ライフサイエンスコーパス: vacuolar

1 PI(3,5)P2 activates V-ATPases containing the vacuolar a-subunit isoform in Saccharomyces cerevisiae H

2 Vacuolar accumulation of acidic metabolites is an import

3 e regulatory circuitry that controls petunia vacuolar acidification and Arabidopsis hair development.

4 ole identity, is thought to be necessary for vacuolar acidification in yeast.

5 on factor previously studied for its role in vacuolar acidification, in floral volatile emission.

6 conditionally viable and retains significant vacuolar acidification, pointing to a so far undetected

7 our study revealed an intimate link between vacuolar acidification, redox physiology, and virulence

8 rs glucose-dependent V-ATPase reassembly and vacuolar acidification.

9 acids stimulate, in a Rag-, Ragulator-, and vacuolar adenosine triphosphatase-dependent fashion, the

10 itable D244G mutation causes a myopathy with vacuolar aggregates, whereas its M87T "variant" is weakl

11 The vacuolar amino acid transporter CAT2 from Solanum lycope

12 We identified a yeast vacuolar amino acid transporter, Ypq1, that is selective

13 Pib2 associated with vacuolar and endosomal limiting membranes in unstressed

14 AVE complex (regulator of the H(+)-ATPase of vacuolar and endosomal membranes) is required for biosyn

15 for association of RidL with retromer-coated vacuolar and tubular endosomes.

16 To investigate the link between vacuolar anion uptake and whole-plant ion distribution d

17 The vacuolar Arabidopsis thaliana AtSWEET2 sequesters sugars

18 EhRab35 showed large vacuolar as well as punctate vesicular localization.

19 quencing of resistant mutants implicates the vacuolar ATP synthase as a genetic determinant of resist

20 The a2-isoform of vacuolar ATPase (a2V) is uniquely and highly expressed o

21 Using this technique, we have found that Vacuolar ATPase (V-ATPase) and the V-ATPase regulator Ra

22 In cancer cells, vacuolar ATPase (V-ATPase), a multi-subunit enzyme, is e

23 entified mutants in vacuolar sorting and the vacuolar ATPase (V-ATPase).

24 hich includes the Rag GTPases, Ragulator and vacuolar ATPase (V-ATPase).

25 g and cnj encode the E and G subunits of the vacuolar ATPase (vATPase) and showed that both the V0 an

26 Sestrin2 and the vacuolar ATPase are negative and positive regulators of

27 As bafilomycin A1 is a vacuolar ATPase inhibitor that inhibits autophagic prote

28 ex containing RAG GTPases, RAGULATOR and the vacuolar ATPase.

29 Mechanistically, TMEM106B binds vacuolar-ATPase accessory protein 1 (AP1).

30 TMEM106B deficiency reduces vacuolar-ATPase AP1 and V0 subunits, impairing lysosomal

31 Vacuolar ATPases (V-ATPases) are essential proton pumps

32 ch, SWitch/sucrose nonfermentable (SWI/SNF), vacuolar ATPases) and identified novel recurrent mutatio

33 Because GBPs are critical to target vacuolar bacteria, we determined whether GBP2 and GBP(ch

34 al a new role for TORC1 in the regulation of vacuolar behavior.

35 is, implying a new role for ALIX proteins in vacuolar biogenesis, likely acting as part of ESCRT-III

36 s have distinguished intensely colored intra-vacuolar bodies observed in the cells of highly colored

37 However, increased vacuolar Ca(2+) concentrations caused channel occlusion,

38 hannels: the plasma membrane, Cch1p, and the vacuolar calcium channel, Yvc1p.

39 When HOPS is phosphorylated by the vacuolar casein kinase I, Yck3p, tethering only takes pl

40 ynthesis of vacuolar hydrolases to boost the vacuolar catabolic activity.

41 fluxes in the vacuole, cooperating with the vacuolar cation channel SlTPC1 and the two vacuolar H(+)

42 We have identified a vacuolar cationic amino acid transporter (PhCAT2) that c

43 oncomitantly, a complex was formed between a vacuolar cell-death protease, RESPONSIVE TO DESSICATION-

44 ndria, endoplasmic reticulum distention, and vacuolar changes in PA-treated cells.

