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1           New, curative medicines are needed urgently.
2 ective vaccines against gonorrhea are needed urgently.
3 nst infectious diseases needs to be improved urgently.
4 rms and reporting criteria of IRE are needed urgently.
5 eptides and carbapenems need to be addressed urgently.
6   Thus, novel therapeutic targets are needed urgently.
7                    A Phase 3 trial is needed urgently.
8 r diagnostic challenges need to be addressed urgently.
9  prevent malaria during pregnancy are needed urgently.
10 priate therapeutic regimens should be tested urgently and implemented comprehensively if spread of ar
11 and approved new drugs and treatments, which urgently are needed.
12 sponsible for disease relapse, and should be urgently assessed when considering aborting therapy on t
13                                These studies urgently call for more reliable and accurate segmentatio
14                                These dangers urgently compel the development of agents for ameliorati
15 ge burden of malaria in developing countries urgently demands the development of novel approaches to
16              Treatment guidelines need to be urgently developed and implemented.
17  one of the top 10 vaccines that needs to be urgently developed.
18   The possibility of MoCD type A needs to be urgently explored in every encephalopathic neonate to av
19                Surgical procedures performed urgently had a 12.3% rate of morbidity (n = 2560) and a
20 asis of urgency because operations performed urgently have distinct rates of morbidity and mortality
21 extracorporeal treatment should be initiated urgently in the context of severe poisoning.
22                                        Women urgently need a self-initiated, multipurpose prevention
23 uding subnational health system performance, urgently need assessment.
24 nd increasing drug use in MSM in Bangkok, we urgently need innovative and acceptable HIV prevention i
25                                           We urgently need to adopt strategies that limit further cli
26 s (n = 703) suggests that, as scientists, we urgently need to change our practices for presenting con
27 ence, but on a number of assumptions, and we urgently need to develop better proxy measures (or indic
28                      An effective vaccine is urgently needed against the H7N9 avian influenza virus.
29 of autophagy-related proteins may provide an urgently needed alternative strategy for the elimination
30 g up effective interventions in this area is urgently needed and likely to yield long run benefits of
31  To combat this problem, new antibiotics are urgently needed and some plant-associated bacteria are a
32 ies to define the appropriate SF cutoffs are urgently needed and would also provide an opportunity to
33  strategies to manage this invasive pest are urgently needed as its range continues to expand.
34 dying disease and drug treatment effects are urgently needed as more relevant tools to identify new d
35 eatment choices for paediatric psychosis are urgently needed because extrapolations from adult studie
36 r data from randomized controlled trials are urgently needed because lepirudin was recalled from the
37      The study of marijuana use disorders is urgently needed because of increasing marijuana legalisa
38            Early and convenient diagnosis is urgently needed for acute Stanford type A aortic dissect
39 rring any significant skin reactogenicity is urgently needed for cutaneous vaccination.
40                         Hence, new tools are urgently needed for efficient, inexpensive manipulation
41 petitors of protein-protein interactions are urgently needed for functional analysis of large-scale g
42 c vaccine with high efficacy and low cost is urgently needed for global control of HCV infection.
43                     Effective treatments are urgently needed for hepatocellular carcinoma (HCC), whic
44 rrent TBMs and research areas where data are urgently needed for model parameterization or evaluation
45            Safe and effective treatments are urgently needed for patients with relapsed or refractory
46  have been developed for cryptococcosis) are urgently needed for pneumocystosis, talaromycosis, and h
47 this infectious virus in the environment are urgently needed for public health protection.
48                                New drugs are urgently needed for resistant strains, shortening durati
49 otential as a prognostic biomarker, which is urgently needed for stratification into pathophysiologic
50 point of care molecular diagnostic tests are urgently needed for the analysis of multidrug resistant
51 e problem, and a more efficacious vaccine is urgently needed for the control and prevention of diseas
52                        Better treatments are urgently needed for the control of chronic asthma and re
53 ventions preventing neonatal GBS disease are urgently needed for the increasing group of HIV-exposed
54 kers and non-invasive diagnostic methods are urgently needed for the screening of gastric cancer to r
55                                 A vaccine is urgently needed in areas where HTLV-1 is endemic.
56 o humans and areas in which more research is urgently needed in order to lessen the burden of macrova
57 and affordable CD4 cell counting methods are urgently needed in resource-limited settings.
