ライフサイエンスコーパス: utility

1 volution, which typically undermines vaccine utility.

2 nal, driven by valence rather than objective utility.

3 ion of 2D hierarchical structures with broad utility.

4 otype also possesses clinical and predictive utility.

5 proteases, which may limit their biomedical utility.

6 ry gene editing technology with wide-ranging utility.

7 ion, suggesting that HPLM should be of broad utility.

8 le end points, such as ESRD, has limited its utility.

9 ney, status, trust, or other forms of social utility.

10 ording to their directional stability and/or utility.

11 nts would greatly improve future therapeutic utility.

12 edictive score is needed to confirm clinical utility.

13 re examining their biosensing and related ET utility.

14 mentally and functionally, restricting their utility.

15 int assay to assess for evidence of clinical utility.

16 analysis were derived from the Child Health Utility 9D.

17 To attain maximal utility, a decoding framework must be open-ended, system

18 Additional information on the utility, accuracy, and safety of PLB are needed to optim

19 ssion show considerable promise though their utility against naturally circulating parasites remains

20 r agents that unexpectedly possessed notable utility against the kinetoplastid disease visceral leish

21 -adjusted life-years (QALYs) for use in cost-utility analysis were derived from the Child Health Util

22 vision of a checklist increases the clinical utility and accessibility of these recommendations, by o

23 Purpose To investigate the utility and accuracy of breast magnetic resonance (MR) i

24 Furthermore, cost-effectiveness, cost-utility and budget impact analyses will be performed.

25 ed with the external unit, as it has limited utility and CI users often report a social stigma associ

26 This study investigated the clinical utility and combined yield of post-mortem genetic testin

27 it should be performed to maximize clinical utility and cost-effectiveness.

28 hemicals, compare the approaches, and assess utility and limitations in screening and early tier asse

29 Here, we review the recent advances in and utility and limitations of newly developed mouse and non

30 fies the trade-off between the principles of utility and medical urgency.

31 For the first time, the utility and performance of such a method is fully demons

32 Collectively, the utility and practicality of nanobody-based reagents in b

33 Chlamydomonas reinhardtii, demonstrated the utility and rigor of miRvial in detecting novel microRNA

34 To validate the new technique's utility and versatility, we realize PDMS micropillars on

35 Costs, including price of drug, utilities, and transitional probabilities, were included

36 o enhance its role in cancer biology and its utility as a biomarker and therapeutic target.

37 est that an lncRNA-based blood test may have utility as a diagnostic adjunct for identifying IPMNs an

38 Validating its utility as a discovery pipeline, we establish that two o

39 f PD-MCI over time to determine its clinical utility as a marker of disease.

40 ation demonstrated the novel LFD's potential utility as a rapid test to confirm isolation of M. bovis

41 f genotyping for HPV types 16 and 18 and its utility as a second triage step after hrHPV testing in w

42 ators of ILC2 activation and implicate their utility as a therapeutic approach for the treatment of I

43 up to 90 days post-stroke, and explore their utility as an early diagnostic marker.

44 and immunogenicity of DS-SOSIP.4mut suggest utility as an immunogen or a serologic probe; moreover,

45 rgeting rabbit mAbs demonstrated therapeutic utility as components of chimeric antigen receptor-engin

46 y, DS-SOSIP.4mut-stabilized trimers may have utility as HIV-1 immunogens or in other antigen-specific

47 source use are limited with respect to their utility as surrogates for communities of shared environm

48 Despite lack of evidence of their utility, biomarkers of ovarian reserve are being promote

49 tion by inexpensive iron catalysts has great utility, but the steps through which iron species can br

50 We highlighted this cantilever's biological utility by first resolving a calmodulin unfolding interm

51 of transcription start regions, and show its utility by generating multiple stable transgenic lines e

52 ium for the Barcode of Life, we tested their utility by performing a BLAST search against authenticat

53 We demonstrate its remarkable practical utility by preparing a nanostructured earth abundant met

54 The RNAi scaffold is a general utility chimera that contains a functional RNA duplex wi

55 We evaluated the utility, defined as posttransplant kidney allograft life

56 ality-adjusted life-years were assessed with utilities determined by the European Quality of Life-5 D

57 are no blood-based biomarkers with clinical utility for acute ischemic stroke (IS).

