ライフサイエンスコーパス: vacuolar H ATPase

1 xchanger but opposite to localization of the vacuolar H-ATPase.

2 in receptor and is an essential component of vacuolar H+ ATPase.

3 e demonstrate a requirement for a functional vacuolar H+-ATPase.

4 of ATP were regulated by the activity of the vacuolar H+-ATPase.

5 Acidification of AVO was mediated by the vacuolar H+-ATPase.

6 s a peripheral membrane subunit of the yeast vacuolar H+-ATPase.

7 intenance of transmembrane pH gradients by a vacuolar H+-ATPase.

8 compound, or bafilomycin A1, an inhibitor of vacuolar H+-ATPase.

9 ut does lead to an increased activity of the vacuolar H(+)-ATPase.

10 ergic system, and work as a component of the vacuolar H(+) -ATPase.

11 oxin and a potent inhibitor of the mammalian vacuolar (H(+))-ATPase.

12 bstituted benzolactone enamides that inhibit vacuolar H(+) -ATPases.

13 its in hlh-30 mutant worms, and knockdown of vacuolar H+-ATPase 12 (vha-12) and its upstream regulato

14 ation, but bafilomycin A(1), an inhibitor of vacuolar H(+)-ATPases, abolished resensitization.

15 Furthermore, the vacuolar H+-ATPase accumulated in the perivacuolar class

16 membrane-bound (V(O)) complex of eukaryotic vacuolar H(+)-ATPase acidification machinery.

17 t progress in the involvement of PRR for the vacuolar H(+) -ATPase activity.

18 CYAM accumulated slowly into puncta based on vacuolar H(+)-ATPase activity and dispersed rapidly upon

19 ns as regulators of autophagy by controlling vacuolar H(+)-ATPase activity and mTOR signalling.

20 over, vacuoles from crd1Delta show decreased vacuolar H(+)-ATPase activity and proton pumping, which

21 gi network/early endosome (TGN/EE)-localized vacuolar H(+)-ATPase activity nor the function of the br

22 No vacuolar H(+)-ATPase activity was detectable in isolated

23 ization resulting from loss of Vma-dependent vacuolar H(+)-ATPase activity was not the cause of vma m

24 erevisiae and a Deltavma1 mutant, which lack vacuolar H(+)-ATPase activity, had large (fivefold or gr

25 esigned to identify novel genes required for vacuolar H+-ATPase activity in Saccharomyces cerevisiae.

26 We show that vacuolar H+-ATPase activity regulates sorting of O-glyco

27 Consistent with decreased vacuolar H+-ATPase activity, functional analyses conduct

28 s Ca2+ and also displayed a 22% reduction in vacuolar H+-ATPase activity.

29 Both organelles also possessed a vacuolar H(+)-ATPase, an H(+)-pyrophosphatase, and a Ca(

30 nstituent proteins of the Ragulator complex (vacuolar (H(+))-ATPase and Lamtor1) require dynamic S-pa

31 the proton translocating V0a1 subunit of the vacuolar (H+)-ATPase and targeting to the lysosome.

32 proper levels of the V0a/V100 subunit of the vacuolar H(+)-ATPase and lysosomal pH.

33 tion was minimally affected by inhibition of vacuolar H(+)-ATPase and phosphatases but was markedly s

34 osin interacts with almost all components of vacuolar H(+)-ATPase and the Ragulator complex and with

35 th bafilomycin A1 (Baf), an inhibitor of the vacuolar H(+)-ATPase and therefore of endosomal-lysosoma

36 g permeabilized epimastigotes suggested that vacuolar H(+)-ATPase and V-H(+)-PPase activities are pre

37 enopus analog; and a third is a subunit of a vacuolar H-ATPase, and is named VATPS1.

38 The vacuolar (H(+))-ATPases are ATP-dependent proton pumps t

39 age antimicrobial activity, and identify the vacuolar H(+)-ATPase as a potential target for host-dire

40 protein 115, transmembrane protein 199, and vacuolar H(+)-ATPase assembly integral membrane protein

41 r-specific HXK1 unconventional partners: the vacuolar H(+)-ATPase B1 (VHA-B1) and the 19S regulatory

42 dicate that recurrent stone formers with the vacuolar H(+)-ATPase B1 subunit p.E161K SNP exhibit a ur

43 In addition, inhibition of vacuolar H(+)-ATPases by treatment with bafilomycin A1 a

44 Inhibition of vacuolar H(+)-ATPases by use of the specific inhibitor b

45 ted ATP6S1, a putative accessory unit of the vacuolar H(+)-ATPase complex.

