ライフサイエンスコーパス: urinary albumin

1 nt the development of excessive excretion of urinary albumin.

2 f the controls and was detected earlier than urinary albumin.

3 n of CKD than the current clinical standard, urinary albumin.

4 term graft loss independent of histology and urinary albumin.

5 uted to impaired kidney function (eGFR: 30%; urinary albumin: 5%) but not to inflammation.

6 Urinary albumin and creatinine concentrations were deter

7 C was measured by using a nephelometer, and urinary albumin and creatinine were measured from a spot

8 Urinary albumin and estimated glomerular filtration rate

9 Urinary albumin and N-acetyl-beta-D-glucosaminidase was

10 es and contributing to enhanced excretion of urinary albumin and recruitment/activation of inflammato

11 ater than that with eplerenone, reduction in urinary albumin, and renal protection.

12 d pressure, kidney weight/body weight ratio, urinary albumin, and urinary thiobarbituric acid-reactin

13 clude the albumin:creatinine ratio (ACR) and urinary albumin concentration (UAC) obtained from a sing

14 hin-pair coefficients of variation (CVs) for urinary albumin concentration and other urinary variable

15 After exclusion of urinary albumin concentration pairs with values below th

16 For urinary albumin concentration, exclusion of one mislabel

17 e, diabetes, serum creatinine concentration, urinary albumin concentration, previous cardiovascular e

18 ab38 knockout and control rats showed higher urinary albumin concentrations and reduced amounts of me

19 The relationship between CVD and urinary albumin content (even within the normal range) i

20 interval, 1.21-1.55; P<0.001) and increased urinary albumin-creatinine ratio (P<0.001) were identifi

21 73 m2, and microalbuminuria was defined as a urinary albumin-creatinine ratio of 30 to 300 mg/g.

22 The highest sex-specific quartile of urinary albumin-creatinine ratio was associated with a s

23 l indices of central adiposity and increased urinary albumin-creatinine ratio, which enable further r

24 ) (1.1, 1.4) versus 1.2 (1.0, 1.4)), and AUC urinary albumin-creatinine ratios 69 (40, 112) versus 58

25 h sCrry expression was maximally stimulated (urinary albumin/creatinine = 12.4 +/- 4.3 and 36.9 +/- 7

26 Kidney disease, defined as urinary albumin/creatinine ratio >/=30 mg/g and/or estim

27 beta=-0.21 per 1-SD increment; P=0.005), and urinary albumin/creatinine ratio (beta=-0.15 per 1-SD in

28 o, 1.39 per 1-SD increment; P=0.002) and log-urinary albumin/creatinine ratio (hazard ratio, 1.31 per

29 Urinary albumin/creatinine ratio also was significantly

30 , and endothelial function (homocysteine and urinary albumin/creatinine ratio) measured at the sixth

31 Further adjustment for serum cystatin C, urinary albumin/creatinine ratio, and arterial elasticit

32 sed mice had chronic renal injury, increased urinary albumin/creatinine ratios, and increased tissue

33 pulse pressure, serum fibrinogen levels and urinary albumin/creatinine ratios, and with stepwise inc

34 ultrastructural renal lesions, and measured urinary albumin/creatinine ratios, tissue oxidative stre

35 enalapril attenuated CS-induced increases in urinary albumin/creatinine ratios, tissue oxidative stre

36 Impaired renal function was determined via urinary albumin/creatinine-ratio (uACR).

37 Microalbuminuria was defined as urinary albumin: creatinine ratio between 30-300 mg/g.

38 Epidemiology Collaboration equation) and/or urinary albumin:creatinine ratio >/=30 mg/g.

39 The urinary albumin:creatinine ratio (ACR) was measured usin

40 ar pattern was observed when we adjusted for urinary albumin:creatinine ratio in place of serum creat

41 Albuminuria was defined by the urinary albumin:creatinine ratio.

42 hy Dietary Pattern was associated with lower urinary albumin:creatinine ratios, common carotid intima

43 ulated the contribution of RBP4, prealbumin, urinary albumin, eGFR, and CRP to these associations as

44 s included progression to overt proteinuria (urinary albumin excretion > or = 300 mg/d) in half of th

45 ants had albuminuria, which was defined as a urinary albumin excretion >/=30 mg/24 h.

