ライフサイエンスコーパス: vacuolar H ATPase

1 xchanger but opposite to localization of the vacuolar H-ATPase.

2 in receptor and is an essential component of vacuolar H+ ATPase.

3 e demonstrate a requirement for a functional vacuolar H+-ATPase.

4 of ATP were regulated by the activity of the vacuolar H+-ATPase.

5 Acidification of AVO was mediated by the vacuolar H+-ATPase.

6 s a peripheral membrane subunit of the yeast vacuolar H+-ATPase.

7 intenance of transmembrane pH gradients by a vacuolar H+-ATPase.

8 compound, or bafilomycin A1, an inhibitor of vacuolar H+-ATPase.

9 ut does lead to an increased activity of the vacuolar H(+)-ATPase.

10 oxin and a potent inhibitor of the mammalian vacuolar (H(+))-ATPase.

11 ation, but bafilomycin A(1), an inhibitor of vacuolar H(+)-ATPases, abolished resensitization.

12 Furthermore, the vacuolar H+-ATPase accumulated in the perivacuolar class

13 membrane-bound (V(O)) complex of eukaryotic vacuolar H(+)-ATPase acidification machinery.

14 CYAM accumulated slowly into puncta based on vacuolar H(+)-ATPase activity and dispersed rapidly upon

15 over, vacuoles from crd1Delta show decreased vacuolar H(+)-ATPase activity and proton pumping, which

16 gi network/early endosome (TGN/EE)-localized vacuolar H(+)-ATPase activity nor the function of the br

17 No vacuolar H(+)-ATPase activity was detectable in isolated

18 ization resulting from loss of Vma-dependent vacuolar H(+)-ATPase activity was not the cause of vma m

19 erevisiae and a Deltavma1 mutant, which lack vacuolar H(+)-ATPase activity, had large (fivefold or gr

20 esigned to identify novel genes required for vacuolar H+-ATPase activity in Saccharomyces cerevisiae.

21 s Ca2+ and also displayed a 22% reduction in vacuolar H+-ATPase activity.

22 Both organelles also possessed a vacuolar H(+)-ATPase, an H(+)-pyrophosphatase, and a Ca(

23 the proton translocating V0a1 subunit of the vacuolar (H+)-ATPase and targeting to the lysosome.

24 tion was minimally affected by inhibition of vacuolar H(+)-ATPase and phosphatases but was markedly s

25 osin interacts with almost all components of vacuolar H(+)-ATPase and the Ragulator complex and with

26 th bafilomycin A1 (Baf), an inhibitor of the vacuolar H(+)-ATPase and therefore of endosomal-lysosoma

27 g permeabilized epimastigotes suggested that vacuolar H(+)-ATPase and V-H(+)-PPase activities are pre

28 enopus analog; and a third is a subunit of a vacuolar H-ATPase, and is named VATPS1.

29 The vacuolar (H(+))-ATPases are ATP-dependent proton pumps t

30 age antimicrobial activity, and identify the vacuolar H(+)-ATPase as a potential target for host-dire

31 r-specific HXK1 unconventional partners: the vacuolar H(+)-ATPase B1 (VHA-B1) and the 19S regulatory

32 dicate that recurrent stone formers with the vacuolar H(+)-ATPase B1 subunit p.E161K SNP exhibit a ur

33 In addition, inhibition of vacuolar H(+)-ATPases by treatment with bafilomycin A1 a

34 Inhibition of vacuolar H(+)-ATPases by use of the specific inhibitor b

35 ted ATP6S1, a putative accessory unit of the vacuolar H(+)-ATPase complex.

