ライフサイエンスコーパス: uromodulin

1 esponsible for the physiological cleavage of uromodulin.

2 by mutations in the UMOD gene, which encodes Uromodulin, a glycosylphosphatidylinositol-anchored prot

3 correlation found between urinary levels of uromodulin and markers of UTIs in the general population

4 Variants in UMOD, which encodes uromodulin, are associated with renal function, and urin

5 Common variants in the UMOD gene encoding uromodulin, associated with risk of hypertension and CKD

6 Uromodulin-associated kidney disease (UAKD) is caused by

7 ameliorating the progressive renal damage in uromodulin-associated kidney diseases.

8 damage that exposes the renal interstitium, uromodulin becomes an endogenous danger signal.

9 Our findings define a key aspect of uromodulin biology and identify the first in vivo substr

10 They also provide insights into uromodulin biology and the association of UMOD variants

11 ase UMOD expression and urinary excretion of uromodulin, causing salt-sensitive hypertension and rena

12 enle's loop cells with wild-type and mutated uromodulin cDNA were evaluated to test this hypothesis.

13 Higher serum uromodulin concentration associated with a favorable met

14 set, we tested the genotype association with uromodulin concentration in the Atherosclerosis Risk in

15 Adding serum uromodulin concentration to established cardiovascular r

16 dy, we investigated the association of serum uromodulin concentration with cardiovascular biomarkers

17 Low urinary uromodulin concentrations have been associated with incr

18 We observed lower urinary uromodulin concentrations per each copy of the C allele

19 In summary, elevated uromodulin concentrations precede the onset of CKD and a

20 Geometric means of uromodulin concentrations were 51% higher in case than i

21 Uromodulin concentrations were available in 3057 of 3316

22 Baseline urinary uromodulin concentrations were related to case-control s

23 loop cells that were transfected with mutant uromodulin constructs.

24 Uromodulin contains three epidermal growth factor (EGF)-

25 Familial hyperuricemia due to uromodulin deficiency precedes but does not cause kidney

26 Full release of IL-1beta in response to uromodulin depended on priming of pro-IL-1beta expressio

27 itro abnormalities and to be the only mutant Uromodulin detected in conditioned medium from transfect

28 However, the genetic factors regulating uromodulin excretion are unknown.

29 spheric vancomycin aggregates entangled with uromodulin explained the vancomycin-associated ARF.

30 ion among DDAH1 expression, NO activity, and uromodulin expression supported by data from both animal

31 As a consequence of uromodulin gene mutations, individuals develop precociou

32 e similar clinical disorders associated with uromodulin gene mutations.

33 the progressive renal damage associated with uromodulin gene mutations.

34 The mutant Uromodulins had significantly delayed maturation, retent

35 allele, driving higher urinary excretion of uromodulin, has been kept at a high frequency because of

36 s, and sensitive assays for the detection of uromodulin in blood have become available.

37 dulin (UMOD) gene is associated with reduced uromodulin in the proximal tubule cilia.

38 However, measuring uromodulin in urine has several preanalytic drawbacks, a

39 e zona pellucida sperm binding proteins, and uromodulin, In addition, there is a repeat of a motif ca

40 Each study measured uromodulin indexed to creatinine and conducted linear re

41 In addition, uromodulin-induced secretion of mature IL-1beta depended

42 Taken together, these data suggest that uromodulin is a NLRP3 agonist handled by antigen-present

43 Uromodulin is expressed exclusively in the thick ascendi

44 The mucoprotein uromodulin is the most abundant protein in mammalian uri

45 Uromodulin is the most abundant protein in the urine.

46 Tamm-Horsfall protein (THP), also known as uromodulin, is a kidney-specific protein produced by cel

47 Here, we noted that uromodulin isolated from human urine aggregates to large

48 , had the strongest association with urinary uromodulin levels (P<0.001).

49 Whether uromodulin levels associate with UMOD variants or with t

50 associated with renal function, and urinary uromodulin levels may be a biomarker for kidney disease.

51 ers of a G allele of this variant had higher uromodulin levels than noncarriers did (geometric means

52 We conducted a meta-analysis of urinary uromodulin levels to identify associated common genetic

53 e UMOD promoter region may influence urinary uromodulin levels.

54 J1, SORL1, and CAB39 associated with urinary uromodulin levels.

55 d in the thick ascending limb associate with uromodulin levels.

56 Uromodulin mainly exerts its function as an extracellula

57 Uromodulin may, therefore, be a useful marker for cardio

58 Thus, FJHN-causing Uromodulin mutants are retained in the ER, with impaired

59 cking, thereby indicating mechanisms whereby Uromodulin mutants may cause the phenotype of FJHN.

60 These uromodulin nanoparticles activated isolated human monocy

61 Activation of NLRP3 required phagocytosis of uromodulin particles into lysosomes, cathepsin leakage,

62 ach, including extensive characterisation of uromodulin processing in cellular models and in specific

63 we generated a transgenic mouse in which the uromodulin promoter controlled expression of human HO-1.

64 tions in the UMOD gene, resulting in altered uromodulin protein in the gout-associated disorders fami

65 expression exacerbates renal injury through uromodulin-related mechanisms.

66 netic studies of urate transportation and of uromodulin-related nephropathy emphasize the pivotal imp

67 Kidney-specific DAMPs include crystals and uromodulin released by renal tubular damage.

68 al cells to secrete IL-1beta may explain why uromodulin remains immunologically inert inside the lumi

69 n the region of the UMOD gene, which encodes uromodulin (Tamm-Horsfall protein), associate with chron

70 r CKD is clear, because the encoded protein, uromodulin (Tamm-Horsfall protein), is exclusively produ

71 ut not the prevalent soluble urinary protein uromodulin (Tamm-Horsfall protein), potently inhibited g

72 dies suggest that pathologic accumulation of uromodulin/Tamm-Horsfall glycoprotein (THP) occurs in th

73 Uromodulin/Tamm-Horsfall protein is not immunostimulator

74 ry with roles for proteolytic degradation of uromodulin (UMOD) and several collagens, including COL1A

75 impairment attributable to mutations of the uromodulin (UMOD) gene is associated with reduced uromod

76 disease (UAKD) is caused by mutations in the uromodulin (UMOD) gene that result in a misfolded form o

77 We previously reported that Uromodulin (UMOD) protects against nephrolithiasis by up

78 Uromodulin (UMOD)-associated kidney disease (UAKD) belon

79 Uromodulin (UMOD)/Tamm-Horsfall protein, the most abunda

80 atio of CKD per 1-SD higher concentration of uromodulin was 1.72 (95% confidence interval 1.07 to 2.7

81 Wild-type and mutant Uromodulins were functionally studied by expression in H

82 In conclusion, the interaction of uromodulin with nanospheric vancomycin aggregates repres