ライフサイエンスコーパス: use-dependent

1 endent, indicating that the action of RBO is use dependent.

2 rature sensitivity can be highly dynamic and use-dependent.

3 The activity of PD-307243 was use-dependent.

4 (V)1.7 by BPBTS was found to be voltage- and use-dependent.

5 Use-dependent accumulating channel blockade progressivel

6 icantly different from WT-IKs and attenuated use-dependent accumulation of the current.

7 acing; the latter may contribute to "reverse use-dependent" action potential prolongation.

8 s property enables Kv1.2 channels to exhibit use-dependent activation during trains of very brief dep

9 Our findings illustrate that use-dependent activation is a unique property of Kv1.2 t

10 The use-dependent activation of presynaptic mGluRs that we d

11 suggest that this strategic placement allows use-dependent activation of these synaptic modulators.

12 that other Kv1 channel types do not exhibit use-dependent activation, but this property is conferred

13 e kinetics of recovery from inactivation and use-dependent activity of the channel in both the presen

14 the constraint, followed by a longer-lasting use-dependent aftereffect in the direction of the constr

15 It is widely thought that persistent, use-dependent alterations in synaptic strength such as l

16 after a small uIPSC1, suggesting that PPD is use dependent and due to a decrease in the quantal conte

17 f NMDAR currents (current run-down) that was use dependent and not readily reversible.

18 e receptors (GlyRs) has been shown to be non-use-dependent and nonselective between the picrotoxin co

19 bryonic alpha2 homomeric GlyR is known to be use-dependent and reflects a channel-blocking mechanism,

20 d His-880 in Na(V)1.5 are proton sensors for use-dependent and slow inactivation and have implication

21 ivalent cation-pi interaction underlies both use-dependent and tonic block by TTX.

22 arative studies of chimeric channels between use-dependent and use-independent homologs, we have dete

23 Here, we identify the molecular basis of the use-dependent and voltage-independent inhibitory effect

24 Inhibition of Na+ currents by 8,9-EET was use dependent, and channel recovery was slowed.

25 signaling pathways, is neither voltage- nor use-dependent, and does not affect channel gating.

26 emporally-stable processes that are strictly use-dependent, and dynamically-evolving and context-depe

27 We then examined the action of a use-dependent antagonist of GluA2-containing AMPARs, phi

28 of synaptic NMDARs with a slowly reversible, use-dependent antagonist protected nearly fully against

29 uration in either chamber but induced potent use-dependent atrial-selective depression of the sodium

30 ted recombinant CPI-17 into cells produced a use-dependent attenuation of glutamate-evoked responses

31 The overgrowth appears to be use-dependent because it can be prevented by restricting

32 chain (Me12), leads to a further increase of use-dependent behavior versus the phenyl Mex derivative

33 noxy-propranol-amine moiety, with consequent use-dependent behavior.

34 To understand the neural substrate for the use-dependent behavioral improvement, we studied the den

35 This effect is similar to the use-dependent biases observed for other movement paramet

36 38 also showed use dependent block of Na(v)1.6 in HEK cells.

37 cell types but did not affect the frequency (use)-dependent block of Na(+) currents.

38 Use-dependent block (10 ms pulses to -10 mV, at 20 Hz) i

39 Flecainide (1-300 mM) caused tonic and use-dependent block (UDB) of I(Na) in a concentration-de

40 frequency-dependent manner, consistent with use-dependent block (UDB).

41 The terfenadine-induced tonic and use-dependent block and the steady state inhibition of I

42 The qualitative differences in use-dependent block appear to be the result of differenc

43 fices to explain the presence and absence of use-dependent block by benzocaine homologs during repeti

44 brane and cytoplasmic regions of IVS5 in the use-dependent block by diltiazem and verapamil.

45 panied by a reduced or by a complete loss of use-dependent block by diltiazem.

46 -fold, and mutations I409A and N418A reduced use-dependent block by etidocaine.

47 e paths should affect the characteristics of use-dependent block by influencing drug on- and off-rate

48 However, the use-dependent block by isradipine was retained by these

49 rane segments, shifted activation gating and use-dependent block by lidocaine toward that seen in hH1

50 Use-dependent block by mexiletine was greater in inactiv

51 tween inactivation gating of the channel and use-dependent block by phenylalkylamines and benzothiaze

52 ptor transmission is rendered sensitive to a use-dependent block by polyamine compounds.

