ライフサイエンスコーパス: urogenital

1 (pelvic organ prolapse, colorectal-anal, and urogenital).

2 Nine patients (32%) had an underlying urogenital abnormality.

3 ing presumption that anatomic differences in urogenital anatomy confer protection from UTI in males;

4 al structures of the body plan including the urogenital and anorectal complex, and the perineum regio

5 y vertebrate group to divide the cloaca into urogenital and anorectal portions, exhibit complex muscl

6 The urogenital and anorectal sinuses develop from the embryo

7 hypoplastic perineum tissue between external urogenital and anorectal tracts; hypospadias - ectopic v

8 ic exchange has manifested itself in ocular, urogenital and LGV C. trachomatis strains, including the

9 element, ECR1, which is active in developing urogenital and other tissues; we propose that disruption

10 for the study of human Chlamydia trachomatis urogenital and respiratory tract infections.

11 Oropharyngeal, urogenital, and gastrointestinal tissues along with bloo

12 ow birth weight are strong predictors of the urogenital anomalies cryptorchidism (undescended testis)

13 tors cause both fetal growth restriction and urogenital anomalies was supported by comparison of urog

14 hearing loss, cardiovascular malformations, urogenital anomalies, and growth retardation.

15 e co-twin was associated with higher risk of urogenital anomalies, suggesting an effect of relative f

16 The etiologies of the male urogenital anomalies--cryptorchidism and hypospadias--ar

17 etal growth restriction as a risk factor for urogenital anomalies.

18 tly of birth weight were not associated with urogenital anomalies.

19 ner-Wunderlich syndrome is a rare congenital urogenital anomaly characterised by uterus didelphys wit

20 tal anomalies was supported by comparison of urogenital anomaly risks in singletons and twins and by

21 udy, we find that, when mice investigate the urogenital areas of a conspecific animal, the urinary ph

22 ibitors (AI) are associated with significant urogenital atrophy, affecting quality of life and drug c

23 Based on our analyses, all but one previous urogenital B serotype was identified as Ba.

24 Chlamydia muridarum, a murine model of human urogenital C. trachomatis, with severely attenuated dise

25 rogens to enhance production of female mouse urogenital cancers.

26 pared with azithromycin for the treatment of urogenital chlamydia and about 7% increased efficacy for

27 omycin with doxycycline for the treatment of urogenital chlamydia infection among adolescents in yout

28 on receiving directly observed treatment for urogenital chlamydia infection, the efficacy of azithrom

29 ne twice daily (7 days) for the treatment of urogenital chlamydia infection.

30 fficacy of azithromycin for the treatment of urogenital chlamydia infection.

31 Urogenital Chlamydia serovars replicating in reproductiv

32 Urogenital Chlamydia trachomatis infection remains preva

33 noninferior to Vibramycin for uncomplicated urogenital chlamydia treatment, better tolerated, and de

34 ly for 7 days for treatment of uncomplicated urogenital chlamydia.

35 nd nonpregnant women aged 19-45 years with a urogenital chlamydial diagnosis or a sexual partner with

36 erence strains and 10 present-day ocular and urogenital clinical isolates using phylogenetic reconstr

37 capsule biosynthetic genes, indicating that urogenital colonization and urethritis caused by N. meni

38 i previously suggested to be associated with urogenital colonization.

39 pharyngeal GC, 10.2% for rectal GC, 8.4% for urogenital CT, 2.9% for pharyngeal CT, and 14.1% for rec

40 haryngeal GC, 50.4% for rectal GC, 81.4% for urogenital CT, 31.7% for pharyngeal CT, and 45.9% for re

41 und that Shh mutant fetuses display abnormal urogenital development and fail to form prostate buds.

42 ritical regulatory roles in neurological and urogenital development and the development of cardiac di

43 m 1 is a homeobox gene required for head and urogenital development in the mouse but most Lim 1-defic

44 1) gene plays an important role in mammalian urogenital development, and dysregulation of this gene i

45 in the epigenetic control of germ-cell fate, urogenital development, and gamete functions.

46 ular requirements for Dlg1 expression during urogenital development, we used a floxed Dlg1 allele and

47 immediately downstream of Wt1 during murine urogenital development.

