ライフサイエンスコーパス: uridine

1 lated plant material, including nicotine and uridine.

2 glycosidic bond is C-C rather than C-N as in uridine.

3 nucleosides such as guanosine, cytidine and uridine.

4 ) which is 170 nm red-shifted as compared to uridine.

5 e in this position confers high activity for uridine.

6 ex, as had been observed earlier for product uridine.

7 any cytidines (up to 40%) are converted into uridine.

8 d together with uridine or when given before uridine.

9 this end, i.e., C5-functionalization of LNA uridines.

10 nce, a GAUC repeat framed by single-stranded uridines.

11 RNA, to which it added a distinct number of uridines.

12 n, ~20% of siRNA 3' ends carry non-templated uridines.

13 expressed uptake of alpha-methylglucoside or uridine 1 hour later, we identified a RS1 domain (RS1-Re

14 nsor (viz., 2'-O-[(4-CF3-triazol-1-yl)methyl]uridine, 1) for (19)F NMR spectroscopic monitoring of RN

15 PIWI protein Aubergine typically begin with uridine (1U), while piRNAs bound to Argonaute3, which ar

16 le incorporation of a reversible pyrenylated uridine 2'-conjugate into an RNA sequence, the conjugati

17 -O-aminooxymethyl uridine provides permanent uridine 2'-conjugates, which are left essentially intact

18 of dFdC: the natural pyrimidine nucleosides uridine, 2'-deoxyuridine and thymidine inhibited mycopla

19 thylsilyl)germanes gave (Z)-5-(2-germylvinyl)uridine, 2'-deoxyuridine, or ara-uridine as major produc

20 Furthermore, we find that 5'-uridine, 3'-mid base pairing, and 5'-mid mismatches with

21 Uridine 34 (U34) at the wobble position of the tRNA anti

22 tions of transfer RNAs (tRNAs) at the wobble uridine 34 (U34) base are highly conserved and contribut

23 on and diminished 2'-O-methylribosylation at uridine 34 in mutant tRNA[Ser]Sec.

24 nability to distinguish the diastereomers of uridine 5'-beta,gamma-fluoromethylenetriphosphate (beta,

25 mutant p53 target gene, which functions as a uridine 5'-diphosphatase (UDPase) in the endoplasmic ret

26 og was readily transformed in cells into the uridine 5'-diphosphate (UDP)-activated form, it was not

27 P2Y2 (UTP/ATP) and P2Y6 [ADP/UTP/uridine 5'-diphosphate (UDP)] have been shown to have pr

28 ch species, the galactan is constructed from uridine 5'-diphosphate-alpha-d-galactofuranose (UDP-Galf

29 Uridine 5'-diphosphate-N-acetylglucosamine (UDP-GlcNAc)

30 (CYP) isoform 7A1 (CYP7A1), CYP27A1, CYP8B1, uridine 5'-diphospho-glucuronosyltransferase 1A1, 1A3, 1

31 t of murine cN-III with a natural substrate, uridine 5'-monophosphate, in the active site at 1.74A re

32 (ADO) and nucleotides such as ATP, ADP, and uridine 5'-triphosphate (UTP), among others, may serve a

33 as confirmed with fluorescein isothiocyanate-uridine 5'-triphosphate labeling, RNA fluorescence in si

34 rminal deoxynucleotidyl transferase-mediated uridine 5'-triphosphate-biotin nick end-labeling stainin

35 Furthermore, we observed that uridine 5-diphosphoglucose enhanced the in vitro migrati

36 ges from WT but not KO mice, and that plasma uridine 5-diphosphoglucose levels were significantly hig

37 an aldol-type condensation with glycine and uridine-5'-aldehyde to furnish GlyU.

38 t during GlyU biosynthesis as an l-threonine:uridine-5'-aldehyde transaldolase.

39 e, Pac13, which catalyses the dehydration of uridine-5'-aldehyde.

