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1  measurements of tissue coagulation than did utilizing full power for 12 minutes.
2 lded more peptides than conventional methods utilizing chemical denaturation for 18 proteins out of 2
3                                           By utilizing screening data for 194 potent uncharged hERG a
4                     Here, we have found that utilizing ligands for 3 TLRs (TLR2/6, TLR3, and TLR9) gr
5 mental approaches to understand, modify, and utilize baculoviruses for a variety of applications.
6 n to increase gradually until it was able to utilize the acetate for a secondary round of growth.
7                                     SR tasks utilize the tendency for a male to sniff and interact wi
8                                           We utilized mice heterozygous for a Snap25 null allele and
9         A validated questionnaire for CC was utilized to assess for a relationship between caffeine a
10  and to a potentially futile transplant that utilizes an ECD for a critically ill recipient.
11 BP dimers for inhibition while other targets utilize CtBP monomers for activation of their expression
12 easing number of cellular signaling pathways utilize protein ubiquitination for activation of signali
13 tor, the type 1 receptor for angiotensin II, utilizes this mechanism for activation of NF-kappaB in e
14 NF-TrkB activation, and whether this pathway utilizes histone modifications for activity-dependent tr
15 hese themes, we discuss the growing trend to utilize nanoplasmonic sensors for advanced measurement c
16                           Many countries are utilizing reclaimed wastewater for agriculture because d
17  for variable selection with approaches that utilize direct adjustment for all potential confounders
18 high-efficiency multiple-capillary LC system utilizes switching valves for all operations, enabling a
19 cular decarboxylative allylation, a commonly utilized method for allylation of carbon anions, deacyla
20 ces, external amino acids are preferentially utilized as substrates for aminoacyl-tRNA precursors for
21 via mean-shift) and code parallelization are utilized to provide for an efficient implementation of t
22                                              Utilizing mice transgenic for an influenza virus NP366-3
23 d (TCA) cycle for ATP production rather than utilizing it for anabolic purposes.
24 m in ways indicative of a greater ability to utilize nutrients for anabolism.
25                                      We have utilized GemiNI for analyzing six data sets of solid can
26              Cancer cells were considered to utilize primarily glycolysis for ATP production, referre
27     Furthermore, cell adhesion proteins that utilized F-actin for attachment became properly distribu
28 n result in self-toxicity, producing strains utilize multiple mechanisms for autoimmunity against pro
29                       AMPA receptors seem to utilize distinct mechanisms for basal synaptic localizat
30     Despite the fact that a majority of AAVs utilize sialic acid for binding and transduction, this v
31 nd optical properties, have been extensively utilized as probes for bioanalysis and continue to gener
32 robe interactions, microbial communities, to utilize microbes for bioenergy, bioremediation, etc.
33       Here we investigate the possibility of utilizing solar energy for biomass conversion by perform
34                             Previous studies utilized SPR for blood group antigen detection, however,
35                                         When utilized as electrocatalysts for both cathode and anode,
36 P in a modified glucose breakdown module and utilizes both cofactors for building terpenes.
37 coupling reactions are among the most widely utilized methods for C-C bond formation; however, the re
38 lar components of the neoplastic process and utilizing the data for cancer classification.
39                                  Capacity to utilize amino acids for carbon and energy is also presen
40               Finally, a concise outlook for utilizing POPs for carbon capture is discussed, noting a
41  significantly enough to allow the enzyme to utilize Co(2+) for catalysis.
42 and the ability of the D153H/K328W enzyme to utilize cobalt for catalysis, we determined the structur
43 by bulge deletion, this decreased ability to utilize magnesium ions for catalysis appears to be due t
44 oduction, has 18 free cysteine residues, and utilizes a cysteine for catalysis, we investigated the f
45 e have previously proposed that Ad37 may not utilize CAR for cell entry because of the geometric cons
46                  Members of the Parvoviridae utilize glycan receptors for cellular attachment and sub
47 urce for complex polysaccharides that can be utilized as precursors for cellulosic biofuels.
48 ce plasmon resonance (LSPR) spectrometer was utilized to account for changes in SER signal as a funct
49                                           To utilize biofilms for chemical transformations in biorefi
50                     Despite the potential in utilizing microbial fermentation for chemical production
51  providing more opportunities to efficiently utilize terrestrial emission for clean energy.