58 ma survivors and could inform development of urgently needed intervention strategies.
59 e, it may be of use to explore the effect of urgently needed more specific anti-inflammatory mediator
60                             Investigation is urgently needed on the full diversity of Cannabis chemot
61                       Additional research is urgently needed on the risk, pathogenesis, and effective
62 st that studies of NTEs in other tissues are urgently needed prior to long-term space missions outsid
63                          More information is urgently needed regarding how human practices influence
64 ic tests for tuberculosis case detection are urgently needed that are affordable, robust, and easy to
65 roteostasis capacity, which may help develop urgently needed therapies for neurodegeneration and othe
66                An international consensus is urgently needed to achieve comparability with respect to
67                          New diagnostics are urgently needed to address emerging antimicrobial resist
68 iatric, and adolescent medicine settings are urgently needed to address mental health and substance d
69                     Novel antibacterials are urgently needed to address the growing problem of bacter
70 d hence informative immunological assays are urgently needed to address these knowledge gaps and guid
71 th LTBI at risk of progressing to disease is urgently needed to address this latent reservoir if the
72 need for more efficient data collection, are urgently needed to advance ABDD and to improve HABP/VABP
73 rack large numbers of cells in real time are urgently needed to advance our understanding of importan
74                 Large prospective trials are urgently needed to answer this question.
75 cted and unprotected tropical ecosystems are urgently needed to avoid further defaunation.
76 eliable tools for patient stratification are urgently needed to avoid overtreatment of low-risk patie
77 nfectious and tropical diseases in Africa is urgently needed to better describe the distribution of p
78 EM can cause injury or death, strategies are urgently needed to better understand its causes so that
79 y shifting legal landscape, more research is urgently needed to better understand the impact of legal
80                                More data are urgently needed to better understand this variability an
81 nkey model of Zika virus (ZIKV) infection is urgently needed to better understand transmission and pa
82                   Potent immunotherapies are urgently needed to boost antitumor immunity and control
83                        Detailed datasets are urgently needed to characterize temporal changes in popu
84 ith new targets and mechanisms of action are urgently needed to combat potential pandemics, emerging
85           New antibiotics and strategies are urgently needed to combat S. aureus associated infection
86                    Collaborative efforts are urgently needed to combat the emerging hypertension burd
87                        Novel antibiotics are urgently needed to combat the rise of infections due to
88 o cross-resistance to CQ or CNS toxicity are urgently needed to combat this deadly human disease.
89 es for novel antiviral strategies, which are urgently needed to control dengue virus infections.
90 e risk of AF development and progression are urgently needed to curtail the AF epidemic and improve o
91  Additional research in broad populations is urgently needed to develop a precise definition for ACOS
92 nding of how aging promotes CVD is therefore urgently needed to develop new strategies to reduce dise
93        A better knowledge of connectivity is urgently needed to develop sound environmental managemen
94 stic value; however, improved approaches are urgently needed to enable rapid detection of nucleic aci
95 tion of the adequacy of ecological models is urgently needed to enhance their utility in developing t
96 and care of this population, and efforts are urgently needed to enhance tuberculosis screening in thi
97 n of multiple bacterial pathogens in food is urgently needed to ensure food safety.
98 ed by urinary thiocyanate, interventions are urgently needed to ensure improved processing of cassava
99                          Further studies are urgently needed to explore the contribution of eosinophi
100 chniques for intracellular pH monitoring are urgently needed to gain new insights into single-cell re
101 flammation promotes lymphatic dysfunction is urgently needed to guide the development of novel therap
102 ognition and protection of roadless areas is urgently needed to halt their continued loss.