40 5 but not pan-Akt inhibitor MK2206 increased uridine-5'-diphosphate-hexose cell content which was sup

41 ase was observed in ATII cells stimulated by uridine-5'-triphosphate (UTP) and PMA, agonists inducing

42 In a recent study we revealed that Uridine-5'-triphosphate (UTP) uptake in living cells lab

43 s a Gq protein-coupled receptor activated by uridine-5'-triphosphate (UTP), which is widely expressed

44 estigated the role of hydrocortisone (HC) on uridine-5'-triphosphate (UTP)-stimulated ion transport i

45 tended N(4)-(3-arylpropyl)oxy derivatives of uridine-5'-triphosphate were synthesized and potently st

46 We have studied how uridine 56 and 93 pseudouridylation impacts conformation

47 Uridines 56 and 93 are both modified to pseudouridines (

48 eplacement of T by 2'-deoxy-5-(hydroxymethyl)uridine (5hmU) in the genomic DNA of Escherichia coli.

49 5-((4-methoxy-phenyl)-trans-vinyl)-2'-deoxy-uridine, 6, as a fluorescent uridine analogue exhibiting

50 Uridine, a pyrimidine nucleoside present at high levels

51 cell surface hENT1 expression, and decrease uridine accumulation when presented together with uridin

52 plicing, and RNA editing by substitution and uridine additions both reconstituting crucial coding seq

53 human and murine colon muscles also release uridine adenosine tetraphosphate (Up4A) spontaneously an

54 d, most notably, four nucleosides: cytidine, uridine, adenosine, and thymidine.

55 We synthesized P1-(uridine/adenosine-5')-methylenebisphosphonodithioate, 2

56 bisphosphonodithioate, 2 and 3, and P1,P2-di(uridine/adenosine-5')-methylenebisphosphonodithioate, 4

57 vinyl)-2'-deoxy-uridine, 6, as a fluorescent uridine analogue exhibiting a 3000-fold higher quantum y

58 The anti-HIV activity of 29 (uridine analogue), 31 (thymidine analogue), and 34 (cyti

59 us time scales by incorporating the (6-(13)C)uridine and -cytidine labels into biologically relevant

60 This transporter had low affinity for uridine and 2'deoxyuridine and was the sole pyrimidine t

61 onuclease that posttranscriptionally removes uridine and adenosine nucleosides from the 3' end of spl

62 DA) catalyzes the deamination of cytidine to uridine and ammonia in the catabolic route of C nucleoti

63 ar syntheses of 4'-C-aminomethyl-2'-O-methyl uridine and cytidine nucleoside phosphoramidites were ac

64 5, 100, and 250 muM MPA) and upregulation of uridine and cytidine nucleotides (p < 0.001 at 24 h; 5 m

65 3A/L442I) previously shown to be involved in uridine and dipyridamole binding, suggested that BCR-ABL

66 f metal ions by the nucleobases of conserved uridine and guanosine in helix P4 of the RNA subunit (P

67 nding conformationally locked sugar modified uridine and guanosine nucleosides was achieved via Vorbr

68 The uridine and guanosine nucleosides were found to be inact

69 d predominantly directed the misinsertion of uridine and guanosine, respectively.

70 ced by supplementation of culture media with uridine and N-acetylglucosamine (GlcNAc), precursors for

71 s a basis for understanding the evolution of uridine and purine nucleoside phosphorylases with respec

72 ese cells lack mtDNA and are auxotrophic for uridine and pyruvate, which may explain the apparent let

73 electronic effects at the 2-exo position of uridine and replacing the 2-exo oxygen with a selenium a

74 osine, while the other is more active toward uridine and xanthosine.

75 c protein in vivo are covalently marked with uridines and subsequently identified from extracted RNA

76 t may be important for the provision of CTP, uridine, and cytidine nucleotides.

77 -acetylalanine, andro-steroid monosulfate 2, uridine, and gamma-glutamyl-leucine, showed independent

78 tes like tryptophan, proline, phenylalanine, uridine, and guanosine was found.

79 biosynthesis; ELP3, 5-methoxycarbonylmethyl uridine; and RSAD1 and viperin, both of unknown function

80 itical mediators of insulin sensitivity, and uridine as an important metabolite contributed by the ad

81 germylvinyl)uridine, 2'-deoxyuridine, or ara-uridine as major products.

