ライフサイエンスコーパス: urothelium

1 amina propria) and targeting the epithelium (urothelium).

2 fections without causing lasting harm to the urothelium.

3 advanced transitional-cell carcinoma of the urothelium.

4 nd normally to mannosylated receptors in the urothelium.

5 thways including primary afferent nerves and urothelium.

6 wards developing specific endodermal derived urothelium.

7 erficial, 72 invasive lesions, and 52 normal urothelium.

8 eatment of patients with advanced TCC of the urothelium.

9 line expressing a cyclin D1 oncogene in the urothelium.

10 een UPEC and terminally differentiated human urothelium.

11 ponents originate from the same cells in the urothelium.

12 ill develop recurrent lesions throughout the urothelium.

13 id not cause histologic abnormalities of the urothelium.

14 el of expression compared to adjacent normal urothelium.

15 cell lineages in the prostate epithelium and urothelium.

16 24 was elevated compared with normal bladder urothelium.

17 ceptor (B1R) is expressed in control bladder urothelium.

18 study as compared to their respective normal urothelium.

19 l pilus for UPEC persistence in the inflamed urothelium.

20 here through the interstitium to beneath the urothelium.

21 major differentiation products of mammalian urothelium.

22 ced transitional-cell carcinoma (TCC) of the urothelium.

23 iously shown that p63 is expressed in normal urothelium.

24 m; strong expression was also seen in normal urothelium.

25 matic BK virus latency is established in the urothelium.

26 g growth, differentiation, and repair of the urothelium.

27 e specific differentiation of a transitional urothelium.

28 hanically evoked purinergic signaling by the urothelium.

29 vivo involved a direct effect on neoplastic urothelium.

30 itional cell carcinomas compared with normal urothelium.

31 and one major type in the sub-urothelium and urothelium.

32 te in promoting COM crystal retention by the urothelium.

33 th the level of potential carcinogens in the urothelium.

34 in the treatment of advanced cancers of the urothelium.

35 for patients with advanced carcinoma of the urothelium.

36 duction pathway in TCC cell lines and normal urothelium.

37 major differentiation products of mammalian urothelium.

38 ngle-agent activity against carcinoma of the urothelium.

39 ssary for the proliferative action of KGF on urothelium.

40 in mechanically-induced ATP release from the urothelium.

41 alized pannexin 1 to all three layers of the urothelium.

42 naling, Ret expression, and apoptosis of the urothelium.

43 by the urethra and external adherence to the urothelium.

44 y and raised P2X3 receptor expression in the urothelium.

45 uld contribute to spread of cells within the urothelium.

46 ctivated beta-catenin signaling in the adult urothelium.

47 d invade the epithelial cells of the bladder urothelium.

48 ld higher than in wild type mice with intact urothelium.

49 ormation and terminal differentiation of the urothelium.

50 in the developing and mature murine bladder urothelium.

51 d ATP release which presumably occurs in the urothelium.

52 P and type 1 pili for attachment to the host urothelium.

53 commonly predicted were biliary tract (18%), urothelium (11%), colorectal (10%), and non-small-cell l

54 rcinomatous urothelium but not in the normal urothelium; (2) uptake was detected at a very early stag

55 , synthesis of the HB-EGF precursor by human urothelium also suggests the possibility of using the DT

56 ed to increased proliferation of the bladder urothelium although this was not associated with hyperpl

57 Urothelium, an anatomical barrier for innate immune resp

58 due to their strategic position between the urothelium and afferent fibres.

59 amined the expression of PPARgamma in normal urothelium and bladder cancer in an attempt to assess it

60 distinct layer of smooth muscle between the urothelium and bladder detrusor, termed the muscularis m

61 in nine bladder cancer cells, paired normal urothelium and bladder tumor samples (n = 25), and tissu

62 ar bacterial reservoirs, which reside in the urothelium and can seed recurrent infections.