46 d to a normoalbuminuric or macroalbuminuric (urinary albumin excretion <30 mg/24 hours and >300 mg/24

47 ient sFlt-1 mice also showed markedly higher urinary albumin excretion (467+/-74 versus 174+/-23 mug/

48 o -0.4; P=0.003) but positively with 24-hour urinary albumin excretion (beta=0.11; 95% CI, 0.01 to 0.

49 nuria, indicated by repeated measurements of urinary albumin excretion (estimated on the basis of alb

50 btained and are reliable indices of elevated urinary albumin excretion (microalbuminuria) in IDDM.

51 ase-line blood pressure predicted increasing urinary albumin excretion (P=0.006), and higher base-lin

52 We examined the association of urinary albumin excretion (spot urine albumin indexed to

53 The prevalence of elevated urinary albumin excretion (UAE) (albumin-to-creatinine r

54 An F(1) hybrid of S and SHR showed a low urinary albumin excretion (UAE) and low urinary protein

55 Urinary albumin excretion (UAE) increased significantly

56 Elevated urinary albumin excretion (UAE) is a predictor of the de

57 Twenty-four-hour urinary albumin excretion (UAE) is considered the gold s

58 The authors characterized urinary albumin excretion according to blood pressure, d

59 Here, we examined whether higher levels of urinary albumin excretion among African Americans contri

60 n in 13 type 1 diabetic subjects with normal urinary albumin excretion and 13 healthy volunteers.

61 brisentan attenuated the increases in BP and urinary albumin excretion and ameliorated endotheliosis

62 hat there is an association between elevated urinary albumin excretion and apolipoprotein B fraction

63 red the glomerular filtration rate (GFR) and urinary albumin excretion and assessed the prevalence of

64 ly overt manifestations, including increased urinary albumin excretion and decreased glomerular filtr

65 ssessed cross-sectional associations between urinary albumin excretion and dietary patterns and intak

66 iation was lost after further adjustment for urinary albumin excretion and eGFR [HR:1.15 (95% CI, 0.8

67 the frequency of a significant reduction in urinary albumin excretion and factors affecting such red

68 treatment with CTLA4-Ig prevented increased urinary albumin excretion and improved kidney pathology

69 /-1.2 vs 7.9+/-0.6 micromol/L p<0.01), while urinary albumin excretion and mesangial expansion were r

70 delay the onset and progression of increased urinary albumin excretion and reduced GFR in patients wi

71 We examined the association between urinary albumin excretion and the risks of hypertension

72 sion, extracellular matrix accumulation, and urinary albumin excretion as well as NOX4 protein expres

73 Urinary albumin excretion at 24 wk was also significantl

74 ted that treatment with sTbetaRII.Fc reduced urinary albumin excretion by 36% at 4 weeks, 59% at 8 we

75 ) with fasting lipids, apolipoprotein B, and urinary albumin excretion determined at baseline.

76 with type 1 diabetes indicates that elevated urinary albumin excretion does not imply inexorably prog

77 Decreased mGFR, metabolic syndrome, and urinary albumin excretion emerged as strong predictors o

78 Urinary albumin excretion exceeded 300 mg/d per 100 g bo

79 A risk of higher urinary albumin excretion exists at blood pressure level

80 ich was defined as a 50 percent reduction in urinary albumin excretion from one two-year period to th

81 d statistical significance with variation in urinary albumin excretion in family members with type 2

82 tive oxygen species generation and to reduce urinary albumin excretion in type 1 diabetes.

83 n and podocyte apoptosis that contributes to urinary albumin excretion in type 1 diabetes.

84 Calpain inhibition also attenuated urinary albumin excretion in ZDF rats.

85 Urinary albumin excretion is an important diagnostic and

86 The rate of urinary albumin excretion is an important risk factor fo

87 Excess urinary albumin excretion is more common in black than w

88 Urinary albumin excretion level worsened to proteinuria

89 uria may occur in diabetes and how increased urinary albumin excretion may be indicative of CV risk.