45 AtRBOHD and Ca(2+) release dependent on the vacuolar channel TPC1.

46 during salinity, we used mutants of the only vacuolar Cl(-) channel described to date: the Arabidopsi

47 her, our study uncovers that the capacity of vacuolar Cl(-) loading in vascular cells plays a crucial

48 localization of a YFP-ATG8 reporter and its vacuolar cleavage during nitrogen or fixed-carbon starva

49 n scavenger histidine and was accompanied by vacuolar collapse and the appearance of serpin-protease

50 acterial-derived MavN (more regions allowing vacuolar colocalization N) protein to the surface of the

51 within the parasite lysosomal organelle (the vacuolar compartment or VAC) in turnover of autophagosom

52 asis via sequestration of labile Fe(2+) into vacuolar compartments.

53 osomal; the remainder are from lysosomal and vacuolar compartments.

54 the HFD+Casein mice showed increased hepatic vacuolar degeneration accompanied with elevated inflamma

55 These mice showed severe vacuolar degeneration of the spinal cord white matter to

56 Autophagy is a conserved process mediating vacuolar degradation and recycling.

57 s-of-function mutant alix-1 displays reduced vacuolar degradation of PHT1;1.

58 Molecular chaperones and cytosolic and vacuolar degradation systems collaborate to detect, repa

59 gen starvation, proteasomes are targeted for vacuolar degradation through autophagy.

60 echanisms, together with distinct labels for vacuolar degradation, determines the final fate of the i

61 e early replication without interfering with vacuolar disruption.

62 les was sufficient to induce sterol-enriched vacuolar domains without stress.

63 To identify these vacuolar effector proteins, a list of predicted C. burne

64 The spatiotemporal dynamics of vacuolar EhRab35 and its exchange with soluble cytosolic

65 This protection requires the vacuolar/endolysosomal signaling lipid PI3,5P2 We show t

66 volves protrusion formation, engulfment, and vacuolar escape.

67 hondria, and vacuoles, and the site at which vacuolar Fe(II) is oxidized to Fe(III).

68 estore PI3,5P2 homeostasis nor did it induce vacuolar fragmentation in VPA-treated cells, suggesting

69 ional factors required for ER stress-induced vacuolar fragmentation, we conducted a high-throughput,

70 differences in transpiration, pointing to a vacuolar function in regulating xylem loading during sal

71 to concomitantly increased mitochondrial and vacuolar function.

72 al genes shown previously to be required for vacuolar fusion and/or fission, validating the utility o

73 Although vacuolar fusion has been reconstituted with purified com

74 ring; Rho1p has a role in the late stages of vacuolar fusion, but its mode of action is unknown.

75 s based on a method developed to study yeast vacuolar fusion.

76 ors that appear to be able to regulate yeast vacuolar fusion.

77 les including that formed by yeast Vam3p for vacuolar fusion.

78 eEF1A does not promote vacuolar fusion; however, overexpression of the Rho1p-in

79 ensitivity due to retention of an IES in the vacuolar gene DOP1 (Dopey domain-containing protein).

80 AMP3, and AtNRAMP4 limits Fe accumulation in vacuolar globoids.

81 ated in chmp1 as indicated by an increase in vacuolar green fluorescent protein (GFP) cleavage from t

82 The vacuolar H(+) ATPase (V-ATPase) is a complex multisubuni

83 rmeability to protons, together with reduced vacuolar H(+)-adenosine triphosphatase (V-ATPase) activi

84 omal acidification through inhibition of the vacuolar H(+)-adenosine triphosphatase (V-ATPase) increa

85 es (GTPases), the Ragulator complex, and the vacuolar H(+)-adenosine triphosphatase (v-ATPase).