53 udied affected inactivated-state affinity or use-dependent block by the neuroprotective drug sipatrig

54 mulated infrequently and produces additional use-dependent block during repetitive pulses.

55 In contrast, for all three drugs, use-dependent block during repetitive stimulations was s

56 the vastly different rates of recovery from use-dependent block for bupivacaine and lidocaine.

57 y slowed inactivation and a complete loss of use-dependent block for mutations in the cytoplasmic con

58 soform specificity can be attained, the huge use-dependent block may help in the development of new s

59 izing shift in activation curves and greater use-dependent block of Ca(V)3.2 channels.

60 ressed channels; (2) suggest that flecainide use-dependent block of DG channels underlies its therape

61 The reduction in use-dependent block of F430C was consistent with alterat

62 onstrate that prenylamine has both tonic and use-dependent block of hNav1.5 channels similar to that

63 ntials, and (3) elicited a tonic block and a use-dependent block of ICa,L.

64 There was no use-dependent block of IFM/QQQ mutant channels with trai

65 Model simulations show that the reduced use-dependent block of IVS6 mutants derives primarily fr

66 Use-dependent block of Na(+) channel isoforms by ranolaz

67 issociates too fast to accumulate sufficient use-dependent block of Na+ currents.

68 lse ratio at L4-L2/3 synapses and slowed the use-dependent block of NMDA receptor currents by MK-801

69 We now characterize the tonic and use-dependent block of prenylamine on wild-type human ca

70 vity for the action of ranolazine to produce use-dependent block of sodium channels, leading to suppr

71 erpolarized potentials, whereas the enhanced use-dependent block of the IS6 mutant was due to a highe

72 assumes Class IC characteristics with potent use-dependent block of the sodium channel.

73 e effects of anticonvulsant drugs acting via use-dependent block of voltage-gated Na(+) channels on G

74 ilic drug of clinical relevance, by studying use-dependent block using a two-electrode voltage clamp

75 ry component with intermediate kinetics, and use-dependent block was attenuated in both W402A and W40

76 Use-dependent block was best explained by a significant

77 mutations in IIS6 (S804F) and IIIS6 (V1293I) use-dependent block was not statistically different from

78 Recovery from use-dependent block was slowed when cardiac isoform-spec

79 This was also true for use-dependent block, for which 25-microM lidocaine produ

80 F1236C mutant channels reduced recovery from use-dependent block, indicating an allosteric effect of

81 F1586C mutation only partially impaired the use-dependent block, suggesting that additional amino ac

82 nto the slow inactivated state, resulting in use-dependent block.

83 e conditions, and also induced resistance to use-dependent block.

84 the amino function enhance both potency and use-dependent block.

85 h greatly enhances high-affinity binding and use-dependent block.

86 icity and optimal alkyl chain length enhance use-dependent block.

87 n I and F1236C in domain III exhibit reduced use-dependent block.

88 also markedly accelerated the recovery from use-dependent block.

89 rsal root ganglion (DRG) neurons indicated a use-dependent blockade of sodium channels.

90 imine maleate (MK-801), a well characterized use-dependent blocker of NMDA receptors.

91 Flecainide and RAD-243 retained their use-dependent blocking action and accelerated macroscopi

92 ticonvulsant drugs are known to exert potent use-dependent blocking effects on voltage-gated Na(+) ch

93 te of macroscopic inactivation and exhibit a use-dependent blocking phenomenon reminiscent of the act

94 Both tonic and use-dependent blocks of ICa,L by terfenadine at -40 mV w

95 onal principles that govern the induction of use-dependent change in excitatory synaptic efficacy als

96 However, to date, evidence for persistent use-dependent change in the strength of this synapse has

97 All use-dependent changes appeared in the order NaV 1.8 KO >

98 However, animal studies showing use-dependent changes in motor cortex organization sugge

99 compound action potential (AP), we evaluated use-dependent changes in mouse peripheral nerves, and th

100 , providing an unexpected mechanism by which use-dependent changes in slow afterhyperpolarizations mi

101 ry to invoke such a mechanism to account for use-dependent changes in synaptic release probability.