103 neurological, and substance use disorders is urgently needed to help reduce the large and increasing
104                              Further work is urgently needed to identify other sources of, and pathwa
105                     Phylogenomic studies are urgently needed to identify the global population struct
106 ize models of care for PHIVY as they age are urgently needed to improve long-term outcomes among PHIV
107 uing clinical and translational research are urgently needed to improve, and, crucially, to personali
108     Novel health policies and programmes are urgently needed to increase awareness of diabetes and to
109 ty of new entities toward the AOX enzyme are urgently needed to increase effectiveness, reduce costs,
110 monitoring of wild pollinator populations is urgently needed to inform management strategies into the
111 Biomarkers that reflect disease activity are urgently needed to inform patient management and for use
112 detecting ricin in a variety of matrixes are urgently needed to limit exposure to individuals as well
113  Novel intervention strategies are therefore urgently needed to maintain the current momentum for con
114 ilure of artemisinin combination therapy are urgently needed to monitor the spread of partner drug re
115 es in their use, and the progress that is so urgently needed to overcome the devastating effect of fu
116                      Accurate biomarkers are urgently needed to predict response in these settings an
117  patient adherence across health sectors are urgently needed to prevent this.
118       Ongoing research into this pathogen is urgently needed to produce viable vaccine and therapeuti
119                             New vaccines are urgently needed to protect the vulnerable from bacterial
120    Adequate trials with low risk of bias are urgently needed to provide better evidence.
121  combined with well-validated biomarkers are urgently needed to provide early indicators of effective
122 the soil and hence comprehensive studies are urgently needed to quantify the environmental impacts of
123     Rapid large-scale mapping activities are urgently needed to quantify tropical wetland extent and
124 y, and suicide among young female adults are urgently needed to reduce injury deaths and morbidity in
125                           New techniques are urgently needed to replace conventional long and costly
126            New antituberculosis regimens are urgently needed to shorten tuberculosis treatment.
127                            Interventions are urgently needed to significantly reduce both mortality a
128 HIV, hepatitis C virus, and tuberculosis are urgently needed to stem the multiple overlapping epidemi
129                 Innovative interventions are urgently needed to strengthen community buy-in, to incre
130 revents hepatitis C virus (HCV) infection is urgently needed to support an emerging global eliminatio
131                          Further research is urgently needed to test the effectiveness of different m
132 Health and American College of Surgeons for "urgently needed" research, the objectives of the present
133                          Further research is urgently needed, given the burden of congestion and data
134 o document longer-term clinical outcomes are urgently needed, in order to address the question whethe
135 l chemical properties and fluxes of OPEs are urgently needed, in order to estimate their environmenta
136 eration and the post-incarceration period is urgently needed, particularly studies using rigorous exp
137 nt, drug resistance, new drug candidates are urgently needed, which should preferably act via novel m
138 roducts in a real-life exposure scenario are urgently needed, yet very rare.
139 tology; thus, identifying novel therapies is urgently needed.
140 alid mechanism-based prognostic biomarker is urgently needed.
141  detection and therapeutic stabilization are urgently needed.
142 he development of a robust sensing system is urgently needed.
143 ns targeting the most vulnerable children is urgently needed.
144 derately iodine-deficient pregnant women are urgently needed.
145  new treatment and diagnostic approaches are urgently needed.
146 ic and functional heterogeneity of DLBCL are urgently needed.
147 e reactivated latent HIV reservoir cells are urgently needed.
148 olesterolemia for which novel treatments are urgently needed.
149          Animal models of infection are thus urgently needed.
150 rent practices, and more level 1 evidence is urgently needed.
151 rnate approaches for vaccine development are urgently needed.
152 functional sites among correlated markers is urgently needed.
153 c, and cost-effective diagnostic methods are urgently needed.
154 haracterize protein-protein interactions are urgently needed.
155 ation of new human-specific therapeutics are urgently needed.
156 th data, and describe areas in which data is urgently needed.
157 and computationally predicted structures are urgently needed.
158 effective vaccine against ExPEC infection is urgently needed.
159 educe the burden of bacterial infections are urgently needed.
160 andemic, and global public health action was urgently needed.
161 vior, especially highly lethal behavior, are urgently needed.
162 eventive vaccine to protect against HIV-1 is urgently needed.
163  study these processes in living T cells are urgently needed.
164 ce invariably emerges, and new therapies are urgently needed.
165 ies to promote lung allograft acceptance are urgently needed.
166  most aggressive form of lung cancer, remain urgently needed.
167    Therefore, novel analgesic treatments are urgently needed.
168 vel molecular-driven therapeutic options are urgently needed.