90 Elevated urinary albumin excretion may share common causal pathwa

91 in excretion (P=0.006), and higher base-line urinary albumin excretion predicted a decline in the glo

92 Urinary albumin excretion predicts blood pressure progre

93 Higher urinary albumin excretion predicts future cardiovascular

94 correlation between plasma PK levels and the urinary albumin excretion rate (AER) was also observed (

95 survival studies in NIDDM, microalbuminuria (urinary albumin excretion rate 20-200 microg/min) predic

96 to high-density lipoprotein cholesterol, and urinary albumin excretion rate and with the mean glycosy

97 Increased urinary albumin excretion rate is widely accepted as the

98 poproteins, glycosylated hemoglobin, and the urinary albumin excretion rate were measured in a centra

99 t smoking, preexisting CHD, and high initial urinary albumin excretion rate were risk factors for the

100 dex, higher von Willebrand factor levels and urinary albumin excretion rate, hypertension, and smokin

101 and proximal tubule (PT) reclamation affect urinary albumin excretion rate.

102 Whether urinary albumin excretion relates to higher levels of at

103 gher in type 1 diabetic subjects with normal urinary albumin excretion than in control subjects.

104 Urinary albumin excretion values were higher in the obes

105 Percentage change in urinary albumin excretion was 5.7% (95% CI, -0.3% to 11.

106 -0.57 g per square meter per year, P<0.001); urinary albumin excretion was reduced by 3.77% with the

107 Such modification was also observed when urinary albumin excretion was stratified into normo-, mi

108 sive, nondiabetic individuals, low levels of urinary albumin excretion well below the current microal

109 rular capillary basement membrane width, and urinary albumin excretion were increased in diabetic rat

110 Histologic evidence of glomerular injury and urinary albumin excretion were more pronounced in double

111 Glomerular morphology and urinary albumin excretion were normal in Nmt mice.

112 We assessed the relationship of urinary albumin excretion with apolipoprotein B fraction

113 xplain, in part, the association of elevated urinary albumin excretion with cardiovascular disease ri

114 protein B fractions modified associations of urinary albumin excretion with incident cardiovascular d

115 termined whether the association of elevated urinary albumin excretion with incident cardiovascular e

116 LDO pod GC-A cKO mice demonstrated increased urinary albumin excretion with marked mesangial expansio

117 FR167653 also suppressed urinary albumin excretion without reducing SBP.

118 tid ultrasound, ankle-brachial pressure, and urinary albumin excretion) and stratified by body mass i

119 nal function (glomerular filtration rate and urinary albumin excretion), and routine biochemistry sho

120 Urinary albumin excretion, an index of renal damage, was

121 omerular filtration rate, renal plasma flow, urinary albumin excretion, and blood pressure were measu

122 lar filtration rate, serum creatinine level, urinary albumin excretion, and blood pressure; the rates

123 oponin-T, high-sensitive C-reactive protein, urinary albumin excretion, and cystatin-C had similar ri

124 ation of hypertension with serum creatinine, urinary albumin excretion, and ESRD in the United States

125 The rates of decline in the estimated GFR, urinary albumin excretion, and other secondary outcomes

126 imaging, we related arterial stiffness, GFR, urinary albumin excretion, and potential mediators, incl

127 In this study, the prevalence of urinary albumin excretion, determined in 308 Pima Indian

128 Whether incremental increases in urinary albumin excretion, even within the normal range,

129 At 2 mo, inulin clearance, urinary albumin excretion, fractional albumin clearance,

130 Urinary albumin excretion, fractional albumin clearance,

131 VC suppressed urinary albumin excretion, fractional albumin clearance,

132 betic Cav2.2(-/-) mice significantly reduced urinary albumin excretion, glomerular hyperfiltration, b

133 00 mg/kg body wt/d) in the drinking water on urinary albumin excretion, glomerular transforming growt

134 anced by lack of both B1R and B2R, including urinary albumin excretion, glomerulosclerosis, glomerula

135 -B-type natriuretic peptide, troponin-T, and urinary albumin excretion, increasing model accuracy to

136 m and long-term benefits of empagliflozin on urinary albumin excretion, irrespective of patients' alb

137 Urinary albumin excretion, mesangial expansion, glomerul

138 itor, reduced systolic blood pressure (SBP), urinary albumin excretion, segmental sclerosis, podocyte

139 nce renal vascular integrity as reflected by urinary albumin excretion.