102 Use-dependent changes in the behavior of potassium chann

103 Knocking out TTXr sodium channels influences use-dependent changes of conductive properties (action p

104 velopment and whether this is accompanied by use-dependent changes of inhibitory synaptic strength.

105 Use-dependent changes of latency, AP amplitude, and dura

106 activity is not the underlying mechanism for use-dependent changes of neural conduction.

107 of the functional alleles exhibited reduced use-dependent channel inhibition.

108 inly closed-state channels, although a small use-dependent component was observed in Ca(V)3.1 channel

109 ne promotes slow monomorphic VT, probably by use-dependent conduction slowing and wavelength shorteni

110 fast inactivation, which produced a profound use-dependent current attenuation not seen in the wild t

111 tions > or =60 micromol/L, the difference in use-dependent current reduction between IZs and NZs was

112 This potentiation was in contrast to the use-dependent decrease in current for Nav1.2 with beta1.

113 The use-dependent decrease in paired-pulse facilitation occu

114 naptic depression at these synapses and this use-dependent decrease in paired-pulse facilitation occu

115 This suggests that biases are not based on a use-dependent decrease in response strength but involve

116 Long-term depression (LTD) is a use-dependent decrease in synaptic efficacy widely recog

117 We observed use-dependent decreases of single fibre and compound act

118 mpounds produced concentration-dependent and use-dependent decrements in CAP amplitude, but cocaethyl

119 ciated GTPase Rab35 are key elements of this use-dependent degradative pathway.

120 ite morphology, indicating an upper limit of use-dependent dendrite growth.

121 Use-dependent depression at the fast-spiking interneuron

122 Both EPSCs and IPSCs showed use-dependent depression during trains.

123 large changes in [Cl-]i that could underlie use-dependent depression of GABA-dependent synaptic tran

124 Ranolazine produced a marked use-dependent depression of sodium channel parameters, i

125 ells led to an initial summation followed by use-dependent depression of the averaged postsynaptic re

126 has either been physiologically exhausted by use-dependent depression, or has been artificially deple

127 regulates recovery of synaptic vesicles from use-dependent depression, probably by a direct interacti

128 and vestibular synapses exhibit conventional use-dependent depression, weakening to a greater extent

129 gonists, the mechanisms responsible for this use-dependent down-regulation remain unclear.

130 in the therapeutically desirable property of use-dependent drug action.

131 below the selectivity filter, is critical in use-dependent drug block.

132 ng in neuronal networks is determined by the use-dependent dynamics of synaptic transmission.

133 nitric oxide cascade generates a short-term, use-dependent enhancement of release.

134 synaptic enhancement when combined with the use-dependent facilitation of MF synapses.

135 and blockade of this enzyme can enhance the use-dependent facilitation of neurohypophysial secretion

136 age-gated sodium and potassium currents in a use-dependent fashion, but had only a small effect on th

137 cking voltage-activated sodium channels in a use-dependent fashion.

138 Use-dependent fatigue accompanies many neuromuscular mya

139 This use-dependent fatigue is shown to be a consequence of a

140 neral muscle weakness is also accompanied by use-dependent fatigue.

141 on potential generation, thus accounting for use-dependent fatigue.

142 weakness, but is not solely responsible for use-dependent fatigue.

143 ociated contraction failures are manifest as use-dependent fatigue.

144 e, at the cortical level sleep has local and use-dependent features suggesting that it is a property

145 vation, with a 4-fold delay in recovery from use-dependent flecainide block.

146 suggests that neuroligins contribute to the use-dependent formation of neural circuits.

147 Use-dependent forms of synaptic plasticity have been ext

148 Substantial use-dependent functional upregulation was found for muta

149 tion of a subthreshold dose of picrotoxin, a use-dependent gamma-aminobutyric acid receptor antagonis

150 uromuscular junction, in the presence of the use-dependent glutamate receptor (GluR) blocker philanth

151 le residue that is apparently missing in the use-dependent homologs could largely eliminate the use d

152 ificantly reduced the maximum probability of use-dependent inactivation and slow inactivation, relati

153 terminated primarily by a highly localized, use-dependent inactivation of RyRs but not by the stocha

154 close to the resting potential, and enhanced use-dependent inactivation on high-frequency stimulation

155 proton block, abolished proton modulation of use-dependent inactivation, and altered pH modulation of

156 d slower recovery from inactivation, greater use-dependent inactivation, and reduced action potential

157 ery high threshold of activation and lack of use-dependent inactivation.