48 able genetic reagents for in vivo studies of urogenital development.

49 rom the same primordium present during early urogenital development.

50 of steroidogenic cell differentiation during urogenital development.

51 null allele of Dlgh1 and studied its role in urogenital development.

52 echanisms underlying heart morphogenesis and urogenital development.

53 mutant mice die perinatally due to defective urogenital development.

54 ecognized, roles in multiple lineages during urogenital development.

55 e an important tool for researchers studying urogenital development/malformation in mouse models and

56 ulted in distinct phenotypes, with heart and urogenital developmental defects in Osr1(-/-) mice and w

57 with severe forms of mental retardation and urogenital developmental defects.

58 st divergent, compared to ocular and non-LGV urogenital disease groups.

59 ium has been associated with male and female urogenital disease syndromes, including urethritis, cerv

60 ns by which vaginal microbiomes help prevent urogenital diseases in women and maintain health are poo

61 ell and the causative agent of a spectrum of urogenital diseases.

62 apy yielded better outcomes over time on the Urogenital Distress Inventory and the Overactive Bladder

63 , defined as a reduction in the score on the Urogenital Distress Inventory of 70% or more and a respo

64 re, manifested as orthostatic hypotension or urogenital dysfunction, with combinations of parkinsonis

65 >1 Mbp of genomic DNA surrounding Gata2 for urogenital enhancer activity.

66 separate regionally and temporally specific urogenital enhancer elements, two of which reside far 3'

67 particularly to the presence of an essential urogenital enhancer located near the translocation break

68 Tbx18, identify a novel and likely essential urogenital enhancer, and introduce a new tool for dissec

69 tudies have shown that the hematopoietic and urogenital enhancers are located hundreds of kbp 5' and

70 ene as well as the distant hematopoietic and urogenital enhancers into a single, contiguous piece of

71 s in the United States may have adapted to a urogenital environment by loss of capsule and gene conve

72 s of the parasite during its transition to a urogenital environment.

73 aining biallelic inactivation of Pten in the urogenital epithelia.

74 twitching motility, and attachment to human urogenital epithelial cells were not restored by express

75 e a tissue-specific requirement for FGFR2 in urogenital epithelial cells--the precursors of prostatic

76 (i) T. vaginalis disruption of urogenital epithelial monolayers could facilitate passag

77 develops by branching morphogenesis from the urogenital epithelium and mesenchyme.

78 specifically inactivate Rb and/or p53 in the urogenital epithelium and the intestine.

79 elopmental signals may be interpreted in the urogenital epithelium to regulate branching morphogenesi

80 ouse line that conditionally deletes Pten in urogenital epithelium.

81 Notch1 signaling is derepressed in BMP7 null urogenital epithelium.

82 men at both visual inspection and palpation; urogenital examination revealed a small left-sided palpa

83 The rescuing YAC did not display appropriate urogenital expression of Gata2, implying the existence o

84 strate a strong association between abnormal urogenital findings and detection of myoplasmas, particu

85 Of 21 994 MSM, 83.9% were tested for urogenital GC, 65.9% for pharyngeal GC, 50.4% for rectal

86 Of MSM tested, 11.1% tested positive for urogenital GC, 7.9% for pharyngeal GC, 10.2% for rectal

87 who have sex with men (MSM) be screened for urogenital GC/CT, rectal GC/CT, and pharyngeal GC.

88 ged 15-60 years diagnosed with uncomplicated urogenital gonorrhea were randomly assigned to either ge

89 ntimicrobials for treatment of patients with urogenital gonorrhea.

90 mycin were highly effective for treatment of urogenital gonorrhea.

91 ovars, E and F, clustered distantly from the urogenital group for five pmp genes.

92 Finally, women with C. trachomatis urogenital infection developed high titers of antibodies

93 tridial toxin homologs, suggesting a role in urogenital infection or pathogenesis.

94 y, antibodies from women with C. trachomatis urogenital infection preferentially recognized proteins

95 emotherapy, control of Chlamydia trachomatis urogenital infection will likely require a vaccine.

96 Urogenital infection with Chlamydia trachomatis in some

97 primary outcome was microbiological cure of urogenital infections (negative follow-up culture) at 10

98 nt human pathogen responsible for a range of urogenital infections and pathologies.

