ライフサイエンスコーパス: vacuolar ATPase

1 olysis driven proton pumping activity of the vacuolar ATPase.

2 it C is not able to stably assemble with the vacuolar ATPase.

3 n a fashion analogous to that of the related vacuolar ATPase.

4 r effect of bafilomycin, an inhibitor of the vacuolar ATPase.

5 reversed by bafilomycin, an inhibitor of the vacuolar ATPase.

6 protein important for regulated assembly of vacuolar ATPase.

7 protein sorting, vesicle transport, and the vacuolar ATPase.

8 otein trafficking even in the absence of the vacuolar ATPase.

9 ex containing RAG GTPases, RAGULATOR and the vacuolar ATPase.

10 -2 receptor beta and gamma chains and the H+ vacuolar ATPase.

11 The a2-isoform of vacuolar ATPase (a2V) is uniquely and highly expressed o

12 Mechanistically, TMEM106B binds vacuolar-ATPase accessory protein 1 (AP1).

13 nomic screening, we hypothesize that loss of vacuolar ATPase activity reduces uptake of sertraline in

14 the endolysosomal compartments by inhibiting vacuolar ATPase activity.

15 Here, by blocking the vacuolar ATPase, alkalinizing the extracellular pH, or e

16 nteracts with the 16-kDa component of the H+ vacuolar ATPase and cooperates with bovine papillomaviru

17 ch, SWitch/sucrose nonfermentable (SWI/SNF), vacuolar ATPases) and identified novel recurrent mutatio

18 d phosphoinositide-3-class 3 (PIK3C3), Rab7, vacuolar ATPase, and lysosomal enzymes revealed that vac

19 TMEM106B deficiency reduces vacuolar-ATPase AP1 and V0 subunits, impairing lysosomal

20 Sestrin2 and the vacuolar ATPase are negative and positive regulators of

21 Vacuolar ATPases are ATP hydrolysis-driven proton pumps

22 Giardia has a typical vacuolar ATPase as observed from the common motifs share

23 These results suggest that assembly of vacuolar ATPase at the early endosome is required for tr

24 An inhibitor of vacuolar ATPases, bafilomycin, selectively inhibits the

25 r the CHGB locus, with polymorphisms for the vacuolar-ATPase beta-subunit (ATP6V1B1, exon 1, Ile30Thr

26 e phenotypes suggest connections between the vacuolar ATPase, bud morphology, and cytokinesis that ha

27 the early steps in biosynthesis of the yeast vacuolar ATPase by biosynthetically labeling wild-type a

28 P-Ub, a modified subunit of the multiprotein vacuolar ATPase complex, which carries an in-frame fusio

29 ductase activity, as well as subunits of the vacuolar ATPase complex.

30 tone bafilomycin A(1), a potent inhibitor of vacuolar ATPases, could not be achieved.

31 presence of bafilomycin, an inhibitor of the vacuolar ATPase, did not block DC anti-Histoplasma activ

32 Together with the inhibition of the vacuolar ATPase (due to the interaction between E5 and 1

33 ized compartments and their acidification by vacuolar ATPase, enabling aggregate catabolism by lysoso

34 ucturally more related to the proton-pumping vacuolar ATPase found in the endomembrane system of euka

35 tructure of the proton channel domain of the vacuolar ATPase from bovine brain clathrin-coated vesicl

36 The structure of the vacuolar ATPase from bovine brain clathrin-coated vesicl

37 tation at three residues in subunit c of the vacuolar ATPase from Neurospora crassa conferred strong

38 ochondrial proteins, urea cycle enzymes, and vacuolar ATPase functions.

39 The vacuolar ATPase has been implicated in a variety of phys

40 highly potent and specific inhibitors of the vacuolar ATPase, have been widely used to investigate th

41 and replication, and also includes GTPases, vacuolar ATPase homologs, and most tRNA synthetases.

42 cys4 mutants arises from inactivation of the vacuolar ATPase in the less reducing cytosol resulting f

43 ransfer process is impaired by inhibition of vacuolar ATPases in T cells as well as by fixation of de

44 oncanamycin A (CCA), a specific inhibitor of vacuolar ATPases, inhibited growth of Neurospora crassa

45 ysosomotropic agent chloroquine (CQ) and the vacuolar ATPase inhibitor bafilomycin A1 (Baf A1).

46 hibition of endosomal acidification with the vacuolar ATPase inhibitor bafilomycin A1 or concanamycin

47 As bafilomycin A1 is a vacuolar ATPase inhibitor that inhibits autophagic prote

48 aturally occurring enantiomer of this potent vacuolar ATPase inhibitor, is described.

49 minant negative form of dynamin (K44A) and a vacuolar-ATPase inhibitor, concanamycin.

50 f the gene cosegregated, indicating that the vacuolar ATPase is essential in Neurospora crassa.

51 investigated whether Atp6v0a2 (a2 isoform of vacuolar ATPase) is associated with abnormal semen quali

52 nd subsequent recruitment and maintenance of vacuolar ATPase/lgp-containing membranes that enclose re

53 ing vesicles within both cell lines acquired vacuolar-ATPase, lysosomal markers LAMP 1 and 2, and the

54 llomavirus E5 proteins with a subunit of the vacuolar ATPase may also contribute to transformation.

