ライフサイエンスコーパス: vacuolate

1 ich time the tapetum also appears abnormally vacuolated.

2 duced the neurons to become hypertrophic and vacuolated.

3 er, the cortical cataracts were punctate and vacuolated.

4 ain irregular in shape, and the lens becomes vacuolated.

5 both mono-ADP ribosyltransferase (mART) and vacuolating activities known as Community-Acquired Respi

6 ctor with ADP-ribosyltransferase (ADPRT) and vacuolating activities.

7 cid substitutions (P9A and G14A) that ablate vacuolating activity and membrane channel-forming activi

8 N-terminal extension found on s2 VacA blocks vacuolating activity as its removal (to make the strain

9 of mutant VacA proteins that have defects in vacuolating activity despite exhibiting channel activiti

10 rnatant (CS) from H. pylori 60190, which has vacuolating activity for HeLa cells (Tox+), and isogenic

11 s, and VacA Delta346-347 inhibited wild-type vacuolating activity in a dominant-negative manner.

12 t negative effect, completely inhibiting the vacuolating activity of wild-type VacA.

13 th vacA from a toxigenic strain confers full vacuolating activity proving that this activity is entir

14 and m1b-m2 alleles produced higher levels of vacuolating activity than did isolates with m2 alleles (

15 The gene for V. cholerae vacuolating activity was cloned and was found to corresp

16 med by a VacA s2m1 chimera (which lacks cell-vacuolating activity) and VacADelta301-328 (which retain

17 ctivity) and VacADelta301-328 (which retains vacuolating activity) each contain p33 central cores sim

18 g truncated VacA fragments for intracellular vacuolating activity, we reduced the minimal functional

19 organelle, and are independent of the toxin vacuolating activity.

20 nts, p37 and p58, that are both required for vacuolating activity.

21 acellular site are important for the toxin's vacuolating activity.

22 protein and a marked enhancement of its cell-vacuolating activity.

23 t remain noncovalently associated and retain vacuolating activity.

24 cked toxin required to mediate intracellular vacuolating activity.

25 lls and were internalized but had defects in vacuolating activity.

26 uds, which contained microspores at the late-vacuolate and bicellular stages of development.

27 These cells become vacuolated and expand, and lead to failure in pollen mot

28 Instead, these cells are highly vacuolated and express large amounts of vesicular ATPase

29 Protegrin-treated N. gonorrhoeae became vacuolated and had striking membrane changes when viewed

30 ng bovine papillomavirus (BPV) E5 are highly vacuolated and have a much enlarged, distorted and fragm

31 eurone occurs only after cells become highly vacuolated and is manifested in an abrupt loss of plasma

32 late bodies, examples of binary fission, and vacuolated and nonvacuolated intermediate bodies, wherea

33 to transient degenerative changes; RPE were vacuolated and separated from photoreceptor outer segmen

34 Cell bodies of affected neurons are vacuolated, and apparently empty spaces are present in a

35 normal antipodal cells that are larger, more vacuolated, and fewer in number than wild type.

36 We find that CSMN display vacuolated apical dendrites with increased autophagy, sh

37 als) that divide asymmetrically to produce a vacuolate basal cell, a stalk cell, and a cytoplasmicall

38 ree to four epithelial cell layers; swollen, vacuolated basal epithelial and endothelial cells; and e

39 al myocardial fibrosis and the appearance of vacuolated cardiomyocytes.

40 es, clasmatodendrocytes were swollen and had vacuolated cell bodies.

41 e(K1831E Delta fyve) protein, incompetent to vacuolate cells, implying that an active PIKfyve enzyme

42 that the high density of caveolae present in vacuolated cells [5, 6] could buffer mechanical tension.

43 Upon loss of caveola function, vacuolated cells collapse at discrete positions under th

44 During morphogenesis, vacuolated cells maintain their structural integrity des

45 indicate that nucleotides released by dying vacuolated cells promote sheath cell vacuolization and t

46 ion and spine development, consists of giant vacuolated cells surrounded by an epithelial sheath [1-3

47 ress a spore coat protein gene (cotB) within vacuolated cells that form part of the stalk and they ex

48 d that VacA-CFP and VacA-YFP interact within vacuolated cells, supporting the belief that monomer ass

49 e the inner notochord and differentiate into vacuolated cells, thereby restoring notochord function a

50 e VacA with mutant forms of the toxin within vacuolated cells.