86 and ATP6AP1, which encode components of the vacuolar H(+)-ATP ATPase (V-ATPase) known to be necessar

87 Plasma membrane vacuolar H(+)-ATPase (V-ATPase) activity of tumor cells

88 lated cells (ICs) express the proton pumping vacuolar H(+)-ATPase (V-ATPase) and are extensively invo

89 dy capitalized on the mechanisms suppressing vacuolar H(+)-ATPase (V-ATPase) in pfk2Delta to gain new

90 Eukaryotic vacuolar H(+)-ATPase (V-ATPase) is a multisubunit enzyme

91 The vacuolar H(+)-ATPase (V-ATPase) is a rotary motor enzyme

92 rane protein and an accessory subunit of the vacuolar H(+)-ATPase (V-ATPase) that may also function w

93 Key to this restoration is activation of the vacuolar H(+)-ATPase (V-ATPase), a proton pump that acid

94 Moreover, ZnT2 directly interacted with vacuolar H(+)-ATPase (V-ATPase), and ZnT2 deletion impai

95 d glucose-stimulated reassembly of the yeast vacuolar H(+)-ATPase (V-ATPase).

96 uolar H(+)-pyrophosphatase (V-PPase) and the vacuolar H(+)-ATPase (V-ATPase).

97 A intercalated cells (A-ICs), which contain vacuolar H(+)-ATPase (V-type ATPase)-rich vesicles that

98 e surrounding the algae abundantly expresses vacuolar H(+)-ATPase (VHA), which acidifies the symbioso

99 Loss of function of the vacuolar H(+)-ATPase (vma1) or a defect in the biosynthe

100 CYAM accumulated slowly into puncta based on vacuolar H(+)-ATPase activity and dispersed rapidly upon

101 gi network/early endosome (TGN/EE)-localized vacuolar H(+)-ATPase activity nor the function of the br

102 osin interacts with almost all components of vacuolar H(+)-ATPase and the Ragulator complex and with

103 age antimicrobial activity, and identify the vacuolar H(+)-ATPase as a potential target for host-dire

104 dicate that recurrent stone formers with the vacuolar H(+)-ATPase B1 subunit p.E161K SNP exhibit a ur

105 nd lytic vacuole/lysosome, and contained the vacuolar H(+)-ATPase subunit a3, alias TCIRG1, a known a

106 r with mislocalization of the Golgi-enriched vacuolar H(+)-ATPase subunit isoform a2.

107 Vacuolar H(+)-ATPases (V-ATPases) drive organelle acidif

108 e vacuolar cation channel SlTPC1 and the two vacuolar H(+)-pumps, SlAVP1 and SlVHA-A1, which in turn

109 ransmembrane domain interactions of a unique vacuolar H(+)-pyrophosphatase (EC 3.6.1.1) from Vigna ra

110 e combined activity of two proton pumps, the vacuolar H(+)-pyrophosphatase (V-PPase) and the vacuolar

111 choline, thus giving rise to a net efflux of vacuolar H(+).

112 We identify that genetic disruption of the Vacuolar H+ ATPase (V-ATPase), the key proton pump for e

113 in receptor and is an essential component of vacuolar H+ ATPase.

114 ) is closely associated with a multi-subunit vacuolar H+-ATPase (V-ATPase).

115 The vacuolar (H(+))-ATPases (V-ATPases) are a family of ATP-

116 Consistent with a role for Abc3 as vacuolar hemin exporter, results with hemin-agarose pull

117 The hexameric vacuolar HOPS (homotypic fusion and vacuole protein sort

118 hat involves leakage of luminal lysosomal or vacuolar hydrolases into the cytoplasm.

119 aptation, including the de novo synthesis of vacuolar hydrolases to boost the vacuolar catabolic acti

120 f highly colored tissues, termed anthocyanic vacuolar inclusions (AVIs), from more globular, membrane

121 Vacuolar invertase is a key enzyme of sugar metabolism i

122 ed glycoproteomic approach demonstrates that vacuolar invertase is glycosylated at all twelve potenti

123 down-regulation of SbVIN1, a gene encoding a vacuolar invertase.

124 e Ca(2+) wave system, the involvement of the vacuolar ion channel TWO PORE CHANNEL1 (TPC1) has been r

125 It has been observed that vacuolar ion uptake is tied to fluxes across the plasma

126 One key protein involved in vacuolar iron storage is the iron importer Ccc1, which f

127 Our results show that by enhancing vacuolar iron transport in the endosperm, this essential

128 accharomyces cerevisiae) mutant defective in vacuolar iron transport.