63 Mutation of Dlg1 in urothelium and collecting ducts (via HoxB7-Cre or Pax2-C

64 family member expressed in both normal human urothelium and cultured normal human urothelial (NHU) ce

65 alized throughout the bladder, including the urothelium and detrusor smooth muscle.

66 ic hedgehog secreted by the nascent ureteric urothelium and ending with ureteric smooth muscle cell d

67 fection, we showed that MRSA attached to the urothelium and implant in patterns that colocalized with

68 erents, but new findings have pointed to the urothelium and interstitial cells as key participants in

69 hich are considered to be progenitors in the urothelium and other specialized epithelia.

70 t that it is also detected in mature bladder urothelium and primary urothelial cultures.

71 an 8-fold increase) is reminiscent of normal urothelium and remains slow-cycling.

72 se but few studies have investigated how the urothelium and sensory pathways are affected.

73 he PTCH, SMOH and GLI3 transcripts in normal urothelium and TCC cell lines and rare PTCH mutations in

74 Normal urothelium and TCC cell lines express these three genes

75 m of transitional cells of the human bladder urothelium and that the soluble form of the growth facto

76 y be attributed to the interplay between the urothelium and the release of urothelially derived media

77 y signal feedback between basal cells of the urothelium and the stromal cells that underlie them.

78 erally, a prominent role has emerged for the urothelium and the underlying suburothelium in mechanose

79 ophosphamide (CYP)-induced cystitis) bladder urothelium and their contribution to lower urinary tract

80 s not expressed by normal or malignant human urothelium and therefore is unlikely to play a role in a

81 etrusor muscle and one major type in the sub-urothelium and urothelium.

82 s that block bacterial interactions with the urothelium and vaccines focused on preventing both acute

83 le of regenerating all cell types within the urothelium, and are marked by expression of the secreted

84 ed that B7-H3 is expressed within the liver, urothelium, and fetal kidney.

85 increases with age, is not present in normal urothelium, and occurs early in tumorigenesis, it can be

86 epithelial layers in the epidermis, cervix, urothelium, and prostate.

87 onal crystals covering the apical surface of urothelium, and provide unique opportunities for studyin

88 to the permeability barrier function of the urothelium, and UPIII deficiency can lead to global anom

89 nvasive tumors with matched normal-appearing urothelium, and urothelium from 12 age-matched UC-free p

90 VNUT was abundantly expressed in the bladder urothelium, and when the urothelium was weakly stimulate

91 m the apical and basolateral surfaces of the urothelium appears to be mediated by separate mechanisms

92 een low-grade, noninvasive tumors and normal urothelium are needed to identify genes involved in earl

93 It is proposed that ATP is released from the urothelium as a sensory mediator for the degree of diste

94 ER1 interaction, and identification of human urothelium as a site of HB-EGF precursor (proHB-EGF) syn

95 e examined the distribution of nAChRs in the urothelium, as well as their ability to influence the re

96 Deletion of Klf5 from the developing bladder urothelium blocked epithelial cell differentiation, impa

97 served in the hyperplastic and carcinomatous urothelium but not in the normal urothelium; (2) uptake

98 rategy: 67LR was not expressed in the normal urothelium but was present in the tumor, whereas TATI ex

99 was confined to umbrella cells in the normal urothelium, but extended to all cell layers in the tumor

100 mirabilisrapidly invades the bladder urothelium, but generally fails to establish an intracel

101 ns innervated the detrusor, vasculature, and urothelium, but only part of this innervation was sensor

102 esent in most normal human tissues including urothelium, but was reduced or absent in the majority of

103 reduce contact time between carcinogens and urothelium by diluting urinary metabolites and increasin

104 GFR3 may confer a selective advantage in the urothelium by overcoming normal contact inhibition of pr

105 ctivation of tumor suppressor p53 and pRb in urothelium by SV40 T antigen resulted in urothelial carc

106 ne, our data establish that normal mammalian urothelium can function not only as a permeability barri