99 esins of the Dr/Afa family frequently causes urogenital infections during pregnancy in humans and has

100 ae, CT795, elicit strong immune responses in urogenital infections, but their role in trachomatous di

101 ith men, and is increasingly associated with urogenital infections.

102 ncrease LDL cholesterol and the incidence of urogenital infections.

103 ortal fibrosis with portal hypertension, and urogenital inflammation and scarring.

104 We report that a common urogenital inhabitant and opportunistic pathogen, group

105 e mice intravaginally with a human serovar D urogenital isolate that had undergone multiple in vitro

106 ched into clades that were separate from the urogenital isolates.

107 tal complications is enhanced after ART, and urogenital malformations can be present in boys, even in

108 gin of upper vagina fails to explain complex urogenital malformations like OHVIRA syndrome; the Acien

109 For instance, compared with the incidence of urogenital malignancies in the control (0%), arsenic alo

110 BMP7 is expressed in the periurethral urogenital mesenchyme prior to formation of the prostate

111 ttenuated for Tak1 were engrafted with fetal urogenital mesenchyme, the histopathology of the grafts

112 were tested by serial recombination with rat urogenital mesenchyme.

113 1 gram of azithromycin for the treatment of urogenital MG has decreased to approach 60%.

114 participants aged >/=12 years diagnosed with urogenital MG, and had microbial cure measured within 12

115 he zebrafish may offer insights into midline urogenital migration anomalies in humans.

116 lformations has evolved to include the total urogenital mobilization and an appreciation of the compl

117 malian embryo, DLGH1 is essential for normal urogenital morphogenesis and the development of skeletal

118 ally transmitted pathogens that colonize the urogenital mucosa.

119 presence of polyamines in fluids that bathe urogenital mucosal surfaces could alter the susceptibili

120 restricted pathogen that primarily colonizes urogenital mucosal surfaces.

121 Future urogenital Nm infection studies should focus on pathogen

122 evelopment of the cloaca (the common gut and urogenital opening).

123 Thirty-seven ocular, urogenital, or nasal swabs were obtained from 21 wild we

124 intracranial hemorrhage or gastrointestinal, urogenital, or other bleeding.

125 ular biology and pathogenesis of this unique urogenital organism.

126 onstrated as an important chromosome-encoded urogenital pathogenicity factor of C. muridarum and the

127 to determine its individual contribution to urogenital pathogenicity.

128 h hematopoietic progenitor cell function and urogenital patterning.

129 ation of the prostate gland by examining the urogenital phenotype of Shh mutant fetuses.

130 ncreased risk for retrograde ejaculation and urogenital problems.

131 fidence interval [CI], 1.6-37), history of a urogenital procedure (OR, 5.4; 95% CI, 2-14.7), and pres

132 effector of peptide hormone signaling during urogenital ridge development as evidenced by both the ac

133 a telomeric regulator is required for proper urogenital ridge differentiation, axial skeleton specifi

134 osit a cord of cells along the length of the urogenital ridge.

135 k3 and Smad8, but downregulates Smad5 in the urogenital ridge.

136 lopmental defects in organs derived from the urogenital ridge.

137 tive interactions and lateral input from the urogenital ridges are required to drive HSC development

138 The MDs of urogenital ridges from mutant female embryos showed less

139 nges in the elongating Mullerian duct in rat urogenital ridges in organ culture manipulated by microi

140 coelomic epithelium of both male and female urogenital ridges, and then migrate into the mesenchyme

141 Discarded urogenital samples from 7,593 women (18 to 89 years old)

142 To accomplish this, 507 urogenital samples from a multicenter U.S. study were an

143 ccelerate discoveries in the pathogenesis of urogenital schistosomiasis (UGS): (1) comparative genomi

144 rcinogenesis and infertility associated with urogenital schistosomiasis and discuss the basic hormona

145 his outbreak, showing how easily and rapidly urogenital schistosomiasis can be introduced and spread

146 approach to investigate the epidemiology of urogenital schistosomiasis in Corsica, aiming to elucida

147 es, as appears to be the case with increased urogenital schistosomiasis in humans around Lake Malawi