51 mids expressing both p33 and p70 resulted in vacuolated cells.

52 nique adenosine diphosphate-ribosylating and vacuolating Community Acquired Respiratory Distress Synd

53 cells in the THLs had abundant eosinophilic vacuolated cytoplasm and pleomorphic nuclei, and express

54 ed by cell shrinkage, substratum detachment, vacuolated cytoplasm, and DNA degradation.

55 entified 10 mutant VacA proteins that lacked vacuolating cytotoxic activity when added to HeLa cells.

56 VacA and that both domains are required for vacuolating cytotoxic activity.

57 alidate a simple PCR-based system for typing vacuolating cytotoxin (vacA) alleles of H. pylori and sh

58 enetic diversity is particularly striking in vacuolating cytotoxin (vacA) alleles.

59 The Helicobacter pylori vacuolating cytotoxin (VacA) binds and enters mammalian

60 er pylori have a 12-residue extension to the vacuolating cytotoxin (VacA) compared with cytotoxic typ

61 At early time points, vacuolating cytotoxin (VacA) constituted a major extrace

62 gy that occur following cell exposure to the vacuolating cytotoxin (VacA) from Helicobacter pylori.

63 hogenicity island and contained a degenerate vacuolating cytotoxin (vacA) gene.

64 The Helicobacter pylori vacuolating cytotoxin (VacA) induces degenerative vacuol

65 The Helicobacter pylori vacuolating cytotoxin (VacA) induces the degenerative va

66 Previous studies have shown that H. pylori vacuolating cytotoxin (VacA) inhibits proliferation of g

67 Helicobacter pylori vacuolating cytotoxin (VacA) is a secreted protein that

68 The Helicobacter pylori toxin vacuolating cytotoxin (VacA) promotes gastric colonizati

69 The H. pylori vacuolating cytotoxin (VacA) recently has been shown to

70 Helicobacter pylori secretes an 88-kDa vacuolating cytotoxin (VacA) that may contribute to the

71 he amino terminus of the Helicobacter pylori vacuolating cytotoxin (VacA) was investigated by analyzi

72 with acid activation of Helicobacter pylori vacuolating cytotoxin (VacA).

73 acteria produce two main cytotoxic proteins: Vacuolating cytotoxin A (VacA) and Cytotoxin-Associated

74 The vacuolating cytotoxin A (VacA) is both essential and suf

75 r example, in-vitro experiments showing that vacuolating cytotoxin A affect the regulation of T or B

76 ation upon H. pylori infection, and identify vacuolating cytotoxin A and cag pathogenicity island as

77 omplished through many mechanisms, including vacuolating cytotoxin A and CagA activities, and may be

78 H. pylori vacuolating cytotoxin A and cytotoxin-associated gene A

79 studies have investigated the interaction of vacuolating cytotoxin A or cytotoxin-associated gene A w

80 tension to type s1 vacA completely abolishes vacuolating cytotoxin activity but has no effect on VacA

81 ssociation between neutrophil activation and vacuolating cytotoxin activity was also investigated.

82 and function), neutral red uptake (to detect vacuolating cytotoxin activity), and adhesion assays.

83 uently identified in H. pylori isolates with vacuolating cytotoxin activity.

84 s and i regions are the key determinants of vacuolating cytotoxin activity.

85 ed within oligomeric structures and retained vacuolating cytotoxin activity.

86 lori from the West have linked production of vacuolating cytotoxin and a particular signal sequence (

87 elated to H. pylori infection, including the vacuolating cytotoxin and the cag pathogenicity island.

88 Lipopolysaccharide, urease, and vacuolating cytotoxin are among the factors that allow H

89 tructural organization and processing of the vacuolating cytotoxin are characteristic of a family of

90 These results indicate that Sat, a vacuolating cytotoxin expressed by uropathogenic E. coli

91 omenon, we analyzed the transcription of the vacuolating cytotoxin gene (vacA) in eight Tox+ strains

92 Alleles of the vacuolating cytotoxin gene (vacA) of Helicobacter pylori

93 cagA gene and in vacAm1 type alleles of the vacuolating cytotoxin gene (vacA) of strains from native

94 n associated gene (cagA), the cagA-EPIYA and vacuolating cytotoxin gene (vacA) were typed by PCR and