129 e functionally characterized homologs of the VACUOLAR IRON TRANSPORTER (VIT).

130 ural studies to advance understanding of the vacuolar iron transporter family of membrane proteins fr

131 overexpression and purification of PfVIT, a vacuolar iron transporter homologue from the human malar

132 Vacuolar iron transporters (VITs) are a poorly understoo

133 age compartments, mediated by members of the vacuolar iron-transporter (VIT) family of proteins.

134 non-amyloid inclusion bodies at the nuclear-vacuolar junction, and it utilizes cellular chaperones s

135 PS) motif within HOPS Vps41, a target of the vacuolar kinase Yck3, is dispensable for tethering and f

136 After phosphorylation by the vacuolar kinase Yck3p, phospho-HOPS needs both Ypt7p:GTP

137 SNARE disassembly chaperones Sec17p/Sec18p, vacuolar lipids, and the Rab-effector complex HOPS (homo

138 Remarkably, vacuolar localization is required for NIa-Pro's ability

139 at is selectively sorted and degraded in the vacuolar lumen following lysine withdrawal.

140 ior to the release of their cargoes into the vacuolar lumen, sorting endosomes mature into multivesic

141 es are directly linked through GBP-dependent vacuolar lysis.

142 ) containing cargo proteins destined for the vacuolar/lysosomal lumen.

143 1 is important for multivesicular body (MVB)-vacuolar lysosome fusion, the last step of endocytosis r

144 studied fragment formation during homotypic vacuolar lysosome membrane fusion in Saccharomyces cerev

145 Vacuolar malate transport has been characterized at the

146 ponse directly targeting the parasitophorous vacuolar membrane (PVM) harbouring the parasite.

147 yeast, CsHMA5.1 and CsHMA5.2 localize to the vacuolar membrane and are activated by monovalent copper

148 for the endocytosis, FgRab7 localizes to the vacuolar membrane and regulates the fusion of vacuoles a

149 internalization from the cell surface to the vacuolar membrane and that the transporter Abc3 particip

150 to gain access to this metal across the host vacuolar membrane are poorly characterized.

151 propose that RAVE cycles between cytosol and vacuolar membrane in a glucose-dependent manner, positio

152 Expression of a vacuolar membrane marker confirmed that the enlarged str

153 escribe the association between FaEO and the vacuolar membrane of strawberry fruits.

154 We show here that the tomato vacuolar membrane possesses such a transport property: t

155 to regulate the composition and lifetime of vacuolar membrane proteins.

156 Inactivation of abc3(+), encoding a vacuolar membrane transporter, results in hem1Delta abc3

157 tes virulence (effector) proteins across its vacuolar membrane via the SPI-2 type III secretion syste

158 not with RB In the case of AO treatment, the vacuolar membrane was observed to disintegrate.

159 ucose-dependent association of RAVE with the vacuolar membrane, consistent with its role in glucose-d

160 erial cell surface as it associates with the vacuolar membrane, driving the secretion of SPI-2 effect

161 on exchange at the plasma membrane (SOS1) or vacuolar membrane.

162 concentrations, Shu1-HA4 re-localizes to the vacuolar membrane.

163 elles such as endoplasmic reticulum (ER) and vacuolar membranes in yeast.

164 rch into ion transport across the plasma and vacuolar membranes of guard cells that drive stomatal mo

165 imaging and direct patch-clamping of apical vacuolar membranes revealed that ML1 mediates a PKA-acti

166 ar processing generates peptides loaded onto vacuolar MHC-I molecules, how and where exogenous peptid

167 ckout mutants characterized the protein as a vacuolar Mn transporter suitable to prevent plant cells

168 gests that the adaptation of SNARE-dependent vacuolar morphogenesis allows auxin to limit cellular ex

169 lar SNAREs interrelates with auxin-resistant vacuolar morphogenesis and cell size regulation.

170 VTI11 is strictly required for auxin-reliant vacuolar morphogenesis and loss of function renders cell

171 nization of actin filaments but also impacts vacuolar morphogenesis in an actin-dependent manner.

