 criptomics, proteomics and metabolomics) are
urgently needed.
236 e, a unified language for image reporting is
urgently needed.
237 e mechanisms underlying PARPi sensitivity is
urgently needed.
238 ng therapy in children with brain tumors are
urgently needed.
239 deficiency virus (HIV)-positive patients are
urgently needed.
240 lopment of additional therapeutic agents are
urgently needed.
241 dual patient response to novel therapies are
urgently needed.
242 mize AKI and halt the progression of CKD are
urgently needed.
243 e, new solutions for plastic degradation are
urgently needed.
244 Novel painkillers are
urgently needed.
245 s in vivo for which effective treatments are
urgently needed.
246 ion against influenza B viruses is therefore
urgently needed.
247 oactivity against ACR acute neurotoxicity is
urgently needed.
248 r fisheries productivity where both are most
urgently needed.
249 rther development of EVs isolation protocols
urgently needs a quantitative method of EVs purity asses
250 ncrasies in CC responses detected so far and
urgently needs more careful consideration in design and
251 ack of safe vaccines or antiviral treatments
urgently needs to be addressed.
252 ovascular events and its molecular mechanism
urgently needs to be clarified.
253 MPI is limited to around 1 mm currently and
urgently needs to be improved for clinical applications
254 r the Surgery of Trauma definition, admitted
urgently or emergently, who underwent an operative proce
255 A 23-year-old man was
urgently referred for evaluation of rapidly enlarging ce
256 multifactor effects on plants and soils are
urgently required across different world regions.
257 New technologies are
urgently required for reliable drug screening given a wo
258 t drug resistance, new chemical entities are
urgently required for use in next generation anti-malari
259 Rapid diagnostics are
urgently required given the large numbers of suspected e
260 Consequently, new therapeutic targets are
urgently required to achieve this aim.
261 New approaches are
urgently required to address increasing rates of gonorrh
262 Interventions are therefore
urgently required to address overweight and obesity amon
263 Therapeutic agents are
urgently required to cure several common and fatal neuro
264 Further functional studies are
urgently required to examine their specific roles in the
265 sed on primary data at a household level are
urgently required to guide effective adaptation, particu
266 slow and variable release, an alternative is
urgently required to improve effectiveness.
267 ultiple stages of the parasite lifecycle are
urgently required to tackle the emerging problem of resi
268 l healthcare crisis, and new antibiotics are
urgently required, especially those with modes of action
269 gimens to shorten and simplify treatment are
urgently required, however a major challenge to TB drug
270 options are limited and novel treatments are
urgently required, however current cell-based high-throu
271 Effective treatments are
urgently required, however, their development is hampere
272 e and minimally invasive, diagnostic test is
urgently required, not only to confirm the presence of t
273 Novel treatment strategies are therefore
urgently required, particularly for patients bearing BRA
274 r studies investigating this possibility are
urgently required.
275 Accordingly, new therapies are
urgently required.
276 tics and antifungal strategies are therefore
urgently required.
277 development of new anti-viral strategies is
urgently required.
278 Hence, effective antifibrotic therapies are
urgently required.
279 eventative and therapeutic interventions are
urgently required.
280 erous cancers, and drugs to inhibit this are
urgently required.
281 Novel anti-TB vaccines are therefore
urgently required.
282 cancer; therefore, different strategies are
urgently required.
283 eeds of survivors of head and neck cancer is
urgently required.
284 d, and therefore effective new therapies are
urgently required.
285 als and standardized clinical algorithms are
urgently required.
286 ance and therefore new control chemicals are
urgently required.
287 tegies to both prevent and treat disease are
urgently required.
288 respect to both childhood and adult SEP are
urgently required.
289 eatment for all diagnosed RR-TB patients are
urgently required.
290 unction with other diagnostic parameters are
urgently required.
291 ional social and environmental interactions,
urgently requires additional approaches to conceptualizi
292 um of the asthma-COPD overlap phenotype that
urgently requires disease modification.
293 livers, while ensuring that patients who are
urgently requiring a liver transplant are prioritized.
294 r pinpoints geographic areas and clades most
urgently requiring additional systematic study-an import
295 Investigators are
urgently searching for options to treat negative symptom
296 opose priority measures that should be taken
urgently to address this issue.
297 Randomised clinical trials are needed
urgently to assess different treatment modalities for st
298 h a broad range of stakeholders, need to act
urgently to decrease the prevalence of obesity.
299 This needs to be addressed
urgently to enable nursing research to increase the impa
300 our management toolbox should be considered
urgently to prepare for the challenges of managing reefs