140 foot processes in the kidney glomerulus, and urinary albumin excretion.

141 trasound, ankle-brachial blood pressure, and urinary albumin excretion.

142 overlaps with genes controlling variation in urinary albumin excretion.

143 wed for 4 years with repeated assessments of urinary albumin excretion.

144 erally is assessed by measurement of GFR and urinary albumin excretion.

145 ricular-mass index, and greater reduction in urinary albumin excretion.

146 ced glomerular filtration rate and increased urinary albumin excretion.

147 r adjustment for clinical covariates such as urinary albumin excretion.

148 inhibitor type 1), and microvascular damage (urinary albumin excretion; n=2673) to incident AF (n=209

149 bstantially attenuated, but the excretion of urinary albumin factored for creatinine clearance was no

150 s did not respond to nonrenal toxicants, and urinary albumin faithfully reflected alterations in rena

151 These results show that the generation of urinary albumin fragments occurs independently of renal

152 athophysiological implications of changes in urinary albumin fragments require reevaluation.

153 degradation of albumin forms the detectable urinary albumin fragments.

154 n reabsorbing, processing, and transcytosing urinary albumin from the glomerular filtrate.

155 e utility of measuring plasma creatinine and urinary albumin, has been almost entirely focused on the

156 Concomitant normal levels of urinary albumin, IgM and RBP identified normal histology

157 S have suggested that binding of diuretic to urinary albumin is one of the mechanisms that may be ope

158 Proteinuria (urinary albumin level and albumin/creatinine ratio) was

159 in diet significantly slowed the increase in urinary albumin level or the decline in glomerular filtr

160 Urinary albumin levels increased but reversed on discont

161 Urinary albumin levels increased, with tinnitus and atri

162 uclear factor-kappaB activity, and increased urinary albumin levels, all of which is similar to chang

163 ose and HbA1c levels, retinopathy, lipid and urinary albumin levels, cardiovascular events, hypoglyce

164 hose MPs in nondiabetic mice, despite normal urinary albumin levels.

165 It is unknown at what threshold of urinary albumin loss HDL structure is altered, and it is

166 r composite (3.8 vs 3.7, P = .93), or year 5 urinary albumin (median, 7.5 vs 7.4 mg/g of creatinine,

167 increased baseline systolic blood pressure, urinary albumin, plasma creatinine, and Indian-Asian eth

168 ea under the curve [AUC] 0.93) compared with urinary albumin routinely used to determine the diagnosi

169 Patients with glomerular lesions had higher urinary albumin than those with normal histology, while

170 s a critical mechanism for excessive loss of urinary albumin that eventuates in kidney fibrosis.

171 Albuminuria was defined as a ratio (mg/g) of urinary albumin to creatinine of >/=30.

172 The urinary albumin to creatinine ratio (ACR) assessed in a

173 Biomarkers included urinary IL-18, urinary albumin to creatinine ratio (ACR), and urinary a

174 he prevalence and prognostic value of a spot urinary albumin to creatinine ratio (UACR) in patients w

175 5 years with proteinuria (first morning void urinary albumin to creatinine ratio [UACR] 100-3000 mg/g

176 gression, on the basis of either eGFR or the urinary albumin to creatinine ratio, in MESA participant

177 ption and rate of eGFR decline or changes in urinary albumin to creatinine ratio.

178 +/- 1, mutant versus control), albuminuria (urinary albumin to creatinine ratio: 23 +/- 15 versus 0.

179 ities of urinary trefoil factor 3 (TFF3) and urinary albumin to detect acute renal tubular injury hav

180 In the subgroup of patients with baseline urinary albumin-to-creatinine ratio >/=30 mg/g, urinary

181 1.73 m(2) and macroalbuminuria defined by a urinary albumin-to-creatinine ratio >300 mg/g, were rand

182 th diabetes duration >20 years and a maximum urinary albumin-to-creatinine ratio <150 mg/g.