58 nsmission hazard (TH) model and assessed its utility for analyzing data from a household cohort maint

59 INTERPRETATION: AV-1451 may have limited utility for in vivo selective and reliable detection of

60 the retinohypothalamic tract, with potential utility for investigating alterations in homeostatic mec

61 hat SIRS criteria and qSOFA may have limited utility for predicting mortality in an ICU setting.

62 e retained as a functional pair due to their utility for solving the difficult protein folding proble

63 gs suggest that R-baclofen may have clinical utility for some of the core symptoms of human 16p11.2 m

64 cipate that our method will have significant utility for studying viral fusion and maturation.

65 ction within the bulk material with possible utility for sustained release in robust, programmably sh

66 pheromone-based technology will be of global utility for the monitoring of this important invasive sp

67 d use of humanized mice and highlights their utility for the study of human diseases.

68 vivo functions of CaMKK2 and demonstrate its utility for treating metabolically-related hepatic disea

69 Here, we introduce this dynamic utility function to several games.

70 g DNA-cleavage complexes, but their clinical utility has been compromised by resistance.

71 of using neuroscientific methods to measure utility in a context-free manner and have important impl

72 However, their utility in biological fluids can be compromised through

73 Pluripotent stem cells have broad utility in biomedical research and their molecular regul

74 Human Methylation BeadChips has shown great utility in clinical studies, no equivalent tool is avail

75 UPER high resolution TWIM platform has broad utility in conjunction with MS and is expected to enable

76 nd in the bulk of metal oxides that delivers utility in different applications.

77 and type-2 mutations suggest their potential utility in disease monitoring.

78 n exploration of their present and potential utility in domestication study shows that all three fiel

79 Measurement of lactate levels may have utility in early risk stratification of pediatric sepsis

80 an lead to cost-effective production for its utility in emerging wearable uses in a foreseeable futur

81 powerful data transformation method of broad utility in genetic research.

82 array 'Axiom_Arachis' with 58 K SNPs and its utility in groundnut genetic diversity study.

83 m periostin, both of which have demonstrated utility in identifying patients most likely to benefit f

84 on into consideration, VCFs may have limited utility in influencing rates of PE.

85 The method that we introduce can have broad utility in membrane protein research, as it can be appli

86 -catalyzed oxidation reactions exhibit broad utility in organic synthesis; however, they often featur

87 mputational models have potential prognostic utility in patients after an acute ST-segment-elevation

88 ss or in fact precede stress and, thus, have utility in pre-identifying stress-susceptible individual

89 ompelling evidence for potential therapeutic utility in some cases of human botulism.

90 ials inspired by natural materials and their utility in the construction of flexible devices.

91 crystalline suspension, may be of particular utility in the developing world.

92 operating via redox mechanism that may find utility in the storage and capture of other noxious and

93 also contribute to its potential therapeutic utility in the treatment of cocaine abuse.

94 stance protein (ABCG2), thereby limiting its utility in the treatment of non-small cell lung cancer m

95 s for tumor growth control and may also find utility in therapeutic planning to avoid postsurgery met

96 We demonstrate this system's utility in transcriptional reporter analysis, site-of-ac

97 ia cases than controls for some viruses, the utility in using viral load of URT specimens to define v

98 Utilities incorporating the potable reuse of municipal w

99 adner reading charts and QoL with the Health Utilities Index issue 3 (HUI-3) questionnaire in 184 par

100 Utility is highlighted by gram-scale preparation of repr

101 Their utility is validated in examining protein S-persulfidati

102 y was this coagulant increase costly for the utility, it also resulted in compromised filter performa