158 activation and deactivation kinetics and no use-dependent inactivation.

159 4)(=) influx, indicating that Sul2p exhibits use-dependent inactivation; the transport process itself

160 Recently, it has been demonstrated that a use-dependent increase in the density of dendritic spine

161 ivation processes and by inducing frequency (use)-dependent inhibition of Na(+) currents.

162 y cyclohexane, for example, strongly reduces use-dependent inhibition and speeds recovery of lidocain

163 cific inhibitor of cationic MSCs, showed the use-dependent inhibition characteristic of open channel

164 any of the substituted sites, high-affinity use-dependent inhibition displays substantial cation-pi

165 sting channels but induced a characteristic, use-dependent inhibition during rapid, repetitive stimul

166 under resting conditions but causes a potent use-dependent inhibition during repetitive depolarizatio

167 ceptors, which is a prevailing mechanism for use-dependent inhibition in the nucleus accumbens core a

168 agus nerve recordings, QX-314 induced marked use-dependent inhibition of C-spike amplitude, with IC50

169 TROX-1 displayed use-dependent inhibition of Ca(V)2.2 with a 10-fold IC(5

170 ACh also contributes to the use-dependent inhibition of DA release through muscarini

171 Interestingly, the use-dependent inhibition of hippocampal neurons was depe

172 Compound 4 exhibited strong use-dependent inhibition of hNa(v)1.5 with pIC50 values

173 F and wild-type sodium currents at baseline, use-dependent inhibition of I(Na) by lidocaine was more

174 he N395K mutation also significantly reduced use-dependent inhibition of lidocaine on Nav1.7 current.

175 te at 1 mM, like benzocaine, elicited little use-dependent inhibition of Na+ currents, whereas ethyl

176 diverging effects, we examined the effect of use-dependent inhibition of NMDA receptors on the sponta

177 ays enhanced slow inactivation and exhibited use-dependent inhibition of peak Na(+) currents during r

178 tivation of voltage-gated Ca(2+) channels or use-dependent inhibition of release machinery by presyna

179 akalant and ranolazine were characterized by use-dependent inhibition of sodium channel-mediated para

180 Cocaine induced a use-dependent inhibition of the non-inactivating mutant

181 , these rapidly reversible blockers produced use-dependent inhibition through an unusual mechanism--t

182 thoxybenzoate at 0.5 mM elicited substantial use-dependent inhibition--up to 55% of peak Na+ currents

183 neutral LA that fails to produce appreciable use-dependent inhibition.

184 ey affect the ability of blockers to produce use-dependent inhibition.

185 Like the endogenous blocking protein, these use-dependent inhibitors bind most effectively at depola

186 Use-dependent inhibitors of voltage-gated sodium channel

187 philanthotoxins (PhTXs), and argiotoxins are use-dependent ion channel blockers of AMPARs widely empl

188 slow inactivation gating track the distinct use-dependent kinetic properties of diverse LA compounds

189 -redundant dimension, we were able to induce use-dependent learning by passively guiding movements in

190 a second study, we show that error-based and use-dependent learning can change motor behavior simulta

191 Here, we show that a second mechanism, use-dependent learning, simultaneously changes movements

192 These mutations eliminated use-dependent lidocaine block with no effect on tonic/re

193 ) and in II-S6 (I782C and V786C) reduced the use-dependent lidocaine block.

194 esults show that lowering [Na+]o potentiates use-dependent lidocaine block.

195 direction of depolarization and antagonized use-dependent lidocaine inhibition of fast-inactivated s

196 mechanistic basis of depolarization-induced 'use-dependent' lidocaine block remains uncertain.