172 r nuclear position with some contribution by vacuolar morphology and of actin-dependent outer polar n

173 lly regulates triacylglycerol metabolism and vacuolar morphology through the long-chain fatty acyl-Co

174 n of the Rho1p-interacting subdomain affects vacuolar morphology.

175 e refractory to ER stress-induced changes in vacuolar morphology.

176 re root cells accumulated more cytosolic and vacuolar Na(+), suggesting that the higher sensitivity o

177 resence of an interconnected protein storage vacuolar network in embryo cells, rather than discreet,

178 We suggest that these vacuolar networks are involved in direct sea water uptak

179 evated expression of genes encoding putative vacuolar NO3(-) chloride channel transporters plus elect

180 in-dependent mechanism controls the relative vacuolar occupancy of the cell, thus suggesting an unant

181 Found in vacuolar or endolysosomal membranes, they regulate the c

182 SWEETs carry mono- and disaccharides across vacuolar or plasma membranes.

183 e conferring resistance to the intracellular vacuolar pathogen Toxoplasma gondii by inducing the dest

184 plays a central role in the defense against vacuolar pathogens and describe a mechanism evolved by a

185 ective in the IFN-gamma-induced clearance of vacuolar pathogens such as Toxoplasma.

186 cruitment of interferon-inducible GTPases to vacuolar pathogens.

187 proteasome acquires a role in the endocytic-vacuolar pathway.

188 etion, it may have a role in stabilizing the vacuolar pH during salt shock.

189 oplast-localized H(+) -ATPase that maintains vacuolar pH homeostasis.

190 at quantitatively assessed the lysosomal and vacuolar pH in PtdIns(3,5)P2-depleted cells.

191 nthocyanins and, potentially, for estimating vacuolar pH inside intact plant cells.

192 Although the steady-state vacuolar pH is not affected by PtdIns(3,5)P2 depletion,

193 In comparison, the vacuolar pH of the V-ATPase mutant vph1Delta or vph1Delt

194 Tighter coupling restored vacuolar pH when glucose was abundant and glycolysis ope

195 Anthocyanins are pigmented at the lower vacuolar pH, but in the cytoplasm they can be visualized

196 color is influenced by chemical decorations, vacuolar pH, the presence of copigments, and metal ions.

197 network/early endosome-localized V-ATPase to vacuolar pH.

198 ontext of floral scent through regulation of vacuolar pH.

199 6B expression results in the appearance of a vacuolar phenotype in multiple cell types, including neu

200 Concomitant with the development of this vacuolar phenotype, cells over-expressing TMEM106B exhib

201 Moreover, we observed that vacuolar phosphatase, Pho8, is partially required for ss

202 Betalains are vacuolar pigments composed of a nitrogenous core structu

203 The vacuolar pool of anthocyanins exhibited shorter taum tha

204 nd cathepsin B activation was independent of vacuolar processing enzyme (VPE).

205 Vacuolar processing enzymes are cysteine proteases respo

206 e proteases, cathepsin B-like proteases, and vacuolar processing enzymes, coinciding with the remobil

207 e proteases, cathepsin B-like proteases, and vacuolar processing enzymes.

208 While vacuolar processing generates peptides loaded onto vacuo

209 t the C. burnetii secreted effector Coxiella vacuolar protein B (CvpB) binds PI(3)P and phosphatidyls

210 r of the Dot/Icm substrates, termed Coxiella vacuolar protein B (CvpB), CvpC, CvpD, and CvpE, labeled

211 We validated the role of a set of vacuolar protein sorting (VPS) genes during infection, V

212 The vacuolar protein sorting (Vps) protein Vps27 is a compon

213 ed single amino acid substitutions in Vps13 (vacuolar protein sorting 13), a large universally conser

214 ompound heterozygous truncating mutations in vacuolar protein sorting 13C (VPS13C).