52 ic health records (EHRs) are an increasingly utilized resource for clinical research.
53 erse animal species, from insects to humans, utilize acoustic signals for communication.
54 naturation of CcO, the obtained results were utilized only for comparison purposes of kinetic stabili
55 ing metal, needs to be addressed in order to utilize TE technology for competitive, sustainable energ
56 the mechanisms regulating this migration, we utilize mAbs selective for conformational epitopes as pr
57 site of cleavage from caspase-8-cleaved Bid, utilizes Bak for cytochrome c release, and therefore, su
58                     The innate immune system utilizes many approaches for defense against invading mi
59 trasts with the favorable entropic mechanism utilized by gp130 for degenerate cytokine interaction.
60 al DNA associates with condensed chromosomes utilizing spindle microtubules for delivery.
61 of two or more treatments have traditionally utilized methods for demonstrating superiority, and, if
62       Several large-scale projects worldwide utilize the HPO for describing phenotype information in
63 chial blood pressure index (ABI) is a widely utilized measure for detecting peripheral arterial disea
64                  Luminophores are frequently utilized probe labels for detecting biological analytes.
65  (HPLC)-tandem mass spectrometry method that utilizes benzoyl chloride for determination of the most
66                                           By utilizing geochemical methods for determining their diet
67              MiR profiles have been recently utilized as biomarkers for diagnosis and prognostic purp
68      Disease gene expression profiles can be utilized as biomarkers for diagnostic, prognostic, and t
69                    Radiation is increasingly utilized in medicine for diagnostic and therapeutic proc
70  output is dominated by the NG; these can be utilized complementarily for different applications.
71 manner, the question as to how the beta cell utilized RhoGDI for differential Cdc42 and Rac1 cycling
72 nsmitter release whereas electrical synapses utilize gap junctions for direct ionic and metabolic cou
73                In this study we designed and utilized an apparatus for directly measuring the osmotic
74                             Diverse microbes utilize aromatic compounds for diverse purposes.
75 aeruginosa is an opportunistic pathogen that utilizes QS for diverse activities, including disease pa
76 , animals and plants, mitochondria no longer utilize FtsZ for division, but several mitochondrial div
77               Many viruses and bacteriophage utilize chaperone systems for DNA replication and viral
78                                Investigators utilize gap estimates for DNA sequencing projects.
79 K1 expression and the extent to which tumors utilize thymidine salvage for DNA synthesis decouple [(1
80            To establish if exosomes could be utilized effectively for drug delivery, a better underst
81 generated a homology model for GLUT4 that we utilized to screen for drug-like compounds from a librar
82 m cells to enhance regenerative capacity and utilizing stem cells for drug discovery have expanded th
83                                           We utilized synthetic peptides for EA, EB, and a scrambled
84 a two-dimensional multiplexing workflow that utilizes synthetic peptides for each protein to prompt t
85 er progression, and multiple human pathogens utilize CD147 for efficient infection.
86 These results show conclusively that PrP can utilize copper for electron transfer, which would be exp
87                   Thus, we propose that Erv1 utilizes diverse pathways for electron shuttling in the
88 extensive cancer research has been conducted utilizing animal models for elucidating mechanisms and d
89                       Tumour cells primarily utilize aerobic glycolysis for energy production, a phen
90 n humans is low or absent in organs known to utilize fatty acids for energy such as heart, muscle, an
91    The C2H2 zinc finger is the most commonly utilized framework for engineering DNA-binding domains w
92 controlling biofilm formation, and emphasize utilizing these tools for engineering applications.
93  possibility that the bisubstrate inhibitors utilize a transporter for entry across the mycobacterial
94                     Although individual CNTs utilize distinct proteins for entry, they share common g
95  responsible for the inability of B virus to utilize HVEM for entry.
96 of the alphavirus Ross River virus (RRV) and utilize them for entry into cells.
97 lated GAGs are attachment receptors that are utilized by filoviruses for entry and infection.
98 member of the Filoviridae family of viruses, utilizes PtdSer receptors for entry into target cells.
99 une epitopes from selected infectious agents utilizing complementary methods for epitope discovery.