36 and concanamycin A, a selective inhibitor of vacuolar H+ ATPases, demonstrating that these viruses re

37 bafilomycin A1, a specific inhibitor of the vacuolar H+-ATPase, did not alter the fusion protein mob

38 ical gradient (Deltamu(H+)) generated by the vacuolar H(+)-ATPase drives the accumulation of classica

39 ing mutants in transporters (pmr1, pdr5, and vacuolar H+-ATPase), ergosterol biosynthesis (erg3, erg6

40 cin A1 and concanamycin A, inhibitors of the vacuolar H(+)-ATPase, for its dependence on Rag GTPase i

41 nd shows weak homology to a component of the vacuolar H+-ATPase found in organisms as diverse as inse

42 al renal tubular acidosis (dRTA), absence of vacuolar H(+)-ATPase from collecting duct intercalated c

43 Vacuolar H(+)-ATPase functions as a vacuolar proton pump

44 The 56-kDa B1 subunit of the vacuolar H(+)ATPase has a C-terminal DTAL amino acid mot

45 pump subunit (VPP-c, the 16-kDa subunit c of vacuolar H+-ATPase) has been identified as an interactin

46 Vacuolar H+-ATPases have an essential role in renal hydr

47 ss requires (i) apical proton secretion by a vacuolar H(+)-ATPase, (ii) actin cytoskeleton reorganiza

48 We studied the role of the kidney vacuolar H(+)-ATPase in this adaptational response by an

49 These effects were duplicated by the vacuolar (H+)-ATPase inhibitor bafilomycin A1.

50 hydrostilbene-2, 2' -disulfonic acid and the vacuolar H(+)-ATPase inhibitor bafilomycin A(1).

51 icroscopy, lysosomotropic agents such as the vacuolar H(+)-ATPase inhibitor bafilomycin A1 blocked th

52 locked by the NAADP antagonist Ned-19 or the vacuolar H(+)-ATPase inhibitor bafilomycin A1, indicatin

53 In the presence of a vacuolar H(+)-ATPase inhibitor, concanamycin A, oxidized

54 E-1 inhibitors (SM-19712, PD-069185) and the vacuolar H(+)ATPase inhibitor bafilomycin A(1), which pr

55 Treatment with the vacuolar H+-ATPase inhibitor bafilomycin A1 caused pHTf

56 addition of either NH4Cl, nigericin, or the vacuolar H+-ATPase inhibitor bafilomycin A1.

57 ore monensin, and bafilomycin A1, a specific vacuolar H+-ATPase inhibitor, each caused inhibition of

58 Bafilomycin A1, the vacuolar H+-ATPase inhibitor, inhibited degradation of L

59 dose-dependent manner by treatment with the vacuolar H+-ATPase inhibitors concanamycin A and bafilom

60 However, a functional vacuolar (H+) ATPase is required for early steps of TeNT

61 We have shown that a vacuolar (H+)-ATPase is expressed at high levels on the

62 Proton translocation by the vacuolar H(+)-ATPase is mediated by a multicopy transmem

63 nolocalization studies demonstrated that the vacuolar H+-ATPase is associated with this cupped cister

64 The vacuolar H+-ATPase is inhibited with high specificity an

65 In Deltacwh36 cells, the vacuolar H+-ATPase is not assembled and there are reduce

66 An intraluminal acidic pH, maintained by the vacuolar H+-ATPase, is one of the critical factors for s

67 mpartments of the Golgi complex in which the vacuolar H+-ATPase maintains an acidic pH.

68 reestablished across the tonoplast by either vacuolar H(+)-ATPase or vacuolar H(+)-pyrophosphatase.

69 The vacuolar (H(+))-ATPases (or V-ATPases) are structurally

70 Proton translocation by the vacuolar (H+)-ATPase (or V-ATPase) has been shown by mut

71 The vacuolar (H+)-ATPase (or V-ATPase) is an ATP-dependent p

72 Altogether, these findings indicate that the vacuolar (H+ ATPase plays a specific role in early sorti

73 Subunit a of the vacuolar H(+)-ATPases plays an important role in proton

74 environment, consistent with a role for the vacuolar (H+)-ATPase proton pump in copper assembly of l