215 The class III PI3K Vacuolar protein sorting 34 (Vps34) plays a role in both

216 ass 3 phosphatidylinositol (PtdIns) 3-kinase vacuolar protein sorting 34 (Vps34), in podocytes result

217 However, beclin 1 is a core component of the vacuolar protein sorting 34 (Vps34)/class III phosphatid

218 AP2M1 (AP-2 adaptor protein), RAB5A, VPS35 (vacuolar protein sorting 35 homolog), and M6PR (mannose

219 bserved the retromer core component FgVps35 (Vacuolar Protein Sorting 35) in the cytoplasm as fast-mo

220 eye development, we identified an allele of Vacuolar protein sorting 4 (Vps4), which encodes an AAA

221 The vacuolar protein sorting 4 AAA-ATPase (Vps4) recycles en

222 in binding protein C, fast type [MYBPC2] and vacuolar protein sorting 8 [VPS8], 2 families, 4.2%) or

223 from Myzus persicae associates with the host Vacuolar Protein Sorting Associated Protein52 (VPS52).

224 maturation and release that is controlled by vacuolar protein sorting protein 33b (VPS33B).

225 unit version of PI3KC3-C1 consisting of VPS (vacuolar protein sorting) 34, VPS15, BECN1 (Beclin 1), a

226 loss of other retromer components SNX-3 and vacuolar protein sorting-associated protein 35 (VPS-35)

227 i (BEACH)-domain proteins contribute to both vacuolar protein transport and effector-triggered immuni

228 ultiple BEACH-domain proteins contributes to vacuolar protein transport and plant defense.

229 Yeast Vps13 is involved in vacuolar protein transport and, like hVps13A, participat

230 ochondrial import receptors Tom70/71 and the vacuolar protein Vac8, respectively.

231 Vacuolar protein-sorting 34 (Vps34), the catalytic subun

232 eine proteases responsible for maturation of vacuolar proteins.

233 lkaloid biosynthetic genes by recruiting the vacuolar proton pool for the signaling process.

234 lagellar calcium binding protein) and TcVP1 (vacuolar proton pyrophosphatase), and two proteins of un

235 capacities of (1) sodium-dependent efflux of vacuolar protons and (2) elicitor-triggered overproducti

236 e, and (2) a subsequent, transient efflux of vacuolar protons, resulting in a peak of cytosolic H(+).

237 ression of AVP1, encoding type 1 ARABIDOPSIS VACUOLAR PYROPHOSPHATASE1.

238 eoliposomes bearing a Rab:GTP and either the vacuolar R-SNARE or one of the three integrally anchored

239 of approximately 100 nm, only when the yeast vacuolar Rab GTPase Ypt7p is present in both tethered me

240 Two HOPS subunits bind vacuolar Rabs for tethering, another binds the Qc SNARE,

241 ere affected for lysis of the nascent SCV or vacuolar replication in epithelial cells, indicating tha

242 he ankB mutant of strain AA100/130b in intra-vacuolar replication.

243 anslocate at least 28 effector proteins from vacuolar-resident bacteria into host cells.

244 Here, we identified eEF1A as a vacuolar Rho1p-interacting protein.

245 Transformation to AsIII and vacuolar sequestration is believed to be the As detoxifi

246 KEY MESSAGE: The vacuolar SlCAT2 was cloned, over-produced in E. coli and

247 Atg17 and Atg11 interact with the vacuolar SNARE (soluble N-ethylmaleimide-sensitive facto

248 T7) function and to a lesser extent on VTI11 vacuolar SNARE activity.

249 lationally controls the protein abundance of vacuolar SNARE components.

250 ins lacking the active Rab7-like Ypt7 or the vacuolar SNARE fusion machinery, alpha-factor still proc

251 Vacuolar SNARE VTI11 is strictly required for auxin-reli

252 We replaced the TMDs of all vacuolar SNAREs (Nyv1, Vam3, and Vti1) by a lipid anchor

253 HOPS also has specific affinities for the vacuolar SNAREs and catalyzes SNARE complex assembly, bu

254 labeling reveals that the binding sites for vacuolar SNAREs and the Habc domain are located in the l

255 HOPS-tethered membranes and all four vacuolar SNAREs formed a complex that underwent an even

256 ogical interference with the auxin effect on vacuolar SNAREs interrelates with auxin-resistant vacuol

257 The assembly of yeast vacuolar SNAREs into complexes for fusion can be studied

258 ich is recruited by the Rab GTPase Ypt7, and vacuolar SNAREs to drive membrane fusion.