100 th distinct replication strategies, they all utilize common mechanisms for establishment of long-last
101                       Streptococcus pyogenes utilizes numerous mechanisms for evading the host immune
102                 To address this question, we utilized zebrafish mutants for ewsa and tp53.
103 ion in the energy conversion/storage devices utilizing basic electrolytes, for example, alkaline fuel
104 helps advance our understanding of how brain utilizes repetition for faster information processing.
105 of lung transplantation in the United States utilizing EVLP for functional optimization leading to su
106 rder to integrate data from such studies and utilize it for further biological discovery, we collecte
107                              In vitro assays utilizing recombinant substrates for gamma-secretase, an
108                   The best carboplatin model utilized canine lines for gene identification and model
109                 For example, the most highly utilized platforms for gene expression microarrays, Affy
110 etworks, in which multiple memory nodes that utilize atoms for generation, storage and processing of
111 erated on the Zea mays reference inbred B73, utilizing ApeKI for genome reduction and single-end read
112  VHL-/- cells but not in VHL+/+ cells, which utilized glucose oxidation for glutamate and aspartate p
113 roorganisms to tolerate and even exclusively utilize aromatic compounds for growth, making them good
114 abundant intracellular folate, and could not utilize exogenous homocysteine for growth.
115  Salmonella enterica serovar Typhimurium can utilize molecular hydrogen for growth and amino acid tra
116 in contrast to normal cells, which primarily utilize oxidative phosphorylation for growth and surviva
117 t is further shown that MG1655 predominantly utilizes glycolytic substrates for growth in the mouse i
118 eta signaling, suggesting that InR signaling utilizes Dap for GSC cell cycle regulation.
119                                      Studies utilizing collagen membranes for guided tissue regenerat
120  quality improvement projects are summarized utilizing the Institute for Healthcare Improvement frame
121 he work delineates the very first example of utilizing CO2 for heterogeneous C-H activation and carbo
122 der mixotrophic conditions but was unable to utilize these reserves for heterotrophic growth.
123 lysis provides a model for how tetanus toxin utilizes coreceptors for high-affinity binding to neuron
124                                          QPI utilizes optical interference for high-precision measure
125 e parameter assay, future work will focus on utilizing the platform for highly multiplexed, label-fre
126  requirement of adenosine triphosphate (ATP)-utilizing motor proteins for histone deposition in vivo.
127 poson-based vector adjacent to the host DNA, utilizing repetitive sequences for homologous recombinat
128 xes encoded by CRISPR-associated (cas) genes utilize small RNAs for homology-directed detection and s
129 coding the genotype 5a glycoproteins able to utilize CLDN6 for host cell entry.
130                                           We utilized mice transgenic for human leukocyte antigens (H
131  unable to metabolize storage oil and cannot utilize applied sucrose for hypocotyl elongation in the
132 effective SAM-mediated delivery systems have utilized nonspecific interactions for immobilization; ho
133 es a new explanation why pathogenic microbes utilize plasmin(ogen) for immune evasion and tissue pene
134 ic indole fluorophore of tryptophan has been utilized extensively for in vitro studies to advance our
135 t high doses of Rapamycin, the most commonly utilized mTOR inhibitor for inducing autophagic killing,
136                     In the corpus, H. pylori utilizes chemotaxis for initial localization but not for
137 modified membranes termed membranous web and utilizes lipid droplets for initiating the viral nucleoc
138 omain, suggesting that different Ets factors utilize different domains for interaction with AML1.
139         Cox proportional hazards models were utilized to test for interaction between chemotherapy tr
140                             Cath and CMR are utilized together for interventions and assessment of ao
141                           These measurements utilized Fluo5N-AM for intra-SR Ca2+ from intact cells a
142 meability barrier of Gram-negative pathogens utilizing enterobactin for iron acquisition.
143 ng to the increase of lysosomal iron that is utilized by ART for its cytotoxic effect on cancer cells
144 ransposon Dme1_chrX_2630566, a candidate for utilizing slippage for its GagPol synthesis, exhibits st
145 d polyelectrolyte, in a predetermined order, utilizing electrostatic interactions for layer growth.
146 constants for high-affinity hemoglobins that utilizes a competition for ligands between the "target"
147 he others are FtsE, FtsX, and FtsQ) shown to utilize the SRP for localization, which may in part expl
148 nti-infective nanomaterial is developed that utilizes two strategies for localization: i) a biodegrad
149 orms with robust regenerative capacities and utilize epidermal cilia for locomotion.