46 and concanamycin A, a selective inhibitor of vacuolar H+ ATPases, demonstrating that these viruses re

47 bafilomycin A1, a specific inhibitor of the vacuolar H+-ATPase, did not alter the fusion protein mob

48 ical gradient (Deltamu(H+)) generated by the vacuolar H(+)-ATPase drives the accumulation of classica

49 ing mutants in transporters (pmr1, pdr5, and vacuolar H+-ATPase), ergosterol biosynthesis (erg3, erg6

50 cin A1 and concanamycin A, inhibitors of the vacuolar H(+)-ATPase, for its dependence on Rag GTPase i

51 nd shows weak homology to a component of the vacuolar H+-ATPase found in organisms as diverse as inse

52 al renal tubular acidosis (dRTA), absence of vacuolar H(+)-ATPase from collecting duct intercalated c

53 Vacuolar H(+)-ATPase functions as a vacuolar proton pump

54 One of these mutants, affecting the vacuolar H+-ATPase gene atp6ap1b, revealed specific requ

55 The 56-kDa B1 subunit of the vacuolar H(+)ATPase has a C-terminal DTAL amino acid mot

56 pump subunit (VPP-c, the 16-kDa subunit c of vacuolar H+-ATPase) has been identified as an interactin

57 Vacuolar H+-ATPases have an essential role in renal hydr

58 erexpression on the stoichiometry within the vacuolar H(+)-ATPase heteromer and on neurological funct

59 ss requires (i) apical proton secretion by a vacuolar H(+)-ATPase, (ii) actin cytoskeleton reorganiza

60 We studied the role of the kidney vacuolar H(+)-ATPase in this adaptational response by an

61 in the membrane bound integral domain of the vacuolar H+-ATPase, in 27 patients with neurodevelopment

62 These effects were duplicated by the vacuolar (H+)-ATPase inhibitor bafilomycin A1.

63 hydrostilbene-2, 2' -disulfonic acid and the vacuolar H(+)-ATPase inhibitor bafilomycin A(1).

64 icroscopy, lysosomotropic agents such as the vacuolar H(+)-ATPase inhibitor bafilomycin A1 blocked th

65 locked by the NAADP antagonist Ned-19 or the vacuolar H(+)-ATPase inhibitor bafilomycin A1, indicatin

66 In the presence of a vacuolar H(+)-ATPase inhibitor, concanamycin A, oxidized

67 E-1 inhibitors (SM-19712, PD-069185) and the vacuolar H(+)ATPase inhibitor bafilomycin A(1), which pr

68 Treatment with the vacuolar H+-ATPase inhibitor bafilomycin A1 caused pHTf

69 addition of either NH4Cl, nigericin, or the vacuolar H+-ATPase inhibitor bafilomycin A1.

70 ore monensin, and bafilomycin A1, a specific vacuolar H+-ATPase inhibitor, each caused inhibition of

71 Bafilomycin A1, the vacuolar H+-ATPase inhibitor, inhibited degradation of L

72 dose-dependent manner by treatment with the vacuolar H+-ATPase inhibitors concanamycin A and bafilom

73 However, a functional vacuolar (H+) ATPase is required for early steps of TeNT

74 We have shown that a vacuolar (H+)-ATPase is expressed at high levels on the

75 Proton translocation by the vacuolar H(+)-ATPase is mediated by a multicopy transmem

76 The vacuolar H+-ATPase is an enzymatic complex that function

77 nolocalization studies demonstrated that the vacuolar H+-ATPase is associated with this cupped cister

78 The vacuolar H+-ATPase is inhibited with high specificity an

79 In Deltacwh36 cells, the vacuolar H+-ATPase is not assembled and there are reduce

80 An intraluminal acidic pH, maintained by the vacuolar H+-ATPase, is one of the critical factors for s

81 mpartments of the Golgi complex in which the vacuolar H+-ATPase maintains an acidic pH.

82 reestablished across the tonoplast by either vacuolar H(+)-ATPase or vacuolar H(+)-pyrophosphatase.