82 al nucleotidyl transferase activity, prefers uridine as the substrate nucleotide, and is completely i

83 ently introduced C5-functionalization of LNA uridines as an alternative and synthetically more straig

84 sporter from Vibrio cholerae in complex with uridine at 2.4 A.

85 A uridine at position 206 (U206), which is located in smal

86 iolation of the universally conserved methyl-uridine at position 54 stabilizes tRNAs from thermophili

87 to convert 5-hydroxyuridine into 5-oxyacetyl uridine at the wobble position of multiple tRNAs in Gram

88 Each BP lacked canonical uridines at position -2 relative to the BP adenines, wit

89 ombination (CSR) by deaminating cytidines to uridines at V region (V) genes and switch (S) regions.

90 e outlined and the syntheses of cytidine and uridine azo dye analogues derived from 6-aminouracil are

91 These proteins convert cytidine bases to uridine bases in retroviral DNA.

92 in a mechanism involving adipocyte-dependent uridine biosynthesis and leptin signaling.

93 ria results in the conversion of cytidine to uridine by deamination.

94 uoro-3'-C-hydroxymethyl-2',3'-endo-methylene-uridine by X-ray crystallography yielded the principal c

95 sperm organelles, cytidines are converted to uridines by a deamination reaction in the process termed

96 organelle genes are modified by cytidine-to-uridine (C-to-U) RNA editing, often changing the encoded

97 The simple nonredox substitution of the C2-uridine carbonyl oxygen by sulfur is catalyzed by tRNA t

98 les the deamination signature of cytidine to uridine carried out by members of the APOBEC3 family of

99 Quantum chemical modeling identified a uridine conformer whose calculated BIE's match the exper

100 -containing cofactor FAD and highly abundant uridine-containing cell wall precursors, UDP-Glucose and

101 ecisely defined by the frequency of specific uridine-containing motifs.

102 (UBER) enzymes target and cleave A3G-edited uridine-containing viral cDNA.

103 ough TLR7, the activation is proportional to uridine-content, and more precisely defined by the frequ

104 th metal ions, demonstrating that the bulged uridine coordinates at least one catalytic metal ion thr

105 munity depend primarily on the length of the uridine core within this motif.

106 ne structures of U2AF(65) bound to the deoxy-uridine counterparts and compared the original, RNA-boun

107 r that rapidly metabolizes DAC into inactive uridine counterparts, severely limiting exposure time an

108 K2 gene indicates that the disruption of the uridine-cytidine kinase affects E. chaffeensis replicati

109 RIG-I protein, where RIG-I recognizes a poly-uridine/cytosine motif in the viral genome.

110 m in vitro, unless supplemented with uracil, uridine, deoxyuridine or UMP.

111 f a terminal alkyne at the 5' position of an uridine derivative and O-glycosylation with a protected

112 strategy for the synthesis of 5'-substituted-uridine derivatives is described.

113 dation, performed at a multigram scale, of a uridine-derived alkene.

114 A sensitive uridine-derived sensor (viz., 2'-O-[(4-CF3-triazol-1-yl)

115 zes the reversible conversion of sucrose and uridine diphosphate (UDP) into fructose and UDP-glucose,

116 o GlcNAc-1-phosphate during the synthesis of uridine diphosphate (UDP)-GlcNAc, a sugar nucleotide cri

117 ic steps of this pathway involve a series of uridine diphosphate (UDP)-linked peptidoglycan intermedi

118 ltransferase MurU catalyzes the synthesis of uridine diphosphate (UDP)-MurNAc, a crucial precursor of

119 Unnatural uridine diphosphate (UDP)-sugar donors, UDP-4-deoxy-4-fl

120 46.82 mukat/Kg protein toward phloretin and uridine diphosphate glucose (UDPG) at an optimal tempera

121 Uridine diphosphate glucunosyltransferases (UGTs) metabo

122 ance of bilirubin requires the expression of uridine diphosphate glucuronosyltransferase (UGT) 1A1; w

123 ome for sequences with similarity to terpene URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASES (UGTs) from Ara

124 iphosphate N-acetylhexosamine (UDP-HexNAc)]/[uridine diphosphate hexose (UDP-hexose)] ratio exhibited