148 Urogenital schistosomiasis is a major public health prob

149 stosoma mansoni infections, the pathology of urogenital schistosomiasis is related mainly to the egg

150 he summer of 2013, an unexpected outbreak of urogenital schistosomiasis occurred in Corsica, with mor

151 ns, we combined the first tractable model of urogenital schistosomiasis with an established mouse mod

152 We combined a mouse model of urogenital schistosomiasis with macrophage-depleting lip

153 e blood fluke Schistosoma haematobium causes urogenital schistosomiasis, a neglected tropical disease

154 developing world, is the causative agent of urogenital schistosomiasis, and is associated with a hig

155 Urogenital schistosomiasis, caused by Schistosoma haemat

156 Urogenital schistosomiasis, caused by the parasitic trem

157 nvestigational diagnostic tests utilized for urogenital schistosomiasis, highlighting new insights an

158 Urogenital schistosomiasis, infection with Schistosoma h

159 Urogenital schistosomiasis, Schistosoma haematobium worm

160 Despite the significant global impact of urogenital schistosomiasis, the mechanisms of bladder gr

161 eventing or treating the bladder sequelae of urogenital schistosomiasis.

162 dicating that macrophages prevent death from urogenital schistosomiasis.

163 ma haematobium worms, the etiologic agent of urogenital schistosomiasis.

164 Chlamydia trachomatis urogenital serovars replicate predominantly in genital t

165 ing natural infections Chlamydia trachomatis urogenital serovars replicate predominantly in the epith

166 The mammalian urogenital sinus (UGS) develops in a sex specific manner

167 conditionally delete or stabilize Ctnnb1 in urogenital sinus (UGS) epithelium from which the prostat

168 rostate development, epithelial cells in the urogenital sinus (UGS) express Sonic Hedgehog (Shh) and

169 velopment by regulating Ar expression in the urogenital sinus (UGS) from which the prostate derives.

170 Urogenital sinus (UGS) isolated from p63(+/+) and p63(-/

171 ired for normal prostate ductal budding, the urogenital sinus (UGS) of the Gli2(-/-) mutant mouse dis

172 ncomplete separation of the hindgut from the urogenital sinus (UGS), absence of the ventral mesenchym

173 e prostate gland develops from the embryonic urogenital sinus (UGS).

174 tic buds as they emerge from the fetal mouse urogenital sinus (UGS).

175 syndrome (n=4), meningomyelocele (n=2), and urogenital sinus abnormality (n=1).

176 The mammalian prostate arises from the urogenital sinus and few factors have been identified to

177 ortion of the nephric duct did not reach the urogenital sinus at embryonic day 10.5, formation of the

178 differentiated cells lining the lumen of the urogenital sinus but not in rapidly dividing, Ki67 posit

179 3 prevents intestinal differentiation of the urogenital sinus endoderm and is therefore required to m

180 Foxa1 expression marks the entire embryonic urogenital sinus epithelium (UGE), contrasting with Shh

181 promoter activates at embryonic day 11.5 in urogenital sinus epithelium, we generated a conditional

182 and basal cells - both of which develop from urogenital sinus epithelium.

183 e found that DeltaNp63-positive cells of the urogenital sinus generated all epithelial lineages of th

184 hich may account for development of a single urogenital sinus in females exposed to excessive androge

185 assaged spheres were recombined with E17 rat urogenital sinus mesenchyme and grafted in vivo, they ge

186 prostate tissue when combined with embryonic urogenital sinus mesenchyme and grafted in vivo.

187 s in a coculture system: Compared with mouse urogenital sinus mesenchyme or normal prostate fibroblas

188 a and also exert morphogenic effects via the urogenital sinus mesenchyme.

189 of prostate epithelial buds into surrounding urogenital sinus mesenchyme.

190 elongation of the Mullerian duct towards the urogenital sinus occurs in part by proliferation at the

191 with the secretory and basal cells being of urogenital sinus origin.

192 of which is thought to be assimilated by the urogenital sinus primordial mesenchyme in males during f

193 but the mechanism for its elongation to the urogenital sinus remains to be defined.