107 ith our recent finding that transgenic mouse urothelium can secrete ectopically expressed human growt

108 ur data strongly support the hypothesis that urothelium can undergo at least three pathways of differ

109 ct4 is expressed in normal and in neoplastic urothelium carrying implications for a bladder cancer st

110 e developing prostate epithelium and bladder urothelium, cell lineages in these endoderm-derived epit

111 toxicity to telomerase-negative human normal urothelium cells but was highly cytotoxic to telomerase-

112 null mice develop a bladder with an abnormal urothelium, constituted by a single layer of cells that

113 cultures from the rat demonstrated that the urothelium contains both alpha3* and alpha7 receptors.

114 inogen activators of ruminants are therefore urothelium derived rather then kidney derived as in some

115 der tumour-derived cell lines and one normal urothelium-derived cell line for genome-wide copy number

116 s to examine p63 isoforms in mouse and human urothelium during embryogenesis and tumor progression, r

117 thogenic Escherichia coli (UPEC) in the host urothelium during urinary tract infection (UTI) via the

118 interplay between invading bacteria and the urothelium elicits a mucosal response aimed at clearing

119 The bladder urothelium exhibits dynamic sensory properties that adap

120 Primary urothelium expressed high levels of FGFR3 transcripts.

121 Urothelium-expressed p53 mutant binds to and stabilizes

122 However, our findings also indicate that urothelium expresses a variety of other Oct4 splice-vari

123 Normal urothelium expresses myopodin in the cytoplasm and nucle

124 epithelial lining of the urinary bladder, or urothelium, expresses two subtypes of nicotinic acetylch

125 expressing FGFR3b-S243C in transgenic mouse urothelium expressing SV40T converted carcinoma-in-situ

126 al inactivation of both RB1 alleles in mouse urothelium failed to accelerate urothelial proliferation

127 The bladder urothelium failed to stratify and did not express termin

128 The UPIII-depleted urothelium features small plaques, becomes leaky, and ha

129 luding the bladder, is lined by a stratified urothelium forming a highly differentiated, superficial

130 ith matched normal-appearing urothelium, and urothelium from 12 age-matched UC-free patients.

131 We isolated the urothelium from a low-grade tumor and corresponding norm

132 ethylation patterns between normal-appearing urothelium from bladders with cancer and urothelium from

133 ci were hypermethylated in apparently normal urothelium from bladders with cancer, indicating an epig

134 ing urothelium from bladders with cancer and urothelium from cancer-free bladders.

135 the various stages in the differentiation of urothelium from ES cells, including the commitment to an

136 n and, in ketamine-induced cystitis, loss of urothelium from large areas of the bladder wall is a rep

137 with the prostate findings, analysis of the urothelium from rescued p63-/- chimeras shows that umbre

138 When the bladder is distended, the urothelium functions as a sensor to initiate the voiding

139 Nonmalignant urothelium had uniform expression of LN5 genes and lacke

140 ced transitional-cell carcinoma (TCC) of the urothelium has promising activity and acceptable toxicit

141 ve diseases of the human bladder epithelium (urothelium), however a cognate HER1 ligand that can act

142 atic carcinoma, but not in the nonneoplastic urothelium, implicates BKV as an etiologic agent in the

143 The luminal surface of mouse urothelium in contact with the urine is almost entirely

144 The release of ATP from urothelium in response to distension and its action on P

145 he release of several neurotransmitters from urothelium in response to distension and its action on r

146 s decreased pannexin 1 expression in the rat urothelium in vivo and increased bladder capacity.

147 K3CA may confer a selective advantage in the urothelium in vivo by overcoming normal contact-mediated

148 evels were greatly reduced (to <5% of normal urothelium) in cultured urothelial cells, which synthesi

149 from the bladder epithelium, also termed the urothelium, in response to mechanical or chemical stimul

150 n of a constitutively active Ha-ras in mouse urothelium induces simple urothelial hyperplasia that is

151 We employed a culture model of UPEC-urothelium interactions to examine the biochemical event

152 rom being a passive container for urine, the urothelium is a crucial area within the bladder wall and

153 rom being a passive container for urine, the urothelium is a crucial part of the bladder.

