ライフサイエンスコーパス: v-Myb

1 itially called mab or amv, but later renamed v-myb).

2 ted to the different activities of c-Myb and v-Myb.

3 for increasing the transforming activity of v-Myb.

4 as created by combining Myb repeats of P and v-Myb.

5 distinct DNA binding specificities of P and v-Myb.

6 intaining a fully functional conformation of v-Myb.

7 to play a critical role in the regulation of v-Myb activity.

8 sgenic mice shows that ectopic expression of v-Myb affects the ratio of helper to cytotoxic T cells,

9 These results suggest that mutations in v-Myb allow it to evade a negative regulatory mechanism

10 l activation and oncogenic transformation by v-Myb Amv.

11 Therefore, v-myb and c-myb can cooperate to induce T cell lymphomas

12 ific genomic rearrangement between potential v-myb and c-myb consensus binding sites within introns 2

13 his differential effect of D-type cyclins on v-Myb and c-Myb might help to explain the mechanism unde

14 In human cells, the v-Myb and c-Myb proteins displayed strikingly different

15 e combined structure-function studies of the v-Myb and c-Myb proteins with unbiased microarray-based

16 Our results show that while v-myb and c-myb transactivated transcription equally wel

17 Differences in the DNA binding domains of v-Myb and P, which are conserved among animal and plant

18 number of different fusion proteins between v-Myb and the human estrogen receptor (ER).

19 Furthermore, IFN regulatory factor 1, c/v-Myb, and p53 binding sites are present in the promoter

20 This exon is not present in v-myb, and proteins containing these amino acids have ne

21 l3 which harbor myb transgenes; derived from v-myb, and the ABPL-1, ABPL-2, ABPL-4 and NFS-60 cell li

22 Regions flanking this central domain of v-Myb are required for transcriptional activation by the

23 two angiocentric gliomas in the related gene v-myb avian myeloblastosis viral oncogene homolog (MYB)

24 ly of salivary gland origin, has a signature v-myb avian myeloblastosis viral oncogene homolog-nuclea

25 P and v-Myb bind different DNA sequences in vitro.

26 t repressor of transcriptional activation by v-Myb but not c-Myb.

27 vely studied as a transcriptional activator, v-Myb can repress biologically relevant genes such as Et

28 f the N and/or C terminus of c-Myb, found in v-Myb, can potentiate its transforming ability.

29 The v-Myb conformation is thus suggested to play a critical

30 arboxyl terminus of c-Myb that is deleted in v-Myb contains negative regulatory domains.

31 The v-Myb DNA-binding domain differs from that of c-Myb main

32 bit transcription when activated through the v-Myb DNA-binding domain, but not the c-Myb DNA-binding

33 and CCd, while doubly truncated Myb proteins v-Myb (dVd) and dCd did not exhibit any differences in t

34 The nuclear protein v-Myb, encoded by the avian myeloblastosis virus (AMV),

35 hown that some genes that are regulated by a v-Myb-ER fusion protein may not be relevant to the biolo

36 Nevertheless, transformation by a v-Myb-ER fusion was estrogen dependent, and upon withdra

37 The Ets-2 gene was not expressed in v-Myb-ER transformed cells in the presence of estradiol,

38 presence but not the absence of estradiol in v-Myb-ER transformed cells.

39 LIM-3 expression was estradiol-inducible in v-Myb-ER transformed monoblasts, LIM-3 was expressed nei

40 cells transformed by a retrovirus encoding a v-Myb-estrogen receptor (ER) fusion protein.

41 Each type of mutation that distinguished v-Myb from c-Myb, including the N- and C-terminal deleti

42 Both c-Myb and v-Myb functioned as repressors and reduce the basal acti

43 The N terminus of v-Myb functions as the DNA-binding domain, and multiple

44 peat region of c-Myb that is also present in v-Myb functions only in conjunction with the Myb DNA-bin

45 The avian retroviral v-myb gene and its cellular homologues throughout the an

46 Thus, the v-myb gene encoded by the Avian Myeloblastosis Virus, is

47 We conclude that although v-Myb has been intensively studied as a transcriptional

48 hout affecting transcriptional activation by v-Myb in budding yeast.

49 The results suggest that v-Myb is not just a de-repressed version of c-Myb.

50 T cell lymphomas develop, demonstrating that v-Myb is oncogenic in T cells.

51 To date, v-myb is the only myb gene directly implicated in tumori

52 t studies have demonstrated that A-myb, like v-myb, is a potent transcriptional activator, raising th

53 factor, in cooperation with either c-Myb or v-Myb, is active in the combinatorial activation of myel

54 d by all of the mutants analyzed here except v-Myb itself exhibited the same phenotype as those trans

55 ement of the c-myb proto-oncogene to yield a v-Myb-like protein leads to myeloid and B cell lymphomas

56 V-myb myeloblastosis viral oncogene homolog (MYB) protei

57 rimary yolk sac cells transformed by unfused v-Myb nor in BM2 cells.

58 To study the effects of deregulation of v-Myb on T cell development, we have generated lines of

59 The v-Myb oncogene causes late onset T cell lymphomas when e

60 The v-Myb oncogene causes monoblastic leukemia and transform

61 The v-myb oncogene of the avian myeloblastosis virus (AMV) i

62 The v-myb oncogene of the avian myeloblastosis virus has led

63 In order to make conditional alleles of the v-myb oncogene, we constructed and tested avian retrovir

64 uctural and functional similarities with the v-myb oncogene.

65 The v-Myb oncoprotein encoded by Avian Myeloblastosis Virus

66 erated lines of transgenic mice in which the v-Myb oncoprotein is expressed in a T-cell-specific fash

67 nimal transcription activation domain of the v-Myb oncoprotein was initially mapped to a central clus

68 tive regulatory domain that is absent in the v-Myb oncoprotein, but conserved among all the known Myb

69 the AML1-ETO, AML1-MDS1, CBFbeta-SMMHC, and v-Myb oncoproteins.

70 In contrast, the full length v-Myb protein from BM2 cells only bound to the middle on

71 The v-Myb protein is a mutated and truncated version of c-My

72 The v-Myb protein is nuclear and binds to specific DNA seque

73 n electrophoretic mobility shift assays, the v-Myb protein is shown to be present in different confor

74 nt to the biological function of the unfused v-Myb protein.

75 The c-Myb and v-Myb proteins are transcription factors that regulate c

76 hat is recognized by an antibody against the v-myb repeat domain.

77 v-Myb, the transforming protein of avian myeloblastosis

78 w analyzed a series of C-terminal mutants of v-Myb to further investigate this domain.

79 phorbol ester-induced differentiation of the v-Myb-transformed BM2 cell line.

80 Analysis of T cell development in the v-Myb transgenic mice shows that ectopic expression of v

81 h s-Myb to cause lymphomas, we have infected v-Myb transgenic mice with Moloney murine leukemia virus

82 To identify genes regulated by v-Myb, we utilized primary cells transformed by a retrov

83 chanism underlying the oncogenic activity of v-Myb, which appears to be a stronger transcriptional ac

84 to bind or inhibit the oncogenic derivative v-Myb, which has a mutated Cyp-40 binding site.

85 his region is essential for the functions of v-Myb without requiring a heptad leucine repeat.