103 Moreover, we exactly map the complex utility maximization problem to the classic K -means clu

104 -and show that risks can be balanced against utility more effectively than with traditional approache

105 To give this information clinical utility, new methods of detecting nucleic acid sequences

106 In the present study, we demonstrate the utility of "admixture screening" for the discovery of ne

107 of autoimmune encephalitides, comparing the utility of (18)F-FDG PET/CT versus conventional brain im

108 We retrospectively evaluated the utility of (68)Ga-PSMA-11 PET for planning (223)RaCl2 th

109 These studies support the potential utility of (R)-BPO-27 for therapy of CFTR-mediated secre

110 These findings highlight the utility of 3xTg-AD brain slice cultures as a rapid and r

111 l, these results do not support the clinical utility of 5-HT2C agonists and 5-HT2A inverse agonists/a

112 The utility of 6''-(18)F-fluoromaltotriose to help monitor a

113 In this study, we examined the utility of [(18)F](2S,4R)4-fluoroglutamine ([(18)F]4F-Gl

114 The synthesis, photophysics, and biochemical utility of a fluorescent NAD(+) analogue based on an iso

115 udy objective was to evaluate the prognostic utility of a modified HEART score (m-HS) within this tri

116 e as model for DTDS to explore the potential utility of a novel combinatorial adeno-associated viral

117 New England Journal of Medicine describe the utility of abiraterone acetate, an androgen biosynthesis

118 tly suffer from many problems, including low utility of active materials, limited multidirectional st

119 We demonstrate the utility of AD-LIBS with synthetic data.

120 Purpose To compare the diagnostic utility of an investigational optoacoustic imaging devic

121 disease biology, our results demonstrate the utility of association mapping without directly observin

122 Results highlight the utility of association studies in non-model tree species

123 the perspective of maximizing the scientific utility of available data, they come with heavy costs.

124 nate is deactivated by L1 at a low rate; the utility of avibactam might be compromised by mutations t

125 e aptamer-mediated inhibition, the potential utility of broad-spectrum aptamers to overcome resistanc

126 The utility of cancer cell lines is affected by the similari

127 Overall, the model also shows the utility of casting Tourette syndrome within a system-lev

128 These results establish the utility of cell-specific interventions in the GPe to tar

129 llular pathogenesis and highlights the broad utility of cerebral organoids for modeling human neurode

130 To demonstrate the utility of CLAM, we applied it to a wide range of public

131 ether, the analysis presented here shows the utility of combining computational and experimental appr

132 th relationship by oxidative stress, and the utility of complex regression models in capturing mediat

133 Our results demonstrate the utility of computational mapping of the protein-protein

134 Our study demonstrates the utility of CrowdCurio as a crowdsourcing tool for the co

135 This study demonstrates the utility of cryo-EM in revealing structure dynamics withi

136 Although several groups have explored the utility of DBS by focusing on protein detection, the rep

137 These data demonstrate the utility of droplet compartments for the quantitative cha

138 e temporal dynamics of eDNA and validate the utility of eDNA metabarcoding for tracking seasonal dive

139 These data demonstrate the utility of employing an anti-idiotype antibody to monito

140 These results demonstrate the utility of engineered bacteria for querying pathogen beh

141 h different modes of action that improve the utility of entomopathogens as a technology that is compa

142 A nascent area of research focuses on the utility of epigenetic marks in capturing this intersecti

143 Purpose To assess the utility of established functional markers versus two add

144 This study shows the utility of extreme trait selection for genetic study of

145 These results support the utility of FES imaging for assessing tumor heterogeneity

146 Our study underlines the feasibility and utility of gauging the selective forces operating on bac

147 proteome and transcriptome, emphasizing the utility of global proteomic studies.