154 The urothelium is a multilayered epithelium that serves as a

155 The urothelium is also known to secrete proteins into the ur

156 enes or inactivation of tumor suppressors in urothelium is considered critical for development of uro

157 Although urothelium is constantly bathed in high concentrations o

158 The apical surface of mammalian urothelium is covered by 16-nm protein particles packed

159 The apical surface of mammalian bladder urothelium is covered by large (500-1000 nm) two-dimensi

160 The apical surface of mouse urothelium is covered by two-dimensional crystals (plaqu

161 The bladder urothelium is more than just a barrier.

162 Mutant RXRA-driven growth of urothelium is reversible by PPAR inhibition, supporting

163 tivation of all Rb family genes in the mouse urothelium is sufficient to initiate bladder cancer deve

164 Urothelium is the protective lining of the urinary tract

165 first- or second-line setting in TCC of the urothelium is warranted.

166 ncer arises in the superficial lining of the urothelium, it is a likely candidate for site-directed a

167 In the urothelium, its expression can be up-regulated after act

168 PPARgamma reportedly is expressed in normal urothelium, its function is unknown.

169 on; more broadly, our findings indicate that urothelium itself directly modulates voiding.

170 g in the ureteral mesenchyme, but not in the urothelium itself, led to urothelial disorganization, hi

171 und in both the smooth muscle (detrusor) and urothelium layers of the urinary bladder.

172 e direct effects of ketamine on normal human urothelium maintained in organ culture or as finite cell

173 invasive cancers (n = 56) or benign adjacent urothelium (n = 49).

174 sed angiogenesis when compared to the normal urothelium (NU) from which they are derived.

175 e-driven system ablating Foxa1 expression in urothelium of adult mice resulted in sex-specific histol

176 ansion but occurred independently across the urothelium of bladders with cancer.

177 CPV was detected in the urothelium of graft ureters, associated with ureteritis

178 ser capture microdissection from the bladder urothelium of infected C3H/HeJ female mice.

179 we eliminated beta1-integrin selectively in urothelium of mice using Cre-LoxP targeted gene deletion

180 increase in cytokeratin 14 expression in the urothelium of the female Foxa1 knockout mouse and an inc

181 ble hyperplasia of intestinal epithelia, and urothelium of the urinary bladder and ureters.

182 akin II gene promoter, we have targeted into urothelium of transgenic mice a dominant-negative mutant

183 of an activated form of beta-catenin to the urothelium of transgenic mice using Cre-Lox technology (

184 provide compelling evidence, indicating that urothelium, one of the slowest cycling epithelia, is rem

185 rase (ChAT) were performed in wholemounts of urothelium or detrusor or cryostat sections of the bladd

186 d in quiescent (G(0)) cells, indicating that urothelium overexpressing the cyclin D1 (an 8-fold incre

187 lin E immunoreactivity, compared with normal urothelium (P < 0.01).

188 ct and HA degeneration and bladder repair by urothelium proliferation and differentiation.

189 D34(+) grafts provided the impetus for rapid urothelium regeneration.

190 my, ensuring complete removal of susceptible urothelium, remains to be determined.

191 d that disrupting the uroplakin layer of the urothelium resulted in water and urea permeabilities (P)

192 onclude that loss of integrin signaling from urothelium results in incontinence and overactive bladde

193 both patients relative to a panel of normal urothelium samples obtained from individuals free of bla

194 Moreover, we demonstrate that the urothelium secretes these proteins in a polarized fashio

195 Bladder urothelium senses and communicates information about bla

196 ty of the UPII promoter in the generation of urothelium-specific adenoviral vectors and provide a pot

197 We recently showed that the urothelium-specific expression of activated H-ras and SV

198 Using a urothelium-specific promoter of the uroplakin II gene, w

199 Here we report cloning of the urothelium-specific promoter uroplakin-II (UPK II) and g

200 b promoter of uroplakin II gene to drive the urotheliums-specific expression of oncogenes.