75 Measurements of pH-dependent vacuolar H+/ATPase pump activity and H+ leak in Golgi pr

76 al mechanisms of proton translocation by the vacuolar H(+)-ATPase require that a transmembrane acidic

77 rol of net acid excretion and for regulating vacuolar H+-ATPases residing on the plasma membrane inde

78 ron microscopy of prokaryotic and eukaryotic vacuolar H(+)-ATPases, respectively, clarifying their or

79 Interestingly, the inhibition of vacuolar H(+)-ATPases significantly increased the levels

80 nd lytic vacuole/lysosome, and contained the vacuolar H(+)-ATPase subunit a3, alias TCIRG1, a known a

81 CSL5 was allelic to VMA5, the vacuolar H(+)-ATPase subunit C, and one third of csl5 cd

82 r with mislocalization of the Golgi-enriched vacuolar H(+)-ATPase subunit isoform a2.

83 ouring an antisense construct for one of the vacuolar H(+)-ATPase subunits.

84 ence of clonogenic death after inhibition of vacuolar H+-ATPase suggest that formation of acidic orga

85 ng 4-acetyldiphyllin, a selective blocker of vacuolar H(+)-ATPase that increases the pH of intracellu

86 nships in the catalytic subunit of the yeast vacuolar H(+)-ATPase, the gene encoding this subunit (VM

87 ysis indicate that Tca1 colocalizes with the vacuolar H+-ATPase to the plasma membrane and to intrace

88 BE, bis-enoxacin; V-ATPase, vacuolar H(+)-ATPase; TRAP, tartrate-resistant acid phos

89 Accordingly, inhibition of the vacuolar (H+) ATPase under conditions that completely ab

90 teoclasts, one of which is the d2 isoform of vacuolar (H(+)) ATPase (v-ATPase) V(0) domain (Atp6v0d2)

91 The vacuolar (H(+))-ATPase (V-ATPase) is crucial for mainten

92 The 100 kDa a-subunit of the yeast vacuolar (H(+))-ATPase (V-ATPase) is encoded by two gene

93 ty to specific sites within subunit B of the vacuolar (H(+))-ATPase (V-ATPase) of yeast.

94 ecruitment of extrinsic V(1) subunits of the vacuolar (H(+))-ATPase (V-ATPase) to rat liver endosomes

95 N1 results in alterations in vacuolar pH and vacuolar (H(+))-ATPase (V-ATPase)-dependent H(+) transpo

96 The vacuolar (H(+))-ATPases (V-ATPases) are a family of ATP-

97 The vacuolar (H(+))-ATPases (V-ATPases) are ATP-dependent pr

98 The vacuolar (H(+))-ATPases (V-ATPases) are ATP-driven proto

99 hermore, we show that Rab5a colocalizes with vacuolar (H(+))-ATPases (V-ATPases) on transport vesicle

100 The integral V(0) domain of the vacuolar (H(+))-ATPases (V-ATPases) provides the pathway

101 potent and highly specific inhibitors of the vacuolar (H(+))-ATPases (V-ATPases), typically inhibitin

102 The vacuolar (H+) ATPases (V-ATPases) are large, multimeric

103 The B subunit of the vacuolar (H+)-ATPase (V-ATPase) has previously been show

104 The vacuolar (H+)-ATPases (V-ATPases) are ATP-dependent prot

105 Vacuolar (H+)-ATPases (V-ATPases) are multisubunit compl

106 The vacuolar (H+)-ATPases (V-ATPases) are multisubunit compl

107 Vacuolar (H+)-ATPases (V-ATPases) are ubiquitous, ATP-dr

108 The vacuolar [H(+)]-ATPases (V-ATPases) are composed of a pe

109 in the presence of low concentrations of the vacuolar H(+) -ATPase (V-H(+) -ATPase) inhibitor bafilom

110 The vacuolar H(+) ATPase (V-ATPase) is a complex multisubuni

111 The vacuolar H(+) ATPases (V-ATPases) are ATP-driven proton

112 Plasma membrane vacuolar H(+)-ATPase (V-ATPase) activity of tumor cells

113 tion is due to a modulation of both NHE3 and vacuolar H(+)-ATPase (V-ATPase) activity.