125 uridine diphosphate N-acetylglucosamine and uridine diphosphate N-acetylgalactosamine, leading to th

126 osamine biosynthetic pathway (HBP) generates uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) for

127 Glucose and glutamine are precursors of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a

128 e fate of the chitin-biosynthesis precursor, uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), wa

129 nsferase pp-alpha-GanT2 able to utilize both uridine diphosphate N-acetylglucosamine and uridine diph

130 ich catalyzes a key step in the synthesis of uridine diphosphate N-acetylglucosamine, which is requir

131 fect on the biosynthetic reactions involving uridine diphosphate N-acetylglucosamine.

132 decreased, whereas the distribution of the [uridine diphosphate N-acetylhexosamine (UDP-HexNAc)]/[ur

133 ferred by GlmU to afford their corresponding uridine diphosphate(UDP)-sugar nucleotides.

134 O-GlcNAcylation requires uridine diphosphate-GlcNAc, a precursor responsive to nu

135 in the glycosyltransferase active site above uridine diphosphate-GlcNAc.

136 We used rs6742078 located in the uridine diphosphate-glucuronosyltransferase locus as an

137 ted by decreased enzyme activity and reduced uridine diphosphate-N-acetyl-D-glucosamine, along with d

138 GlcNAc) levels are modulated by two enzymes: uridine diphosphate-N-acetyl-D-glucosamine:polypeptidylt

139 nce studies indicated thatlymphostatin binds uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) but

140 mine biosynthetic pathway (HBP), to increase uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc).

141 Uridine diphospho glucuronosyltransferase 2B17 (UGT2B17)

142 Uridine diphospho-N-acetylglucosamine, a product of the

143 ng glycosyltransferase O-GlcNAc transferase (uridine diphospho-N-acetylglucosamine:polypeptide beta-N

144 We demonstrate that recombinant JGT utilizes uridine diphosphoglucose to transfer glucose to hmU in t

145 Uridine-disphosphate glucuronosyl transferase (UGT) enzy

146 sed binding isotope effects (BIE's) to probe uridine distortion in the complex with TcUP and sulfate

147 A predominant uridine downstream PSSs served as a processing signature

148 biting viral cDNA production and cytidine-to-uridine-driven hypermutation of this cDNA.

149 ing is converting hundreds of cytosines into uridines during organelle gene expression of land plants

150 by the earlier discovery of tRNA cytosine-to-uridine editing in eukaryotes, a reaction that has not b

151 Additionally, by employing 5-ethynyl uridine (EU) incorporation analysis, ablation of PADI1 f

152 Using 5-ethynyl uridine (EU) to metabolically label nascent RNA, we meas

153 Our results indicate that plasma uridine governs energy homeostasis and thermoregulation

154 R-133a, -146a, and -208a) were diminished by uridine-->adenosine mutation and by RNase pretreatment.

155 findings that implicate leptin signaling in uridine homeostasis and consequent metabolic control and

156 Further, feeding-induced clearance of plasma uridine improves glucose metabolism.

157 Replacing the uridine in CCUG repeats with pseudouridine (Psi) resulte

158 of cytidine but also CMP, cytosine, and some uridine in seeds.

159 dition of mcm(5) and ncm(5) modifications to uridine in the tRNA anticodon 'wobble' position in both

160 way responsible for the thiolation of wobble uridines in cytoplasmic tRNAs tK(UUU), tQ(UUG) and tE(UU

161 tidines in McA7777 cells were converted into uridines in the hypermutated apoB mRNA.

162 disease exhibit elevated lactate and reduced uridine; in McArdle disease purine nucleotide metabolite

163 ntaining nascent transcript levels and (14)C-uridine incorporation.