150 sis of virus replication and the capacity to utilize imaging systems for longitudinal measurements of
151 ytosis, or toward a degradation process that utilizes AEs either for lysis within the terminal or for
152 of telomerase by Est1 appears to be a widely utilized mechanism for maintaining telomere length homeo
153  for high-performance computation, the PEPIS utilizes C/C++ for mathematical matrix computing.
154 to teach from a broadened perspective and to utilize new strategies for maximizing student learning.
155  anti-VEGF injection was the most frequently utilized treatment for mCNV.
156 resonance energy transfer (FRET) is a widely utilized optical technique for measuring small distances
157 iate outcomes of dialytic care were examined utilizing the Center for Medicare & Medicaid Services' (
158 observations could inform future attempts to utilize NovP for methylating a range of glycosylated com
159 comparative analyses with osteoclasts, which utilize podosomes for migration.
160 roblasts derived from the Rac2 knockout mice utilize Rac1 for migration via alphavbeta3/alphavbeta5 a
161 ractable heart failure have been more widely utilized than therapies for mild-to-moderate heart failu
162                   Although many studies have utilized archived plasma for miRNA biomarker discovery,
163 ical for assessing the cost-effectiveness of utilizing cellulosic ethanol for mitigating GHG emission
164  as well as the signal transduction pathways utilized by them for MNC homing in vitro and in vivo.
165  regulatory mechanism may represent a widely utilized strategy for modulating replication.
166                                           To utilize gap junctions for molecular delivery we have dev
167         While there are a number of commonly utilized approaches for monitoring microbial abundance,
168                            The most commonly utilized microarrays for mRNA profiling (Affymetrix) inc
169             The FDT response operator can be utilized directly for multiple climate change scenarios,
170 est hydrocarbon target is methane, which can utilize existing infrastructure for natural gas storage,
171                      However, although NKp65 utilizes Syk for NK cell activation, a physical associat
172 racker-positivity implies that healthy cells utilize active caspases for non-apoptotic physiological
173 -active ligand allows high-valent rhenium to utilize a mechanism for O(2) activation that is atypical
174                        Most experiments have utilized transfection models for ORF57 and have not syst
175    Lastly, we anticipate that the conditions utilized herein for orthogonal cysteine unmasking are no
176 , these studies also support the concept for utilizing agents designed for other clinical application
177         These data prompt the examination of utilizing this strategy for other musculoskeletal tissue
178                                 Nature often utilizes molecular oxygen for oxidation reactions throug
179 ted (hypoxic) regions, which were thought to utilize glucose for oxidative and glycolytic metabolism,
180 via monocarboxylate transporter 1 (MCT1) and utilize it for oxidative phosphorylation (see the relate
181 via monocarboxylate transporter 1 (MCT1) and utilize it for oxidative phosphorylation (see the relate
182 mous carcinoma cell line that preferentially utilized lactate for oxidative metabolism.
183 nclude that choline oxidase must necessarily utilize a strategy for oxygen reduction different from t
184                            In this report we utilize orthology assignments for pairs of genes co-regu
185 e introduce an exogenous contrast agent that utilizes vaporization for photoacoustic signal generatio
186 ucts were identified using Internet searches utilizing keywords for phthalates.
187 opteran systematists, as well as researchers utilizing rRNA sequences for phylogeny estimation in any
188 ssor genes that induce DDR activation can be utilized as biomarkers for poor outcome.
189                                    M. prunae utilizes VapC toxins for post-transcriptional regulation
190         Multivariate logistic regression was utilized to adjust for potential confounding.
191 in mice challenged with 10 LD50 of virus and utilized the model for preclinical evaluation of a vacci
192         Small molecules investigated to date utilizing (68)Ga for preclinical CA IX imaging are scarc
193                                     Here, we utilized 6 for preparation of labeled oligodeoxynucleoti
194 The Balz-Schiemann reaction remains a highly utilized means for preparing aryl fluorides from aniline
195          Here, we report an FN3 library that utilizes alternative positions for presenting amino acid
196 attention because of its ability to directly utilize solar energy for production of solar fuels, such
197          We hypothesized that these peptides utilize several mechanisms for protection.
198                                              Utilizing receptor for protein kinase 1 (RACK1) as the r
199                                   Instead of utilizing single spectrum for proteoform quantitation, i
200 iruses of the Reoviridae family is that they utilize these sites for purposes of replication and caps
201                  The small molecule approach utilizes pairing rules for pyrrole-imidazole polyamides
202                              The most widely utilized approaches for quantifying DNA methylation invo
203 ilm platinum electrodes (20 mumx300 mum) and utilized these for quantitative detection of catecholami
204 tifies that diverse molecular mechanisms are utilized by HCMV for rapid NF-kappaB activation.