114 The vacuolar H(+)-ATPase (V-ATPase) along with ion channels

115 lated cells (ICs) express the proton pumping vacuolar H(+)-ATPase (V-ATPase) and are extensively invo

116 An interaction between the B2 subunit of vacuolar H(+)-ATPase (V-ATPase) and microfilaments is re

117 in inhibits binding between the B-subunit of vacuolar H(+)-ATPase (V-ATPase) and microfilaments, and

118 Vacuolar H(+)-ATPase (V-ATPase) binds actin filaments wi

119 Vacuolar H(+)-ATPase (V-ATPase) binds microfilaments, an

120 that an activator subunit (Vma13p) of yeast vacuolar H(+)-ATPase (V-ATPase) binds to the cytoplasmic

121 investigate the function of subunit D in the vacuolar H(+)-ATPase (V-ATPase) complex, random and site

122 units in close proximity to subunit B in the vacuolar H(+)-ATPase (V-ATPase) complex.

123 The function of the vacuolar H(+)-ATPase (V-ATPase) enzyme complex is to aci

124 (vha14) encoding the 14-kDa F-subunit of the vacuolar H(+)-ATPase (V-ATPase) has been cloned via homo

125 dy capitalized on the mechanisms suppressing vacuolar H(+)-ATPase (V-ATPase) in pfk2Delta to gain new

126 The vacuolar H(+)-ATPase (V-ATPase) is a major contributor t

127 The vacuolar H(+)-ATPase (V-ATPase) is a multisubunit comple

128 The yeast Saccharomyces cerevisiae vacuolar H(+)-ATPase (V-ATPase) is a multisubunit comple

129 Eukaryotic vacuolar H(+)-ATPase (V-ATPase) is a multisubunit enzyme

130 The vacuolar H(+)-ATPase (V-ATPase) is a rotary motor enzyme

131 The vacuolar H(+)-ATPase (V-ATPase) is an ATP-dependent prot

132 The vacuolar H(+)-ATPase (V-ATPase) is an ATP-driven proton

133 The vacuolar H(+)-ATPase (V-ATPase) is responsible for acidi

134 tein gelsolin plays a key role in regulating vacuolar H(+)-ATPase (V-ATPase) recycling.

135 The ability of a vacuolar H(+)-ATPase (V-ATPase) subunit homolog (subunit

136 rane protein and an accessory subunit of the vacuolar H(+)-ATPase (V-ATPase) that may also function w

137 ation-dependent interaction of the endosomal vacuolar H(+)-ATPase (V-ATPase) with cytohesin-2, a GDP/

138 The vacuolar H(+)-ATPase (V-ATPase), a multisubunit proton p

139 Key to this restoration is activation of the vacuolar H(+)-ATPase (V-ATPase), a proton pump that acid

140 fus-1 encodes the e subunit of the vacuolar H(+)-ATPase (V-ATPase), and loss of other V-ATP

141 Moreover, ZnT2 directly interacted with vacuolar H(+)-ATPase (V-ATPase), and ZnT2 deletion impai

142 in is a potent and specific inhibitor of the vacuolar H(+)-ATPase (V-ATPase), binding to the V(0) mem

143 The screen also revealed the vacuolar H(+)-ATPase (V-ATPase), which acidifies the lys

144 al evidence that it encodes subunit C of the vacuolar H(+)-ATPase (V-ATPase).

145 H(+)/Ca(2+) antiporter (Vcx1p) driven by the vacuolar H(+)-ATPase (V-ATPase).

146 d glucose-stimulated reassembly of the yeast vacuolar H(+)-ATPase (V-ATPase).