194 ina depends on sexual differentiation of the urogenital sinus ridge, an epithelial thickening that fo

195 Importantly, our urogenital sinus transplantation studies demonstrate tha

196 tigen was present in epithelial cells of the urogenital sinus when endogenous androgen levels were hi

197 ia, masculinization of the urethra, a single urogenital sinus, and clitoral hypertrophy or ambiguous

198 Epithelial cells isolated from the fetal urogenital sinus, the newborn, and adult prostate formed

199 controversial: a stem cell hypothesis with a urogenital sinus-derived progeny of all prostatic epithe

200 s the cloaca into dorsal hindgut and ventral urogenital sinus.

201 ith the Wolffian duct as it elongates to the urogenital sinus.

202 tips are enlarged and fail to merge with the urogenital sinus.

203 ession of Gata2, implying the existence of a urogenital-specific enhancer(s) lying outside the bounda

204 otic resistance phenotype were determined in urogenital specimens collected from female and male subj

205 Pooling urogenital specimens for the detection of Chlamydia trac

206 ing was performed on C. trachomatis-positive urogenital specimens obtained from patients at enrollmen

207 Urogenital specimens were obtained from 13 patients who

208 The striated urogenital sphincter, the smooth muscle sphincter in the

209 polymorphic among C. trachomatis ocular and urogenital strains.

210 nvolve the cardiovascular, gastrointestinal, urogenital, sudomotor, and pupillomotor systems, occur i

211 erplasia (56% vs 19%; P = .04), a history of urogenital surgery (63% vs 28%; P = .001), and presentat

212 male endocervical swabs and 84 male urine or urogenital swab specimens) were screened using the COBAS

213 tis and Neisseria gonorrhoeae from urine and urogenital swab specimens.

214 perative to understanding these inflammatory urogenital syndromes, particularly in females, consideri

215 e, nerves/ganglia and epithelia of the lower urogenital system are also presented.

216 ecific functions for Gata2 in the developing urogenital system are conferred by at least three separa

217 The vertebrate urogenital system forms due to inductive interactions be

218 To date, there is no case of penile or urogenital system metastasis from CCA described in the l

219 ous studies have investigated defects in the urogenital system of Foxc1 null mutants, but the mechani

220 confirmed Nrip1 expression in the developing urogenital system of the mouse.

221 To identify lineages within the developing urogenital system that have a cell-autonomous requiremen

222 Arsenic alone induced some urogenital system tumors, including mostly benign tumors

223 for bacteria and harmful substances into the urogenital system, but not in further centrally located

224 Pax2 is essential for the development of the urogenital system, neural tube, otic vesicle, optic cup

225 ssential for development of the neural tube, urogenital system, optic vesicle, optic cup and optic tr

226 er DLG1 and CASK cooperate in the developing urogenital system, we generated mice deficient in both D

227 ional regulators in the developing mammalian urogenital system.

228 oinformaticians interested in the developing urogenital system.

229 fully recapitulated GATA-3 expression in the urogenital system.

230 udy the morphogenesis of this portion of the urogenital system.

231 chestrating the development of the mammalian urogenital system.

232 athways in the organization of the mammalian urogenital system.

233 gulating diverse components of the mammalian urogenital system.

234 nic epithelium of the hindgut and within the urogenital system.

235 eventing infection of internal organs of the urogenital system.

236 ption factor critical for development of the urogenital system.

237 Pax2 is essential for the development of the urogenital system.

238 eloped an anatomical ontology for the murine urogenital system.

239 ains protein 2 (FHL2) is highly expressed in urogenital systems and has been implicated in Wnt/beta-c

240 mice, we identified a previously unreported urogenital tissue for Lim1 expression, the epithelium of

241 e significance of the HDPs in protecting the urogenital tissues from infection.

242 Urinary stasis, surgical disruption of urogenital tissues, and a bacterial capsule characterist

243 ed as early as embryonic day 13 (E13) in the urogenital track.

244 n 88.2% of the patients), lungs (26.4%), the urogenital tract (17.6%), and eyes (8.8%).

245 cific types of visceral pain, related to the urogenital tract (n=3), to the gastrointestinal tract (n

246 which is distinct from the lineages causing urogenital tract (UGT) and lymphogranuloma venerum disea

247 olecular anatomy of the developing mammalian urogenital tract (UGT).