83 The vacuolar (H(+))-ATPases (or V-ATPases) are structurally

84 Proton translocation by the vacuolar (H+)-ATPase (or V-ATPase) has been shown by mut

85 The vacuolar (H+)-ATPase (or V-ATPase) is an ATP-dependent p

86 Altogether, these findings indicate that the vacuolar (H+ ATPase plays a specific role in early sorti

87 Subunit a of the vacuolar H(+)-ATPases plays an important role in proton

88 environment, consistent with a role for the vacuolar (H+)-ATPase proton pump in copper assembly of l

89 Measurements of pH-dependent vacuolar H+/ATPase pump activity and H+ leak in Golgi pr

90 al mechanisms of proton translocation by the vacuolar H(+)-ATPase require that a transmembrane acidic

91 rol of net acid excretion and for regulating vacuolar H+-ATPases residing on the plasma membrane inde

92 ron microscopy of prokaryotic and eukaryotic vacuolar H(+)-ATPases, respectively, clarifying their or

93 Interestingly, the inhibition of vacuolar H(+)-ATPases significantly increased the levels

94 nd lytic vacuole/lysosome, and contained the vacuolar H(+)-ATPase subunit a3, alias TCIRG1, a known a

95 CSL5 was allelic to VMA5, the vacuolar H(+)-ATPase subunit C, and one third of csl5 cd

96 r with mislocalization of the Golgi-enriched vacuolar H(+)-ATPase subunit isoform a2.

97 Here we reveal that silencing specific vacuolar H(+)-ATPase subunits (for example, vha-6), whic

98 ouring an antisense construct for one of the vacuolar H(+)-ATPase subunits.

99 ence of clonogenic death after inhibition of vacuolar H+-ATPase suggest that formation of acidic orga

100 ng 4-acetyldiphyllin, a selective blocker of vacuolar H(+)-ATPase that increases the pH of intracellu

101 nships in the catalytic subunit of the yeast vacuolar H(+)-ATPase, the gene encoding this subunit (VM

102 ysis indicate that Tca1 colocalizes with the vacuolar H+-ATPase to the plasma membrane and to intrace

103 BE, bis-enoxacin; V-ATPase, vacuolar H(+)-ATPase; TRAP, tartrate-resistant acid phos

104 Accordingly, inhibition of the vacuolar (H+) ATPase under conditions that completely ab

105 teoclasts, one of which is the d2 isoform of vacuolar (H(+)) ATPase (v-ATPase) V(0) domain (Atp6v0d2)

106 The vacuolar (H(+))-ATPase (V-ATPase) is crucial for mainten

107 The 100 kDa a-subunit of the yeast vacuolar (H(+))-ATPase (V-ATPase) is encoded by two gene

108 Vacuolar (H(+))-ATPase (V-ATPase) is fundamental in infl

109 ty to specific sites within subunit B of the vacuolar (H(+))-ATPase (V-ATPase) of yeast.

110 ecruitment of extrinsic V(1) subunits of the vacuolar (H(+))-ATPase (V-ATPase) to rat liver endosomes

111 N1 results in alterations in vacuolar pH and vacuolar (H(+))-ATPase (V-ATPase)-dependent H(+) transpo

112 The vacuolar (H(+))-ATPases (V-ATPases) are a family of ATP-

113 The vacuolar (H(+))-ATPases (V-ATPases) are ATP-dependent pr

114 The vacuolar (H(+))-ATPases (V-ATPases) are ATP-driven proto

115 hermore, we show that Rab5a colocalizes with vacuolar (H(+))-ATPases (V-ATPases) on transport vesicle

116 The integral V(0) domain of the vacuolar (H(+))-ATPases (V-ATPases) provides the pathway

117 potent and highly specific inhibitors of the vacuolar (H(+))-ATPases (V-ATPases), typically inhibitin

118 The vacuolar (H+) ATPases (V-ATPases) are large, multimeric

119 The B subunit of the vacuolar (H+)-ATPase (V-ATPase) has previously been show

120 The vacuolar (H+)-ATPases (V-ATPases) are ATP-dependent prot

121 The vacuolar (H+)-ATPases (V-ATPases) are multisubunit compl

122 Vacuolar (H+)-ATPases (V-ATPases) are multisubunit compl

123 Vacuolar (H+)-ATPases (V-ATPases) are ubiquitous, ATP-dr

124 The vacuolar [H(+)]-ATPases (V-ATPases) are composed of a pe

125 in the presence of low concentrations of the vacuolar H(+) -ATPase (V-H(+) -ATPase) inhibitor bafilom

126 The vacuolar H(+) ATPase (V-ATPase) is a complex multisubuni

127 A striking example is the Vacuolar H(+) ATPase (V-ATPase), which, unexpectedly, wa

128 The vacuolar H(+) ATPases (V-ATPases) are ATP-driven proton

129 Plasma membrane vacuolar H(+)-ATPase (V-ATPase) activity of tumor cells

130 tion is due to a modulation of both NHE3 and vacuolar H(+)-ATPase (V-ATPase) activity.