95 potentially toxigenic vacAs1 alleles of the vacuolating cytotoxin gene (vacA), independent of diseas

96 The vacuolating cytotoxin gene of Helicobacter pylori, vacA,

97 the vaccine group acquired mutations in the vacuolating cytotoxin gene vacA, resulting in loss of va

98 irulence gene, cagA, and active forms of the vacuolating cytotoxin gene, vacA, are major determinants

99 The Helicobacter pylori vacuolating cytotoxin gene, vacA, is naturally polymorph

100 Strains lacking a TPM were typically vacuolating cytotoxin genotype vacA m2.

101 These results suggest that the H. pylori vacuolating cytotoxin interferes with EGF-activated sign

102 H. pylori strains that express the vacuolating cytotoxin or the outer membrane protein OipA

103 he gamma-glutamyl-transpeptidase GGT and the vacuolating cytotoxin VacA, are required and sufficient

104 he gamma-glutamyl transpeptidase GGT and the vacuolating cytotoxin VacA, contribute critically and no

105 nd exclusively through its pro-apoptotic and vacuolating cytotoxin VacA.

106 ase in humans, secretes a toxin called VacA (vacuolating cytotoxin) into culture supernatants.

107 he cag PAI had no effect on synthesis of the vacuolating cytotoxin, but this deletion and several cag

108 identified from H. pylori strains, known as vacuolating cytotoxin, induces vacuole formation in euka

109 polysaccharide); and (3) damage host tissue (vacuolating cytotoxin, protease, CagA-related factors, i

110 The vacuolating cytotoxin, VacA, is an important virulence f

111 effects of H. pylori MV with and without the vacuolating cytotoxin, VacA, which inhibits human T cell

112 eceptor type Z were not damaged by H. pylori vacuolating cytotoxin.

113 tion, aging lynx1 null mutant mice exhibit a vacuolating degeneration that is exacerbated by nicotine

114 deeply into the gradient developed bulbous, vacuolated endings that looked remarkably similar to dys

115 striatum and motor cortex areas included 1) vacuolated endothelial cells containing large autophagos

116 stration resulted in neutrophil margination, vacuolated endothelium, intra-alveolar hemorrhage and ma

117 e show that spe-5 mutants contain defective, vacuolated FB-MOs and usually arrest spermatogenesis at

118 IBM vacuolated fibers also contain accumulations of several

119 s been shown to accumulate abnormally in the vacuolated fibers and to localize to amyloid-like fibril

120 ls invade non-vacuolated fibers, whereas the vacuolated fibers are not invaded by T cells, implying t

121 ereditary inclusion body myopathy, only rare vacuolated fibers had immunoreactive inclusions, whereas

122 y myositis the inflammatory cells invade non-vacuolated fibers, whereas the vacuolated fibers are not

123 wed a focal increase of TIA1 in atrophic and vacuolated fibers.

124 We found that the vacuolated giant cells had multiple signs of organelle d

125 We found similar vacuolated giant cells in human tuber specimens.

126 rt early in sexual development, resulting in vacuolated, highly disarranged, and disintegrating paras

127 et cells, and the anterior cortical lens was vacuolated in Klf4CN mice.

128 atives including Abeta, and phospho-tau into vacuolated inclusions is an early pathogenic event.

129 The vacuolated lens (vl) mouse mutant causes congenital cata

130 nsgene-the cultures were dominated by highly vacuolated macrophages.

131 signs include gliosis, dystrophic neurites, vacuolated mitochondria, and accumulation of soluble hyp

132 ibire(ts1) contain terminals with widespread vacuolated mitochondria, reduced numbers of vesicles and

133 lta(346-347) also co-immunoprecipitated from vacuolated monolayers, supporting the hypothesis that th

134 Between 80% and 90% of IBM vacuolated muscle fibers contained well-defined ERK-immu

135 inclusion body myositis muscle biopsies are vacuolated muscle fibers containing intracellular amyloi

136 monstrates mononuclear cell inflammation and vacuolated muscle fibers containing paired helical filam

137 le diseases, characterized pathologically by vacuolated muscle fibers containing paired helical filam

138 Seventy to eighty percent of the vacuolated muscle fibers of both s-IBM and autosomal-rec

139 Vacuolated muscle fibers of both s-IBM and the h-IBMs co

140 As in Alzheimer-disease (AD) brain, vacuolated muscle fibers of inclusion-body myositis (IBM

141 Approximately 80 to 90% of the vacuolated muscle fibers of sporadic inclusion body myos

142 loid and congophilic amyloid deposits within vacuolated muscle fibers.