197 f learning and memory are thought to involve use-dependent long-term changes in synaptic function, in

198 Block was enhanced in a use-dependent manner at higher stimulation rates.

199 This drug inhibited Kv1.3 in a use-dependent manner by preferentially blocking the C-ty

200 pyramidal neurons is reliably inhibited in a use-dependent manner by the prototypical Na(+) channel b

201 ynaptic NMDA receptors can be modulated in a use-dependent manner even when the postsynaptic membrane

202 apses can change their strength rapidly in a use-dependent manner, but the mechanisms of such short-t

203 sulfonanilide block is known to develop in a use-dependent manner, suggesting a potential role for in

204 xybutoxy)psoralen (PAP-1), blocks Kv1.3 in a use-dependent manner, with a Hill coefficient of 2 and a

205 tially decreased by MK-801 within 2 min in a use-dependent manner.

206 aptic strength is dynamically regulated in a use-dependent manner.

207 a spark is less than unity and declines in a use-dependent manner.

208 ugs blocked the wild-type Na(+) channel in a use-dependent manner.

209 ase neurotransmitters and neuropeptides in a use-dependent manner.

210 s AMPA receptors lacking GluR2 subunits in a use-dependent manner.

211 y and inhibitory inputs into the muscle in a use-dependent manner.

212 ents, sotalol prolonged the APD in a reverse use-dependent manner; such an effect was not seen with e

213 nel may undergo a physical modification in a use-dependent manner; thus, a model that closely simulat

214 inding during normoxia and hypoxia suggest a use-dependent mechanism for CPP binding during hypoxia,

215 nhibitory interneurons is weakened through a use-dependent mechanism involving group II metabotropic

216 hat reorganization is driven by passive, not use-dependent mechanisms.

217 Previously identified potent and/or use-dependent mexiletine (Mex) analogs were used as temp

218 The use-dependent model of paired-pulse responsiveness holds

219 However, the applicability of the use-dependent model to inhibitory synapses is controvers

220 The use-dependent modification of synapses is strongly influ

221 iable and that SRF plays a prominent role in use-dependent modification of synaptic strength in the a

222 val of retinal input on neural activity- and use-dependent modifications of cortical AChE activity.

223 Use-dependent modifications of synapses have been well d

224 Use-dependent modifications, such as long-term potentiat

225 NMDAR-dependent mechanisms and contribute to use-dependent modulation of circuit properties.

226 l TGF-beta signaling pathway is critical for use-dependent modulation of GABA(A) synaptic transmissio

227 onstrate that baclofen selectively maintains use-dependent modulation of largely subcortical but not

228 Persistent, use-dependent modulation of synaptic strength has been d

229 d change in cone-AC voltage gain exemplifies use-dependent modulations of synaptic transmission in th

230 Use-dependent movement therapies can lead to partial rec

231 two physiological processes is causal to the use-dependent muscle fatigue.

232 current may therefore be less susceptible to use-dependent Na channel inhibitors used as local anesth

233 619C89 is a use-dependent Na+ channel antagonist that decreases the

234 (LA) that elicits depolarization-dependent ('use-dependent') Na+ channel block, does not slow recover

235 srupted OFC activity in behaving rats with a use-dependent NMDA antagonist to model the NMDA hypofunc

236 facilitation and the rate of blockade by the use-dependent NMDA receptor blocker (+)-5-methyl-10,11-d

237 Third, experiments using the use-dependent NMDAR blocker MK-801 show that these indir

238 Experiments with the use-dependent NMDAR blocker, MK-801, indicate that poten

239 extrasynaptic receptors of a neuroprotective use-dependent NMDAR channel blocker, memantine.

240 s, different developmental strategies may be used, dependent on when in the year conception takes pla

241 is study, we reveal the existence of a novel use-dependent phenomenon in potassium channels, which we

242 In this study, we have examined the use-dependent phenomenon of three benzocaine homologs: e

243 a potential therapeutic target for promoting use-dependent plasticity after spinal cord injury.

244 ses that can be characterized as model-free: use-dependent plasticity and operant reinforcement.