148 ndings demonstrate the potential therapeutic utility of GSTO1-1 inhibitors in the modulation of infla

149 These results demonstrate the utility of GWA combined with reverse mutagenesis technol

150 Herewith, we showed the potential utility of IN application of FTA loaded HNPs as a non-in

151 We evaluated the diagnostic utility of induced sputum microscopy and culture in pati

152 The clinical utility of inhibiting cytochrome P450 17A1 (CYP17), a cy

153 Our results demonstrate the utility of integrating transcriptomics into the study of

154 More generally, our results demonstrate the utility of IS and GRs in discriminating closely related

155 our succinct total synthesis underscores the utility of long-avoided aryne intermediates for the intr

156 ly relevant concentrations, highlighting the utility of lysine-targeted sulfonyl fluoride probes in d

157 Purpose To investigate the utility of magnetic resonance (MR) elastography-derived

158 Application and utility of mass cytometry in vaccine development.

159 We demonstrate the utility of mass spectrometry-based global exposure metab

160 he midbrain and hindbrain, demonstrating the utility of measuring intrinsic functional connections in

161 Finally, the high utility of MEGA was demonstrated by the one-pot synthesi

162 o identify dysregulated genes and assess the utility of miRNAs for improved outcome prediction.

163 In particular, we argue for the utility of more standardized data collection, adopting a

164 This study thus demonstrates the utility of MSCs as OV carriers to disseminated brain les

165 rillogenesis and more broadly highlights the utility of multimodal measurements as critical test-beds

166 ped the methodology for and investigated the utility of multiparametric imaging of tumor hypoxia and

167 Such knowledge may extend the utility of multiparametric imaging to yield information

168 Indirect evidence supports the utility of multiple screening tests for identifying pres

169 Here, we assess the applicability and utility of multispectral optoacoustic tomography (MSOT)

170 d-bearing polymer network, demonstrating the utility of mussel-inspired bonding for processing a wide

171 ge and temperature conditions may impact the utility of NAATs in some settings and screening programs

172 The target article highlights the utility of new technology to study sign language and ges

173 While the utility of NFL declines in advanced glaucoma, GCC remain

174 medies and yields insight into the potential utility of non-biocide virulence inhibitors in treating

175 The utility of our approach is demonstrated by the late-stag

176 The practicability and utility of our approach is further demonstrated by the c

177 We demonstrate the utility of our method in the efficient, gram-scale synth

178 resent studies suggest potential therapeutic utility of OXR antagonists in reducing psychostimulant-i

179 on may be a plausible approach to expand the utility of PARP inhibitors to endometrioid endometrial c

180 owed that results were most sensitive to the utility of patients post-LT, treatment sustained virolog

181 Here we describe the utility of peptide macrocyclization through perfluoroary

182 rition research that are meant to assess the utility of personalized nutritional strategies.

183 options with glutaminase inhibitors and the utility of PET to identify and manage patients with ccRC

184 udomonas aeruginosa We also investigated the utility of PllA as a probe for detecting alpha-galactosi

185 fabrication of microfluidic networks and the utility of polyacrylamide gel electrophoresis (PAGE), we

186 Previous estimates of the utility of polygenic risk score analysis for the predict

187 ss multiple brain regions and highlights the utility of polygenic risk scores for identifying molecul

188 These findings illustrate the utility of pooled analysis of mouse and human sequencing

189 the first study to demonstrate the clinical utility of predictive genetic testing for MYOC glaucoma.

190 tams and non-beta-lactams and illustrate the utility of PrOF NMR for efficiently analyzing metal chel

191 Here we demonstrate the utility of protein markers to select for disease-resista

192 tained in established CRC cell lines and the utility of proteomics for predicting therapeutic respons

193 ce for future LD studies and demonstrate the utility of proximity labeling to study the regulation of

194 ex chromosome of C. gomesi and highlight the utility of RAD-seq for studying the composition and evol

195 gene discovery, this study demonstrates the utility of rare disease genomic studies to parse gene fu

196 ed with bath-applied RVF5, demonstrating the utility of RVF5 and molecular wire-based voltage sensors