147 uolar H(+)-pyrophosphatase (V-PPase) and the vacuolar H(+)-ATPase (V-ATPase).

148 otic membrane fusion and have implicated the vacuolar H(+)-ATPase (V-ATPase).

149 atp6ap2 encodes a subunit of the vacuolar H(+)-ATPase (V-H(+)-ATPase), which modulates pH

150 A intercalated cells (A-ICs), which contain vacuolar H(+)-ATPase (V-type ATPase)-rich vesicles that

151 Bafilomycin A1, a potent inhibitor of vacuolar H(+)-ATPases (V-ATPase), inhibited growth of Ne

152 Vacuolar H(+)-ATPases (V-ATPases) acidify intracellular

153 Vacuolar H(+)-ATPases (V-ATPases) are a family of highly

154 The vacuolar H(+)-ATPases (V-ATPases) are a universal class

155 Vacuolar H(+)-ATPases (V-ATPases) are essential for acid

156 Vacuolar H(+)-ATPases (V-ATPases) are highly conserved p

157 Vacuolar H(+)-ATPases (V-ATPases) are multisubunit enzym

158 Vacuolar H(+)-ATPases (V-ATPases) drive organelle acidif

159 unit C is a V(1) sector subunit found in all vacuolar H(+)-ATPases (V-ATPases) that may be part of th

160 We identify that genetic disruption of the Vacuolar H+ ATPase (V-ATPase), the key proton pump for e

161 hibitor of binding between the B2-subunit of vacuolar H+-ATPase (V-ATPase) and microfilaments.

162 Here, we provide evidence that a vacuolar H+-ATPase (V-ATPase) in the ocular ciliary epit

163 age differentiation, the cellular content of vacuolar H+-ATPase (V-ATPase) increases more than 4-fold

164 The effect of selective vacuolar H+-ATPase (V-ATPase) inhibitor bafilomycin A1 o

165 The yeast vacuolar H+-ATPase (V-ATPase) is a multisubunit complex

166 The Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a multisubunit complex

167 The vacuolar H+-ATPase (V-ATPase) is an ATP-driven rotary mo

168 It has been previously demonstrated that the vacuolar H+-ATPase (V-ATPase) of clathrin-coated vesicle

169 of the peripheral cytoplasmic domain of the vacuolar H+-ATPase (V-ATPase) were present in a SOS2-con

170 ) is closely associated with a multi-subunit vacuolar H+-ATPase (V-ATPase).

171 Vacuolar H+-ATPases (V-ATPases) are a family of ATP-driv

172 ew naturally occurring class of inhibitor of vacuolar H+-ATPases (V-ATPases) isolated from vacuolar m

173 The vacuolar H+-ATPases (V-ATPases) of lemon fruits and epic

174 ivated soluble adenylyl cyclase (sAC) to the vacuolar H+ATPase (V-ATPase).

175 salt, the activities of both the tonoplast (vacuolar) H(+)-ATPase (V-ATPase) and Na+/H+ antiporter i

176 related molecules, such as the d2 isoform of vacuolar H(+)-ATPase V0 domain and the dendritic cell-sp

177 e surrounding the algae abundantly expresses vacuolar H(+)-ATPase (VHA), which acidifies the symbioso

178 demonstrated that a 16-kDa subunit (16K) of vacuolar H(+)-ATPase via one of its transmembrane domain

179 Loss of function of the vacuolar H(+)-ATPase (vma1) or a defect in the biosynthe

180 acuolar protease carboxypeptidase Y, and the vacuolar H+-ATPase Vph1p.

181 However, when activity of the vacuolar H+-ATPase was also inhibited, disulfide reducti

182 on is due to a differential targeting of the vacuolar (H+) ATPase, which is not present on moving TeN

183 s is exacerbated in strains with a defective vacuolar H(+)-ATPase, which abolishes the ability of yea

184 itive regulatory E subunit (V-ATPase E) of a vacuolar H(+)-ATPase, which is responsible for acidifica