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1 sion in promoting the cell-to-cell spread of vaccinia.
2 however, reduces the cell-to-cell spread of vaccinia.
6 : replication-deficient adenovirus; modified vaccinia Ankara (a poxvirus); protein with alum; and pro
7 veral months, we boosted ChAd3 with modified vaccinia Ankara (MVA) and generated, for the first time,
8 en of peptide priming followed by a modified vaccinia Ankara (MVA) boost in a nonhuman primate model,
9 denovirus serotype 26 (Ad26) prime, modified vaccinia Ankara (MVA) boost) and stimulation of TLR7 (To
10 old range of an admixed recombinant modified vaccinia Ankara (MVA) expressing rhesus GM-CSF (MVA/GM-C
12 of lactating rhesus monkeys with a modified vaccinia Ankara (MVA) prime/intramuscular (i.m.) protein
13 ffect of adding a booster dose of a modified vaccinia Ankara (MVA) strain, encoding the same Ebola vi
15 tein from a clinically proven safe, Modified Vaccinia Ankara (MVA) vector, thus averting the potentia
19 effect of boosting of Malians with modified vaccinia Ankara expressing Zaire Ebola virus glycoprotei
20 enhanced, T and B cell responses to modified vaccinia Ankara vaccination in a nonhuman primate model
21 using PBMCs isolated on day 7 post-modified vaccinia Ankara vaccination, the earliest time point at
24 enicity evaluation of PENNVAX-G DNA/modified vaccinia Ankara-Chiang Mai double recombinant (MVA-CMDR)
28 human somatostatin receptor 2 (hSSR2) in the vaccinia-based OV and tested viral constructs for their
30 nhibits intravenously administered oncolytic vaccinia delivery to and consequent spread within the tu
31 trated that many envelope viruses, including vaccinia, dengue, West Nile, and Ebola viruses, utilize
38 logous prime-boost regimens, with a New York vaccinia HIV clade B (NYVAC-B) vaccine and a recombinant
41 e further characterize the role of B1 during vaccinia infection to gain novel insights into its regul
42 vealed that PP2A dephosphorylates BAF during vaccinia infection, thus counterbalancing the activity o
43 previously identified a nonsense mutation in Vaccinia-related kinase 1 (VRK1), R358X, as a cause of S
53 ed interactions between genetically-modified vaccinia virus (GLV-1h68) and radiotherapy in melanoma c
54 ract of inflamed rabbit skin inoculated with vaccinia virus (Neurotropin((R))) enhanced efficiency of
55 of a CXCR4 antagonist expressed by oncolytic vaccinia virus (OVV) against an invasive variant of the
56 adults, with or without immunity to CMV and vaccinia virus (previous DryVax smallpox vaccination).
57 owed by intranasal boosting with recombinant vaccinia virus (rVV) encoding S436 or S525 resulted in a
61 produced in excess in cells infected with a vaccinia virus (VACV) decapping enzyme mutant and by wil
70 This work reveals the prototypic poxvirus Vaccinia virus (VACV) exploits cellular retrograde trans
71 ses; instead, we identified mutations in two vaccinia virus (VACV) genes, A24R and A35R, either of wh
73 assessed several routes of immunization with vaccinia virus (VACV) in protecting mice against ectrome
75 -knockout CD8(+) TRM cells generated by skin vaccinia virus (VACV) infection were less effective at p
76 In establishing a respiratory infection, vaccinia virus (VACV) initially replicates in airway epi
82 elicited protective immunity.IMPORTANCE The vaccinia virus (VACV) K1 protein inhibits NF-kappaB acti
89 PKRs were able to restrict replication of a vaccinia virus (VACV) strain that lacks the PKR inhibito
90 high-throughput RNAi screen directed against vaccinia virus (VACV) to identify the VACV AAA+ ATPase D
93 virus (ECTV), a natural mouse pathogen, and vaccinia virus (VACV), a heterologous virus that neverth
94 arly every step in the reproductive cycle of vaccinia virus (VACV), a large DNA virus with about 200
101 are antigen-transporting cells that generate vaccinia virus (VACV)-specific T-cell responses, yet how
115 Chimpanzee adenovirus-6 (AdC6) or -7 (AdC7), Vaccinia virus (VV), and DNA given by electroporation (D
116 each viral protein in persons immunized with vaccinia virus (VV), either recently or more than 40 yea
119 e-prototype JX-594), a replication-competent vaccinia virus administered by intravenous injection, to
120 steria monocytogenes, Shigella flexneri, and Vaccinia virus among other pathogens use the same common
122 oping potent neutralizing antibodies against vaccinia virus and comprehensively characterizing their
128 bisbenzimide derivatives are potent against vaccinia virus and other poxviruses but ineffective agai