197 ed signals that convey information about the utility of secreted proteins during nutrient-limited gro

198 More importantly, the utility of SELDOM goes beyond basic network inference (i

199 To explore the utility of SFM4-3, we now report the characterization of

200 We assessed the diagnostic utility of skin surface temperature in differentiating c

201 These results demonstrate the utility of SMLM in efficiently uncovering ultrastructura

202 The utility of sodium triflate in facilitating this reaction

203 We examine the utility of solar photovoltaic (PV) system deployment on

204 topic of significant research because of the utility of such assays in resource limited settings.

205 e development of related processes given the utility of sulfides in target-directed synthesis.

206 DLBCL) of the ocular region is rare, and the utility of surgery and radiation therapy remains unresol

207 the hypothalamus is needed to establish the utility of targeting oxytocin signalling in obesity.

208 s made in the field thus far demonstrate the utility of TERS as an approach to interrogate single-mol

209 To demonstrate the utility of the algorithm, we also apply it to cluster ne

210 These results demonstrate the utility of the approach for the discovery of host protei

211 The utility of the approach is highlighted by stereospecific

212 The utility of the approach is highlighted by synthesis of t

213 across multiple sectors and demonstrate the utility of the approach through a case study.

214 We demonstrate the utility of the assay by isolating Ag-reactive plasmablas

215 However, the utility of the commonly used Acidaminococcus sp. BV3L6 C

216 Our results illustrate the utility of the directional phonon suppression function,

217 n questions related to the acceptability and utility of the EQA scheme was distributed to all partici

218 Secondary outcomes were the utility of the goggles in patients with visual suppressi

219 The use and utility of the IEDDA reaction is interdisciplinary and p

220 Several illustrations of the clinical utility of the information obtained for improving treatm

221 vivo Collectively, our studies validate the utility of the Lu-iPSC model for elucidating epigenetic

222 les are detectable in vitro, and explore the utility of the method in vivo in mice with time-lapse im

223 The utility of the method was demonstrated by amplifying CTX

224 sion curve analysis to evaluate the clinical utility of the model by calculating its net benefit in v

225 More broadly, our results establish the utility of the new live-imaging tools for the study of m

226 The utility of the nucleophile-catalyzed (Lewis base) aldol

227 To determine the utility of the pigmented lesion assay (PLA) for LINC0051

228 We assessed the utility of the plaque reduction neutralization test (PRN

229 The utility of the probes for bulk measurements extends also

230 nervous system functions, they challenge the utility of the proposed (ant)agonists as tools to imply

231 signed several RhoGC mutants to increase the utility of the protein for optogenetic studies.

232 Furthermore, the synthetic utility of the protocol is demonstrated by performing a

233 The synthetic utility of the reaction has been further demonstrated by

234 ions were performed to explore the synthetic utility of the synthesized hydroxy indoles.

235 uman placental vessels; (ii) demonstrate the utility of the technique in the comparison of placental

236 This study confirms the utility of the UAD assay for HIV-infected adults compari

237 th case scenarios to illustrate the clinical utility of the website.

238 herapy are required to evaluate the clinical utility of these agents in the treatment of Ph-like ALL.

239 The utility of these compounds is demonstrated in a range of

240 al human gene products, and we exemplify the utility of these data in several applications.

241 additional mechanism towards the therapeutic utility of these drugs as immunosuppressants.

242 Our results suggest a utility of these markers in predicting the presence of e

243 We demonstrate the utility of these nanostructures for photocatalytic chemi

244 The utility of these products is further explored through a

245 The utility of these small hydrogels is demonstrated through

246 Despite the extensive utility of these tools, locus-specific delivery of synth

247 Our results expand the utility of thiolase-based pathways and provide biosynthe

248 le chemical genetics projects highlights the utility of this and related approaches to the extraction

249 upport for the first time, demonstrating the utility of this approach for the synthesis of heterofunc

250 use of exclusive human milk feeding and the utility of this approach in preventing NEC.