169 genesis, vulnerabilities, and treatments are urgently needed.
170  cancer deaths, and effective treatments are urgently needed.
171 mportance, and new approaches to therapy are urgently needed.
172 cially those measurable in the periphery are urgently needed.
173 on--individuals for whom real-world data are urgently needed.
174 ral insight into ligand-binding to HSP70s is urgently needed.
175  the identification of actionable targets is urgently needed.
176 diction uncertainty, and detection limit are urgently needed.
177 ant EGFR-driven tumors and new therapies are urgently needed.
178 t spans multiple sectors and stakeholders is urgently needed.
179 novative approaches to tackle infections are urgently needed.
180 revention, including effective vaccines, are urgently needed.
181 ication, new drugs to treat hypertension are urgently needed.
182 ogies in finding new plant-derived drugs are urgently needed.
183 ar and phenotypic features of the disease is urgently needed.
184 cit approach to allocating recovery funds is urgently needed.
185 nes to protect against tuberculosis (TB) are urgently needed.
186 ible vaccines against dengue are hence still urgently needed.
187  respectful, evidence-based care for all, is urgently needed.
188  and rapidly scalable production platform is urgently needed.
189                             Its reduction is urgently needed.
190 odels with greater relevance to human AKI is urgently needed.
191 IV testing and linkage to care among men are urgently needed.
192 fficacy and broader spectrum of activity are urgently needed.
193  that is clean, renewable and inexpensive is urgently needed.
194 d rapid diagnostic platform technologies are urgently needed.
195 slative changes and consumer information are urgently needed.
196 nce and antimicrobial resistance patterns is urgently needed.
197 ls and new approaches to developing them are urgently needed.
198 ays involved in pancreatic tumorigenesis are urgently needed.
199 llowed by SRS at intracranial progression is urgently needed.
200 , intracellular accumulation of the drug, is urgently needed.
201 l strategies of prevention and treatment are urgently needed.
202 ly pure form through asymmetric synthesis is urgently needed.
203 nts' behaviours driving these differences is urgently needed.
204  against acute organophosphorus poisoning is urgently needed.
205  the development of curative therapeutics is urgently needed.
206 ting trafficking of CLL cells to LNs is thus urgently needed.
207                         Novel fungicides are urgently needed.
208 ability; therefore, effective treatments are urgently needed.
209 any important technological applications are urgently needed.
210 for triple-negative breast cancer (TNBC) are urgently needed.
211 or detection of Zaire ebolavirus (ZEBOV) are urgently needed.
212 ent and spread of miltefosine resistance are urgently needed.
213 ication of a generic gene-based treatment is urgently needed.
214 rted actions to address these challenges are urgently needed.
215  caused by multidrug resistant pathogens are urgently needed.
216 s in less-developed regions of the world are urgently needed.
217  therapies to improve treatment outcomes are urgently needed.
218 atients to individual treatment regimens are urgently needed.
219      Therefore, new treatment strategies are urgently needed.
220 or developed tumor resistance mechanisms are urgently needed.
221 atic assessments of its actual potential are urgently needed.
222       As a consequence, novel chemotypes are urgently needed.
223  or bivalent EV71/CVA16 vaccine is therefore urgently needed.
224 hus, cross-protective immunotherapeutics are urgently needed.
225 ppropriate plasma transfusion strategies are urgently needed.
226 re sensitive detection methods are therefore urgently needed.
227 ilizes starch and includes a colour blank is urgently needed.
228 ing is limited, and research in this area is urgently needed.
229 ic strategies for malignant mesothelioma are urgently needed.
230  practice and new therapeutic approaches are urgently needed.
231    Therefore, novel, non-toxic therapies are urgently needed.
232 nt outcomes, alternatives to antibiotics are urgently needed.
233 ve measures, especially, when surgery is not urgently needed.
234 and undertreatment of aggressive disease are urgently needed.
235 criptomics, proteomics and metabolomics) are urgently needed.
236 e, a unified language for image reporting is urgently needed.
237 e mechanisms underlying PARPi sensitivity is urgently needed.
238 ng therapy in children with brain tumors are urgently needed.