131 The vacuolar H(+)-ATPase (V-ATPase) along with ion channels

132 ne protein that serves as a component of the vacuolar H(+)-ATPase (V-ATPase) and also activates (pro)

133 lated cells (ICs) express the proton pumping vacuolar H(+)-ATPase (V-ATPase) and are extensively invo

134 An interaction between the B2 subunit of vacuolar H(+)-ATPase (V-ATPase) and microfilaments is re

135 in inhibits binding between the B-subunit of vacuolar H(+)-ATPase (V-ATPase) and microfilaments, and

136 Vacuolar H(+)-ATPase (V-ATPase) binds actin filaments wi

137 Vacuolar H(+)-ATPase (V-ATPase) binds microfilaments, an

138 that an activator subunit (Vma13p) of yeast vacuolar H(+)-ATPase (V-ATPase) binds to the cytoplasmic

139 investigate the function of subunit D in the vacuolar H(+)-ATPase (V-ATPase) complex, random and site

140 units in close proximity to subunit B in the vacuolar H(+)-ATPase (V-ATPase) complex.

141 The function of the vacuolar H(+)-ATPase (V-ATPase) enzyme complex is to aci

142 (vha14) encoding the 14-kDa F-subunit of the vacuolar H(+)-ATPase (V-ATPase) has been cloned via homo

143 dy capitalized on the mechanisms suppressing vacuolar H(+)-ATPase (V-ATPase) in pfk2Delta to gain new

144 Here we report that vacuolar H(+)-ATPase (V-ATPase) inhibition differentiall

145 The vacuolar H(+)-ATPase (V-ATPase) is a highly conserved pr

146 The vacuolar H(+)-ATPase (V-ATPase) is a major contributor t

147 The vacuolar H(+)-ATPase (V-ATPase) is a multisubunit comple

148 The yeast Saccharomyces cerevisiae vacuolar H(+)-ATPase (V-ATPase) is a multisubunit comple

149 Eukaryotic vacuolar H(+)-ATPase (V-ATPase) is a multisubunit enzyme

150 The vacuolar H(+)-ATPase (V-ATPase) is a rotary motor enzyme

151 The vacuolar H(+)-ATPase (V-ATPase) is an ATP-dependent prot

152 The vacuolar H(+)-ATPase (V-ATPase) is an ATP-dependent prot

153 The vacuolar H(+)-ATPase (V-ATPase) is an ATP-dependent prot

154 The vacuolar H(+)-ATPase (V-ATPase) is an ATP-driven proton

155 The vacuolar H(+)-ATPase (V-ATPase) is responsible for acidi

156 The yeast vacuolar H(+)-ATPase (V-ATPase) of budding yeast (Saccha

157 tein gelsolin plays a key role in regulating vacuolar H(+)-ATPase (V-ATPase) recycling.

158 The ability of a vacuolar H(+)-ATPase (V-ATPase) subunit homolog (subunit

159 rane protein and an accessory subunit of the vacuolar H(+)-ATPase (V-ATPase) that may also function w

160 ation-dependent interaction of the endosomal vacuolar H(+)-ATPase (V-ATPase) with cytohesin-2, a GDP/

161 The vacuolar H(+)-ATPase (V-ATPase), a multisubunit proton p

162 Key to this restoration is activation of the vacuolar H(+)-ATPase (V-ATPase), a proton pump that acid

163 fus-1 encodes the e subunit of the vacuolar H(+)-ATPase (V-ATPase), and loss of other V-ATP

164 Moreover, ZnT2 directly interacted with vacuolar H(+)-ATPase (V-ATPase), and ZnT2 deletion impai

165 in is a potent and specific inhibitor of the vacuolar H(+)-ATPase (V-ATPase), binding to the V(0) mem

166 The screen also revealed the vacuolar H(+)-ATPase (V-ATPase), which acidifies the lys

167 uins to deacetylate and subsequently inhibit vacuolar H(+)-ATPase (v-ATPase), which leads to AMPK act

168 al evidence that it encodes subunit C of the vacuolar H(+)-ATPase (V-ATPase).

169 H(+)/Ca(2+) antiporter (Vcx1p) driven by the vacuolar H(+)-ATPase (V-ATPase).

170 d glucose-stimulated reassembly of the yeast vacuolar H(+)-ATPase (V-ATPase).