251 We exemplify the utility of this approach on several non-essential and es

252 We demonstrate the utility of this approach to detect somatic retrotranspos

253 esting is required to determine the clinical utility of this assay, particularly for the diagnosis of

254 To compare the utility of this Bayesian basket (BB) design with that of

255 available data point to a relevant clinical utility of this imaging technique.

256 To explore the utility of this internal model estimate for brain-machin

257 We demonstrate the utility of this method for detecting abnormalities in ch

258 Versatility and utility of this methodology is demonstrated by postfunct

259 We demonstrate the utility of this model by combining it with previously pu

260 We showcase the utility of this model by evaluating its prediction capab

261 We consider the utility of this perspective for differential diagnosis i

262 MethylationEPIC (EPIC) array expands on the utility of this platform, but has not yet been well char

263 The utility of this reaction is demonstrated through the dir

264 The utility of this reaction is showcased by the constructio

265 otein in mice, which illustrates the general utility of this strategy to modulate the stability and b

266 veloping zebrafish embryo, demonstrating the utility of this system in the acquisition of high-resolu

267 Furthermore, we demonstrate the utility of this system to study neonatal hematopoiesis,

268 While earlier studies have demonstrated the utility of this technology for detection of novel pathog

269 that Cas9 variants can be used to expand the utility of this technology.

270 We further showed the utility of this transition by designing smart, cell-pene

271 Our findings show the utility of trans-ethnic GWASs for discovery and characte

272 We demonstrate the utility of Variant Ranker to identify causal genes using

273 CDR) asymmetry in U.S. adults and assess the utility of vCDR asymmetry in the diagnosis of glaucoma.

274 To assess the clinical utility of WBMRI in germline TP53 mutation carriers at b

275 Further study of the utility of WES in the evaluation and care of patients wi

276 oieties arrayed in a controlled fashion, the utility of which we demonstrate with extensive small mol

277 ysis in the F0 generation, and advancing the utility of X. laevis as a subject for biological researc

278 ith mitochondrial dysfunction, the potential utility of xCT antiporter inhibition should be further t

279 The utility of Xenopus laevis, a common research subject for

280 In addition, our study reinforces the utility of zebrafish as a robust model for studying the

281 Zwitch will extend the utility of zebrafish in organ development and regenerati

282 esearchers, investors, technology providers, utilities, regulators, and other stakeholders to acceler

283 ological factors associated with lower EQ-5D utility score were age, randomisation outside of China,

284 s of general health on a 3-level scale, with utility scores ranging from 0 [death] to 1 [ideal health

285 tant first step to evaluate e-POCT, its true utility should be evaluated through future implementatio

286 hod is a well-recognized reaction of general utility, the associated para-selective C-allylation reac

287 Findings demonstrate this model's utility to delineate mechanisms underlying epileptogenes

288 nt for catalysis and stability in vitro with utility to evaluate potential inhibitors as a platform f

289 This paper describes UPS-indel, a utility tool that creates a universal positioning system

290 sensitive to variations in DAA costs, in the utility value of patients in fibrosis stages F0-F3 post-

291 The analytical utility was further assessed by the selective determinat

292 To demonstrate practical utility, we analyzed the proteomes of 10 human pancreati

293 To illustrate its utility, we applied the correction to HX-MS excipient sc

294 To demonstrate its utility, we applied the framework to examine a growth-mo

295 To advance their utility, we use noncovalent interactions to incorporate

296 To demonstrate its utility, we used ME-Class to analyze 32 datasets from di

297 ts were the mean score for disability on the utility-weighted modified Rankin scale (which ranges fro

298 Transition probabilities and utilities were based on the literature and hepatologist

299 pectrum MMP inhibitors have limited clinical utility, which has spurred the development of inhibitors

300 ver, its underlying mechanisms and potential utility with targeted anticancer therapies remain unknow