164 ergoes an essential process of mitochondrial uridine insertion and deletion RNA editing catalyzed by

165 Uridine insertion and deletion RNA editing generates fun

166 Uridine insertion and deletion RNA editing generates fun

167 Here, we review the mechanism of uridine insertion/deletion mRNA editing in kinetoplastid

168 Uridine insertion/deletion RNA editing is an essential p

169 Elevation of plasma uridine is required for the drop in body temperature tha

170 ted substrate stem-loop, in which the target uridine is substituted by 5-fluorouridine (5-FU), reveal

171 The third uridine is turned outwards or inward, wedging between th

172 We found that plasma uridine levels are regulated by fasting and refeeding in

173 In contrast, refeeding reduces plasma uridine levels through biliary clearance.

174 Fasting increases plasma uridine levels, and this increase relies largely on adip

175 rent subfamilies selectively reduce distinct uridines, located at spatially unique positions of folde

176 ion in Elp1 may be essential for tRNA wobble uridine modification by acting as tRNA binding motif.

177 on, ubiquitination and cytosolic tRNA wobble uridine modification via 5-methoxycarbonylmethyl-2-thiou

178 tial for Elongator's function in tRNA wobble uridine modification.

179 ranslation elongation factor eEF2 and wobble uridine modifications of tRNAs.

180 alpha-L-LNA uridine monomers that are conjugated to small C5-alkynyl

181 ted into aspartate (a nucleotide precursor), uridine monophosphate (a precursor of pyrimidine nucleos

182 ated 5'-adenosine monophosphate (AMP) and 5'-uridine monophosphate (UMP) molecules confined in multi-

183 showcase our workflow by annotating N-methyl-uridine monophosphate (UMP), lysomonogalactosyl-monopalm

184 e that catalyzes the conversion of uracil to uridine monophosphate (UMP).

185 ng allosteric and substrate binding sites of uridine monophosphate kinase, and suggested that in solu

186 gulation of the near-terminal pathway enzyme uridine monophosphate kinase.

187 the genome, we determined that the conserved uridine monophosphate phosphoribosyltransferase (UMPS),

188 We find that uric acid directly inhibits uridine monophosphate synthase (UMPS) and consequently r

189 and selected against, such as deficiency of uridine monophosphate synthase, complex vertebral malfor

190 Moreover, the presence of several umami (uridine monophosphate, inosine monophosphate, adenosine,

191 eads to build-up of the pathway intermediate uridine monophosphate, which is in turn degraded by a co

192 ts changes hundreds of selected cytidines to uridines, mostly in coding regions of mRNAs.

193 The uridine nucleotide analogue sofosbuvir is a selective in

194 sed the safety and efficacy of sofosbuvir, a uridine nucleotide analogue, in treatment-naive patients

195 ngs to the class of 2'-deoxy-2'-spirooxetane uridine nucleotide prodrugs which are known as inhibitor

196 alyze deamination of cytidine nucleotides to uridine nucleotides (C-to-U) in single-strand DNA substr

197 eaves mitochondrial mRNA, inserts or deletes uridine nucleotides at specific positions and re-ligates

198 aracterized by the insertion and deletion of uridine nucleotides into otherwise nontranslatable messe

199 ce sites while adapting to both cytidine and uridine nucleotides with nearly equivalent frequencies.

200 y originate from an epoxy amide derived from uridine, obtained via reaction of uridyl aldehyde 19 wit

201 lino)ethane sulfonic acid] mimics the target uridine of an RNA substrate.

202 onylmethylation, respectively, of the wobble uridine of cytoplasmic (tK(UUU)), (tQ(UUG)), and (tE(UUC

203 Surprisingly, two uridines of the signature sequence make triple interacti

204 ditional insights into the effects of 2-thio-uridine on RNA base pairing.

205 encoded cytidine or adenosine nucleotides to uridine or inosine, respectively, in mRNAs.

206 ne accumulation when presented together with uridine or when given before uridine.

207 report, the discovery of a beta-d-2'-Cl,2'-F-uridine phosphoramidate nucleotide 16, as a nontoxic pan

208 Selective inhibitors of human uridine phosphorylase (hUP) have been proposed as a stra

209 e transition state for the Trypanosoma cruzi uridine phosphorylase (TcUP) reaction has an expanded S(

210 e 5'-monophosphate decarboxylase (OMPDC) and uridine phosphorylase (UP) genes.

211 Thymidine phosphorylase and uridine phosphorylase double knockout mice recapitulated

212 ansfer explains the occurrence of unexpected uridine phosphorylases in some genomes.