259 rganic pyrophosphatases (PPase), also called vacuolar soluble proteins (VSPs), which are localized to

260 -sensitive mutants and identified mutants in vacuolar sorting and the vacuolar ATPase (V-ATPase).

261 nsist of a tubular network that emerges from vacuolar sorting endosomes and diverts cargoes toward th

262 In fact, the alix-1 mutation also hampered vacuolar sorting of the brassinosteroid receptor BRI1.

263 rs containing storage protein precursors and vacuolar sorting receptors (VSRs).

264 erization persists upon UapA endocytosis and vacuolar sorting.

265 raphs indicating enlarged vacuoles suggested vacuolar storage of NO3(-) Triacylglycerol concentration

266 4) transporters to remobilize iron from seed vacuolar stores and thereby acquire photosynthetic compe

267 starvation of ino1Delta cells perturbed the vacuolar structure and decreased V-ATPase activity and p

268 at postnatal day 17 revealed the presence of vacuolar structures that distorted rod photoreceptor out

269 We discovered novel vacuolar structures that form in LPS-activated but not r

270 abolic organelles are a dynamic continuum of vacuolar structures that impact a number of cell physiol

271 some plants, they accumulate as discrete sub-vacuolar structures.

272 an actively accumulate infectious virions in vacuolar subcellular structures mostly connected to the

273 Upon genotoxic stress, Wss1 is vacuolar, suggesting a link between genotoxic stress and

274 We propose that root-expressed vacuolar SWEET2 modulates sugar secretion, possibly by r

275 ntous fungi lack the equivalent of the yeast vacuolar syntaxin Vam3p, making unclear how these organi

276 issociation, nuclear export, and independent vacuolar targeting of CP and RP.

277 ance is regulated by endosomal recycling and vacuolar targeting, but the role of vacuole-related prot

278 s-Golgi network/early endosomes (TGN/EE) for vacuolar targeting.

279 minal pH and supports the notion that proper vacuolar trafficking and proteolytic processing of stora

280 The compound does not affect recycling or vacuolar trafficking of PIN1 but leads to its intracellu

281 osis but not other functions of Vps1 such as vacuolar trafficking or peroxisome fission.

282 ant and human cells and enhancement of plant vacuolar trafficking.

283 function of Vps13 protein in endocytosis and vacuolar transport, although the level of the protein is

284 ern previously shown to be determined by the vacuolar transporter VIT1.

285 id oxygenation upregulated2 (fou2) mutant in vacuolar two-pore channel 1 (TPC1(D454N) ) displays high

286 Here we present the crystal structure of a vacuolar two-pore channel from Arabidopsis thaliana, AtT

287 Vacuolar two-pore K(+) (TPK) channels are important play

288 the antitumor activity of inhibitors of the vacuolar-type ATPase (V-ATPase), a heteromultimeric prot

289 Vacuolar-type ATPases (V-ATPases) are ATP-powered proton

290 y and polarity-dependent localization of the vacuolar-type H(+)-ATPase (V-ATPase) mediate the impact

291 rom inhibition of proton pumping activity of vacuolar-type H(+)-ATPase (v-ATPase).

292 Mutations in the vacuolar-type H(+)-ATPase B1 subunit gene ATP6V1B1 cause

293 ng of phagosomal acidification by inhibiting vacuolar-type H(+)-ATPase enabled macrophages to elicit

294 din B is structurally similar to more potent vacuolar-type H(+)-ATPase inhibitors, which all inhibite

295 CO2 Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase that blocks lysosomal degradat

296 determinant of acidic pH at the Golgi is the vacuolar-type H(+)-translocating ATPase (V-ATPase), whos

297 nts, the precise molecular mechanism whereby vacuolar (V-type) ATP synthase fulfills its biological f

298 focused on the relative contributions of the vacuolar versus cytosolic pathways of antigen processing

299 Pase activity and proton pumping in isolated vacuolar vesicles.

300 ted a manganese transporter mutant but not a vacuolar zinc transporter mutant.

301 Zn(2+) levels trigger the downregulation of vacuolar Zn(2+) transporters.