130 bility to monkeypox virus, cowpox virus, and vaccinia virus and thus providing a unique model for stu
131 r of the Orthopoxvirus genus, which includes Vaccinia virus and Variola virus (the causative agent of
133 uential immunizations with DNA (D), modified vaccinia virus Ankara (MVA) (M), and protein immunogens,
134 The clinically relevant vectors modified vaccinia virus Ankara (MVA) and the chimpanzee adenoviru
135 impanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankara (MVA) and used to immunize mice in
138 priming with DNA and boosting with modified vaccinia virus Ankara (MVA) expressing HIV-1 Env on viru
140 asal administration of the poxvirus modified vaccinia virus Ankara (MVA) is sufficient to induce high
141 ctors simian adenovirus 63 (ChAd63)-modified vaccinia virus Ankara (MVA) is the most potent inducer o
142 we show that a CD40L-adjuvanted DNA/modified vaccinia virus Ankara (MVA) simian immunodeficiency viru
143 M1L is absent in the attenuated modified vaccinia virus Ankara (MVA) strain of VACV, a strain tha
144 We have constructed a recombinant modified vaccinia virus Ankara (MVA) that expresses an H5N1 mosai
145 to adjuvant the DNA prime of a DNA/modified vaccinia virus Ankara (MVA) vaccine in rhesus macaques.
146 ity to both insert Ag85A and vector modified vaccinia virus Ankara (MVA) was assessed by ex-vivo inte
148 ific T cells induced by a DNA-prime modified vaccinia virus Ankara (MVA)-boost vaccination strategy,
149 virus (SIV) challenges in seven DNA/modified vaccinia virus Ankara (MVA)-vaccinated rhesus macaques w
152 /IL-15, SIV Gag/Pol/Env recombinant modified vaccinia virus Ankara (rMVA), and AT-2 SIVmac239 inactiv
153 imate model that vaccination with a modified vaccinia virus Ankara encoding hemagglutinin from a hete
154 f a candidate tuberculosis vaccine, modified vaccinia virus Ankara expressing antigen 85A (MVA85A), i
156 e questions in the context of a DNA/modified vaccinia virus Ankara SIV vaccine with and without gp140
157 r SIVmac239 envelope-expressing DNA/modified vaccinia virus Ankara vector- and protein-based vaccinat
158 oost regimen with a mixture of MVA (Modified Vaccinia virus Ankara) and Ad5 (human adenovirus type 5)
159 far, well-described vectors such as modified vaccinia virus Ankara, complex adenovirus, vesicular sto
160 impanzee adenovirus 63, ChAd63, and modified vaccinia virus Ankara, MVA, expressing AgAPN1, Pfs230-C,
161 ized with SIVmac239-based DNA-prime/modified vaccinia virus Ankara-boost vaccine regimens that includ
162 ther a chimpanzee adenovirus 63 and modified vaccinia virus Ankara-vectored vaccine expressing a mult
164 as been developed using the immunogenic live vaccinia virus as a vaccine vector, expressing multiple
165 protein toxins, potently prevented spread of vaccinia virus as well as monkeypox virus, a human patho
167 and ovarian cancer models that an oncolytic vaccinia virus attracts effector T cells and induces PD-
168 t that dynamic phosphorylation involving the vaccinia virus B1 kinase and cellular enzymes is likely
170 The most well characterized role for the vaccinia virus B1 kinase is to facilitate viral DNA repl
172 HIV-1 antigens, with one of them lacking the vaccinia virus B19 protein, an inhibitor of the type I i
175 uperinfection exclusion may be beneficial to vaccinia virus by selecting particles that can infect ce
177 red improved protection against Listeria and vaccinia virus challenges compared with the Armstrong bo
181 nsight into the role of D4 as a co-factor of vaccinia virus DNA polymerase and allows a better unders
187 vides complete immune control of recombinant vaccinia virus expressing the same epitope if KCSRNRQYL
190 rhtrs1-amplified viruses, there arose in two vaccinia virus genes mutations that improved viral repli
191 t on the rapid positive selection of a novel vaccinia virus genomic duplication mutant in the presenc
192 omologs of the Bcl-2 family of proteins, and vaccinia virus harbors antiapoptotic F1L that potently i
194 modified by the insertion of the K1L and C7L vaccinia virus host range genes and express the clade C(
195 per by applying it to SIM and STED images of vaccinia virus in isolation and when engaged with host c
196 , we analyzed the responses of host cells to vaccinia virus infection at both the transcriptional and
197 minor groove of double-stranded DNA, inhibit vaccinia virus infection by blocking viral DNA replicati
202 dependent of infection or during a surrogate vaccinia virus infection to identify how MC159 prevented