248 eaplasma species commonly colonize the adult urogenital tract and are implicated in invasive diseases

249 of a decrease in average wet weights of the urogenital tract and prostate gland in 1 and 2 mg DATS-t

250 Infection of the urogenital tract by C. trachomatis causes chronic inflam

251 ection with Chlamydia muridarum in the mouse urogenital tract can induce both protective immunity and

252 t, emphasising its etiology as a disorder of urogenital tract development.

253 te that binds to the epithelium of the human urogenital tract during infection.

254 So far, the urogenital tract has been considered to lack this cell t

255 Trichomonas vaginalis is a parasite of the urogenital tract in men and women, with a worldwide pres

256 leading cause of preventable blindness, and urogenital tract infection by Chlamydia causes sexually

257 Mycoplasma genitalium causes persistent urogenital tract infection in humans.

258 ways, was evaluated in a Chlamydia muridarum urogenital tract infection model.

259 ix metalloproteinases in Chlamydia muridarum urogenital tract infection of female mice.

260 yndrome is a very rare congenital anomaly of urogenital tract involving Mullerian ducts and mesonephr

261 upport of the first hypothesis, here we show urogenital tract isolates representing the most common P

262 Trichomonas vaginalis colonizes the urogenital tract of humans and causes trichomonosis, the

263 Mycoplasma penetrans is a urogenital tract pathogen implicated in the deterioratio

264 Malformation of the urogenital tract represents a considerable paediatric bu

265 endocrine, not epithelial, origin within the urogenital tract to give prostate cancer in the males an

266 phenotype, suppressing absolute and relative urogenital tract weights by 86% and 85%, respectively, a

267 ored the innate protective mechanisms of the urogenital tract with the aim of boosting such defences

268 shedding of viable chlamydiae from the lower urogenital tract, but the administration of either MMPi

269 During development of the urogenital tract, fibroblast growth factor 8 (Fgf8) is e

270 rvum, an opportunistic pathogen of the human urogenital tract, has been implicated in contributing to

271 , involved in the development of the kidney, urogenital tract, pancreas, liver, brain, and parathyroi

272 a survival or transmission advantage in the urogenital tract, perhaps via increased resistance to co

273 t pH values found in the body and the female urogenital tract, respectively.

274 hronically contaminate and infect the female urogenital tract, thereby potentially contributing to th

275 pulation rather than novel adaptation to the urogenital tract.

276 nizes the nasopharynx and rarely infects the urogenital tract.

277 in the developing intermediate mesoderm and urogenital tract.

278 mitted, opportunistic pathogens of the human urogenital tract.

279 biology of chlamydial dissemination from the urogenital tract.

280 al surfaces of the gut, the airways, and the urogenital tract.

281 hat orchestrate embryonic development of the urogenital tract.

282 bacterial pathogen that infects the eyes and urogenital tract.

283 by adhering to the mucosal epithelium of the urogenital tract.

284 xhibit distinct organotropism for the eye or urogenital tract.

285 ver enzymes, and congenital anomalies of the urogenital tract.

286 formation of the anal canal and parts of the urogenital tract.

287 a, is capable of invading and colonizing the urogenital tract.

288 l resident of the human gastrointestinal and urogenital tracts and also a prevalent fungal pathogen.

289 of other proinflammatory cytokines in mouse urogenital tracts during the early stages of the infecti

290 zing the rectum and the gastrointestinal and urogenital tracts of adults, but it can be transmitted t

291 omatically colonize the gastrointestinal and urogenital tracts of adults.

292 The addition of Gdnf protein to urogenital tracts taken from Gdf11 null embryos induced

293 lar courses of chlamydial infection in their urogenital tracts, suggesting that Chlamydia-activated c

294 encoding human VAMP7 mimicked the defective urogenital traits observed in boys with masculinization

295 after in utero arsenic, it greatly enhanced urogenital tumor incidence, multiplicity, and progressio

296 Of the urogenital tumors induced by arsenic plus diethylstilbes

297 Tamoxifen alone did not increase urogenital tumors or affect arsenic-induced neoplasia bu

298 he newly recognized association of PVAN with urogenital tumors.

299 cally, inducing a 48% incidence of malignant urogenital tumors.

300 geted therapy in solid tumors, including the urogenital tumors.