205                                 The platform utilizes flow chemistry for rapid in-line synthesis, aut
206                                 Our approach utilizes robotic automation for rapid analysis of sequen
207 targeted MS(E) approach is also demonstrated utilizing IMS for rapid characterization of small molecu
208 lecules to proteins, is emerging as a widely utilized mechanism for rapidly regulating cell signaling
209 ed with cervical ultrasonography (US): US is utilized to search for recurrences within the thyroid be
210      Our results demonstrate the benefits of utilizing aminoxyTMT reagents for reliable quantitation
211 pressional divergences suggest that FACs are utilized mainly for removal of excessive nitrogen in gen
212   Human immunodeficiency virus-1 (HIV-1) may utilize autophagy for replication as the autophagy-relat
213 nome into a host cell chromosome in order to utilize host factors for replication and expression of v
214                          A combined approach utilizing MTA for root surface repair, and DFDBA and cal
215            Here we report a simple strategy, utilizing sortase A, for routine preparation of recombin
216                      Additionally, this work utilized direct injection for sample introduction throug
217                                              Utilizing models for SARS-CoV infection, key components
218 nance contribution to a complex trait and to utilize dominance for selecting individuals with favorab
219                 Moreover recent designs that utilize beads for sensing DNA have been limited towards
220 hat inactivation of ytpB, encoding a C35 -PP utilizing enzyme required for sesquarterpenoid synthesis
221                                Advantages of utilizing phospholipid pseudogels for sieving are the ea
222 o distinguish between SecA residues that are utilized more exclusively for signal peptide recognition
223                   Nanopores are increasingly utilized as tools for single-molecule detection in biote
224                            Here, the authors utilize a nanocarrier for siRNA for treatment of arterie
225                                           We utilized this chemistry for site-specific fluorescence l
226                     This format has not been utilized previously for solid-phase extraction of drugs
227                                         PET, utilizing probes for specific metabolic processes, detec
228         One allele-defining SNP per gene was utilized to test for statistical associations of sire al
229                             Polycystin-1 may utilize this association for structural, storage, or sig
230 including structure-specific colour schemes, utilizing helper applications for structure prediction a
231                           Bacteria and yeast utilize different strategies for sulfur incorporation in
232 ng triple-negative breast cancers (TNBC), to utilize glutamine for survival and growth.
233                  Taken together, complexin-1 utilizes distinct mechanisms for synchronization of Ca(2
234 unterpart Smad4, Drosophila Medea appears to utilize different mechanisms for TGF-beta-induced or bas
235                                      Here we utilize antibodies specific for the nitrosothiol (SNO) m
236                 In higher plants, which also utilize arginine for the production of polyamines and NO
237 ce a mechanism by which 4CL1 can selectively utilize caffeate for the support of monolignol biosynthe
238         Transgene integration is believed to utilize existing machinery for the detection and repair
239 educed germinative capacity and inability to utilize glucose observed for the DeltapkaC1DeltapkaC2 st
240 lphaP360A/alphaH361A/betaR265A was unable to utilize glutamine for the synthesis of carbamoyl phospha
241  topaquinone (TPQ) containing amine oxidases utilize O2 for the metabolism of biogenic amines while c
242                                 Studies that utilize stem cells for the efficient derivation of megak
243                                      Here we utilize the capacity for the Xenopus oocyte to chromatin
244 s in the area of materials chemistry, and to utilize them for the transformation of biomass derived m
245  methods for the quantification of motion to utilize this framework for the classification of two dif
246                              Furthermore, we utilize this triphosphate for the enzymatic preparation
247 croorganisms having multiple chromosomes may utilize unique mechanisms for the control of replication
248                                The processes utilized allow for the conformal deposition of other mat
249 lly innocuous enantiotopic methyl groups are utilized as probes for the distinct environments that de
250                           UDP-GlcNAc is also utilized as substrate for the glycosyltransferase MurG,
251 its insoluble all-trans-retinyl esters to be utilized as substrate for the synthesis of a new visual
252 nd A3 adenosine receptors are differentially utilized by inosine for the down-regulation of tissue da
253 carbons (PAHs) in mammals, but they are also utilized by microorganisms for the degradation of these
254              The critical adhesion molecules utilized by Tregs for the interaction with their target
255 that the majority of the 52 CDR residues are utilized differently for the two antigen binding functio
256  The peroxidase-like activity of CoOxH-GO is utilized herein for the quantitation of H2O2 in a wide c
257                                    ICUs that utilized invasive techniques for the diagnosis of ventil
258                                        While utilized previously for the construction of alternating
259          Pediatric intensive care units that utilized protocols for the initiation and advancement of
260  have shown that MT-stabilizing drugs can be utilized to compensate for the loss of tau function and
261 mining, and whether mass spectrometry can be utilized to screen for the co-expression of functionally
262 w common in organic synthesis, have not been utilized widely for the synthesis of clusters.