201 excitatory and inhibitory mediators from the urothelium such as ATP and nitric oxide.

202 (Uro) A subtype shares features with normal urothelium such as keratin 5 (KRT5), P-cadherin (P-Cad),

203 diminish the proliferative effect of KGF on urothelium, suggesting that the contribution of urinary

204 Hierarchical clustering classified normal urothelium, superficial, and invasive tumors with 82.2%

205 ltilayered water-tight epithelium called the urothelium, surrounded by smooth muscle layers that, by

206 Urothelium synthesizes a group of integral membrane prot

207 Our data indicate that normal bovine urothelium synthesizes, as its major differentiation pro

208 er level of the EGFr mRNA and protein in the urothelium than the nontransgenic controls.

209 , and intrinsic signalling mechanisms of the urothelium that may contribute to the altered sensory pr

210 lving ATP and NO release presumably from the urothelium, that in turn could act on bladder C-fiber af

211 Cs are progenitors in the adult regenerating urothelium, that P cells, a transient population, are pr

212 Within the urothelium, the IL-6 native-tissue origin, the target ce

213 s to frank carcinoma nor regresses to normal urothelium through a period of one year.

214 lls, followed by rapid reconstitution of the urothelium through differentiation of underlying basal a

215 GF-beta1) may stimulate ATP release from the urothelium through vesicular exocytosis mechanisms with

216 Immunohistochemical staining revealed normal urothelium to express PPARgamma uniformly.

217 evidence that p53 deficiency predisposes the urothelium to hyperproliferation, but is insufficient fo

218 Exposure of urothelium to ketamine resulted in apoptosis, with cytoc

219 f uropathogenic Escherichia coli to the host urothelium to trigger the infection.

220 either low- or high-grade carcinomas in the urothelium transitional epithelium supporting a key role

221 least three pathways of differentiation: (a) urothelium-type pathway; (b) epidermis-type pathway; and

222 in metaplastic recombinants reflected human urothelium undergoing KSM.

223 -dsP21-322-2'F into mouse bladder results in urothelium uptake and extends survival of mice with esta

224 imian vacuolating virus 40 T (SV40T), in the urothelium (Uro-SV40T-AR(-/y)) had a similar incidence o

225 ering to mannosylated receptors on the human urothelium via the carbohydrate-binding domain of the Fi

226 tability by stimulating ATP release from the urothelium via vesicular exocytosis mechanisms with mini

227 facet cell layer of the bladder epithelium (urothelium) via its FimH adhesin.

228 e fibers in the urinary bladder detrusor and urothelium was decreased or eliminated after SCI.

229 rganization, terminal differentiation of the urothelium was not significantly affected.

230 ing of the urethral diameter and with normal urothelium was noted in all dogs surviving at least 28 d

231 ssed in the bladder urothelium, and when the urothelium was weakly stimulated (i.e. in the early fill

232 ts with measurable stage IV carcinoma of the urothelium were enrolled onto this trial.

233 arker of exposure, and are found also in the urothelium, where they give rise to a unique mutational

234 All four PARs are co-expressed in the urothelium, whereas PAR-1 and PAR-2 are predominant in t

235 dinary high level (0.1% of total protein) in urothelium, whereas Rab27b levels were greatly reduced (

236 in PNCA in Uro-AR(-/y) than that found in WT urothelium, which suggests that Uro-AR may modulate blad

237 Patients with cancers of the urothelium who had no prior chemotherapy (prior adjuvant

238 ing water develop hyperplasia of the bladder urothelium within 4 weeks of exposure.