55 lomycin A1 and concanamycin A, inhibitors of vacuolar ATPases, prevented HCV entry when they were pre

56 etical models of proton translocation by the vacuolar ATPase require that Glu140 should be protonated

57 2 is an essential accessory component of the vacuolar ATPase required for lysosomal degradative funct

58 The resulting atomic model of the yeast vacuolar ATPase serves as a framework to help understand

59 Within these proteins, subunits of the vacuolar ATPase, small GTPases, actinin 4, and, of speci

60 riants of the yeast Saccharomyces cerevisiae vacuolar ATPase subunit (VMA) intein inserted within Gal

61 The protein splicing element (intein) of the vacuolar ATPase subunit (VMA) of Saccharomyces cerevisia

62 himeric protein containing the intein of the vacuolar ATPase subunit (VMA) of Saccharomyces cerevisia

63 ts, E5 interacts with both the 16-kilodalton vacuolar ATPase subunit and the platelet-derived growth

64 ctivity and decreased N-glycoyslation of the vacuolar ATPase subunit V0a1, a modification required fo

65 The vacuolar ATPase subunit Vph1p transits to the vacuole in

66 Eleven of the twelve known vacuolar-ATPase subunits were identified.

67 e to bafilomycin A1, a specific inhibitor of vacuolar ATPase, suggesting that activation was dependen

68 its proteolipid subunit and other eukaryotic vacuolar ATPases, suggesting that the former enzyme work

69 active oxygen intermediates inactivate human vacuolar ATPase, supporting the validity of the yeast sc

70 t is an essential assembly chaperone for the vacuolar ATPase, the major proton pump of cellular membr

71 oles that progressively acquire lgps and the vacuolar ATPase, the majority of sifA(-) bacteria lost t

72 reted virulence factors that target the host vacuolar ATPase to withstand phagosomal acidity, the Mgt

73 uming large amounts of energy, including the vacuolar-ATPase, translation, and phosphoinositide metab

74 ve RANKL-mediated induction of d2 isoform of vacuolar ATPase V(o) domain that is involved in cell fus

75 The proton-translocating vacuolar ATPase (V-ATPase) acidifies the endocytic netwo

76 similarity with the catalytic subunit of the vacuolar ATPase (V-ATPase) and complements the loss of t

77 Using this technique, we have found that Vacuolar ATPase (V-ATPase) and the V-ATPase regulator Ra

78 The yeast vacuolar ATPase (V-ATPase) contains three proteolipid su

79 The structure of the proton-pumping vacuolar ATPase (V-ATPase) from bovine brain clathrin co

80 regulation, we evaluated the function of the vacuolar ATPase (V-ATPase) in RAW264.7 Mo infected with

81 ession of the gene encoding the C subunit of vacuolar ATPase (V-ATPase) in the medial cells of the ri

82 Retardation of endosomal trafficking through vacuolar ATPase (V-ATPase) inhibition enhanced caspase-8

83 Pre-incubation with the vacuolar ATPase (V-ATPase) inhibitors bafilomycin A(1) a

84 The vacuolar ATPase (V-ATPase) is a 1MDa transmembrane proto

85 The yeast Saccharomyces cerevisiae vacuolar ATPase (V-ATPase) is a multisubunit complex div

86 The vacuolar ATPase (V-ATPase) is a multisubunit complex tha

87 The vacuolar ATPase (V-ATPase) is a multisubunit enzyme that

88 The vacuolar ATPase (V-ATPase) is a multisubunit enzyme that

89 The Saccharomyces cerevisiae vacuolar ATPase (V-ATPase) is composed of at least 13 po

90 Eukaryotic vacuolar ATPase (V-ATPase) is regulated by a reversible

91 he proton pumping activity of the eukaryotic vacuolar ATPase (V-ATPase) is regulated by a unique mech

92 Drosophila genes that encode subunits of the vacuolar ATPase (V-ATPase) proton pump.

93 the transport of mature V0a1 subunits of the vacuolar ATPase (V-ATPase) to lysosomes.

94 The subunit architecture of the yeast vacuolar ATPase (V-ATPase) was analyzed by single partic

95 In cancer cells, vacuolar ATPase (V-ATPase), a multi-subunit enzyme, is e

96 In cancer cells, vacuolar ATPase (V-ATPase), a multi-subunit enzyme, is e

97 required for the biogenesis of a functional vacuolar ATPase (V-ATPase), but are not part of the fina

98 entified mutants in vacuolar sorting and the vacuolar ATPase (V-ATPase).

99 hich includes the Rag GTPases, Ragulator and vacuolar ATPase (V-ATPase).

100 within VMA1, the catalytic subunit A of the vacuolar ATPase (V-ATPase).

101 e membrane sector (Vo) of the proton pumping vacuolar ATPase (V-ATPase, V1Vo-ATPase) from Saccharomyc

102 s achieved by means of rotary motors, namely vacuolar ATPases (V-ATPase), which are present at many o

103 Vacuolar ATPases (V-ATPases) are essential proton pumps

104 Vacuolar ATPases (V-ATPases) are important for many cell

105 The vacuolar ATPases (V-ATPases) are multisubunit complexes

106 Vacuolar ATPases (V-ATPases) are multisubunit enzymes th

107 There has been no previous indication that vacuolar ATPases (V-ATPases) require sphingolipids for f

108 ilomycin A(1) is a specific inhibitor of the vacuolar-ATPase (V-ATPase), which is responsible for pH

109 g and cnj encode the E and G subunits of the vacuolar ATPase (vATPase) and showed that both the V0 an

110 filomycin A1 (BafA), a specific inhibitor of vacuolar ATPase (vATPase) required for lysosomal functio

111 ysoTracker red and acquisition of the proton vacuolar ATPase (vATPase) using immunofluorescence withi

112 d that zymogen activation is mediated by the vacuolar ATPase (vATPase), a proton transporter.

113 address questions about the structure of the vacuolar ATPase, we have generated mutant strains of Neu

114 o analyze the phenotype of cells lacking the vacuolar ATPase, we inactivated the vma-1 gene, which en