203 infection with either virus, after a cleared vaccinia virus infection, and during a persistent/latent
204 f oxidative phosphorylation increased during vaccinia virus infection, while inhibition of the cellul
216 nd vaccination of patients with AD with live vaccinia virus is contraindicated because of a heightene
217 present evidence that the impact of VRK2 on vaccinia virus is largely independent of BAF phosphoryla
218 Until now, all known rifampin-resistant vaccinia virus isolates have contained missense mutation
221 nd D10, but not of either enzyme alone, halt vaccinia virus late protein synthesis and inhibit virus
224 sion in other viral systems, did not prevent vaccinia virus membrane fusion, suggesting that these in
225 revealed that this protein is essential for vaccinia virus morphogenesis and that its absence result
231 t rabbits immunized with a novel recombinant vaccinia virus prime-gp120 protein boost regimen generat
232 network is also assembled downstream of the Vaccinia virus protein A36 and the phagocytic Fc-gamma r
236 n and luciferase reporters demonstrated that vaccinia virus recognized MOCV intermediate and late pro
237 depend on host cells to provide, to support vaccinia virus replication during a host shutoff.IMPORTA
238 iscovered that TRAF2 is a proviral factor in vaccinia virus replication in both HeLa cells and mouse
240 the beginning of the 1980s, research on the vaccinia virus replication mechanism has basically stall
245 ection of C57BL/6 mice with 1 x 10(7) PFU of vaccinia virus strain WR results in blepharitis, corneal
247 In this study, we show across a range of vaccinia virus strains, including the current clonal sma
249 antiviral protein PKR, enabled a recombinant vaccinia virus to replicate in resistant cells from huma
250 here that this expanded tropism of oncolytic vaccinia virus to the endothelial compartment is a conse
253 deep study of the covalent structure of the vaccinia virus virion using the various tools of contemp
255 We report here that the engineered oncolytic vaccinia virus VVWR-TK(-)RR(-)-Fcu1 can induce immunogen
259 at causes a persistent/latent infection, and vaccinia virus, a poxvirus that is cleared by the host.
260 es of fatty acid in the diet on infection by vaccinia virus, an acute infection that begins in the re
262 immunization with Plasmodium sporozoites or vaccinia virus, but a few weeks later their numbers seve
263 onocytogenes, vesicular stomatitis virus, or Vaccinia virus, but dispensable in the case of mouse cyt
264 gression are arrested in cells infected with vaccinia virus, but mass fluctuations continue until cel
265 n a murine model of cutaneous infection with vaccinia virus, dermal gammadelta T cell numbers increas
266 aa 21-84), a recombinant envelope protein of vaccinia virus, for glycosaminoglycans (GAGs)-specific t
267 fficacy of a replication-competent oncolytic vaccinia virus, GLV-1h153, carrying human sodium iodide
269 on, and in the case of influenza B virus and vaccinia virus, ISG15 conjugation has been shown to rest
270 Upon infections with Toxoplasma gondii and vaccinia virus, mice with stabilized DC beta-catenin dis
271 icited against allogeneic RhD+ erythrocytes, vaccinia virus, rotavirus, or tetanus toxoid provides ev
274 e inhibitor 1 (SPI-1) of rabbitpox virus and vaccinia virus, two closely related orthopoxviruses, pre
276 ymphocytic choriomeningitis virus (LCMV) and vaccinia virus, where the pathogens are cleared, but it
277 sease is induced by intradermal injection of vaccinia virus, whereas a protective response occurs wit
280 virion preparations, >88% of the theoretical vaccinia virus-encoded proteome was detected with high c
281 RNAs were translationally upregulated during vaccinia virus-induced host protein synthesis shutoff.
282 ured the host mRNA translation rate during a vaccinia virus-induced host shutoff by analyzing total a
284 ia virus B1 protein is a homolog of cellular vaccinia virus-related kinases (VRKs) and is needed for
285 xhibits a remarkable degree of similarity to vaccinia virus-related kinases (VRKs), a family of cellu
296 perator sequence) into oncolytic recombinant vaccinia viruses (rVACV), which were further characteriz
297 peptide-pulsed dendritic cells, recombinant vaccinia viruses encoding full-length T Ag or epitope mi
298 ges in the cytoskeleton, studies with mutant vaccinia viruses indicated that the cytoskeletal changes
299 res of the antitumor properties of oncolytic vaccinia viruses, all of which can be amplified by the m
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