213 Recently, one subfamily, the uridine phosphorylases, has been subdivided into two typ

214 pK(a) values for proton transfer from C-6 of uridine (pK(CH) = 28.8) and 5-fluorouridine (pK(CH) = 25

215 Uridine provided options to overcome any toxicity in the

216 or dansyl chloride with 2'-O-aminooxymethyl uridine provides permanent uridine 2'-conjugates, which

217 (3)H-uridine pulse-chase assays demonstrate that BLM expressi

218 Independent generation of the C2'-uridine radical (1) in RNA oligonucleotides via Norrish

219 seudouridylation changes the properties of a uridine residue and is likely to alter the role of its c

220 ins to pre-mRNAs with a site-specific 4-thio uridine residue at the -3 position of exon 1 was tested

221 ola virus shows that an addition of a single uridine residue in the glycoprotein gene at the editing

222 key adenine nucleotide (A102) and pausing 5 uridine residues downstream.We show that the 3' ends of

223 Psi) synthase Pus1 (hPus1) modifies specific uridine residues in several non-coding RNAs: tRNA, U2 sp

224 ding with 3' adenine residues to AGO1 and 3' uridine residues to AGO2.

225 gion [CRE(2C)] templates the addition of two uridine residues to the virus genome-encoded RNA replica

226 GAPDH binds to numerous adenine-uridine rich elements (AREs) from various mRNA 3'-untran

227 ein, we explored the role of the adenine and uridine-rich element (ARE)-binding protein tristetraprol

228 R identified numerous copies of adenine- and uridine-rich elements, raising the possibility that unde

229 A 99-nucleotide, uridine-rich hairpin 5'pppRNA termed M8 stimulated an ex

230 their 3' UTRs are too short to accommodate a uridine-rich motif required for stability of the materna

231 A novel, sequence-dependent, uridine-rich RIG-I agonist generated a protective antivi

232 forms hexameric rings, which preferably bind uridine-rich RNA 3' ends on their proximal surface and a

233 Ms) and a glutamine-rich domain and binds to uridine-rich RNA sequences through its C-terminal RRM2 a

234 Furthermore, we found that Dnd1 binds to a uridine-rich sequence in the 3'-UTR of trim36, a vegetal

235 IVmac251 single-stranded RNA encoded several uridine-rich sequences that were potent TLR7/8 ligands i

236 tes the assembly of RNA-protein complexes of uridine-rich small nuclear ribonucleoproteins (UsnRNPs).

237 processing of noncoding RNAs, including the uridine-rich small nuclear RNA (UsnRNA) and enhancer RNA

238 Uridine-rich small nuclear RNAs (snRNAs) are the basal c

239 Although uridine-rich small nuclear RNAs (U-snRNAs) are essential

240 ary DNA sequences, we discovered cytidine-to-uridine RNA editing in position 32 of two nucleus-encode

241 n enrichment of Apobec1-mediated cytosine to uridine RNA editing.

242 the main specificity factors of cytidine to uridine RNA editing.

243 ly incorporated new photocaged guanosine and uridine RNA phosphoramidites into short RNA duplexes.

244 The facilitators for specific cytosine-to-uridine RNA-editing events in plant mitochondria and pla

245 2-Thio-uridine (s(2)U) is a modified nucleobase found in certai

246 de kinase is involved in cytidine as well as uridine salvage.

247 selenium atom by synthesizing the novel 4-Se-uridine ((Se)U) phosphoramidite and Se-nucleobase-modifi

248 hesis of the 2-Se-U-RNAs as well as the 2-Se-uridine ((Se)U) phosphoramidite.

249 indicate a standard deviation of <10% in the uridine signal obtained for each area.

250 on, and identify an amino acid important for uridine specificity.

251 ated histidine 1269 was likely important for uridine specificity.

252 Surprisingly, uridine supplementation increased NTD incidence, indepen

253 the folate-deficient diet, whereas maternal uridine supplementation increased NTD incidence, indepen

254 Uridine supplementation rescued these abnormalities, sug

255 sed 5' cleavage RISC fragments with extended uridine tails.