245 tergic synapses shows a remarkable degree of use-dependent plasticity and such modifications may repr

246 hort-term depression is a widespread form of use-dependent plasticity found in the peripheral and cen

247 entify the underlying mechanisms, we studied use-dependent plasticity in human subjects premedicated

248 Aergic inhibition as mechanisms operating in use-dependent plasticity in intact human motor cortex an

249 Tests were made for use-dependent plasticity in the cholinergic projections

250 In humans, spinal use-dependent plasticity is inferred from modifications

251 Employing a protocol designed to test for use-dependent plasticity resembling N-methyl-D-aspartate

252 dritic spines are now known to be subject to use-dependent plasticity that affects both their structu

253 r development and longer lasting duration of use-dependent plasticity under d-amphetamine compared to

254 Use-dependent plasticity was reduced substantially by de

255 nt a facilitatory effect of d-amphetamine on use-dependent plasticity, a possible mechanism mediating

256 The spinal cord is able to express use-dependent plasticity, as demonstrated in spinalized

257 een implicated in mediating several forms of use-dependent plasticity, but the mechanisms by which it

258 Use-dependent plasticity, thought to contribute to funct

259 n the mature cortex are subject to continual use-dependent plasticity.

260 facilitates the effects of motor training on use-dependent plasticity.

261 ulate the function of a pathway may underlie use-dependent plasticity.

262 uronal activity, potentially contributing to use-dependent plasticity.

263 ortex and probed the dynamical properties of use-dependent plasticity.

264 tiarrhythmic effect of sotalol has a reverse use-dependent positive inotropic effect in the intact he

265 Together, our experiments reveal a novel use-dependent, potent, and local mode of Abeta-mediated

266 The ACh concentration dependence of use-dependent potentiation and the delay in the rising p

267 h Nav1.6 coexpressed with beta1 demonstrated use-dependent potentiation during a rapid train of depol

268 Use-dependent potentiation of the mutant response during

269 First, they caused use-dependent potentiation of the response during a trai

270 tor cortex (FL-SMC) in adult rats results in use-dependent proliferation of dendritic processes, foll

271 The reverse use-dependent prolongation of APD by sotalol is associat

272 The use-dependent properties of synaptic transmission could

273 We compared the state- and use-dependent ranolazine block of Na(+) currents carried

274 in recovery from inactivation, and increased use-dependent reduction in amplitude during rapid (1- to

275 layed enhanced slow inactivation and greater use-dependent reduction in peak current at fast pulsing

276 ostsynaptic spiral ganglion neurons showed a use-dependent reduction in sound-evoked spiking, corrobo

277 very from availability, inducing significant use-dependent reduction of INa.

278 This use-dependent reduction was the result of the entry of T

279 Here, we studied use-dependent regulation of bipolar cell synaptic transm

280 ese receptors but arises from a voltage- and use-dependent relief of block by internal polyamines.

281 espond to stimuli presented at the PRL (the "use-dependent reorganization" hypothesis), then foveal c

282 ptor alpha1 subunits is subject to a delayed use-dependent repression that was observed after, rather

283 The period of run-up was followed by a use-dependent run-down phase.

284 rth membrane segment, a region implicated in use-dependent rundown and NMDA channel inactivation.

285 ROS and whole-cell recordings to measure the use-dependent rundown of ACh-evoked currents.

286 Use-dependent selection of optimal connections is a key

287 g to GluN2 renders these compounds nominally use-dependent, since inhibition will rely on synaptic re

288 that drugs with rapid recovery kinetics from use-dependent sodium channel block could promote oscilla

289 ion in neurite length was ameliorated by the use-dependent sodium channel blocker carbamazepine and b

290 ore distal sites, limiting the expression of use-dependent spike broadening to the most proximal axon

291 Use-dependent synapse remodeling is thought to provide a

292 Deletion of synapsins, however, did increase use-dependent synaptic depression induced by a high-freq

293 In the last five years, a new class of use-dependent synaptic plasticity that requires retrogra

294 ence the possibility of their involvement in use-dependent synaptic plasticity, is not known.

295 c cells, which in turn influence release via use-dependent synaptic plasticity.

296 -term synaptic enhancement of both basal and use-dependent synaptic transmission via specific changes

297 e explore the mechanisms responsible for the use-dependent termination of metabotropic receptor signa

298 ic AMPAR function - inward rectification and use-dependent unblock (UDU), with the latter assayed by

299 They demonstrate that a use-dependent unblock by internal polyamines potentially

300 Logistic regression analyses of medication use (dependent variable) vs. metabolic equivalent hours