183 er 1 SD increment in the log values) and the urinary albumin-to-creatinine ratio (1.20).

184 (1.40), C-reactive protein level (1.39), the urinary albumin-to-creatinine ratio (1.22), homocysteine

185 ifferences in Stroke (REGARDS) study who had urinary albumin-to-creatinine ratio (ACR) and estimated

186 lar filtration rate (eGFR(cys)) and measured urinary albumin-to-creatinine ratio (ACR) in 10 328 men

187 We examined race-stratified associations of urinary albumin-to-creatinine ratio (ACR) in 2 groups: (

188 ing pairs, as well as the quantitative trait urinary albumin-to-creatinine ratio (ACR), were performe

189 al of 1,269 subjects had UAE measured as the urinary albumin-to-creatinine ratio (ACR).

190 diet (food-frequency questionnaire) and the urinary albumin-to-creatinine ratio (ACR; spot urine col

191 Urinary albumin-to-creatinine ratio (albuminuria) was ca

192 GFR-associated SNPs for association with the urinary albumin-to-creatinine ratio (UACR) and albuminur

193 Here, we report urinary albumin-to-creatinine ratio (UACR) data for the

194 cts with eGFR >20 ml/min per 1.73 m(2) and a urinary albumin-to-creatinine ratio (UACR) of 100 to 300

195 variants in CUBN, encoding cubilin, with the urinary albumin-to-creatinine ratio (UACR) were confirme

196 per day) to patients with type 2 diabetes, a urinary albumin-to-creatinine ratio (with albumin measur

197 ral pulse wave velocity associated with both urinary albumin-to-creatinine ratio and microalbuminuria

198 tion was stratified on the basis of baseline urinary albumin-to-creatinine ratio and presence of card

199 rular barrier dysfunction assessed using the urinary albumin-to-creatinine ratio and urinary ratio of

200 we identified B-type natriuretic peptide and urinary albumin-to-creatinine ratio as key risk factors

201 nary albumin-to-creatinine ratio >/=30 mg/g, urinary albumin-to-creatinine ratio decreased more with

202 elimination, B-type natriuretic peptide and urinary albumin-to-creatinine ratio emerged as key bioma

203 Loci suggestive for linkage to urinary albumin-to-creatinine ratio included 1q, 6p, 9q,

204 Estimated GFR, blood pressure, and the urinary albumin-to-creatinine ratio increased significan

205 ior), we observed a significant reduction in urinary albumin-to-creatinine ratio of 15.7% (ratio 0.84

206 B-type natriuretic peptide and urinary albumin-to-creatinine ratio significantly improv

207 Urinary albumin-to-creatinine ratio was calculated in mi

208 respectively) and the mean reduction in the urinary albumin-to-creatinine ratio was greater (between

209 emonstrate that dh404 attenuates functional (urinary albumin-to-creatinine ratio) and structural (mes

210 renin ratio, B-type natriuretic peptide, and urinary albumin-to-creatinine ratio).

211 ohort (R=-0.52 for estimated GFR, R=0.22 for urinary albumin-to-creatinine ratio, and R=0.17 for urin

212 of follow-up, after adjustment for baseline urinary albumin-to-creatinine ratio, eGFR, and Hb1Ac.

213 calize gene regions influencing variation in urinary albumin-to-creatinine ratio, we performed a link

214 inhibitor type 1, and homocysteine; and the urinary albumin-to-creatinine ratio.

215 aortic pulsed wave velocity, cystatin C, and urinary albumin-to-creatinine ratio.

216 wave velocity by magnetic resonance imaging; urinary albumin-to-creatinine ratio; and cystatin C were

217 rasentan (7.5 mg/kg/day) for 4 weeks reduced urinary albumin-to-creatinine ratios by 26.0 +/- 6.5% (P

218 n, the more Lambeta1 was expressed, the less urinary albumin was excreted.

219 F3 protein levels were markedly reduced, and urinary albumin were markedly increased in response to r