256 CDA converts 5hmdC and 5fdC into variants of uridine that are incorporated into DNA, resulting in acc

257 nucleosides such as guanosine, cytidine and uridine, the excellent specificity of this sensor toward

258 due to host metabolism converting orotate to uridine, thereby bypassing the loss of UMPS in the paras

259 mediate the direct conversion of cytidine to uridine, thereby effecting a C-->T (or G-->A) substituti

260 utwards or inward, wedging between the other uridines, thus filling the major groove.

261 folate-deficient diets and supplemented with uridine, thymidine, or deoxyuridine were bred, and litte

262 plementation with the pyrimidine nucleosides uridine, thymidine, or deoxyuridine with and without fol

263 (Escherichia coli); when fed food with a low uridine/thymidine (U/T) level, germline proliferation is

264 However, modification of the initial uridine to a pseudouridine (Psi) allows efficient recogn

265 transferase that prefers to add untemplated uridine to the 3' end of RNA, which is completely abolis

266 ctuation signals, and often adds hundreds of uridines to create protein-coding sequences.

267 The reduction of specific uridines to dihydrouridine is one of the most common mod

268 rough the specific insertion and deletion of uridines to generate functional open reading frames, man

269 ur data reveal key aspects of how XTUT7 adds uridines to RNAs, highlight the role of the basic region

270 To better understand how TUTs add uridines to RNAs, we focused on a putative TUT from Xeno

271 ermined that XTUT7 catalyzed the addition of uridines to RNAs.

272 transferases (TUTs) catalyze the addition of uridines to the 3' ends of RNAs and are implicated in th

273 of interest is fused to an enzyme that adds uridines to the end of RNA.

274 nding, we modeled the saturation of cellular uridine tracts by this protein.

275 ng, explaining the preference for contiguous uridine tracts.

276 ribution of the full-length hnRNP C on short uridine tracts.

277 lice sites is coupled with longer repressive uridine tracts.

278 erevisiae Nilotinib inhibited hENT1-mediated uridine transport most potently (IC50 value, 0.7 mum) fo

279 ine transitions (G to A) and an adenosine-to-uridine transversion (A to U).

280 le in pyrimidine biosynthesis, since neither uridine treatment nor other pyrimidine biosynthesis inhi

281 Glycosylation of uridine triacetate gives products resulting from O- and

282 bstantial levels of 2'-deoxy-2'-spirooxetane uridine triphosphate (8), a potent inhibitor of the HCV

283 ed overflow metabolism allows homeostasis of uridine triphosphate and cytidine triphosphate levels at

284 (UGP) alternatively makes UDP-galactose from uridine triphosphate and galactose-1-phosphate.

285 RRP = resorufin phosphate, DUT = Dyomics-647 uridine triphosphate).

286 ting cleavage signature is the location of a uridine two nucleotides downstream in a single-stranded

287 otein editosomes catalyze pre-mRNA cleavage, uridine (U) insertion or deletion, and ligation as speci

288 e structurally diverse C5-functionalized LNA uridine (U) phosphoramidites were synthesized and incorp

289 al RNA recognition motif (RRM) known to bind uridine (U)-rich sequences.

290 Plant RNA editosomes modify cytidines (C) to uridines (U) at specific sites in plastid and mitochondr

291 Plant RNA editing modifies cytidines (C) to uridines (U) at specific sites in the transcripts of bot

292 tly controls the thiolation status of wobble-uridine (U34) nucleotides present on lysine, glutamine,

293 substituted the universally conserved bulged uridine (U51) in the P4 helix of circularly permuted Bac

294 ncludes at least two metal ions, a universal uridine (U52), and P RNA backbone moieties, but it is un

295 TKIs inhibited [(3)H]uridine uptake in a competitive manner.

296 Uridine (Urd) is a promising biochemical modulator to re

297 protecting groups for secondary alcohol and uridine ureido nitrogen are applied for simultaneous dep

298 More specifically, miRNAs that gained a 3' uridine were associated with the greatest decrease in ex

299 The five binding pockets of RRM recognize uridines with an unusual 5'-to-3' gradient of base selec

300 cancer genomes by converting cytidines into uridines within ssDNA during replication.