171 uolar H(+)-pyrophosphatase (V-PPase) and the vacuolar H(+)-ATPase (V-ATPase).

172 otic membrane fusion and have implicated the vacuolar H(+)-ATPase (V-ATPase).

173 The vacuolar H(+)-ATPase (V-ATPase; V(1)V(o)-ATPase) is an A

174 atp6ap2 encodes a subunit of the vacuolar H(+)-ATPase (V-H(+)-ATPase), which modulates pH

175 A intercalated cells (A-ICs), which contain vacuolar H(+)-ATPase (V-type ATPase)-rich vesicles that

176 Bafilomycin A1, a potent inhibitor of vacuolar H(+)-ATPases (V-ATPase), inhibited growth of Ne

177 Vacuolar H(+)-ATPases (V-ATPases) acidify intracellular

178 Vacuolar H(+)-ATPases (V-ATPases) are a family of highly

179 The vacuolar H(+)-ATPases (V-ATPases) are a universal class

180 Vacuolar H(+)-ATPases (V-ATPases) are essential for acid

181 Vacuolar H(+)-ATPases (V-ATPases) are highly conserved m

182 Vacuolar H(+)-ATPases (V-ATPases) are highly conserved p

183 Vacuolar H(+)-ATPases (V-ATPases) are large, multisubuni

184 Vacuolar H(+)-ATPases (V-ATPases) are multisubunit enzym

185 s required for full assembly and activity of vacuolar H(+)-ATPases (V-ATPases) containing the vacuola

186 Vacuolar H(+)-ATPases (V-ATPases) drive organelle acidif

187 unit C is a V(1) sector subunit found in all vacuolar H(+)-ATPases (V-ATPases) that may be part of th

188 We identify that genetic disruption of the Vacuolar H+ ATPase (V-ATPase), the key proton pump for e

189 Proton-pumping vacuolar H+ ATPases (V-ATPases) are responsible for this

190 hibitor of binding between the B2-subunit of vacuolar H+-ATPase (V-ATPase) and microfilaments.

191 Here, we provide evidence that a vacuolar H+-ATPase (V-ATPase) in the ocular ciliary epit

192 age differentiation, the cellular content of vacuolar H+-ATPase (V-ATPase) increases more than 4-fold

193 The effect of selective vacuolar H+-ATPase (V-ATPase) inhibitor bafilomycin A1 o

194 The Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a multisubunit complex

195 The yeast vacuolar H+-ATPase (V-ATPase) is a multisubunit complex

196 The vacuolar H+-ATPase (V-ATPase) is an ATP-driven rotary mo

197 It has been previously demonstrated that the vacuolar H+-ATPase (V-ATPase) of clathrin-coated vesicle

198 Here, we show that a panel of vacuolar H+-ATPase (v-ATPase) subunits and the target of

199 of the peripheral cytoplasmic domain of the vacuolar H+-ATPase (V-ATPase) were present in a SOS2-con

200 ) is closely associated with a multi-subunit vacuolar H+-ATPase (V-ATPase).

201 Vacuolar H+-ATPases (V-ATPases) are a family of ATP-driv

202 ew naturally occurring class of inhibitor of vacuolar H+-ATPases (V-ATPases) isolated from vacuolar m

203 The vacuolar H+-ATPases (V-ATPases) of lemon fruits and epic

204 ivated soluble adenylyl cyclase (sAC) to the vacuolar H+ATPase (V-ATPase).

205 salt, the activities of both the tonoplast (vacuolar) H(+)-ATPase (V-ATPase) and Na+/H+ antiporter i

206 related molecules, such as the d2 isoform of vacuolar H(+)-ATPase V0 domain and the dendritic cell-sp

207 e surrounding the algae abundantly expresses vacuolar H(+)-ATPase (VHA), which acidifies the symbioso

208 demonstrated that a 16-kDa subunit (16K) of vacuolar H(+)-ATPase via one of its transmembrane domain

209 Loss of function of the vacuolar H(+)-ATPase (vma1) or a defect in the biosynthe

210 acuolar protease carboxypeptidase Y, and the vacuolar H+-ATPase Vph1p.

211 However, when activity of the vacuolar H+-ATPase was also inhibited, disulfide reducti

212 on is due to a differential targeting of the vacuolar (H+) ATPase, which is not present on moving TeN

213 s is exacerbated in strains with a defective vacuolar H(+)-ATPase, which abolishes the ability of yea

214 itive regulatory E subunit (V-ATPase E) of a vacuolar H(+)-ATPase, which is responsible for acidifica