239 deficiency virus (HIV)-positive patients are urgently needed.
240 lopment of additional therapeutic agents are urgently needed.
241 dual patient response to novel therapies are urgently needed.
242 mize AKI and halt the progression of CKD are urgently needed.
243 e, new solutions for plastic degradation are urgently needed.
244                        Novel painkillers are urgently needed.
245 s in vivo for which effective treatments are urgently needed.
246 ion against influenza B viruses is therefore urgently needed.
247 oactivity against ACR acute neurotoxicity is urgently needed.
248 r fisheries productivity where both are most urgently needed.
249 rther development of EVs isolation protocols urgently needs a quantitative method of EVs purity asses
250 ncrasies in CC responses detected so far and urgently needs more careful consideration in design and
251 ack of safe vaccines or antiviral treatments urgently needs to be addressed.
252 ovascular events and its molecular mechanism urgently needs to be clarified.
253  MPI is limited to around 1 mm currently and urgently needs to be improved for clinical applications
254 r the Surgery of Trauma definition, admitted urgently or emergently, who underwent an operative proce
255                        A 23-year-old man was urgently referred for evaluation of rapidly enlarging ce
256  multifactor effects on plants and soils are urgently required across different world regions.
257                         New technologies are urgently required for reliable drug screening given a wo
258 t drug resistance, new chemical entities are urgently required for use in next generation anti-malari
259                        Rapid diagnostics are urgently required given the large numbers of suspected e
260    Consequently, new therapeutic targets are urgently required to achieve this aim.
261                           New approaches are urgently required to address increasing rates of gonorrh
262                  Interventions are therefore urgently required to address overweight and obesity amon
263                       Therapeutic agents are urgently required to cure several common and fatal neuro
264               Further functional studies are urgently required to examine their specific roles in the
265 sed on primary data at a household level are urgently required to guide effective adaptation, particu
266 slow and variable release, an alternative is urgently required to improve effectiveness.
267 ultiple stages of the parasite lifecycle are urgently required to tackle the emerging problem of resi
268 l healthcare crisis, and new antibiotics are urgently required, especially those with modes of action
269 gimens to shorten and simplify treatment are urgently required, however a major challenge to TB drug
270 options are limited and novel treatments are urgently required, however current cell-based high-throu
271                     Effective treatments are urgently required, however, their development is hampere
272 e and minimally invasive, diagnostic test is urgently required, not only to confirm the presence of t
273     Novel treatment strategies are therefore urgently required, particularly for patients bearing BRA
274 r studies investigating this possibility are urgently required.
275               Accordingly, new therapies are urgently required.
276 tics and antifungal strategies are therefore urgently required.
277  development of new anti-viral strategies is urgently required.
278  Hence, effective antifibrotic therapies are urgently required.
279 eventative and therapeutic interventions are urgently required.
280 erous cancers, and drugs to inhibit this are urgently required.
281         Novel anti-TB vaccines are therefore urgently required.
282  cancer; therefore, different strategies are urgently required.
283 eeds of survivors of head and neck cancer is urgently required.
284 d, and therefore effective new therapies are urgently required.
285 als and standardized clinical algorithms are urgently required.
286 ance and therefore new control chemicals are urgently required.
287 tegies to both prevent and treat disease are urgently required.
288  respect to both childhood and adult SEP are urgently required.
289 eatment for all diagnosed RR-TB patients are urgently required.
290 unction with other diagnostic parameters are urgently required.
291 ional social and environmental interactions, urgently requires additional approaches to conceptualizi
292 um of the asthma-COPD overlap phenotype that urgently requires disease modification.
293 livers, while ensuring that patients who are urgently requiring a liver transplant are prioritized.
294 r pinpoints geographic areas and clades most urgently requiring additional systematic study-an import
295                            Investigators are urgently searching for options to treat negative symptom
296 opose priority measures that should be taken urgently to address this issue.
297        Randomised clinical trials are needed urgently to assess different treatment modalities for st
298 h a broad range of stakeholders, need to act urgently to decrease the prevalence of obesity.
299                   This needs to be addressed urgently to enable nursing research to increase the impa
300  our management toolbox should be considered urgently to prepare for the challenges of managing reefs

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