263 ntroduce a filter-optimization method, which utilizes an expression for the signal-to-noise ratio (SN
264 e first Suzuki cross-coupling reaction which utilizes dihalo compounds for the preparation of seconda
265 ers revealed that T. denticola predominantly utilizes TLR2/6 for the induction of cellular responses.
266                                              Utilizing agricultural biomass for the production of bio
267         Taking this system as an example and utilizing Associative Transcriptomics for the first time
268                                              Utilizing colloidal particles for the assembly of the sh
269 of a novel oxidative deprotection procedure, utilizing DMDO, for the conversion of a late-stage benzy
270   There is currently substantial interest in utilizing eukaryotic algae for the renewable production
271 the task of uncovering this organization and utilizing it for the understanding of disease complexity
272     Although there exist a number of studies utilizing microdevices for the creation of molecular gra
273  catalysts to effect the challenging task of utilizing molecular oxygen for the selective epoxidation
274             However, this synthetic strategy utilizing Suzuki reaction for the preparation of 16 was
275 everal recent studies constitute progress in utilizing this knowledge for the development of an HIV-1
276                                              Utilizing this pipeline, for the first time we determine
277                   Almost all viral pathogens utilize a cytoskeleton for their entry and intracellular
278      Second, we found that AtOEP80 and Toc75 utilize different mechanisms for their targeting to the
279                                    To better utilize limited resources for their survival and reprodu
280 m the intestinal lumen into blood as well as utilizing copper for their biosynthetic needs.
281 atabase provides information about the genes utilizing these events for their expression, recoding si
282 S has provoked an intense search for ways to utilize their potential for therapeutic treatments of mu
283             The major hurdle associated with utilizing oligodeoxyribonucleotides for therapeutic purp
284 his technology, most research has focused on utilizing these cells for therapeutic purposes.
285                                    The tools utilized to test for these viruses are quite sensitive h
286        Recent published studies suggest that utilizing bedside ultrasound for these purposes may be b
287           Mass spectrometry (MS) is a highly utilized analytical tool for this due to fast and accura
288 flavin site but can exist as an oxidase that utilizes O2 for this purpose.
289 d "near-infrared imaging" to identify trials utilizing FGS for those received on or before May 2016.
290 eosinophils, like neutrophils and monocytes, utilize PECAM for tissue recruitment to sites of allergi
291              Through a series of experiments utilizing mice deficient for TLR7 together with adoptive
292 ventral-temporal retinal ganglion cell axons utilize reverse signalling for topographic mapping.
293  spectrum of nitroglycerin (NG) was obtained utilizing RIIN for tranducing the mobility separated ion
294 enterica serovar Typhimurium and S. flexneri utilize different mechanisms for triggering the inductio
295 r combined device provides a simple model to utilize multiple droplets for various reactions with low
296          RIP3 regulates autophagy, a process utilized by CVB for viral replication factory assembly,
297 he emerging green bioenergy domains that are utilizing microorganisms for wastewater treatment or ele
298         Conventional interferometers usually utilize beam splitters for wave splitting and recombinat
299 anar array infrared (PA-IR) technique, which utilizes a spectrograph for wavelength dispersion and a
300  these experiments, Vermeulen and colleagues utilize a reporter for Wnt activity and show that colon

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