143 le diseases, characterized pathologically by vacuolated muscle fibres containing paired helical filam

144 Approximately 75% of the vacuolated muscle fibres in all recessive and dominant i

145 ion and 15-18-nm tubulo-filaments within the vacuolated muscle fibres.

146 a lysosomal storage disease (ie, clusters of vacuolated myocytes) but also typical of HCM due to sarc

147 sies, but not in non-myopathic muscle or non-vacuolated myopathic controls.

148 complement has been demonstrated is X-linked vacuolated myopathy.

149 ially uniform cells and encase the inflating vacuolated notochord cells.

150 pathology of white matter tracts comprising vacuolated oligodendrocytes and intramyelinic edema.

151 e only phakic individual exhibited white and vacuolated opacities in the cortical region.

152 Highly vacuolated or foamy macrophages are a distinct character

153 In electron micrographs, the AC is a highly vacuolated part of the cytoplasm.

154 e capacity while maintaining the cytoplasmic vacuolated phenotype.

155 region of s2/m2 vacA does not cause the non-vacuolating phenotype, but if VacA is unblocked, it conf

156 Vacuolated remnant cells were seen throughout the monola

157 ytokinesis was observed in a wide variety of vacuolate shoot cells and in some small root cells, impl

158 While pslA- cells produce mature, vacuolated stalk cells during multicellular development,

159 from amoebae to either refractile spores or vacuolated stalk cells.

160 tiation of hyphal growth, to produce highly "vacuolated" subapical compartments.

161 ggs and embryos, can be interpreted as giant vacuolate sulphur bacteria.

162 ion have recently been discovered within the vacuolate sulphur-oxidizing bacteria.

163 This protein, VCaB45, is enriched in highly vacuolate tissues and is located within the lumen of vac

164 large oligomeric structures and that lacked vacuolating toxic activity for HeLa cells.

165 that bacterial virulence factors such as the vacuolating toxin (VacA) and the cytotoxin-associated ge

166 icates that the secreted Helicobacter pylori vacuolating toxin (VacA) inhibits the activation of T ce

167 in the process by which Helicobacter pylori vacuolating toxin (VacA) intoxicates cells.

168 Helicobacter pylori vacuolating toxin (VacA) is a secreted toxin that is rep

169 Vacuolating toxin (VacA) is crucial in facilitating the

170 was to investigate the capacity of H. pylori vacuolating toxin (VacA) to induce gastric epithelial ce

171 ri secretes a pore-forming exotoxin known as vacuolating toxin (VacA).

172 les in pathogenesis have been recognized for vacuolating toxin A (VacA) and urease, H. pylori membran

173 ydrophobic region that are known to abrogate vacuolating toxin activity.

174 n M. pneumoniae-derived ADP-ribosylating and vacuolating toxin called community-acquired respiratory

175 ently, we identified an ADP-ribosylating and vacuolating toxin of M. pneumoniae, designated Community

176 ), hra (heat-resistant agglutinin), and vat (vacuolating toxin) were significantly associated with ba

177 ence genes, including pap (P fimbriae), vat (vacuolating toxin), kpsM II (group 2 capsule), ibeA (inv

178 on of the genes involved in acidic survival, vacuolating toxin, cag-pathogenicity island, motility, a

179 first direct evidence that alpha-toxin is a vacuolating toxin.

180 related variants of the polyomavirus simian vacuolating virus 40 (SV40) have differing host target r

181 more effective inhibitor of in vitro simian vacuolating virus 40 DNA replication system than that of

182 s a key difference between MCV LT and simian vacuolating virus 40 LT, which activates a DDR but inhib

183 Uro-AR(-/y) mice with the transgene, simian vacuolating virus 40 T (SV40T), in the urothelium (Uro-S

184 in primate polyomaviruses, including simian vacuolating virus 40, BKV, and JCV.

185 s: JC virus (JCV), BK virus (BKV) and Simian Vacuolating virus-40.

186 th, which occurred after cells became highly vacuolated, was manifest by an abrupt loss of plasma mem

187 acidic LE/LYs, and some cells become highly vacuolated, with enlarged Rab7-positive endosomes.